Ufuk Universitesi Akademik Acikerisim Sistemi
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Entübasyon Öncesi Yapılan Esmolol ve Deksmedetomidinin İskemi Modifiye Albumin Seviyeleri Üzerine Etkisi: Randomize Prospektif Bir Çalışma
No full textObjective: Laryngoscopy and intubation cause hypertension, tachycardia and arrhythmia. Ischemia modified albumin (IMA) is formed secondary to endothelial or extracellular hypoxia, acidosis and free oxygen radicals and can be detected in the early stages of ischemia. In this study, we aimed to compare the effects of two agents on preventing hypertension and tachycardia by measuring IMA levels. Methods: Following ethics approval and randomization, dexmedetomidine 0.5 ?g kg-1 in Group D (n=21) or esmolol 0.5 mg kg-1 in Group E (n=21) diluted in 20 mL saline was given as infusion for 5 minutes prior to induction. Patients in Group C (n=21) received only 20 mL saline infusion. An automated perfusor was set at 4 mL min-1 for the delivery of study solutions. Blood samples for IMA measurement were taken following monitorization and at 10th and 20th minutes after intubation. Results: There was no statistically significant difference concerning IMA levels at 10 minutes following intubation. However, IMA levels in Group C were significantly lower compared to Group E and Group D (p=0.025 and 0.015 respectively) at 20 minutes. There was no significant difference between Group E and Group D (p=0.980). In Group D and E, a significant drop in systolic, diastolic and mean arterial pressures compared to baseline was observed after the study drugs were given. Groups were similar in terms of heart rate in the first 5 minutes however Groups E and D had lower heart rates compared to Group C starting from the 6th minute until the end of study period. Conclusion: Inhibiton of hemodynamic response to intubation may have negative results, and pharmacological interventions for this should be carried out with caution in critical patients and close hemodynamic monitorization should be kept in mind. © 2023 Anestezi Dergisi. All rights reserved
Thrombocytosis in children
No full textOBJECTIVE: We aimed to investigate the frequency and causes of thrombocytosis in patients admitted to the Department of Pediatric Hematology and Oncology of Elazig Fethi Sekin City Hospital, Elazig, Turkey. METHODS: Between 2019 and 2021, the laboratory parameters of 2,500 patients admitted to the Hematology Department were studied. During this examination, 319 (12.76%) patients were found to have thrombocytosis. Demographic characteristics (age and gender), hematologic parameters (hemoglobin, white blood cells, and platelets), and ultimate diagnoses ot the cases were recorded from their files. RESULTS: Of these 319 patients with thrombocytosis, 197 (1.8%) were male and 122 (38.2%) were female, and the mean age was 72.0 +/- 69.0 (1-216) months. The median platelet count of the patients was 590.43 +/- 280.12/mu L (450,000-750,000). The most common cause of secondary thrombocytosis was infection, accounting for 37.9% of all patients. Other common causes were sickle cell anemia (21%), iron deficiency anemia (15.4%), colloid tissue disease (6.6%), hemolytic anemia (5.0%), splenectomy (4.5%), and other causes (9.7%). CONCLUSION: In our study, infections were the most common cause of thrombocytosis. In addition to infections, sickle cell anemia and iron deficiency anemia should also be considered in the differential diagnosis of thrombocytosis
Comparison of Albumin and Fresh Frozen Plasma as Colloid Therapy in Patients With Major Burns
No full textBackground: Burn injuries are one of the main causes of morbidity and mortality throughout the world, and burn patients have higher chances of recovery if they are treated with effective fluid and colloid management. Fresh frozen plasma (FFP) and albumin suspension used as a colloid treatment agent are very useful for the treatment of severe burns.Methods: This retrospective clinical trial was conducted at the Numune Education and Research Hospital Burn Center, Ankara, Turkey. Two hundred and nine patients who had severe burns that involved more than 30% of their total body surface area (TBSA) were studied. After the first 24 hours, 13 patients were deceased, leaving 196 patients remaining in the study, including 139 patients in the fresh frozen plasma group and 57 patients in the albumin group. Both the fresh frozen plasma and albumin groups received the standard therapy of the burn center, which was based on a standard protocol. Then, these patients were compared according to their clinical findings and mortality.Results: There were no significant differences between the groups with respect to age, gender, and comorbidities. The laboratory findings, blood, urine, and wound culture results were also similar between groups. The mortality rate was higher in the group receiving albumin than in the group receiving fresh frozen plasma (78.9% and 33.8%, respectively; p=0.0007).Conclusions: According to this study, there was a significant relationship between the improvement in mortality and the mode of colloid treatment in patients with major burns
Borsa İstanbul’da İçeriden Öğrenenlerin Getirileri
No full textAmaç: Bu çalışmada Borsa İstanbul’da içeriden öğrenenlerin işlem yaptığı hisselerin performansları analiz edilmiştir. Tasarım/Yöntem: Araştırmada 2015 ve 2020 yılları arasında içeriden öğrenenler tarafından KAP’a sunulan 2131 adet bildirim indirilmiştir. t testleri vasıtasıyla bu bildirimlere konu olan hisselerin performansları analiz edilmiştir. Bulgular: İçeriden öğrenenler piyasayı etkin bir şekilde zamanlayabilmektedirler. Genellikle düşük performans göstermiş hisseleri almakta ve yüksek performans göstermiş hisseleri satmaktadırlar. Alım tutarlarının yüksekliği ile elde ettikleri performans arasında anlamlı bir ilişki bulunmamaktadır. Davranışsal olarak yüksek performans gösteren hisseleri satma, düşük performans gösteren hisseleri ise alma yönünde yanlılık göstermektedirler. Sınırlılıklar: Araştırma yalnızca BIST100 hisselerini ve 2015-2020 zaman aralığını kapsamaktadır. Özgünlük/Değer: Çalışmanın dönemi, 15 Temmuz 2016 darbe girişimi, 2018 Ağustosundaki kur şoku ve sermaye piyasalarında 2020 yılı Mart ayında Covid 19 nedeniyle yaşanan sert düşüş gibi önemli olayları kapsamaktadır. Bu sayede içeriden öğrenen işlemlerinin değişik piyasa şartlarında değerlendirilebilmesi mümkün olmaktadır. Ayrıca içeriden öğrenen işlemlerinde, geçmiş hisse performanslarının oluşturduğu yanlılık etkisi de incelenmiştir
Ischemic stroke cases presenting with hand weakness mimicking peripheral neuropathy
No full textPure motor monoparesis due to ischemic stroke involving a single extremity is a rare condition that can be easily misdiagnosed. Herein, we present three cases with isolated upper extremity monoparesis. All of our patients had weakness in the left hand. They were previously evaluated in other centers and were diagnosed with peripheral neuropathy by electromyography. When patients whose complaints did not resolve were admitted to our clinic, we performed electromyography again and observed that it was normal. Hereupon, we detected ischemic infarctions in cranial magnetic resonance imaging that would explain the patients' complaints. Isolated monoparesis mimicking peripheral neuropathy is a rare symptom in stroke patients. Pure motor monoparesis should be kept in mind in every patient presenting with acute-isolated monoparesis, and neuroradiological imaging should be performed
A brief overview of the relationship between academic achievement and problematic internet use of adolescents and young adults: What are the main mediators?
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Does Intubation Affect Survival Among Patients Experiencing In-Hospital Cardiopulmonary Arrest?
No full textAim: Cardiopulmonary arrest is an important public health problem that contributes substantially to in-hospital morbidity and mortality. The present study aimed to determine the factors that affect in-hospital mortality and determine whether intubation contributes to survival among patients experiencing in-hospital cardiopulmonary arrest. Material and Methods: This retrospective, cross-sectional study was conducted by examining the event notification forms of all patients with a "Code Blue" call between January 1, 2014, and December 31, 2018. Patients who died and those who did not die after intervention were compared concerning age, sex, location and time of the call, and interventions implemented. Patients who received cardiopulmonary resuscitation alone and those who received cardiopulmonary resuscitation + intubation were compared concerning in-hospital mortality; p-values < 0.05 were considered statistically significant. Results: In total, 924 patients were included in the present study. The most frequent calls were made from the wards in the hospital, at a rate of 64.4%. The in-hospital mortality rate was 42.4%. In-hospital mortality rates were significantly higher in the elderly, in those who were given overtime and service calls, and in those who received cardiopulmonary resuscitation or cardiopulmonary resuscitation + intubation. Among patients who received CPR, intubation did not affect survival. Sex, age, time of call, and intervention were significant predictors of in-hospital mortality. Conclusion: Code blue calls occurred primarily in the hospital wards outside of working hours, and improper call rates were high. Moreover, age, location and time of call, and interventions were independent risk factors for in-hospital mortality; intubation did not contribute to survival among patients experiencing in-hospital cardiopulmonary arrest
7099 SAYILI KANUN İLE TTK M. 585 HÜKMÜNDE YAPILAN DEĞİŞİKLİĞİN ORTAKLARIN KÂR PAYI HAKKINA VE ALACAKLILARIN KORUNMASINA ETKİSİ
No full text6102 sayılı Türk Ticaret Kanunu’nda bir sermaye şirketi olarak düzenlenen limited şirketlerde şirketin temel amacı, kazanç elde etmek ve bu kazancı ortakları ile paylaşmaktadır. Nitekim limited şirket ortaklarının kâr payı hakkı da şirketin bu amacı ile uyumlu olup, ortakların mali hakları içinde önemli bir yere sahiptir. Öte yandan ortakların sahip olduğu bu hakkın kullanılması, kanun koyucu tarafından şirket malvarlığının ve alacaklıların korunması sebebiyle belirli şartlara bağlanmıştır. Ancak 7099 sayılı Kanun ile limited şirketlerin kuruluşunu düzenleyen TTK m.585 hükmünde değişiklik yapılarak, limited şirketin kuruluşunda taahhüt edilen nakdi sermaye paylarının en az yüzde yirmi beşinin tescilden önce ödenmesi koşulunun kaldırılması ile yalnızca nakdi sermaye ile kurulan bir limited şirketin kuruluşundan itibaren yirmi dört aylık süre boyunca sermayesiz bir şekilde ticari faaliyet sürdürebilmesi mümkün kılınmıştır. Bu durum hem ortakların kâr payı hakkını hem de alacaklıların korunmasını olumsuz yönde etkilemiştir. Bu çalışmada limited şirketlerde 7099 sayılı Kanun ile yapılan değişikliğin ortakların kâr payı hakkına ve alacaklıların korunmasına etkisi incelenmiştir.
The Effect of Intraurethrally Applied Anatolian Propolis Extract on Urethral Healing in a Rat Model
No full textPurpose: Urethral stricture may cause irreversible results, as it prevents normal voiding. Although various endoscopic and open surgical options are available, the results are not always satisfactory so the main purpose is to prevent the formation of urethral scar. Our purpose was to examine the effects of intraurethrally administered Anatolian propolis on healing after an experimental urethral injury. Materials and Methods: A total of 40 Wistar male rats were used. Rats were divided into five equal groups: healthy control (Group 1), urethral damage/pathology (Group 2), solvent control (Group 3), 1-week propolis treatment (Group 4) and 3-week propolis treatment (Group 5). Urethral damage was performed with a 29G needle. Intraurethral, 50% ethanol, was administered in the solvent control group and 30% propolis was administered intraurethrally to the rats in Groups 3 and 4. Penile tissues were taken under deep anesthesia and examined under a light microscope. Results: Irregularities and luminal narrowing in the urethral epithelium and connective tissue were found in Group 2, except for one rat. Similarly, hyperemia-bleeding was observed in all rats except for one rat. Irregularities and hyperemia in the urethral epithelium and connective tissue were found in Group 3, except for two rats. Total improvement was observed in one rat, and more than 50% of fibrosis was observed in four rats in Groups 2 and 3. In Group 4, irregularity was observed in the urethral epithelium in four rats, while no inflammation was found in five rats. All of the rats had < 50% fibrosis. In Group 5, six rats had complete recovery and < 30% fibrosis. Conclusion: Anatolian propolis applied into the urethra seems to accelerate recovery after urethral trauma and reduces the formation of fibrosis
EVALUATION OF EARLY MALADAPTIVE SCHEMES IN FEMALE FIBROMYALGIA PATIENTS
No full textAim: Fibromyalgia is a condition characterized by widespread musculoskeletal pain and tenderness without an underlying organic cause. Relationships with psychiatric factors and personality traits have been reported in many studies. In this study, we aimed to examine the relationship between early maladaptive schemes (EMS) and fibromyalgia severity from the perspective of schema theory. Materials and Methods: For the study, 73 patients with fibromyalgia who applied to the Physical Medicine and Rehabilitation outpatient clinic and were diagnosed with fibromyalgia were included. In addition, 78 healthy control patients (without additional psychiatric disease and chronic pain) were included. A sociodemographic data form, Young Schema Questionnaire – Short Form 3 (YSQ -SF3) and Fibromyalgia Impact Questionnaire (FIQ) self-report scale was administered to the participants. Results: We found significantly higher scores on emotional deprivation, failure to achieve, dependence/incompetence, vulnerability to harm, enmeshment, subjugation, self-sacrifice, and pessimism/negativity schemes in the patient group. We also found positive correlations with FIQ scores, emotional deprivation, and vulnerability to harm schemes. Finally, we found that age was a positive predictor on FIQ. After controlling for age, we found that emotional deprivation and vulnerability to harm schemes predicted FIQ scores. Discussion and Conclusion: Fibromyalgia is a disease of unknown etiology. Psychological factors should be considered in the holistic treatment approach. In this sense, schema theory-oriented perspective can contribute to the treatment process