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Antitumor effect of transcatheter arterial embolization in combination with sorafenib in a rabbit VX2 liver tumor model
No full text科学研究費補助金研究成果報告書研究種目: 若手研究(B)研究期間: 2013～2014課題番号: 25861084研究代表者: 友澤 裕樹（滋賀医科大学・医学部・助教
A guide for treatment of psychiatric symptoms in cancer patients
No full text科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2011～2014課題番号: 23590876研究代表者: 森田 幸代（滋賀医科大学・医学部・特任講師）研究分担者: 山田 尚登（滋賀医科大学・医学部・教授）研究分担者: 高橋 正洋（滋賀医科大学・医学部・講師）Questionnaire about mental symptom of cancer patients was done to medical staff in Shiga Prefecture. On the basis of the results, the treatment of derilium was was considered. We have found the effect of intravenous administration combination of a small amount of midazolam and HAL from the retrospective study. In addition, from the investigation for palliative care team request patient, HAL intravenous administration was done before team intervention, further HAL intravenous administration was successful about 70 percent against delirium cancer patients and initial dose recommended amount is 5㎎ / day. Further than only a few lectures to the staff of the psychiatric symptoms in multiple cancer hospitals in Shiga Prefecture, in the hospital in which the continuous direct guidance to the staff, the improvements to the psychiatric symptoms (especially delirium early response) reduced corresponding number of palliative care team by about 40%.滋賀県下でがん患者の精神症状対応に関する医療者アンケートを施行し、その結果に基づいて、せん妄の対応を検討した。後ろ向き調査から少量のミダゾラムとHALの静脈内投与併用例の効果を見出した。また、緩和ケアチーム依頼患者について調査から、HAL静脈内投与はチーム介入以前であり、さらにHAL静脈内投与がせん妄がん患者に対して約70％奏功し、初期投与推奨量は5㎎/日であることを見出した。さらに滋賀県の複数のがん拠点病院で精神症状についての数回のスタッフへの講義のみよりも、スタッフへの継続的直接指導をした病院で、精神症状への対応改善(特にせん妄早期対応)により緩和ケアチーム対応数が約40％減少した
Risk factors for type 2 diabetes among individuals with impaired insulin secretion
No full text科学研究費補助金研究成果報告書研究種目: 研究活動スタート支援研究期間: 2013～2014課題番号: 25882019研究代表者: 森本 明子（滋賀医科大学・医学部・講師）人間ドック受診者を対象とした本研究より、インスリン分泌不全者はより軽度のインスリン抵抗性の増加で2型糖尿病を発症することが明らかになった。また、インスリン分泌不全者は、より少ないメタボリックファクターの集積で2型糖尿病を発症した。そのため、インスリン分泌能の低い日本人においては、軽度のインスリン抵抗性増加や少ないメタボリックファクターの集積にも注意する必要があるといえる。インスリン分泌能を評価し、分泌不全型、抵抗性型に合わせた個別的な保健指導の実施が望まれる。This study included individuals without diabetes at baseline who underwent comprehensive medical check-ups at Saku Central Hospital. Moderate and large increases in homeostasis model assessment of insulin resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes regardless of baseline HOMA-IR values among individuals with impaired insulin secretion in this Japanese population. Moreover, metabolic factors had a strong impact on the development of type 2 diabetes among individuals with impaired insulin secretion, compared with individuals with insulin resistance
Exploratory investigation of circadian clock mediated treatment of affective disorder
No full text科学研究費補助金研究成果報告書研究種目: 研究活動スタート支援研究期間: 2013～2014研究代表者: 松尾 雅博（滋賀医科大学・医学部・講師）うつ病を代表とする気分障害は、年間有病率が3%に至るとする報告があるなど、非常に頻繁に見られる精神疾患である。うつ病治療に一般的に用いられている薬物療法は、治療効果発言に２週間程度かかる一方で、非薬物療法は、薬物療法よりも効果出現が早いことが知られている。本研究では、これまで明らかにすることが困難であった断眠療法・光療法の効果とその時刻依存性について、分子レベルから明らかにすることを目的とした。この結果、生体時計の位相評価法を確立するとともに、分子メカニズム解明基盤のための誘導遺伝子定量計測系を確立した。Affective disorders, including depression, are reported to affect as much as 3% of general population. Although affective disorders are quite common disease nowadays, pharmacotherapy that is used most often used to treat the disease, requires more than 2 weeks to induce first improving effects on the disease. In contrary to conventional pharmacotherapy, interventions focusing on the sleep/wake cycle are used if not common as pharmacotherapy. These include sleep deprivation therapy, light therapy, and they are known to improve disease faster than 2 weeks. In this study, we focused on the anti-depression mechanism of these sleep/wake cycle mediated depression therapy. By examining the molecular mechanisms of therapeutic effects and their time-dependency, it is expected to pave the way to develop more sophisticated therapy of depression
