Jurnal Farmasi Fakultas Kedokteran Universitas Mataram
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Pola penggunaan obat anti diabetes mellitus tipe-II pada pasien rawat inap di RSUD Praya tahun 2021
Full text linkDiabetes mellitus is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. The prevalence of people with diabetes mellitus in Indonesia reached 6.2% per year in 2020 and ranks 7th in the world with 8.5 million people. Based on the results of observations at the Praya Hospital in 2021, type-II diabetes mellitus is the 4th highest-order disease suffered by the community, especially Central Lombok Regency, with a total incidence of 131 patients. This study aims to determine the pattern of drug use and HbA1c profile in patients with type-II diabetes mellitus in the inpatient installation of Praya Hospital in 2021. This study was retrospective, using the Nonprobability Sampling method, namely the type of purposive sampling so that a sample of 96 medical records of diabetes mellitus patients was obtained type-II. The data is presented as pie charts and tables in percentages, which were analyzed using Microsoft Excel and SPSS version 25. From the results of this research, it was found that the pattern of drug use at Praya Hospital in 2021 was given the highest from each group namely the oral antidiabetic drug group (OAD) was in the Biguanid class with 61 drugs (8,13%), while insulin drugs were in the Rapid-Acting class with 343 drugs (45,73%), and the OAD + Insulin combination with 119 drugs (15,87%). For the HbA1c profile, high HbA1c levels were found in 76 patients (79%). This shows that blood glucose control is not reasonable. Based on the study's results, the recommended recommendation is that patients routinely control blood sugar and be educated on the accuracy of drug use to control blood sugar
Profil kadar metabolit sekunder: Steroid, alkaloid, dan tanin ekstrak daun bintangur (Calophyllum soulattri)
Full text linkBintangur leaf is one of the potential plants to be developed into a standardized herbal medicine which has many benefits such as antioxidant, anti-inflammatory and antibacterial. The aim of this study is to determine the steroid, tannin, and alkaloids of bintangur leaf extract. Preparation of bintangur leaves was conducted by soxhletation extraction technique with 96% ethanol as solvent. Determination of tannin tannic acid equivalent, and alkaloid quinine equivalent was analyzed by UV-Vis spectrophotometry method. While the analysis of steroid content β-sitosterol equivalent using a TLC Scanner. The results of the analysis showed that steroid content was 11061,49 µgBSE/g, alkaloid was 307,16 µgQE/g, and tannin was 6,586 %w/w TAE
Peningkatan pengetahuan, sikap, dan psikomotorik melalui pembekalan duta Usaha Kesehatan Sekolah (UKS) SMK Kesehatan Binatama Yogyakarta
Full text linkHealthy behavior must be accustomed to from an early age and become a habit. At the school age, healthy living habits can be carried out by integrating health programs with school activities through School Health Business activities commonly known as School Health Units (UKS). The purpose of this community service is to provide training for class X students of SMK Kesehatan Binatama Yogyakarta as UKS Ambassador candidates and will carry out the UKS mentoring program at the junior high school level. The debriefing is carried out through an interactive method of delivering material using counseling media/tools, discussion, and simulations/direct practice. The themes given are introduction of UKS, communication, counseling methods, Three Basic Threats Adolescent Reproductive Health (TRIAD KRR), basic health and hand washing practices, drug management guidelines and self-medication. From the pre and post test the results are the percentage of participants' knowledge and attitudes increased by 90.5%. Participants also showed an increase in psychomotor abilities through simulations/practices that were directly observed. In order to become a sustainable program, the UKS Ambassador debriefing activities can be attended by students of class XI and XII, with a longer duration of time, and presenting the UKS Advisory Team as one of the presenters
Pengembangan Sistem Evaluasi OSCE Berbasis Aplikasi Ponsel untuk Mahasiswa Kedokteran di Indonesia
Full text linkEvaluation of Objective Structured Clinical Examination (OSCE) is required to assess medical students’ skills in order to meet the Indonesian medical doctor competency standards. This study presents an innovative method for developing a mobile app-based OSCE evaluation system in Med Stud Games (MSG) and explores its condition. To evaluate MSG, we use the focus group discussion (FGD) method. We use a purposeful sampling approach, consisting of a content expert, medical education expert and medical students. The result of an experience in using MSG for two OSCE training was discussed in FGD. Data was analyzed using in vivo coding and divided into categories to advantages, problems, content, interface, and future improvements. The FGD results in 19 codes. Advantages are categorized as easy to use, fast, practical, and automation timer and scoring. Problems categorized in distraction potential of incoming calls and notifications and online only. Content results in the validity of score and checklist quality. Interface results in font size and layout. Future improvement results in saving and sharing data, open feedback and text, and user-generated content. MSG improve assessment and feedback qualities for medical students. Further observational studies are needed to assess OSCE validation to be used in exam setting
Analisa mutu tablet ibuprofen generik berlogo dan generik bermerek yang diproduksi industri X di Gresik
