1578 research outputs found
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A Critical Analysis of the ICJ’s Advisory Opinion on “Obligations of States in Respect of Climate Change”
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Doctor ‒ Patient Relationship in Psychiatric Medicine, Part 9 : An Introduction to the Contract Law of Psychiatric Medicine
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Behavioral economics is the strongest academic field by Namika Sagara, SB Creative Corp., 2023
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Development of a calreticulin-targeting glycan ligands and their application
No full textCalreticulin (CRT) is an endoplasmic reticulum (ER) lectin chaperone that assists glycoprotein folding by recognizing monoglucosylated N-glycans. In this study we present the design, synthesis, and evaluation of novel CRT-targeting glycan ligands based on a hybrid binding concept that integrates glycan and aglycone interaction. Two ligands were synthesized: G1M2-EG8-Fmoc , which consists of a trisaccharide (Glc-α1,3-Man-α1,2-Man) linked to a hydrophobic and aromatic Fmoc group, and G1M2-EG8-ZnChl , which incorporates a photosensitive zinc chlorophyll derivative moiety. Both ligands demonstrated strong binding affinity to recombinant human CRT in thermal shift and isothermal titration calorimetry assays, with G1M2-EG8-Fmoc exhibiting a binding affinity ( Kb = 5.0 × 10 6 M-1 )comparable to that of the ligand Glc1Man9GlcNAc2 . Additionally , G1M2-EG8-ZnChl showed Kb = 1.7× 10 6 M-1. G1M2-EG8-Fmoc inhibited the chaperone activity of CRT, whereas G1M2-EG8-ZnChl exhibited absorption at 660 nm in the near-infrared region and generated singlet oxygen without undergoing photodegradation . These findings establish hybrid-type glycan ligands as a new class of CRT-targeted functional molecules with potential applications in the regulation of protein folding and photodynamic therapy.departmental bulletin pape
Development of semi-solid electrolyte membranes for next-generation battery ahead of the Asia-Pacific region
No full textWith the rapid spread of electric vehicles that do not use fossil fuels for suppression of global warming, all-solid-state batteries (ASSBs) have been studied as a next-generation battery to improve the cruising range and safety. In general, ASSBs use solid-state electrolyte such as polymer or inorganic electrolytes instead of organic electrolyte solutions, which prevent from electrolyte leakage and its degradation especially at high temperatures. Therefore, it is possible to simplify for the cell design and to increase the energy density. However, for the practical use relatively high interface resistance between electrode and solid-state electrolyte is one of the critical problems. Recently, addition of silica nanoparticles into ionic liquid was reported to improve flexibility and mechanical strength. Also, this method can be applied to develop gas permeable membrane and semi solid electrolyte. In this study, we developed a Poly ionic liquid (PIL) DN ion-gel membrane using PIL, ionic liquid (IL) and silica nanoparticles to improve the ionic conductivity, Li+ transference number and the mechanical strength of gel electrolytes. The ion-gels are generally known as a highly safe electrolyte due to the fire resistance derived from the IL. The electrochemical properties were investigated by using SUS|SUS and Li|Li symmetric cells to elucidate the mechanism of ionic transport. Furthermore, we demonstrated the application of flexible Li metal batteries by conducting charge-discharge
tests using Li|LFP full cells.departmental bulletin pape
Political and Social Divisions and Their Impact on Democracy and the Rule of Law in the United State
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The Diversity of Interpretations of ‘Yuri’: An Analysis of the ‘Yuri Shimai’ and ‘Comic Yurihime’ Manga Magazines
Get PDF本論文は、「百合」というジャンルを取り上げ、女性同士の関係性に対する解釈の多様性を検討する。そのため、「百合」マンガ雑誌『百合姉妹』および『コミック百合姫』に掲載された記事を通じて、「百合」という解釈の内実を明らかにし、その解釈が持つ可能性と限界を検討する。そこでは、女性同士の恋愛や友情、絆などの関係性が「百合」として解釈されることもあれば、そうした関係性を定義せず、「百合」という解釈があえて漠然と用いられることもある。このことから、「百合」という解釈の多様性を窺うことができる。異性愛規範が機能している社会では、女性同士の関係性は見えにくく、不可視化されることが多い。そのような社会において、「百合」は女性同士の関係性の多様性を表現するとともに、それを見出す手段として期待される。一方で、そうした解釈の多様性には、唯一の関係性のみを「百合」と捉え、そのほかの関係性を排除するという解釈も含まれる。このような解釈は、「百合」が持つ多様性を制限する可能性もある。departmental bulletin pape
“The Miner’s Canary”: Felix S. Cohen and the Indian Law of the United States
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