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Surveying II (CONT 203) course syllabus
No full textThis is the second of two surveying courses. It expands on terrestrial–based survey, the use of total station and Coordinate Geometry (COGO) software, but it primarily focuses on geomatics and spaced–based survey measuring. Computation methods involve a geodesic 3D coordinate reference system. Use of Global Navigation Satellite Systems (GNSS) equipment, remote sensing, and geographic information systems technologies will be covered. The emphasis of the course is on construction, civil, and environmental engineering applications. Instruction includes lectures and field use of modern instruments to perform subdivision, topographical survey, route alignments, Earthwork, and hydrographic survey.Job Linkage 2019-2020SUNY Tompkins Cortland Community Colleg
Impact of prior antiplatelet therapy on safety and efficacy of alteplase in acute ischemic stroke: a systematic review and meta-analysis.
Get PDFBACKGROUND: Intravenous thrombolysis (IVT), utilizing the clot-dissolving medications alteplase (rt-PA) or tenecteplase (TNK), is the cornerstone in acute ischemic stroke (AIS) emergency intervention. However, the impact of prior antiplatelet therapy (APT) on post-IVT outcomes when utilizing alteplase remains controversial. We conducted a systematic review and meta-analysis to evaluate the effect of prior APT on the outcomes after using alteplase in AIS patients.
METHODS: We conducted a systematic review and meta-analysis synthesizing studies, which were retrieved by systematically searching PubMed, Web of Science, SCOPUS, and Cochrane through June 30, 2024. We used the R language V. 4.3. to pool dichotomous data using odds ratio (OR) with a 95% confidence interval (CI).
PROSPERO ID: CRD42024495393.
RESULTS: Thirty studies were included in our analysis, with 436,232 patients. Prior APT was significantly associated with increased odds of symptomatic intracranial hemorrhage (sICH) (OR, 1.78; 95%CI [1.48, 2.13]; P < 0.01), any ICH (OR, 1.44; 95%CI [1.16, 1.78]; P < 0.01), mortality (OR, 1.39; 95%CI [1.23, 1.58]; P < 0.01), and poor functional outcomes (modified Rankin Scale score of 3-6 [mRS 3-6]) (OR, 1.81; 95%CI [1.03, 3.19]; P = 0.04). Additionally, prior APT significantly reduced the odds of good functional outcome [mRS 0-2] (OR, 0.85; 95%CI [0.74, 0.97]; P = 0.02).
CONCLUSION: Prior APT increased hemorrhagic complications, mortality, and poor functional outcome, while reducing the odds of good functional outcome after IV alteplase. Future research should focus on identifying adjunctive agents that may decrease hemorrhagic complications and investigate the impact of various APT regimens and alternative thrombolytics beyond alteplase in this specific population.VoRSUNY DownstateNeurolog
A category theoretic bridge from classical error correction to quantum error correction
Get PDFBoth the category Set of sets and functions as well as the category EVect of Euclidean vector spaces and their linear maps form monoidal categories under the Cartesian product and the tensor product, respectively. We categorically model classical computing within a full monoidal subcategory of Set, and similarly quantum computing within a full monoidal subcategory of EVect. The free functor offers a map expressing how all classical computing
algorithms can be functorially mapped to a corresponding quantum algorithm. Error correction codes are included in this model using natural transformations and shown by examples, i.e Hamming codes and Toric codes, to maintain the objects and morphisms of
their respective categories.
Keywords: mathematics, math, computer science, linear algebra, Deustch-Josza algorithm, Toric codes, Hamming codes, Three-Bit Repetition code, Three-Qubit Repetition code, category theory, quan-tum computing, classical computing, error correction, classical error correction, quantum error correction, free functor, monoidal category, categoryNASUNY College at New PaltzHonorsN/AGlass, CheyneSullivan, Patrici
Predicting the Risk of Depression Based on the Patient's Chronic Diseases and Other Physiological Attributes
Get PDFThe prevalence of chronic diseases like diabetes, hypertension, and chronic respiratory conditions contributes significantly to global mortality rates. In addition, there is growing evidence that links mental health disorders to physical activity, body mass index (BMI), and chronic diseases, highlighting their importance in public health research. This study investigates the intricate relationship between chronic diseases and depression, employing innovative Machine Learning techniques to predict depression likelihood based on various health comorbidities. Results indicate that Naive Bayes consistently outperforms other models, highlighting its potential for accurate predictions. The trade-off between specificity and accuracy, however, highlights the necessity of balanced datasets in real-world applications.NASUNY PlattsburghManagement Informations Systems and AnalyticsN/ABushaj, Saba
Motivations and Repercussions of Aggressive Behavior: An Evolutionary Perspective
Get PDFSUNY OswegoPsycholog
Exploring the Effectiveness and Accessibility of Diversion and Intervention Programs for Juvenile Offenders in the United States
Get PDFSUNY OswegoCriminal Justic
Expression of the Female Struggle through Theft in Wartime
No full textThroughout historical and criminological study, women have often been viewed as the “milder” sex, and less likely to commit crimes such as theft. However, as Beattie stated, women stole just the same as men, and stole “for the same reason men stole [during the Revolution] – largely as a means of survival, as a way of supplementing inadequate wages or of supplying the most basic wants.”1. It can be inferred that women, who were driven to crime by their needs, would have been greatly impacted by the Revolutionary War and attracted to theft as a support. In a time where women were unable to own property or work in occupations that were traditionally male dominated, there were few options to support oneself or one’s family with many “heads of the household” at war. There is also a factor to be examined in the seasonal frequency of crime. In a temporal context that is highly dependent upon a quality summer and fall harvest, individuals struggled more during the winter months to survive. Through this understanding, we can begin to question the impact of two variables: gender roles and seasonal impact. The goal of this essay is to examine the impact of gender roles on female theft during the time of the Revolutionary War, along with the impact of seasons and the progression of war on crime. To do so, we will examine cases of theft offences with guilty verdicts archived in the Old Bailey On-Line database for 6 periods: January to March 1776, June to August 1776, January to March 1780, June to August 1780, January to March 1783, and Jun to August 1783.VoRSUNY OneontaSociology, Human Services, and Crime StudiesN/AFulkerson, Gregor
microRNAs in Retinal Development and Müller glia Reprogramming
Get PDF"Retinal diseases lead to visual impairments with loss of neurons and often cause blindness. Since the mammalian retina has no regenerative capability, one of attractive strategies is cell replacement, achieved by reprogramming endogenous mature cells. There are attractive molecules that regulate gene expression and are elementary during retinal development (retinogenesis), and also can induce reprogramming in mouse Müller glia (MG). MG, predominant glia in the retina, are known to have regenerative capacity naturally in fish, unlike mammalian. Recent studies demonstrated that microRNAs (miRNAs) play an important role in the embryonic phase of retinogenesis, and the set of miRNAs can induce mouse MG reprogramming into neuronal-like cells that express neuronal markers and have neuronal morphologies. The miRNAs were, however, poorly
understood in the postnatal processes of retinogenesis. Furthermore, the questions include which cell types can be generated and, most importantly whether these neuronal cells are mature and functional were not answered yet.
Therefore, the aims of this study were to 1) analyze the effects of loss of miRNAs in the late retinal progenitor cells (RPCs) during postnatal retinal development, to 2) evaluate the reprogramming efficiency of the RPC-miRNA miR-25 with regard to the generation of functional neurons. Aim 2 included the establishment of an improved cell culture protocol together with calcium imaging in order to investigate the functionality and maturation state of these newly generated neuronal-like cells. Aims one and two included the establishment of luciferase reporter assays to identify a possible underlying mechanism.
Loss of miRNAs in late RPCs is caused by a genetic knock-out of the enzyme Dicer, required for the formation of mature, functional miRNA and Ascl1CreER:tdTomato strain (RPC reporter mouse). The tissue was examined at different timepoints and
evaluated histologically. For MG reprogramming, RPC-miRNA miR-25 was overexpressed using artificially made miRNAs called mimics, in mouse primary MG. Cells were monitored and evaluated over the time course of three weeks. miRNA target gene
analyses were performed to identify potential underlying mechanisms.
Our data showed that loss of miRNAs in late RPC reduced populations of bipolar cells, rod photoreceptors, MG and increased an amacrine cell population. We found that miR-25 directly target amacrine cell mRNAs, Elavl3, a gene that encodes for HuC, a
protein expressed in amacrine cells. Using the RPC-miRNA miR-25 to reprogram young primary MG led to a conversion of the cells to more immature cells. We show for the first time that one miRNA alone, namely miR-25, was sufficient to successfully reprogram primary MG into progenitor cells that subsequently differentiate into functional neurons. This cell conversion might be partly due to the inhibition of the neuronal repressor Rest, a direct target of miR-25. Furthermore, we found that miRNA molecules were taken up efficiently by all glia, however, not all glia were reprogrammed. This suggests that the
competence state of the glia might play a role in reprogramming.
Taken together, late RPC-miRNAs are essential for the proper development of late-born cells and miRNA loss leads to reduced bipolar cells, photoreceptors, and MG populations but an increase in amacrine cells. The reduced bipolar cell number might be partly due to a competent shift of the progenitors towards amacrine cell generation. Furthermore, the RPC-miRNA miR-25 alone is sufficient to successfully reprogram primary MG into progenitor cells that subsequently differentiate into functional neurons. The neuronal repressor Rest might be one of the primary key players in this process. Since miRNA molecules were taken up efficiently, remained at least 4 weeks after transfection, and no toxicity was detected, miR-25 might be a promising tool for in vivo MG reprogramming.
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