Peertechz
Not a member yet
4919 research outputs found
Sort by
The amazing systemic structure of Mathematics
Get PDFStarting with the works of Ludwig von Bertalanffy, the general systems theory went from being applied to biological systems to identifying systemic structures in different natural, technological and social phenomena, even systemic structures are appreciated in different branches of science.</p
A tractroid realization of a 2d black hole vacuum
Get PDFThe two-dimensional black hole vacuum obtained from a spatial slice of the BTZ black hole is mapped explicitly to a tractroid surface minus a bounding circle.</p
Combined treatment with vemurafenib and cobimetinib in Langerhans cell histiocytosis and Erdheim-Chester disease overlap syndrome: A case Report
No full textHistiocytoses are clonal disorders diseases derived from the monocyte-macrophage lineage. The Erdheim–Chester Disease (ECD) and Langerhans Cell Histiocytosis (LCH) may occur in association with overlapping clinical, histopathological and molecular features, harboring somatic MAP2K1 mutations in more than 50% of patients. BRAF and MEK inhibitors have shown to be efficacious in ECD and LCH, including responses in patients with CNS involvement.This case report describes a 59-year-old woman who presented with vemurafenib-refractory ECD/LCH overlap syndrome treated with vemurafenib/cobimetinib dual therapy, with rapidly progressing neurological involvement after its initiation.Although targeted therapy plays a crucial role in the treatment of histiocytosis, only anecdotal clinical cases treated with dual therapy have been reported in ECD or LCH and collaborative trials are needed to improve outcomes.</p
Eco-evolutionary dynamics of intergenomic epistatic QTLs under slight and hard multilevel selections in community genetics
No full textEco-evolutionary community genetics refers to the study of population genetics at multispecies levels since a single species evolves genetically through interactions with other species. The aim of this paper is dynamical modeling of interspecific quantitative trait loci (QTL) under slight and hard multilevel selection to investigate eco-evolutionary genetic relationships among QTL of multispecies. It was found that the simplex explained the intergenomic epistatic QTL (IEQ) dynamics in a discrete-time model according to Wright’s manifold. Besides, the generalized gradient system on the simplex demonstrated the IEQ dynamics in a continuous-time model. The outcomes of slight and hard multilevel selection on the expressions of IEQ in species were explained by the gradient operator of the mean multilevel fitness. IEQ analysis was integrated into community genetics according to Lande’s assumptions, so for slight multilevel selection, the geometric average of the mean multilevel fitness specified Wright’s idea of adaptive topography. The dynamical system for phenotypic eco-evolution under a hard multilevel selection gradient was studied and the relative mean multilevel fitness of two species was estimated. </p
Perrotta Autism Spectrum Disorders Questionnaire for infants and young adolescents (PASD-Qy)
No full textBuilding on the concept of “Autism Spectrum Disorder”, as framed in the DSM-V, and taking up studies on the new etiological theory (PETA) focusing on the developmental model of the neurobiological matrix (PEMA) and related questionnaire (PTAS-Qa), in this research a new questionnaire is proposed that can focus on the presence or absence of 4 functional areas (interactional and movement, language, and communication, ideational and social, emotional and behavioral) and 25 type-deficit traits, grading the impairment according to a precise 5-level severity scale (PASSy). The new questionnaire (Perrotta Autism Spectrum Disorders Questionnaire for infants and young adolescents, PASD-Qy), is composed of 25 items, on a binary S/N scale and based on a total score of 10/10, for a population between 18 months and < 16 years, thus offering a structured view of the individual’s cognitive organization, avoiding diagnostic fragmentations that might be inconsistent with the nosographic framework. By exemplifying the category, it is then possible to more easily frame the patient, who would thus be analyzed from a strictly functional point of view, also facilitating the preparation of therapeutic interventions, according to models already known in the literature (e.g., ABA), exactly as for the questionnaire dedicated to late adolescents and adults.</p
Nutritional, phytochemical and biochemical composition of (Moringa Oleifera) raw seed, seed cake, and leaf meal for Aquaculture feeds
