RocScholar (Rochester Regional Health)
Not a member yet
3788 research outputs found
Sort by
P-1675. BioFire Pneumonia Panel: An Evolving Asset in the Pursuit of Diagnostic Stewardship
No full textComparative safety of futibatinib vs pemigatinib in metastatic cholangiocarcinoma: FAERS-based analysis
No full textP-560. The Genomic Epidemiology of Fulminant Streptococcus pyogenes Infections in Rochester, NY: Why Community Surveillance Matters
No full textHRS/ACC scientific statement: Guiding principles on the performance of intracardiac ablation procedures in ambulatory surgical centers
No full textAmbulatory surgical centers (ASC) in the United States have emerged as an innovative model in health care delivery, potentially serving as a cost-effective, patient-centric alternative to traditional hospital-based care. Supported by Centers for Medicare & Medicaid Services policy expansions, ASCs accommodate procedures across specialties from orthopedics to interventional cardiology. By leveraging technological/procedural advancements and same-day discharge protocols, appropriately selected procedures in the field of cardiac electrophysiology (such as intracardiac ablation procedures and cardiac implantable electronic device implants) could increasingly shift to an ASC setting. This transition aligns with a growing clinical need for arrhythmia interventions and a broader push for operational efficiency. A mounting body of evidence supports the feasibility of performing intracardiac ablation procedures in the ASC setting, with an ongoing need for clinical investigation to track outcomes. Additional barriers to scalable clinical adoption exist, such as regulatory fragmentation, workforce challenges, and heterogeneity in reimbursement. As such, performance of intracardiac ablation procedures in the ASC setting will require collaboration among stakeholders (clinicians, policymakers, payers, and advocacy groups) to investigate and ensure safety and effectiveness, harmonize payment policies, prioritize equitable access, and embed rigorous quality assurance frameworks. By integrating data-driven protocols, clinical excellence, and ethical practices, ASCs could fulfill a defined adjunctive role in a value-based health care system, assuring high-quality care without compromising patient safety while improving access
EEG Pressure Injuries
No full textEEG Pressure Injuries. Paula Ebert, MS, RN, CNS, ACCNS-AG, CCRN, SCRN
Objectives: Understand the clinical impact of pressure injuries related to EEG Understand the implemented changes to reduce pressure injuries related to EEG Understand the multidisciplinary approach to addressing the proble
Smart bioactive hydrogels for myocardial infarction repair: a multifunctional approach integrating stimuli-responsive drug delivery, electroconductivity, and real-time biosensing
No full textBackground: Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, necessitating advanced therapeutic strategies for cardiac repair. Conventional treatments often fail to restore cardiac function effectively, highlighting the need for innovative biomaterials. Smart bioactive hydrogels have emerged as promising candidates due to their ability to provide structural support, controlled drug delivery, electroconductivity, and real-time biosensing capabilities.
Objective: This review explores the multifunctional role of smart bioactive hydrogels in MI repair, focusing on their stimuli-responsive drug delivery, electroconductive properties, and biosensing potential.
Methods: This narrative review synthesized recent advances in multifunctional smart bioactive hydrogels for MI repair, focusing on systems integrating stimuli-responsive drug delivery, electroconductivity, and real-time biosensing. A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published between 2010 and 2025 using relevant keywords. Articles were included if they addressed hydrogel-based platforms featuring at least one of the following: responsive drug release (e.g., pH, temperature, and enzymatic), conductive components (e.g., carbon nanotubes and graphene), or embedded biosensing technologies. Studies limited to conventional hydrogels without multifunctionality were excluded. Relevant data were extracted and thematically categorized by material composition, functional properties, regenerative potential, and translational applicability, with emphasis on preclinical cardiac models. No quantitative synthesis was performed due to heterogeneity across study designs.
Results: Smart bioactive hydrogels have demonstrated significant potential for MI repair by integrating stimuli-responsive drug delivery, electroconductivity, and biosensing within a single therapeutic platform. pH-, ROS-, and enzyme-sensitive systems enable localized, on-demand release of angiogenic factors or cardioprotective drugs, leading to 20-45% infarct size reduction and 1.5-2.3-fold increases in neovascular density in preclinical models. Incorporation of conductive materials such as graphene oxide (GO), polypyrrole, or carbon nanotubes (CNT) has been shown to restore electrical coupling, improve connexin-43 expression, and enhance left ventricular ejection fraction by 8-15%, while narrowing QRS complex duration by ~15 ms in large-animal studies. Emerging biosensing-enabled hydrogels permit real-time monitoring of local biochemical cues, such as pH, oxygen levels, and inflammatory cytokines, maintaining stable signal fidelity for up to 4 weeks without adverse tissue reactions. Advances in 3D/4D bioprinting now allow spatially patterned integration of these functionalities, enabling region-specific therapeutic release and conductivity optimization. Collectively, these multifunctional hydrogels exhibit superior regenerative outcomes compared to conventional scaffolds and hold strong translational promise, although variability in experimental design, lack of standardized endpoints, and limited long-term clinical data remain challenges to widespread adoption.
Conclusion: Smart bioactive hydrogels represent a transformative approach in MI repair by combining structural support with multifunctional properties. Their ability to deliver therapeutics on demand, enhance electroconductivity, and enable real-time biosensing offers new possibilities for precision cardiac medicine
The Last Cigarette Standing - Caring for those Patients who Continue to Smoke in 2025
No full textThe Last Cigarette Standing - Caring for those Patients who Continue to Smoke in 2025. Lorinda Parks, MD, Primary Care Regional Medical Director
Objectives: Tobacco Use remains around 12% in our counties and yet we have significant knowledge of the deleterious health effects from the habit. Quitting smoking has an almost immediate cost benefit to our health systems from a population standpoint. As RRH moves to value based care, primary care needs an invigorated approach from our primary care providers to tackle this outsized health problem. Understand the multifactorial health detriments related to tobacco abuse Comprehend how our population still using cigarettes at RRH will “perform” against their non-smoking peers going into a value based care mode
MMAP-18 Association Between Brain Metastases and Immunosuppression in Lung Cancer - A Retrospective Cohort Study
No full textKnowledge and preventive barriers towards conducting systematic review among undergraduate medical students of Arab countries: A multi country online survey
No full textBACKGROUND: Systematic reviews (SR) provide the highest level of evidence in research. Medical students are encouraged to learn how to conduct SR, yet barriers to engaging in these reviews need to be identified to enhance their implementation. This study aimed to assess the knowledge, practices, and perceived barriers to conducting SR among undergraduate medical students from Arab countries.
METHODS: A cross-sectional study was conducted involving undergraduate medical students from nine Arab countries enrolled in public and private medical schools. Sociodemographic information, as well as data on knowledge and barriers to conducting SR, were collected from participants through an online survey. The level of knowledge regarding SR was measured using a set of questions, with a total score of 19. Adjusted odds ratio (AOR) were used to find the associated factors with good knowledge of SR.
RESULTS: With a response rate of 89.7%, 13,060 participants were enrolled, of whom 58.9% were female and 77.0% were studying at public universities. Additionally, 49.0% were in their clinical years. Approximately 31% had heard about SR, and 3,275 participants (25.1%) had attended training on SR. Overall, only 4.3% of participants demonstrated good knowledge of SRs. Multivariate logistic regression analysis revealed that age (AOR = 1.111, 95% CI: 1.069-1.154) and participation in research-related activities (AOR = 4.501, 95% CI: 3.650-5.551) were significantly associated with good knowledge of SR. The most identified barriers to conducting SRs included a lack of knowledge about SR (47.0%) and a lack of research exposure and opportunities (28.8%). Regarding engagement in secondary research, only 1,567 participants (12.0%) had participated in a secondary research project, and of those, only 471 (30.1%) had published their work. The types of enrolled research projects included SR (62.3%), systematic reviews with meta-analysis (43.3%), and network meta-analysis (33.4%).
CONCLUSION: The findings indicate a poor level of knowledge regarding SR among participants and highlight several barriers preventing undergraduate medical students from engaging in this research. There is a pressing need for further training on SR to enhance the knowledge and practice of SR among undergraduate medical students