Full text linkIbuprofen tablets are one of the most widely used antipyretic analgesic drugs for self-medication in pharmacies. According to the Biopharmaceutical Classification System (BCS), Ibuprofen is included in Class II or drugs with low solubility, but high permeability. This study was carried out to determine the physical quality of branded generic and branded generic ibuprofen drugs.  This research was carried out by dissolution testing on ibuprofen tablets. The results obtained from the physical quality test met the specified requirements. The dissolution test showed that Q30 had dissolved more than 70%. The conclusion is that the drug meets the requirements and there is no difference between generic drugs with the logo and branded generics
Aktivitas antioksidan dan kandungan flavonoid total ekstrak etanol batang bajakah kalalawit (Uncaria cordata (Lour) Merr.) asal Kecamatan Loksado Kalimantan Selatan
Full text linkBajakah kalalawit (Uncaria cordata (Lour) Merr.) is widely used by Dayak Tribes, based on empirical evidence, and often used to treat diabetes and various diseases such as cancer. This research aimed to determine the total flavonoid content and antioxidant activity of the ethanolic extract of U. cordata stems. The sample used bajakah kalalawit from Loklahung village, Loksado District, South Hulu Sungai Regency, South Kalimantan Province. Flavonoid levels were determined using quercetin standards, 10% AlCl3 reagent, and 5% acetic acid, then measured at a wavelength of 416 nm, while the antioxidant activity using DPPH 0.4 mM in UV-Vis spectroscopy at a wavelength of 516 nm. The results obtained were a thick extract mass with a dark brown color and a distinctive aroma. The total flavonoid content of the ethanol extract of U. cordata stems was found to be 3.6 ± 0.086 % w/w equivalent quercetin and showed very strong antioxidant activity with an IC50 value of 9.159 ppm
Kajian efek interaksi antihipertensi dengan obat antiinflamasi nonsteroid (OAINS) terhadap tekanan darah pada pasien hipertensi
Full text linkHypertension causes atherosclerosis which can cause occlusion resulting in subchondral ischemia, which causes the exchange of nutrients and gases into the articular cartilage, which is disrupted and becomes the potential initiator of degradative changes or the so-called osteoarthritis. This review aims to evaluate the effect of antihypertensive drug interactions with NSAIDs on blood pressure. This article review was conducted using a narrative review study. The inclusion criteria in this article are the pharmacodynamic interaction of antihypertensives with NSAIDs in hypertensive patients with osteoarthritis. The results obtained seven articles that meet the inclusion criteria. Hypertensive patients with osteoarthritis receive medications that must be monitored because a drug-drug interaction can decrease the effectiveness of antihypertensives. One of the most widely used drugs in antihypertensive therapy is ACEi, but NSAIDs inhibit the antihypertensive effect on prostaglandin synthesis resulting from bradykinin production. The decrease in blood pressure stimulated by bradykinin plays an essential role in vasodilatation. The interaction of ACEi and NSAIDs can cause an increase in blood pressure with a minimum expansion of 1.1 mmHg. Still, when administering NSAIDs with CCBs, a decrease in blood pressure of 2.86 mmHg is obtained because the action is not dependent on prostaglandins. Based on the results, there were pharmacodynamic changes for both antihypertensive drugs and NSAIDs due to drug interactions that affected the patient's clinical outcome in the form of blood pressure
Peran apoteker dalam edukasi resistensi antibiotik di Kecamatan Keruak Lombok Timur
Full text linkPharmacists is one among others profession whom responsible to manage and to prevent antimicrobial resistance. To perform those function, giving information and educating public are essential to be done. This community service was aimed to provide and to increase knowledge and awareness of antimicrobial usage in public by educational program. Thus, the incidence of antimicrobial resistance could decline. The program was run by classical method and discussion session. There were 30 participants from various village in Keruak district. As speaker, pharmacists delivered some learning materials to participants followed by discussion. On discussion session participant asked some questions about antimicrobial usage. According to questions asked, it showed that participants taking part in this program have not comprehend about how to get, how to use, how to keep and storage and how to dispose antimicrobial yet in a frame to prevent resistance. It is concluded that by taking this educational community service program given by pharmacists, participants in Keruak district could gain information to improve their knowledge about antimicrobial usage in order to prevent and decline antimicrobial resistance
Pemberdayaan masyarakat dalam peningkatan gizi balita melalui olahan produk berbasis pangan lokal jagung di Desa Mekarjaya
Full text linkNutritional problems can hinder the momentum of development of Indonesia's golden generation in 2045. Nutritional problems are also related to the availability of food, where local food that is high in nutrients can be used to fulfill the nutrition of children under five. The local food commonly grown in Mekarjaya Village is corn. Therefore, this community service aims to increase the understanding of posyandu cadre mothers and parents of PAUD students regarding the importance of toddler nutrition and provide insight regarding the processing of local corn-based food products. The methods used are observation, lecture, discussion and demonstration. The activity was held on August 28 2023 with 17 participants, namely posyandu cadres and parents of PAUD students. The material is delivered by expert. The demonstration was carried out by providing a practical guide to processing corn into corn juice, corn pudding and corn dregs nuggets. From the results of the activity satisfaction questionnaire, it was found that the time for organizing the activity, preparation and media used were good. The participants were satisfied with the method and clarity of the material
Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar
Full text linkThe aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats