GreenPrints Institutional repository of De La Salle Medical and Health Sciences Institut
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Artwork 093: Whatever Happens, Happens II
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Nursing students’ perceptions on the impact of self-imposed pressure and self-rated academic performance
No full textThe development of common illnesses as a result of climate change among the residents of Sangley Point, Cavite City
No full textThe perception of critical thinking and decision-making abilities among Bachelor of Science in Nursing students of De La Salle Medical and Health Sciences Institute
No full textPost-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial
No full textBackground: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitalization/death by 79%. This study assessed the impact of amubarvimab/romlusevimab on late outcomes, including Long COVID. Methods: Non-hospitalized high-risk adults within 10 days of COVID-19 symptom onset enrolled in a randomized, double-blind, placebo-controlled phase 2/3 trial of amubarvimab/romlusevimab for COVID-19 treatment. Late symptoms, assessed using a participant-completed symptom diary, were a pre-specified exploratory endpoint. The primary outcome for this analysis was the composite of Long COVID by participant self-report (presence of COVID-19 symptoms as recorded in the diary at week 36) or hospitalization or death by week 36. Inverse probability weighting (IPW) was used to address incomplete outcome ascertainment, giving weighted risk ratios (wRR) comparing amubarvimab/romlusevimab to placebo. Findings: Participants received amubarvimab/romlusevimab (n = 390) or placebo (n = 390) between January and July 2021. Median age was 49 years, 52% were female, 18% Black/African American, 49% Hispanic/Latino, and 9% COVID-19-vaccinated at entry. At week 36, 103 (13%) had incomplete outcome ascertainment, and 66 (17%) on amubarvimab/romlusevimab and 92 (24%) on placebo met the primary outcome (wRR = 0.70, 95% confidence interval (CI) 0.53–0.93). The difference was driven by fewer hospitalizations/deaths with amubarvimab/romlusevimab (4%) than placebo (13%). Among 652 participants with available diary responses, 53 (16%) on amubarvimab/romlusevimab and 44 (14%) on placebo reported presence of Long COVID. Interpretation: Amubarvimab/romlusevimab treatment, while highly effective in preventing hospitalizations/deaths, did not reduce risk of Long COVID. Additional interventions are needed to prevent Long COVID. Funding: National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Amubarvimab and romlusevimab supplied by Brii Biosciences
Detection of antimicrobial properties of pectin from dayap peels on methicillin-resistant Staphylococcus aureus
No full textMethicillin-Resistant Staphylococcus aureus (MRSA) is a bacterium that is known to be resistant to several antibiotics. This has developed resistance to numerous antibiotics which makes it difficult to treat. Pectin extract obtained from Citrus × aurantiifolia (Dayap) peels was assessed for its antimicrobial activity against MRSA. Through a series of laboratory experiments and analyses, this study explored the efficacy of pectin as a natural antimicrobial agent, aiming to contribute to the development of alternative treatments for MRSA infections that are organic and cheap to produce. The study design encompasses extraction procedures, identification procedures, antimicrobial assays, and data analysis techniques to assess the inhibitory effects of pectin on MRSA growth. Based on the results, pectin showed no inhibitory effects to MRSA Bionumber (BN): 05040207376327 growth using Kirby-Bauer disk diffusion assay. Moreover, this study performed a broth dilution method to determine the minimum inhibitory concentration (MIC) using 5, 2.5, 1.25, 0.625, 0.312, and 0.156 mg/mL concentrations and none of these were successful in inhibiting MRSA growth
Metagenomic analysis of respiratory microbiota in stage I and stage II non-small cell lung cancer patients: an in silico study
No full textAnalysis of factors related to the medication adherence of hypertensive patients practicing polypharmacy
No full textThis quantitative descriptive cross-sectional study assessed the factors affecting medication adherence of hypertensive patients practicing polypharmacy in GMA, Cavite. 51 respondents were obtained using purposive sampling, and their sociodemographic profiles were determined. Results showed that the majority were 50–59 years old (88.2%), female (64.7%), had finished elementary or secondary education (76.5%), were unemployed (72.5%), used five medicines (84.3%) for at least four months (88.2%), and had at least one comorbidity (43.1%). The research utilized a modified Medication Knowledge Assessment Questionnaire (MKAQ) and Medication Adherence Rating Scale-10 (MARS-10) to determine their medication knowledge and medication adherence. 84.3% had excellent medication knowledge from doctors (95.9%) and barangay health workers (62.5%), while 60.8% of the respondents adhered to their therapies. Additionally, statistical analysis utilized Chi-square, wherein age had the highest correlation with the level of medication knowledge (0.255), while the number of medicines had the lowest (-0.033). Length of therapy had the highest correlation (0.405) with medication adherence, and educational attainment had the lowest (-0.074). Lastly, the level of medication knowledge and medication adherence gained a weak positive monotonic relationship (0.244). In conclusion, sociodemographic profiles and medication knowledge had a weak correlation with medication adherence
Effectiveness of flip chart intervention on proper medication disposal among primary caregivers in Dasmariñas, Cavite
No full textProper disposal of unused and expired medicines has been a challenging public health concern. Pediatrics are common consumers of medicines, with their primary caregivers responsible for the disposal of unused and expired medicines. Their lack of knowledge and awareness often leads to improper disposal of medicines. This study aimed to evaluate the effects of flip chart-based intervention on the level of knowledge and awareness in proper medication disposal among primary caregivers in Dasmariñas City, Cavite. This employed quasi-experimental study design and intended to establish cause-and-effect relationship between the self-paced and assisted flip chart learning intervention, and the knowledge and awareness of respondents regarding proper medication disposal. Both pre-survey and post-survey questionnaires were given to 90 primary caregivers of selected barangays in which the results established the baseline knowledge and awareness, and effects of the intervention. The socio-demographic profile of the respondents showed that more than half of respondents (55.56%) belonged to age range of 28 to 43 years old, were females (84.44%), a high school graduate (45.56%), and had no work (47.78%). The baseline data showed moderate levels of knowledge and awareness among primary caregivers with an average score of 34 and 27, respectively. No association was observed between the baseline level of awareness and the socio-demographic profile, while sex was found to have an association (p-value = 0.01) with the baseline level of knowledge of primary caregivers. Furthermore, comparing the learning methods, only the assisted flip chart learning is proven to have a significant difference in raising their level of awareness (p-value= 0.04). However, regardless of the learning method, flip chart intervention is indeed successful in improving the level of knowledge (38.16%, p-value= \u3c 0.01) and level of awareness (30.37%, p-value= \u3c 0.01) of primary caregivers. In conclusion, flip chart intervention is an effective educational tool in improving the knowledge and raising the awareness of primary caregivers regarding proper medication disposal
Predictors of Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock despite Intra-Aortic Balloon Pump: Opportunities for Advanced Mechanical Circulatory Support in Asia
No full textIntroduction: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) mortality remains high despite revascularization and the use of the intra-aortic balloon pump (IABP). Advanced mechanical circulatory support (MCS) devices, such as catheter-based ventricular assist devices (cVAD), may impact mortality. We aim to identify predictors of mortality in AMI-CS implanted with IABP and the proportion eligible for advanced MCS in an Asian population. Methods: We retrospectively analyzed a cohort of Society for Cardiovascular Angiography and Intervention (SCAI) stage C and above AMI-CS patients with IABP implanted from 2017–2019. We excluded patients who had IABP implanted for indications other than AMI-CS. Primary outcome was 30-day mortality. Binary logistic regression was used to calculate adjusted odds ratios (aOR) for patient characteristics. Results: Over the 3-year period, 242 patients (mean age 64.1 ± 12.4 years, 88% males) with AMI-CS had IABP implanted. 30-day mortality was 55%. On univariate analysis, cardiac arrest (p \u3c 0.001), inotrope/vasopressor use prior to IABP (p = 0.004) was more common in non-survivors. Non-survivors were less likely to be smokers (p = 0.001), had lower ejection fraction, higher creatinine/ lactate and lower pH (all p \u3c 0.001). On multi-variate analysis, predictors of mortality were cardiac arrest prior to IABP (aOR 4.00, CI 2.28–7.03), inotrope/vasopressor prior to IABP (aOR 2.41, CI 1.18–4.96), lower arterial pH (aOR 0.02, CI 0.00–0.31), higher lactate (aOR 2.42, CI 1.00–1.19), and lower hemoglobin (aOR 0.83, CI 0.71–0.98). Using institutional MCS criteria, 106 patients (44%) would have qualified for advanced MCS. Conclusions: Early mortality in AMI-CS remains high despite IABP. Many patients would have qualified for higher degrees of MCS