Ufuk Universitesi Akademik Acikerisim Sistemi
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Spontaneous age-related changes of attention in unmedicated boys with attention deficit hyperactivity disorder
Get PDFObjective: Neuropsychological, neuroanatomical, and electrophysiological studies have reported a steady increase in the different attention types until the age of 10 years. Moreover,
differences between healthy control (HC) boys and those with
attention deficit hyperactivity disorder (ADHD) become nonsignificant in late childhood. This cross-sectional study aimed to perform a comparative analysis of attentional processing in boys
with ADHD and HC in the 6:00-10:11 years age range. Methods:
Age-related changes in attentional processing were compared
between Caucasian Turkic boys (72-131 months of age) with
ADHD (n ¼ 144) and HC (n ¼ 112). Selective, focused, and inhibitory attention were measured using the Stroop Test (5 scores);
sustained attention was measured using the Cancellation Test (3
scores); and attention span was measured using the Visual Aural
Digit Span Test-Revised (6 scores). Results: At the age of 6 years,
the ADHD group had a significantly lower performance for all
attention types. By the age of 10 years, there were no significant
between-group differences. However, the component structure of
the neuropsychological test scores in the ADHD group differed
from that in the HC group and previous studies. Conclusions:
Attentional processing in boys with ADHD changes within the
age-range of 6:00-10:00 years where it finally becomes similar to
that in HC boys. This delayed maturation is consistent with the
maturational lag model of ADHD. However, there was a betweengroup difference in the component structure of attentional processing, which is consistent with the maturational deviance model
of ADHD
Diagnostic value of lung ultrasonography in children with COVID-19
Get PDFBackground: Lung ultrasound (LUS) has been successfully used in the diagnosis of different pulmonary diseases. Present study design to determine the diagnostic value of LUS in the evaluation of children with novel coronavirus disease 2019 (COVID-19).
Methods and objectives: Prospective multicenter study, 40 children with confirmed COVID-19 were included. LUS was performed to all patients at admission. The chest X-ray and computed tomography (CT) were performed according to the decision of the primary physicians. LUS results were compared with chest X-ray and CT findings and diagnostic performance was determined.
Results: Of the 40 children median (range) was 10.5 (0.4-17.8) years. Chest X-ray and LUS were performed on all and chest CT was performed on 28 (70%) patients at the time of diagnosis. Sixteen (40%) patients had no apparent chest CT abnormalities suggestive of COVID-19, whereas 12 (30%) had abnormalities. LUS confirmed the diagnosis of pulmonary involvement in 10 of 12 patients with positive CT findings. LUS demonstrated normal lung patterns among 15 of 16 patients who had normal CT features. The sensitivity and the area under the receiver operating characteristics (ROC) curve (area under the ROC curve) identified by the chest X-ray and LUS tests were compared and statistically significantly different (McNemar's test: p = .016 and p = .001 respectively) detected. Chest X-ray displayed false-negative results for pulmonary involvement in 75% whereas for LUS it was 16.7%.
Conclusions: LUS might be a useful tool in the diagnostic steps of children with COVID-19. A reduction in chest CT assessments may be possible when LUS is used in the initial diagnostic steps for these children
Comparison of the impacts of different multimodalities on incidental L2 vocabulary learning
Get PDFMultimodality of input in incidental L2 vocabulary learning has recently been a topic of
interest among language acquisition researchers, yet the results have been somewhat
contradictory. This study seeks to compare the impacts of two different multimodalities on
incidental L2 vocabulary learning, namely, reading-plus-watching (experimental group I) vs.
reading-plus-listening (experimental group II), as compared to the reading only condition,
which is included as a control measure. Experimental group I watched and read the
transcriptions of four news texts with electronic glosses for the target words, while
experimental group II read and listened to the same news texts again with electronic glosses
for the same 20 target words. Next, the two experimental groups swapped roles with a new
set of four news texts glossed for another group of 20 target words. The control group only
read the same eight news texts without glosses. The results suggest that reading-plus-listening
can be a more conducive multimodal presentation for incidental vocabulary learning as
compared to reading-plus-watching. The results also challenge the validity of some principles
of the Cognitive Theory of Multimedia Learning in incidental L2 vocabulary learning, while
providing supporting evidence for some other principles
Apendektomi yapılan hastaların kültür ve antibiyotik duyarlılıkları, antibiyotik seçimleri ve klinik duruma etkileri
Get PDFGiriş: İntraabdominal infeksiyonlar genellikle antibiyotik tedavisinin ampirik olarak başlandığı infeksiyonlardır. Artan antibiyotik direnci
ampirik antibiyotik seçiminde önemlidir. Doğru antibiyotik seçiminde toplumumuzdaki mevcut direnç durumunun bilinmesi gereklidir.
Güncel rehberlerde sadece antibiyotik tedavisi ile tedavi edilmesi önerilen apandisit olguları bulunmaktadır. Bu durum ampirik antibiyotik tedavi uygunluğunun önemini daha da arttırmaktadır. Bu çalışmada hastanemizde apendektomi yapılan hasta grubunda ameliyat
materyalinde üreyen etken bakteriler ve direnç durumları araştırılmıştır. Sonuçlar, başlanılan ampirik antibiyotik tedavi seçimleri ve
hastaların klinik durumları ile karşılaştırılmıştır.
Materyal ve Metod: Hastanemizde Haziran 2015-Haziran 2017 tarihleri arasında apandisit nedeniyle opere edilen hastalardan operasyon sırasında doku örneği kültürleri alınabilmiş olanlar çalışmamıza dahil edildi. Hastaların başlanmış olan antibiyotik tedavileri, demografik özellikleri kayıt altına alındı. Operasyon sırasında alınan doku örnekleri mikrobiyoloji laboratuvarımız tarafından aerobik kültür
ekimi yapılarak incelendi. Üreyen bakterilerin antibiyotik duyarlılık testleri EUCAST standartlarına uygun olarak disk difüzyon yöntemi ile
çalışıldı. Vitek 2 (BioMerieux, Fransa) otomatize identifikasyon sistemi kullanılarak bakteri identifikasyonu yapıldı.
Bulgular: Toplam 90 hasta çalışmamıza dahil edilmiştir. Bu hastaların 54 (%60.0)’ü erkekti. Ortalama yaş 29.5 ± 9.08 (16-51) idi.
Alınmış olan kültürlerden 31 (%34.4)’inde üreme olmamıştır. Üreme olan doku kültürlerinde en sık üreyen mikroorganizma (51/90,
%69.9) Escherichia coli idi. Genişlemiş spektrumlu beta-laktamaz (GSBL) üreten gram-negatif bakteri izole edilme oranı 17 (%18.9)
idi. On iki hastada kültürde birden fazla bakteri üremiştir. Ampirik antibiyotik tedavisi olarak 20 (%22.2) hastaya sefazolin ve metronidazol kombinasyon tedavisi, 65 (%72.2) hastaya ise seftriakson ve metronidazol kombinasyon tedavisi başlanmıştır. En sık başlanılan
antibiyotik olan seftriaksona duyarlılık oranı %63.4 olarak saptanmıştır.
Sonuç: Hastalardan alınan doku kültürlerinin üçte birinde bakteri üremesi saptanmadı. GSBL pozitif gram-negatif bakteri üreme oranı
%18.9 idi. Ampirik olarak başlanan antibiyotik tedavilerinin hiçbiri GSBL pozitif bakterilerde etkili değildi. Bu çalışmada hastalarımızın tamamında apendektomi uygulandığından etken bakterilerdeki direnç oranları, ampirik tedavi seçimleri GSBL pozitif bakteri üreyen hastalara uygun olmasa da tedavi başarısızlığı olarak klinik pratiğe yansımadı. Ancak yaygın intraabdominal infeksiyonu olan hastalarda
ve sadece antibiyotik tedavisi ile tedavi edilen apandisit hastalarında uygunsuz ampirik antibiyotik seçimleri klinik tedavi başarısızlığına
sebep olabilir
Granulomatous skin infections
Get PDFGranulomatous skin disorders are a heterogeneous group of disorders characterized by granuloma formation on histopathology. They may
be triggered by various stimuli, including infectious and non-infectious stimuli (foreign bodies, malignancy, metabolites, and chemicals), of
different etiological origins. Although pathophysiological mechanisms are still poorly understood, infectious granuloma formation may occur if
the patient’s immune system could not eliminate an agent. Clinically, localized or disseminated infectious granuloma formation can be related
to the infectious agent’s pathogenicity or the patient’s immunity. Typical infectious agents causing infectious granulomatous reactions are
mycobacteria, fungal infections, or parasites, such as leishmaniasis. This review aims to summarize granulomatous skin diseases encountered
more frequently in our clinical experience because of infectious causes
Mean platelet volume may not be a risk factor for focal involvement in patients with brucellosis
Get PDFA new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line
Get PDFStarting from the 3,5-dimethyl pyrazole ring and acetophenone derivatives, five different N-propargylated C-3 substitutedpyrazoles were obtained. These derivatives were reacted with different amine derivatives using Cs2CO3in methanol and11 different pyrazolo [1,5-a] pyrazine-4(5H)-one derivatives were obtained, which are not found in the literature. The cytotoxiceffects of these derivatives in the A549 cell line were investigated. The 160 µM concentration of two derivatives wasfound to increase cell death rate to 50%, and two derivatives increased cell death rate by up to 40%. The structure–activityrelationship (SAR) study revealed an amide group with a long alkyl chain and benzene ring with a p-CF3 group could beimportant for efficiency. With theoretical ADMET studies of pyrazolopyrazine derivatives, pharmacokinetic phases werepredicted to be suitable
Reproductive outcomes of patients with T-Shaped and septate uterus following metroplasty: an observational study
Get PDFIntroduction: Uterine malformations are common and may contribute to infertility and adverse pregnancy
outcomes. After an accurate diagnosis, correcting the abnormal uterine morphology is the main goal to optimize
reproductive outcomes. The principal objective of this study was to assess the impact of metroplasty for T-shaped
(U1a) and septate uteri (U2) on live birth rates in infertile patients.
Methods: This was a prospective observational study of infertile women with either U1a or U2 uterine anomaly.
Patients with unexplained infertility and repeated (IVF/ICSI) failure were included. Hysteroscopic metroplasty
was performed by a single experienced surgeon. Fertility outcomes of all cases were evaluated prospectively
evaluated. The main outcome parameter was a live birth rate either achieved spontaneously or with assisted
conception.
Results: A total of 48 patients were included in U1a group and bilateral longitudinal uterine-lateral wall incision
was carried out. A total of 63 patients were included in the U2 group and septum incision was carried out, 60 out
of these 63 patients with U2 uterine anomaly required further lateral wall incision during septoplasty.
During the first 12 months following surgery, nearly half of the patients in both groups achieved spontaneous
pregnancy; 45% in the U1a group and 39% in the U2 group delivered at term.
Conclusions: Hysteroscopic metroplasty offers promising reproductive outcomes in the presence of U1a and U2
uterine anomalies for those with unexplained infertility and repeated IVF/ICSI failures. In addition, uterine
septum cases should be carefully evaluated intra-operatively to detect and repair concurrent lateral uterine wall
anomalies
Pre-treatment vitamin B12, folate, ferritin, and vitamin D serum levels in patients with warts: a retrospective study
Get PDFA prognostic marker in idiopathic sudden sensorineural hearing loss serum calprotectin
Get PDFObjectives. Calprotectin, a protein released by neutrophils, has been used in many studies as a biomarker showing the presence of inflammation. In this study, it was aimed to investigate the relationship between serum calprotectin level and response to the treatment of idiopathic sudden sensorineural hearing loss (ISSHL). Methods. The present study is a prospective, cross-sectional historical cohort study.The study group consisted of 44 patients with ISSHL, and the control group consisted of 41 healthy volunteers without ear pathology. At the same time, patients in the study group were divided into three groups according to the response to ISSHL treatment (recovered, partially recovered, unrecovered). The relationship between the groups was statistically evaluated in terms of serum calprotectin levels. Results. The mean serum calprotectin value was 75.67 +/- 19.48 ng/mL in the study group and 50.24 +/- 29.14 ng/mL in the control group (P=0.001). Serum calprotectin value according to the severity of hearing loss in the mild, moderate and severe was 66.20 +/- 8.82, 70.35 +/- 16.77, and 91.23 +/- 1.9.73 ng/mL, respectively. Serum calprotectin value in the severe group was significantly higher compared to the moderate and mild groups (P=0.004, P=0.001, respectively). Serum calprotectin value according to the treatment response in the recovered, partially recovered and unrecovered groups was 63.36 +/- 11.54, 80.17 +/- 12.06, and 85.33 +/- 22.33 ng/mL, respectively. Serum calprotectin value in the recovered group was significantly lower compared to the partially recovered and unrecovered groups (P=0.002, P= 0.001, respectively). Conclusion. Serum calprotectin value informs the clinician about both the severity of hearing loss and the response to treatment. Hence, serum calprotectin can be used as an important biomarker in ISSHL patients for the determination of the prognosis of disease