Ufuk Universitesi Akademik Acikerisim Sistemi
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Prevalence, etiology, and biopsychosocial risk factors of cervicogenic dizziness in patients with neck pain: A multi-center, cross-sectional study
No full text26th National Congress of Physical Medicine and Rehabilitation -- APR 25-29, 2017 -- Antalya, TURKEYObjectives: This study aims to investigate the prevalence, etiology, and risk factors of cervicogenic dizziness in patients with neck pain. Patients and methods: Between June 2016 and April 2018, a total of 2,361 patients (526 males, 1,835 females; mean age: 45.0 +/- 13.3 years; range, 18 to 75 years) who presented with the complaint of neck pain lasting for at least one month were included in this prospective, cross-sectional study. Data including concomitant dizziness, severity, and quality of life (QoL) impact of vertigo (via Numeric Dizziness Scale [NDS]), QoL (via Dizziness Handicap Inventory [DHI]), mobility (via Timed Up-and-Go [TUG] test), balance performance [via Berg Balance Scale [BBS]), and emotional status (via Hospital Anxiety Depression Scale [HADS]) were recorded. Results: Dizziness was evident in 40.1% of the patients. Myofascial pain syndrome (MPS) was the most common etiology for neck pain (58.5%) and accompanied with cervicogenic dizziness in 59.7% of the patients. Female versus male sex (odds ratio [OR]: 1.641, 95% CI: 1.241 to 2.171, p=0.001), housewifery versus other occupations (OR: 1.285, 95% CI: 1.006 to 1.642, p=0.045), and lower versus higher education (OR: 1.649-2.564, p<0.001) significantly predicted the increased risk of dizziness in neck pain patients. Patient with dizziness due to MPS had lower dizziness severity scores (p=0.034) and milder impact of dizziness on QoL (p=0.005), lower DHI scores (p=0.004), shorter time to complete the TUG test (p=0.001) and higher BBS scores (p=0.001). Conclusion: Our findings suggest a significant impact of biopsychosocial factors on the likelihood and severity of dizziness and association of dizziness due to MPS with better clinical status
clinical and demographic characteristics of 197 behçet patients
Get PDFAmaç: Bu çalışmada Behçet hastalığı (BH) ile ilgili son on dört yıl içerisindeki verilerimizi (hastaların demografik, klinik özellikleri) paylaşmayı,
ülkemizde yapılmış benzer araştırmaların sonuçları ile karşılaştırarak BH ile ilgili bilgilerimizi güncellemeyi amaçladık.
Gereç ve Yöntem: Ocak 2006-Ocak 2020 yılları arasında Ufuk Üniversitesi Deri ve Zührevi Hastalıklar Polikliniği’ne başvuran ve Uluslararası BH
Çalışma Grubu (UBÇG) kriterlerine göre BH tanısı konularak BH merkezimizde takip sistemine alınan 111’i kadın, 86’sı erkek toplam 197 hastanın
klinik ve demografik özellikleri incelenerek yapılan retrospektif bir çalışmadır.
Bulgular: Çalışmaya 16-65 yaş arası 111 kadın ve 86 erkek hasta dahil edildi. Hastalardaki 10 erkek/kadın oranı 0,77 idi. Hastaların başvuru anındaki
yaş ortalaması 37,38±13,91, ortalama hastalık başlangıç yaşı 27,07±9,77 olarak saptandı. Hastaların %100’ünde UBÇG kriterleri kullanıldığı için oral
aft gözlendi. Aile öyküsü %20,8’inde pozitifti. Genital ülser %71, eritema nodozum %43,6 ve papülopüstüler lezyonlar %54,3 hastada saptandı.
Hastaların %42,6’sında paterji testi pozitifti. Hastaların %38,8’inde göz, %21,3’ünde artiküler, %7,6’sında vasküler, %0,5’inde gastarointestinal ve
%1,5’inde pulmoner tutulum saptandı.
Sonuç: BH erken tanı ve tedavi ile morbiditesi azaltılabilen ve mortalitesi önlenebilen multisistemik bir hastalıktır. Ülkemizde görülme sıklığının
yüksek olması ve multidispliner yaklaşım gerektiren bir hastalık olması nedeni ile hastalığı her yönü ile ele alacak deneyimli merkezlerin sayılarının
artırılması gerekmektedirObjectives: We aimed to share our data on Behçet’s disease (BD) collected in the last fourteen years (demographic and clinical characteristics of the
patients) and to update our knowledge on BD by comparing it with the results of similar studies conducted in our country.
Materials and Methods: This is a retrospective study conducted by examining the clinical and demographic characteristics of a total 197 patients,
including 111 females and 86 males, who were admitted to the Ufuk University Dermatology and Venereal Diseases Polyclinic between January 2006
and January 2020 and who were diagnosed with BD according to the International BD Study Group Criteria (IBSG) and taken into the follow-up
system in our BD Center.
Results: One hundred eleven female and eighty-six male patients between the ages of 16 and 65 years were included in the study. The ratio of 10
men/women in patients was 0.77. The mean age of the patients at the time of presentation was 37.38±13.91 years, and the mean age at onset of
disease was 27.07±9.77 years. Oral aphthae were observed in 100% of the patients because the IBSG criteria were used. Family history was positive
in 20.8%. Genital ulcer was detected in 71%, erythema nodosum in 43.6% and papulopustular lesions in 54.3%. Pathergy test was positive in 42.6%
of the patients. Eye involvement was detected in 38.8% of the patients, articular in 21.3%, vascular in 7.6%, gastrointestinal in 0.5% and pulmonary
in 1.5%.
Conclusion: BD is a multisystemic disease, morbidity of which can be reduced and mortality of which can be prevented with early diagnosis and
treatment. Due to the high prevalence in our country and the fact that it is a disease that requires a multidisciplinary approach, the number of
experienced centers that will deal with the disease in every aspect should be increased
Diffüz Büyük B Hücreli Lenfoma’da CD10, BCL-6 ve MUM-1 Markerların Ekspresyonu ve Prognoz Üzerine Etkisi
No full textBackground and Aim: Immunohistochemistry may serve as a surrogate to define Diffuse large B-cell lymphoma (DLBCL) cases as germinal center B cell-like (GCB) or non-GCB subtypes and to provide prognostic information. In this study, we aimed to investigate the frequency and prognostic impact of CD10, B-cell lymphoma 2 and 6 (BCL2 and BCL6) and multiple myeloma oncogene 1 (MUM1) expressions in pathology sections of patients with DLBCL to determine the response of these subgroups to the rituximab including chemotherapy regimens. Materials and Method: Patients were grouped into 2 regarding the chemotherapy regimens they were treated, as cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or Rituximab-CHOP. The treatment response, follow-up periods and outcomes of patients were recorded. The immunohistochemical panel was stained in pathology sections for CD10, BCL6 and MUM1/IRF 4 biomarkers. The patients were subgrouped as GCB or ABC regarding the immunohistochemical panel. Results: Totally 81 patients, (39 male, 42 female) were included in the study. At the time of diagnosis, CD10 was positive in 31 patients (38.3%); BCL-6 in 53 patients (65.4%); MUM-1 was positive in 47 patients (58%) and BCL-2 was positive in 53 patients (65.4). With these results, 36 patients (44.4%) were in the GCB group and 45 patients (55.6%) were in the ABC group. No significant difference was found between the individual markers and subgroups in survival analyses. Conclusion: We did not determine any significant effect of CD10, BCL-6, MUM-1 or BCL-2 positivity or GCB and non-GCB groups in the survival of patients with DLBCL.Giriş ve Amaç: İmmünohistokimya kullanılarak, Diffüz büyük B hücreli lenfoma (DBBHL) vakaları germinal merkez B hücresi benzeri (GCB) ve ABC grubu olmak üzere prognostik açıdan önemli olan alt tiplere ayrılabilir. Biz bu çalışmada DBBHL’li hastaların patoloji preparatlarında CD10, B hücreli lenfoma 2 ve 6 (BCL2 ve BCL6) ve multipl miyelom onkogen 1 (MUM1) markerlarının sıklığını ve rituksimab içeren kemoterapi gruplarındaki prognostik etkisini araştırmayı amaçladık. Yöntem ve Gereçler: Hastalar, kemoterapi rejimleri açısından, siklofosfamid, doksorubisin, vinkristin ve prednizon (CHOP) veya Rituksimab-CHOP olarak 2'ye ayrıldı. Hastaların tedaviye yanıtı, takip süreleri ve tedavi sonuçları kaydedildi. Tanı anındaki patoloji preparatlarından CD10, BCL6 ve MUM1 / IRF 4 biyomarkerları için boyama yapılarak hastalar immünohistokimyasal panel açısından GCB veya ABC olarak alt gruplara ayrıldı. Bulgular: Toplam 81 hasta (39 erkek, 42 kadın) çalışmaya dahil edildi. Tanı sırasında 31 hastada (% 38,3) CD10; 53 hastada BCL-6 (% 65,4); MUM-1 47 hastada (% 58) ; BCL-2 53 hastada (65,4) pozitifti. Bu sonuçlarla 36 hasta (% 44.4) GCB grubu, 45 hasta (% 55.6) ABC grubu olarak tanımlandı. Sağkalım analizinde gruplar ve biyomarkerlar arasında istatistiksel olarak anlamlı bir farklılık saptanmamıştır. Tartışma ve Sonuç: DLBCL hastalarının sağkalımında CD10, BCL-6, MUM-1 veya BCL-2 pozitifliği veya GCB ve ABC gruplarının anlamlı bir etkisi saptanmamıştır
Can a patient with pulmonary hypertension travel safely by plane?
Get PDFAir travel is known as the safest way of transportation. Therefore, patients with health problems prefer to travel by air; however, those with heart or lung issues, who do not have any problems under normal conditions, may experience some problems in high altitude and different environmental conditions. In this review, we have described the points to be considered during air travel in patients with pulmonary hypertension
Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours
No full textNeuroendocrine tumors (NETs) are a rare and heterogeneous disease group and constitute 0.5% of all malignancies. The annual incidence of NETs is increasing worldwide. The reason for the increase in the incidence of NETs is the detection of benign lesions, incidental detection due to the highest use of endoscopic and imaging procedures, and higher recognition rates of pathologists. There have been exciting developments regarding NET biology in recent years. Among these, first of all, soma tosta tin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis, hormone secretion, and proliferation. Subsequently, activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism. Finally, the importance of proangiogenic factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblastic growth factor, angiopoietin, and semaphorins) in the progression of NET has been determined. Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment
The effect of carbon monoxide releasing molecule-2 (Corm-2) on healing of ischemic colon anastomosis in rats
Get PDFBackground/aim: Ischemia on the colon wall negatively affects healing of anastomosis. We were aimed to evaluate the effects of carbon
monoxide releasing molecule-2 (CORM-2) on the healing of anastomosis in a rat model of the ischemic colon.
Materials and methods: In this prospective study a total of 60 rats were randomly divided into three groups as colon transection and
end-to-end anastomosis (Group I), colon transection, and end-to-end anastomosis following the induction of ischemia (Group II), and
colon transection and end-to-end anastomosis following the induction of ischemia and treated with daily intraperitoneal administration
of CORM-2 (Group III). Each group was also divided into two equal subgroups as postoperative 3rd and 7th day. Postoperative healing
of anastomoses was evaluated by anastomosis burst pressure (ABP), tissue biomarkers including hydroxyproline (HP), malondialdehyde
(MDA), glutathione (GSH), and histopathological findings.
Results: In the ischemic group treated with CORM-2, lower MDA and higher HP levels were observed in comparison to the untreated
ischemic group on the 3rd day. GSH and HP levels were higher and MDA levels was lower in the ischemic rats treated with CORM-2
than in the ischemic untreated rats on the 7th day. In the ischemic group treated with CORM-2, the mucosal epithelial score decreased
and the neoangiogenesis score increased compared to the untreated rats on the 7th day.
Conclusion: In ischemic colon anastomosis, reduces cell destruction by suppressing the oxidative reaction, and strengthening the
antioxidative mechanisms of the cells. It also increases collagen formation, epithelial development, and neoangiogenesis
The impact of the covid-19 pandemic process on the health of working women WHO have A child
No full textYILMAZ Deniz Simge, COVID-19 Pandemi Sürecinin Çocuğu olan Çalışan Kadınların Sağlığına Etkisi. Yüksek Lisans Tezi. Ankara, 2021. Bu tanımlayıcı çalışma COVID-19 pandemi süreci öncesi ve sonrası döneminde, çocuğu olan çalışan kadınların sağlığına etki eden faktörleri belirlemek amacıyla, Nükleer Düzenleme Kurumu (NDK), Türkiye Enerji Nükleer ve Maden Araştırma Kurumu (TENMAK) ve Hacettepe Üniversitesi Erişkin Hastanesi'nde çalışan, çocuğa sahip 165 kadına 06.01.2021- 10.05.2021 tarihleri arasında yapılmıştır. Veri toplamak için, araştırmacı tarafından literatür taraması ile hazırlanan ''Veri Toplama Formu'' kullanılarak yüzyüze ve online ortamda veriler toplanmıştır. Analizler IBM SPSS Statistics 26.0 programı kullanılarak yapılmıştır. Çalışma verileri değerlendirilirken kategorik değişkenler için sıklıklar (sayı, yüzde), sayısal değişkenler için ise tanımlayıcı istatistikler (ortalama, standart sapma) verilmiştir. Sayısal değişkenlerin normallik varsayımları Kolmogorov Smirnov normallik testi ile incelenmiştir. İki bağımsız kategorik değişken arasındaki ilişkiler Ki Kare, iki bağımlı kategorik değişken arasındaki farklılıklar ise Mc Nemar analizi ile incelenmiştir. Analizlerde istatistiksel anlamlılık 0,05 düzeyinden yorumlanmıştır. Çalışmamıza katılan kadınların sağlığına etki eden faktörler incelendiğinde; kadınların pandemi öncesinde düzenli beslenmelerine dikkat ettikleri, pandemi sonrasında bu oranda azalma olduğu, pandemi sonrası kilolarının pandemi öncesi kilolarından anlamlı derecede fazla olduğu, pandemi öncesinde egzersiz yapan ve kendine kişisel vakit ayıran kadınların oranında pandemi sonrasında azalma olduğu belirlenmiştir. Pandemi öncesi uyku süresinin kendisine yeterli olduğunu düşünenlerin oranı, pandemi sonrasında anlamlı şekilde azalmıştır. Kadınların iş ve ev içi iş yükleri incelendiğinde, pandemi sonrası artış olduğu bulunmuştur. Pandemi öncesi dönemde muayene olmak için sağlık kurumuna gidenlerin oranında pandemi sonrasında azalma olmuştur. Pandemi öncesinde etkili iletişim kuranların oranında pandemi sonrasında azalma olduğu, pandemi sonrasında kadınların psikolojilerini olumlu değerlendirme düzeylerinin anlamlı şekilde azaldığı görülmüştür. Pandemi sürecinde kadınların çocukları ile kaliteli zaman geçirme oranları azalmıştır. Pandemi sonrası hijyen alışkanlıklarında değişiklik olanların oranı pandemi öncesine göre anlamlı şekilde artmıştır. Araştırmanın sonucunda, COVID-19 sürecinin kadınların sağlığına olumsuz etkisinin olduğu belirlenmiştir.YILMAZ Deniz Simge, The Impact of the COVID-19 Pandemic Process on the Health of Working Women Who Have a Child. Master Thesis. