Shiga University of Medical Science Hospital
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ストレス システム リロン オ モチイタ サンジョク ソウキ ノ ハハオヤ ノ ココロ ノ ケンコウ ヒョウカ
No full text学位授与機関： 滋賀医科大学 修士（看護学）第196号 平成27年9月16
ゲンリョウ ゲカ チーム ニ ヨル フククウキョウカ スリーブジョウ イ セツジョジュツゴ ノ コウカ フリョウグン ノ ケントウ
No full textBackground: The bariatric surgery is the most efficacious therapy for morbid obesity today. We have performed bariatric surgeryand have taken a multidisciplinary approach since 2008. The excess weight loss (%EWL) at 1 year after laparoscopic sleeve gastrectomy(LSG) at our institute is 73%, which is better than that of LSGs at the Fourth International Consensus Summit on Sleeve Gastrectomy. On theother hand, there are some patients with less effect after LSG in our series. We investigated the causes of less effectiveness of weight lossafter LSG with a multidisciplinary approach. Methods: The twenty patients were performed LSG at our institute between October 2008 andMay 2014 and followed up with nutritional guidance more than 1 year. Method 1: The shape of a sleeve after LSG was classified accordingto four types of a shape, and evaluated weight loss effect of each type. Method 2: The twenty patients were divided into two groups: Betterweight loss group, which %EWL was more than 50%, and Less weight loss group, which %EWL was less than 50%. Lifestyles werecompared between the two groups. Method 3: Depression before and after LSG were evaluated with Beck Depression Inventory-II (BDI-II).Results: There was no difference in weight loss among types of sleeve shape. The amount of taking calories 1 year after LSG and %EWL 3months after LSG were different between the two groups. Depression was not severe in two groups. Conclusions: We describe ourmultidisciplinary approach for less effectiveness of weight loss after LSG for morbid obesity. The amount of taking calories 1 year after LSGwas more and %EWL 3 months after LSG was less in Less weight loss group than in Better weight loss group
シガ イカ ダイガク イガクブ フゾク ビョウイン ニ オケル コウクウ ケア ノ ゲンジョウ ト テンボウ
No full textPerioperative oral cavity function management is highlighted in the remuneration for dental treatment revision of 2012，and the importance of oral care has been recognized in the Great Society.
In 2009，started with the institution of an individualized dental support system in Shiga University of Medical Science Hospital．The system involved intraoral management of patients before and after treatment and nurse support for specialized daily oral care in difficult patients．The number of patients requesting oral care has increased year by year，and was more than double in 2013 from100 patients in 2009．
We aim for conscious improvement of oral care for everyone, not just by the nurse but also by the team．
We have organized study sessions and provided instructions to patients with hematogenous disease 2012 regarding the importance and methods of oral care．
In addition，we have operated an oral management system specialized for the perioperative
period since November，2014．We hope to promote the importance of a comprehensive dental support system and contribute to the improvement of patient’s quality of life through this system and future improvements
Screen for novel therapeutic target of prostate cancer patient using drosophila as model
No full text科学研究費補助金研究成果報告書研究種目: 基盤研究(B)研究期間: 2012～2014課題番号: 24390373研究代表者: 河内 明宏（滋賀医科大学・医学部・教授）In this study, our objective is to clarify the function of PAX2 in metastatic prostate cancer using prostate cancer cell lines and to identify novel regulators of human prostate cancer cell invasion and growth using the Drosophila accessory gland as a model. In human prostate cancers, PAX2 was hyper-expressed in metastatic cancers, but was expressed at lower levels in non-metastatic cancers. We identified the AR and HGF as target genes of PAX2 by DNA microarray analysis. PAX2 associated with the promoter of AR and HGF and regulated the expression level of AR and HGF through DNA demethylation or histone acetylation. We identified several novel candidate genes regulating invasion and cell growth of secondary cells in drosophila. We found that the human homologues of three of the Drosophila candidate genes regulated invasion and growth of human prostate cancer cells.前立腺癌の増悪メカニズムの解明および新規治療標的の同定を目的にPAX2の前立腺癌における機能解析、ショウジョウバエを用いた前立腺癌増悪因子のスクリーニングを行った。 その成果として(1) 正常部位、原発巣と比較して転移巣においてPAX2が高発現することが判明し、PAX2は転移促進に機能する可能性が考えられた。(2) マイクロアレイ解析の結果、PAX2の標的遺伝子としてAR、HGFを同定した。(3)同定した因子のヒトホモログがヒト前立腺癌細胞の増殖・浸潤を制御することが判明した
セイシンカ チョウキ ニュウイン カンジャカン ノ レンアイ カンケイ ニ トモナウ セイテキ コウドウ ニ タイスル カンゴシ ノ ニンシキ
No full text学位授与機関： 滋賀医科大学 修士（看護学）第197号 平成27年9月16
Establishment of whole ovarian frozen preservation of Macaca
No full text科学研究費補助金研究成果報告書研究種目: 挑戦的萌芽研究研究期間: 2012～2014課題番号: 24659729研究代表者: 竹林 明枝（滋賀医科大学・医学部・助教）We performed experiment of mouse ovaries before beginning experiment of macaca ovaries. To make a study of thawing condition, we froze mouse ovaries and performed immunohistochemistry of frozen mouse ovaries. Then, we froze macaca ovaries with CAS. The ovaries are kept in liquid nitrogen. Now we adjust a schedule for autogenous transplantation.カニクイザルの卵巣を凍結融解する前に、マウスの卵巣を摘出して実験をした。マウスの卵巣組織を凍結した後、融解条件の検討のために免疫組織染色をして至適条件の検討を行った。その後、カニクイザル七頭の卵巣をCASを用いて凍結した。現在、液体窒素の中に凍結保存されており、今後、自家移植にむけて調整を行っている