Portal Journals of Indonesian Public Health-Observer Information Forum (IPHORR)
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Nurses’ behavior toward patient safety in Hospitals: A systematic literature review
Full text linkBackground: Patient safety is a global health priority that is closely related to the quality of nursing care. Nurse behavior is a major determining factor in preventing Patient Safety Incidents (PSIs) in hospitals.
Purpose: To identify and analyze factors that influence nurse behavior in implementing patient safety in hospitals.
Method: The research design was a Systematic Literature Review (SLR) following the PRISMA guidelines. Articles were searched for in the Wiley Online Library, PubMed, and ScienceDirect databases for publications from 2015 to 2025. From the screening results, 11 articles that met the inclusion criteria were selected.
Results: The analysis revealed four main themes that influence nurses' safety behavior: (1) Organizational culture and teamwork; (2) Work environment conditions (night shifts and workload); (3) Psychological factors (stress and burnout); and (4) Effectiveness of interprofessional communication and situational awareness. A strong safety culture was found to increase nurses' courage to speak up (voice behavior), while work stress and physiological fatigue were major barriers to compliance with safety principles.
Conclusion: Nurses' patient safety behavior is influenced by the interaction between systemic management support and individual psychological well-being. Improving patient safety requires a comprehensive approach that focuses not only on technical training but also on improving shift management and creating a non-punitive work environment.
Keywords: Nurses; Nurse Behavior; Patient Safety
Effectiveness of lavender aromatherapy in reducing dysmenore
Full text linkBackground: Adolescence, which occurs between the ages of 11 and 20, is also a period of maturation of the human reproductive organs, also known as puberty. Menstruation is the most common problem experienced by teenagers today. Early menarche, lack of exercise, abnormal menstrual cycles, and alcohol consumption are some of the causes of dysmenorrhea. The World Health Organization reported in 2020 that 1,769,425 adolescent girls experienced dysmenorrhea (90%) of the total and 10%-15% of them experienced severe dysmenorrhea. In Indonesia, 64.25% of productive women experience menstrual pain.
Purpose: To identify the effectiveness of lavender aromatherapy in reducing dysmenorrhea in adolescents.
Method: This research was quantitative, with a pre-experimental design using a single-group pre-post test approach. The study was conducted MTS Mumbulsari Jember with 40 respondents. Data collection used purposive sampling and a Numeric Rating Scale (RRS) instrument to determine pain intensity and aromatherapy candles.
Results: From the T-Test calculation with a p value of 0.000 < α (0.05), which means there is a relationship between lavender aromatherapy in reducing dysmenorrhea. Aromatherapy works by influencing the emotional center in the limbic system, providing a calming and relaxing effect on the body, which can reduce pain.
Conclusion: Relaxation therapy with aromatherapy is recommended as a self-administered technique to treat dysmenorrhea, thereby reducing the use of analgesics.
Suggestion: The results of this study are expected to be a reference for female students regarding non-pharmacological methods to reduce menstrual pain
Pengaruh promosi kesehatan menggunakan media video edukasi terhadap pengetahuan dan sikap tentang pencegahan tb paru pada masyarakat
Full text linkBackground: Tuberculosis (TB) is a contagious infectious disease caused by the bacterium Mycobacterium tuberculosis, which generally attacks the parenchymal tissue of the lungs. In 2024, the Labuhan Ratu Community Health Center (Puskesmas) had a case detection rate of 1,265 suspected cases of pulmonary TB, with a target of 935 cases (73.91%).
Purpose: To determine the effect of health promotion using educational videos on knowledge and attitudes about pulmonary TB prevention in the community.
Method: This quantitative study used an experimental design with a one-group pretest-posttest. The study was conducted in Sepang Jaya Village, within the Labuhan Ratu Community Health Center's working area. The population in this study was 12,046 residents of Sepang Jaya Village, with a sample size of 35 respondents using purposive sampling. Data analysis used univariate and bivariate analysis. The bivariate analysis used the Wilcoxon test.
Results: The bivariate test for the knowledge and attitude variables yielded a p-value of 0.000, indicating that health promotion using educational videos significantly impacts community knowledge and attitudes about pulmonary TB prevention.
Conclusion: Health promotion using educational videos significantly impacts community knowledge and attitudes about pulmonary TB prevention.
Keywords: Attitude; Educational Video; Knowledge; Pulmonary TB.
Pendahuluan: Tuberkulosis (TBC) adalah penyakit infeksius yang dapat menular disebabkan oleh bakteri Mycobacterium tuberculosis yang umumnya menyerang jaringan parenkim pada paru-paru. Puskesmas Labuhan Ratu Tahun pada tahun 2024 memiliki angka cakupan penemuan kasus TB paru yaitu 1.265 (suspek) dengan capaian target 935 kasus (73,91%).
Tujuan: Untuk mengetahui pengaruh promosi kesehatan menggunakan media video edukasi terhadap pengetahuan dan sikap tentang pencegahan tb paru pada masyarakat.
Metode: Penelitian kuantitatif menggunakan eksperimental dengan rancangan one group pretest-posttest. Tempat penelitian dilaksanakan di Kelurahan Sepang Jaya Wilayah Kerja Puskesmas Labuhan Ratu. Populasi dalam penelitian ini adalah masyarakat di kelurahan sepang jaya berjumlah 12.046 orang, jumlah sampel dalam penelitian ini adalah 35 responden dengan menggunakan purposive sampling.. Analisis data yang digunakan adalah analisis univariat dan bivariat. Analisis bivariat menggunakan uji Wilcoxon.
Hasil: Uji bivariat pada variabel pengetahuan dan sikap adalah p-value = 0.000 yang berarti ada pengaruh promosi kesehatan menggunakan media video edukasi terhadap pengetahuan dan sikap tentang pencegahan TB Paru pada masyarakat.
Simpulan: Ada pengaruh promosi kesehatan menggunakan media video edukasi terhadap pengetahuan dan sikap tentang pencegahan TB Paru pada masyarakat
Kata Kunci::Pengetahuan; Sikap; TB Paru; Video Edukasi.
Gambaran upaya pencegahan penyakit skabies terhadap pengetahuan dan sikap siswa
Full text linkBackground: Scabies is a contagious skin infestation often found in densely populated environments such as Islamic boarding schools. Close physical contact between students and limited personal hygiene practices can increase the risk of transmission. Improving knowledge and attitudes regarding scabies prevention is crucial to suppress the spread of this disease.
Purpose: To describe the level of students' knowledge and attitudes regarding scabies prevention.
Method: This study used a quantitative descriptive design using a cross-sectional approach. Ninety-nine students participated. Data were collected using a structured questionnaire that assessed knowledge and attitudes regarding scabies prevention. Data were analyzed univariately and presented as frequency distributions and percentages.
Results: The majority of students (48.5%) had sufficient knowledge about scabies prevention, 32 (32.3%) had poor knowledge, and 19 (19.2%) had good knowledge. Furthermore, the attitude variable showed that the majority of students (62.6%) were in the fair attitude category, while 37 (37.4%) were in the very good attitude category, and no students had poor attitudes.
Conclusion: Students' knowledge and attitudes toward scabies prevention were generally in the fair category, but still need improvement, especially in the group with poor knowledge.
Keywords: Attitude; Knowledge; Scabies; Students.
Pendahuluan: Skabies merupakan infestasi kulit menular yang sering ditemukan pada lingkungan padat hunian seperti pondok pesantren. Kontak fisik yang erat antar siswa serta keterbatasan praktik kebersihan diri dapat meningkatkan risiko penularan. Peningkatan pengetahuan dan sikap terhadap pencegahan skabies menjadi hal penting untuk menekan penyebaran penyakit ini.
Tujuan: Untuk menggambarkan tingkat pengetahuan dan sikap siswa mengenai pencegahan skabies.
Metode: Penelitian dengan desain deskriptif kuantitatif menggunakan pendekatan cross-sectional. Responden berjumlah 99 siswa. Pengumpulan data dilakukan menggunakan kuesioner terstruktur yang menilai pengetahuan dan sikap terkait pencegahan skabies. Data dianalisis secara univariat dan disajikan dalam bentuk distribusi frekuensi serta persentase.
Hasil: Mayoritas siswa memiliki pengetahuan kategori cukup tentang pencegahan skabies sebanyak 48 orang (48.5%), pengetahuan kurang 32 orang (32.3%), dan pengetahuan baik 19 orang (19.2%). Selain itu, variabel sikap menunjukkan sebagian besar siswa berada pada kategori sikap cukup sebanyak 62 orang (62.6%), sedangkan sikap sangat baik sebanyak 37 orang (37.4%), dan tidak ada siswa dengan sikap kurang.
Simpulan: Pengetahuan dan sikap siswa terhadap pencegahan skabies secara umum berada pada kategori cukup, tetapi masih perlu ditingkatkan terutama pada kelompok dengan pengetahuan kurang.
Kata Kunci: Pengetahuan; Siswa; Sikap; Scabies
Gambaran resiko delirium pada pasien gagal ginjal kronik
Full text linkBackground: The lack of data describing the risk of delirium in patients with chronic kidney disease, particularly the elderly, and the lack of routine delirium screening using the AWOL Score at Raden Mattaher Hospital in Jambi have the potential to cause delays in the early detection of delirium.
Purpose: to determine the risk of delirium in patients with chronic kidney failure.
Method: This quantitative study, with a descriptive observational design using a cross-sectional approach, was conducted at Raden Mattaher Hospital in Jambi. Sampling was conducted using an accidental sampling technique on 92 elderly patients with chronic kidney disease undergoing hemodialysis. Delirium risk was measured using the AWOL Score with univariate data analysis.
Results: Patients with chronic kidney disease (CKD) were predominantly elderly, aged 60–65 years, and male (53.3%), with the longest duration of illness ranging from 6 months to 1 year (40.2%). Based on the AWOL score, most patients were in the low-risk delirium category (40.2%), followed by very low-risk (29.3%), and high-risk (26.1%), while only a small proportion were at high to very high risk.
Conclusion: Based on the AWOL score, most patients were in the low-risk delirium category, although patients with moderate to very high risk were still found.
Keywords: AWOL Score for Delirium; Chronic Kidney Disease; Delirium.
Pendahuluan: Kurangnya data mengenai deskripsi risiko delirium pada pasien gagal ginjal kronis khususnya kelompok lansia, dan kurangnya skrining delirium secara rutin menggunakan instrumen AWOL Score di Rumah Sakit Raden Mattaher Jambi berpotensi menyebabkan keterlambatan deteksi dini delirium.
Tujuan: untuk mengetahui gambaran resiko delirium pada pasien gagal ginjal kronik.
Metode: Penelitian kuantitatif dengan desain deskriptif observasional menggunakan pendekatan cross sectional, yang dilakukan di Rumah Sakit Raden Mattaher Jambi. Pengambilan sampel dilakukan menggunakan teknik accidental sampling pada 92 pasien lansia dengan gagal ginjal kronis yang menjalani hemodialisis, dan pengukuran risiko delirium menggunakan instrumen AWOL Score dengan analisis data univariat.
Hasil: Pasien gagal ginjal kronis didominasi oleh lansia berusia 60–65 tahun dan laki-laki (53.3%) dengan durasi penderitaan terlama 6 bulan–1 tahun (40.2%). Berdasarkan penilaian Skor AWOL, sebagian besar pasien berada dalam kategori risiko delirium rendah (40.2%), diikuti oleh risiko sangat rendah (29.3%), dan risiko tinggi (26,1%), sedangkan hanya sebagian kecil yang memiliki risiko delirium tinggi hingga sangat tinggi.
Simpulan: Berdasarkan penilaian Skor AWOL, sebagian besar pasien berada dalam kategori risiko delirium rendah, meskipun pasien dengan risiko sedang hingga sangat tinggi masih ditemukan.
Kata kunci : Awol Score for Delirium; Delirium; Gagal Ginjal Kronik.
Reality orientation therapy for a patient with schizophrenia and paranoid delusions: A case study report
Full text linkBackground: Schizophrenia is a chronic mental disorder that significantly affects cognitive function and behavior, frequently characterized by prominent delusions in Paranoid Schizophrenia. Delusional nursing problems are marked by severe distortions of reality perception, which impair patients’ ability to think logically and interact appropriately with their environment.
Purpose: To describe and evaluate the implementation of Reality Orientation Therapy (ROT) in addressing delusional nursing problems in a patient with Paranoid Schizophrenia.
Method: This research employed an intensive descriptive case study conducted over four days to illustrate and assess the application of Reality Orientation Therapy in Mrs. Y at Liliy 4 Ward, Seorojo Hospital. The primary intervention focused on the consistent, non-confrontational application of ROT through orientation to person, place, and time, integrated with collaborative pharmacological management.
Results: The findings demonstrated that Reality Orientation Therapy was substantially effective in correcting cognitive distortions and enhancing reality-based thinking abilities. This improvement was evidenced by significant clinical progress and increased scores in reality-oriented thought content, indicating that the delusional nursing problem experienced by Mrs. Y was successfully resolved.
Conclusion: Reality Orientation Therapy can be considered an effective nursing intervention for reducing delusions and improving reality-based thinking in patients with Paranoid Schizophrenia when implemented consistently and collaboratively with pharmacological treatment.
Keywords: Delusions; Paranoid Schizophrenia; Reality Orientation Therapy (ROT)
Hubungan kecanduan bermain game online dengan kualitas tidur pada remaja
Full text linkBackground: Online gaming addiction has become a growing concern among adolescents, potentially affecting various aspects of their lives including sleep quality. Poor sleep quality can significantly impact adolescent physical and mental health, academic performance, and overall well-being.
Purpose: to determine the relationship between online gaming addiction and sleep quality among adolescents.
Method : A quantitative study with cross-sectional design involving 85 male students aged 14-20 years. The instruments used were the Indonesian Online Game Addiction Questionnaire (IOGAQ) and the Pittsburgh Sleep Quality Index (PSQI).
Results: The research findings indicated that the majority of respondents (62.4%) experienced moderate online gaming addiction and 65.9% had poor sleep quality. Kendall's Tau test showed a positive correlation (p=0.001) with a low correlation coefficient (r=0.268) between online gaming addiction and sleep quality.
Conclusion: There is a positive relationship between online gaming addiction and sleep quality among adolescents. The higher the level of gaming addiction, the worse the sleep quality experienced.
Keywords: Adolescents; Online Gaming Addiction; Sleep Quality; Students.
Pendahuluan: Kecanduan bermain game online telah menjadi perhatian yang berkembang di kalangan remaja, berpotensi mempengaruhi berbagai aspek kehidupan mereka termasuk kualitas tidur. Kualitas tidur yang buruk dapat berdampak signifikan terhadap kesehatan fisik dan mental remaja.
Tujuan: untuk mengetahui hubungan antara kecanduan bermain game online dengan kualitas tidur pada remaja.
Metode: Penelitian kuantitatif dengan desain cross-sectional, Teknik sampel menggunakan Total Sampling pada 85 siswa laki-laki usia 14-20 tahun. Instrumen yang digunakan adalah Indonesian Online Game Addiction Questionnaire (IOGAQ) dan Pittsburgh Sleep Quality Index (PSQI).
Hasil: sebagian besar responden (62.4%) mengalami kecanduan game online sedang dan 65,9% memiliki kualitas tidur buruk. Uji Kendall's Tau menunjukkan korelasi positif (p=0.001) dengan nilai koefisien korelasi rendah (r=0.268) antara kecanduan game online dengan kualitas tidur.
Simpulan: Terdapat hubungan positif antara kecanduan bermain game online dengan kualitas tidur pada remaja. Semakin tinggi tingkat kecanduan game online, semakin buruk kualitas tidur yang dialami.
Kata Kunci: Kecanduan Game Online; Kualitas Tidur; Remaja; Siswa
Penyuluhan kesehatan dalam meningkatkan pengetahuan dan perilaku pencegahan demam berdarah dengue pada santri di pondok pesantren: Literatur review: Sebuah Studi Literatur Review
No full textBackground: Dengue Hemorrhagic Fever (DHF) is a serious public health problem in Indonesia. The crowded, closed, and dormitory environments of Islamic boarding schools (pesantren) make students vulnerable to dengue fever transmission. Health education is considered an important prevention strategy, but scientific evidence specifically assessing its effectiveness in the student population is limited.
Purpose: To analyze and synthesize scientific evidence regarding the effectiveness of health education in improving knowledge and behavior of dengue fever prevention among students at Islamic boarding schools.
Method: The study was conducted using a narrative systematic literature review. Articles were searched through Google Scholar, PubMed, ScienceDirect, and the Garuda Portal databases using keywords related to health education, dengue fever, knowledge, behavior, students, and Islamic boarding schools.
Results: Health education consistently effectively increased knowledge and behaviors related to dengue fever prevention among Islamic boarding school students. Higher effectiveness was found with interactive methods, the use of audiovisual media, and hands-on approaches such as demonstrations of ovitrap construction. Audiovisual media proved more effective than conventional lectures in increasing knowledge. Increased knowledge was associated with tangible behavioral changes, particularly increased mosquito nest eradication (PSN) activities.
Conclusion: Health education is an effective intervention in increasing knowledge and behaviors related to dengue fever prevention among Islamic boarding school students.