Get PDFThe study was conducted on the nutritional and biochemical composition of the Moringa oleifera plant (Seed, Seed Cake, and leaf meal) at two different locations. The proximate and mineral composition were carried out at the Central Laboratory of the National Institute for Fresh-water Fisheries Research (NIFFR), New Bussa, Niger State, while the Biochemical and phytochemical analyses were conducted at Usmanu Danfodiyo University, Sokoto. The result for the proximate composition of the M. oleifera plant revealed that the moisture content for the M. oleifera leaves sample (8.88 ± 0.39%) was significantly higher when compared with the M. oleifera seed (4.81 ± 0.99%) and seed cake (7.43 ± 0.24%) while the seed having the lowest moisture content (4.81 ± 0.99). The crude protein content for M. oleifera seed cake (53.23 ± 0.42) was significantly (p<0.05) higher than that of M. oleifera seed (40.66 ± 0.34%) and the leaves meal had the lowest crude protein (27.26 ± 0.55). The ash contents for M. oleifera leaves meal (10.61 ± 0.14%) were significantly higher compared with M. oleifera seed cake (8.34 ± 0.07%), and the seed had the lowest ash content (3.44 ± 0.14%). The lipid content of M. oleifera leaves meal (17.17 ± 0.65%) was significantly higher when compared with M. oleifera seed, and the seed cake had the lowest lipid content (13.51 ± 1.23). The fiber content for M. oleifera seed (17.08 ± 0.61) was significantly higher when compared with M. oleifera leaves meal (8.91 ± 0.33%), and the seed has the lowest fiber content (2.48 ± 0.16). The NFE for M. oleifera leaves meal (27.17 ± 0,45%) was significantly higher when compared with M. oleifera seed (18.24 ± 0.94), and the seed cake had the least NFE content (15.02 ± 1.42%). The result of mineral composition showed that the plant contained a higher amount of some minerals; This includes potassium, calcium sodium, magnesium, and manganese. For the amino acid composition, it clearly stated that the plant contains some essential and non-essential amino acids. The results of the phytochemical test revealed that all the plant parts analyzed contain anti-nutritional factors. Further research should be carried out to test the nutritional and biochemical values of Moringa oleifera seed cake and leaf meal using culture fish species.</p
Speed breeding to accelerate crop improvement
Get PDFGlobal food security has become a major issue as the human population grows and the environment changes, with the current rate of improvement of several important crops inadequate to meet future demand. Crop plants have extended generation times, which contributes to the slow rate of progress. However, speed breeding has revolutionized the entire world by reducing generation time and speeding up breeding and research programs to improve crop varieties. In the absence of an integrated pre-breeding program, breeding new and high-performing cultivars with market-preferred traits can take more than ten years. After the first cross with parental genotypes, a large amount of time, space, and resources are committed to the selection and genetic advancement stages during the early stages of breeding. Speed breeding has the ability to shorten the time it takes to develop, market, and commercialize cultivars. Crop improvement in the face of a fast-changing environment and an ever-increasing human population is a major concern for scientists around the world. Current crop enhancement projects are progressing at a rate that is insufficient to meet food demand. Crop redesign is urgently needed for climate resilience, as well as long-term yield and nutrition. Crop progress is slowed significantly by the long generation time required by crop plants during the breeding process. Speed breeding is now being used on a large scale to shorten generation time and support multiple crop generations per year as a solution in this approach. Researchers are now using an integrated approach to improve breeding efficiency, combining speed breeding with current plant breeding and genetic engineering methods. Speed breeding is a promising approach for achieving nutritional security and sustainable agriculture by shortening breeding cycles for food and industrial crop enhancement. Speed breeding is a methodology that allows plant breeders to improve crop production by adjusting temperature, light duration, and intensity to boost plant development. It uses an artificial source of light, which is kept on continuously, to activate the photosynthetic process, which leads to growth and reproduction much earlier than normal. This will assist in meeting the demands of the future’s rising population. This can be accomplished using a variety of technologies, including genotyping, marker-assisted selection, high throughput phenotyping; gene editing, genomic selection, and re-domestication, all of which can be combined with speed breeding to allow plant breeders to keep up with a changing climate and growing human population.</p
Review on the role of soil and water conservation practices on soil properties improvement in Ethiopia
Get PDFSoil erosion is one of several major deterioration processes which result in soil degradation and declining agricultural productivity in Ethiopia due to the dense population, high livestock density, and intensive crop production in the area. Soil and water conservation practices are one of the mechanisms used to reduce erosion and associated nutrient loss, reducing the risk of production. Therefore, the review focuses on the importance of soil and water conservation practices on soil properties in Ethiopia. Several studies conducted in various parts of the country showed that the implemented soil bund reduced annual runoff and soil loss at different rates. Soil and water conservation have improved the soil Physico-chemical properties on conserved cropland (BD, SMC, pH, CEC, av. K, av. P, SOC, and TN) compared to the adjacent cropland without soil and water conservation measures. Soil and water conservation, reduce the removal of fertile topsoil and improves soil moisture, which favors crop growth as a result grain yield of the crops was increased. In general, the use of soil and water conservation strategies had clearly shown a positive impact on soil physico-chemical properties and crop yields. Therefore, to reduce soil erosion sustainably, different soil and water conservation options should be introduced and used considering agroecology, socio-economic profile, and climatic condition of the intervention area.</p
Optimization of NH4NO3 in Phaseolus vulgaris with Bacillus thuringiensis and Micromonospora echinospora plus crude extract of carbon nanoparticles
No full textNitrogenous fertilizer (NF) such as NH4NO3 is required to maintain the healthy growth of Phaseolus vulgaris, but when NF is applied indiscriminately, it causes hyperfertilization of the soil. One option is to reduce NH4NO3 and then optimize in P. vulgaris seed with s Bacillus thuringiensis and Micromonospora echinospora genus and species of endophytic bacteria plus a crude carbon nanoparticle extract (CENC). Under greenhouse conditions, P. vulgaris seeds were inoculated with B. thuringiensis and M. echinospora, then applied a CENC and fed at 50% NH4NO3, the response variables were germination and seedling phenology/biomass. All numerical data of the experimental were validated by ANOVA/Tukey (p < 0.05). The results showed a healthy growth of P. vulgaris with B. thuringiensis and M. echinospora at 50% NH4NO3 plus 20 ppm of CENC according to the percentage of germination, phenology and seedling biomass, including all numerical values have a statistical difference compared to those registered in P. vulgaris without B. thuringiensis and M. echinospora, at 100% NH4NO3, neither CENC nor relative control (CR). The positive effect of B. thuringiensis and M. echinospora on P. vulgaris at 50% NH4NO3 was enhanced by CENC to maximize the optimization of NF without loss of soil fertility or risk of environmental contamination. </p
Review of bacteriophage and its applications
No full textThe most prevalent and ubiquitous organisms in the world are bacteria-killing viruses called bacteriophages. The aim of this paper is to highlight some application areas of bacteriophages. There are both virulent and temperate bacteriophages in the environment, but only virulent bacteriophages are used for treatment, known as phage therapy. Since their discovery, bacteriophages have been considered a vital weapon to fight human and animal illnesses of bacterial origin. Currently, the emergence of growing microbial resistance to antibiotics and attention to bacteriophage use in treatment has all but grown up again. Correspondingly, the applications of bacteriophages for biocontrol purposes have become a remarkable opportunity in a number of fields, including farms and food production. Despite their treatment effects, bacteriophages also maintain a vital relationship with their hosts through moderating microbial populations and promoting their evolution by horizontal gene transfer. Additionally, they serve as vehicles for the transfer of vaccinations, the detection of dangerous microorganisms and systems for displaying proteins and antibodies. Bacteriophages are a varied collection of viruses that are simple to handle, making them suitable for use in treatments and biotechnology research. Hence, the expansion of various phage companies for phage production and the use of phage cocktails for the treatment of various bacterial diseases at different stages is recommended.</p