さざなみ No.49 (2015.10)
No full text「大人のビブリオバトル」を開催しました図書展示「若鮎祭講演会企画」実施中電子リソーストライアル実施中男女共同参画推進（第8回）展示・貸出図書館バイトのおすすめ本 Vol.6若鮎祭でブックバザールを開催しまし
ニッチュウ ランダム ニョウ 6カイブン ワ 7ニチ 24ジカン ニョウ トノ タイヒ ニ オイテ ニチジョウ ノ ナトリウム カリウムヒ オ スイテイスル ウエ デ ジュウブンデ アル
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第739号 平成27年9月9日Hypertens Res. 2014, 37(8), p.765-71
タウロコールサン ノ ジゾクテキ バクロ ニ ヨリ ケッカン シンセイ ガ コウシンサレ サイボウシ ガ ゲンショウシ ショクドウ ヘンペイ ジョウヒガン ノ シンテン ガ オコル
No full text学位授与機関： 滋賀医科大学 博士（医学）乙第419号 平成27年9月9日PLoS One. 2014, 14;9(2), e88831
Association between Pulse Wave Velocity and Coronary Artery Calcification in Japanese men the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
No full text博士（医学）滋賀医科大
ニュウボウ Pagetビョウ ノ ロクレイ
No full textPaget’s disease of the breast shows eczematous changes of the nipple-areolar complex, and characteristichistopathological feature of this condition is the presence of Paget’s cell in the keratinizing epithelium of the nipple, whichhas large and pale cytoplasm and round or oval shape with large nuclei and prominent nucleoli. Paget’s disease of the breastis limited to non-invasive or micro-invasive, and has a favorable prognosis. Paget’s disease with invasive lesions isclassified as Pagetoid cancer. We report six cases of Paget’s disease of the breast. Four cases were performed mastectomyand two cases were performed breast-conserving surgery. Four cases were performed sentinel lymph node biopsy. Skinbiopsy and cytology, and Magnetic resonance imaging (MRI) were useful for the diagnosis of Paget’s disease. In particular,MRI detected the extent of intraductal lesions and identified otherwise disease. MRI for patients with Paget’s disease wasuseful to distinguish it from Pagetoid cancer and determine the extent of surgical treatment
ハイ シュヨウ ニ タイスル タイカンブ テイイ ホウシャセン チリョウ ノ チリョウ セイセキ
No full textStereotactic body radiation therapy (SBRT) for lung tumors has been performed in our hospital from February 2005. We discussed the treatment outcome and the future treatment subjects of SBRT for lung tumors. In 40 cases (43 lesions) confirmed survival after SBRT for lung tumors in our hospital from Feb 2005 to Jul 2015, the average follow-up duration and the over all survival at 3 years was 26.6
months and 68.1 %, respectively. In addition, local recurrence is studied by 29 cases (31 lesions) taken follow-up for computed tomography (CT) after SBRT. Local recurrence was observed in 5 cases (5 lesions) at the average of 21.0 months after SBRT. Local recurrence free survival was the average of 72.5 months. SBRT cases to lung tumors in our hospital included a fewer candidate for urgery, but were mostly inoperable. In view of this fact, treatment outcome in our hospital was comparable to the previous published reports. On local recurrence group and the local control group, we compared the changes of the appearance over or around the original tumors on follow-up CT, and measured the ratio of maximum and minimum diameter of the appearance on follow-up CT. When this ratio suddenly decreased or approached to the nearby value 1 coincided roughly with the diagnosis of local recurrence. For this reason, the variation in the ratio of maximum and minimum diameter was considered to be an aid to suggest local recurrence. By accumulating SBRT cases for lung tumors, it is necessary to evaluate the correlation with local recurrence and this ratio trend