Keywords: Behavior; Dengue Hemorrhagic Fever; Health Education; Knowledge.
Pendahuluan: Demam Berdarah Dengue (DBD) merupakan masalah kesehatan masyarakat yang serius di Indonesia. Lingkungan pesantren yang padat, tertutup, dan berasrama menjadikan santri kelompok yang rentan terhadap penularan DBD. Penyuluhan kesehatan dipandang sebagai strategi penting dalam pencegahan, namun bukti ilmiah yang secara khusus menilai efektivitasnya pada populasi santri masih terbatas.
Tujuan: Untuk menganalisis dan mensintesis bukti ilmiah mengenai efektivitas penyuluhan kesehatan dalam meningkatkan pengetahuan dan perilaku pencegahan DBD pada santri di pesantren.
Metode: Penelitian dilakukan dengan metode tinjauan literatur sistematis naratif. Pencarian artikel dilakukan melalui database Google Scholar, PubMed, ScienceDirect, dan Portal Garuda menggunakan kata kunci terkait penyuluhan kesehatan, DBD, pengetahuan, perilaku, santri, dan pesantren.
Hasil: Penyuluhan kesehatan secara konsisten efektif meningkatkan pengetahuan dan perilaku pencegahan DBD pada santri. Efektivitas lebih tinggi ditemukan pada metode interaktif, penggunaan media audiovisual, serta pendekatan praktik langsung seperti demonstrasi pembuatan ovitrap. Media audiovisual terbukti lebih efektif dibandingkan ceramah konvensional dalam meningkatkan pengetahuan. Peningkatan pengetahuan berhubungan dengan perubahan perilaku nyata, khususnya peningkatan kegiatan Pemberantasan Sarang Nyamuk (PSN).
Simpulan: Penyuluhan kesehatan merupakan intervensi efektif dalam meningkatkan pengetahuan dan perilaku pencegahan DBD pada santri.
Kata Kunci: Demam Berdarah Dengue; Penyuluhan Kesehatan; Pengetahuan; Perilaku.
Faktor risiko kebersihan makanan dan sanitasi rumah tangga terhadap kejadian demam tifoid
Full text linkBackground: Food hygiene and household sanitation practices have a significant impact on the spread of typhoid fever, which remains a major public health problem in low- and middle-income countries. Evidence from four studies examining risk factors for typhoid fever related to food and household sanitation is summarized in this synthesis.
Purpose: To examine the impact of household sanitation conditions and food hygiene practices on the prevalence of typhoid fever, offering evidence that can guide community initiatives and policy improvements.
Method: A systematic review was conducted to examine the results of cross-sectional, cohort, and case-control studies. Key factors for typhoid transmission were identified by extracting reported associations, such as odds ratios (ORs), adjusted odds ratios (aORs), and risk ratios (RRs).
Results: Several studies have shown that consuming raw, unwashed vegetables, food from street vendors, and street food are all strongly associated with an increased risk of contracting typhoid. This increased risk is also associated with access to hazardous drinking water, poor sanitation facilities, and household water treatment has been found to have a protective effect.
Conclusion: Consistent evidence from several study designs suggests that food hygiene, water safety, and household sanitation play a significant role in the spread of typhoid fever.
Keywords: Typhoid Fever; Risk Factors; Food Hygiene; Household Sanitation.
Pendahuluan: Praktik higiene makanan dan sanitasi rumah memiliki dampak besar terhadap penyebaran demam tifoid yang masih menjadi masalah kesehatan masyarakat utama di negara-negara berpenghasilan rendah dan menengah. Bukti dari empat penelitian yang mengkaji faktor risiko demam tifoid terkait makanan dan sanitasi rumah tangga dirangkum dalam sintesis ini.
Tujuan: Untuk mengkaji dampak kondisi sanitasi rumah tangga dan praktik higiene makanan terhadap prevalensi demam tifoid dengan menawarkan bukti yang dapat memandu inisiatif masyarakat dan peningkatan kebijakan.
Metode: Penelitian dengan pendekatan systematic review dilakukan untuk mengkaji hasil dari studi potong lintang, kohort, dan kasus-kontrol. Faktor-faktor kunci penularan tifoid diidentifikasi dengan mengekstraksi asosiasi yang dilaporkan, seperti rasio peluang (OR), rasio peluang yang disesuaikan (aOR), dan rasio risiko (RR).
Hasil: Beberapa penelitian menunjukkan bahwa mengonsumsi sayuran mentah yang tidak dicuci, makanan dari pedagang kaki lima, dan makanan jajanan semuanya sangat terkait dengan peningkatan risiko tertular tifoid. Peningkatan risiko juga dikaitkan dengan akses air minum yang berbahaya, fasilitas sanitasi yang buruk serta pengolahan air rumah tangga ditemukan memiliki efek perlindungan.
Simpulan: Terdapat bukti konsisten dari beberapa desain studi yang menunjukkan bahwa higiene makanan, keamanan air, dan sanitasi rumah tangga berperan penting dalam penyebaran demam tifoid.
Kata Kunci: Demam Tifoid; Faktor Resiko; Kebersihan Makanan; Sanitasi Rumah Tangga.
Efektivitas diet bebas gluten dalam menurunkan gejala dan peradangan mukosa pada celiac disease: A systematic review
Full text linkBackground: Celiac disease is a chronic autoimmune disorder triggered by gluten consumption, leading to persistent intestinal inflammation, villous atrophy, and a wide range of gastrointestinal and extraintestinal symptoms. If left untreated, ongoing mucosal damage may result in malabsorption and long-term complications. A gluten-free diet (GFD) is currently the only established therapeutic approach; however, its effectiveness in alleviating clinical symptoms and promoting mucosal healing requires comprehensive evaluation.
Purpose: To systematically review scientific evidence regarding the effectiveness of a gluten-free diet in reducing clinical symptoms and intestinal mucosal inflammation in patients with celiac disease.
Method: This was a systematic literature review conducted based on the PRISMA guidelines. A literature search was conducted through PubMed, Scopus, and Web of Science databases using keywords related to celiac disease and gluten-free diets for the period 2019–2025.
Results: Ten articles met the inclusion criteria. The study results showed that adherence to a gluten-free diet was associated with a significant reduction in gastrointestinal symptoms, a decrease in serological inflammatory markers, and histopathological improvement in the intestinal mucosa, including villous regeneration and decreased intraepithelial lymphocyte infiltration.
Conclusion: A gluten-free diet is an effective primary intervention in controlling celiac disease activity, characterized by a reduction in clinical symptoms, improvement in inflammatory markers, and restoration of the intestinal mucosa..
Keywords: Celiac Disease; Gluten-Free Diet; Intestinal Inflammation; Mucosal Healing; Systematic Review.
Pendahuluan: Penyakit celiac adalah gangguan autoimun kronis yang dipicu oleh konsumsi gluten yang menyebabkan peradangan usus yang terus-menerus, atrofi vili, dan berbagai gejala gastrointestinal dan ekstra gastrointestinal. Apabila tidak diobati, kerusakan mukosa yang berkelanjutan dapat mengakibatkan malabsorpsi dan komplikasi jangka panjang. Gluten-Free Diet (GFD) saat ini merupakan satu-satunya pendekatan terapeutik yang telah terbukti; namun efektivitasnya dalam mengurangi gejala klinis dan mendorong penyembuhan mukosa memerlukan evaluasi komprehensif.
Tujuan: Untuk meninjau dan mensintesis bukti ilmiah mengenai efektivitas diet bebas gluten dalam menurunkan gejala klinis dan peradangan mukosa usus pada pasien dengan celiac disease melalui pendekatan systematic literature review.
Metode: Penelitian systematic literature review yang disusun berdasarkan pedoman PRISMA. Pencarian literatur dilakukan melalui basis data PubMed, Scopus, dan Web of Science menggunakan kata kunci terkait celiac disease dan gluten-free diet pada periode 2019–2025.
Hasil: Sebanyak 10 artikel memenuhi kriteria inklusi. Hasil kajian menunjukkan bahwa kepatuhan terhadap diet bebas gluten berhubungan dengan penurunan signifikan gejala gastrointestinal, penurunan marker inflamasi serologis, serta perbaikan histopatologi mukosa usus berupa regenerasi vili dan penurunan infiltrasi limfosit intraepitel.
Simpulan: Diet bebas gluten merupakan intervensi utama yang efektif dalam mengendalikan aktivitas penyakit celiac, ditandai dengan penurunan gejala klinis, perbaikan marker inflamasi, serta pemulihan mukosa usus.
Kata Kunci: Diet Bebas Gluten; Penyakit Celiac; Penyembuhan Mukosa; Peradangan Usus; Tinjauan Sistemati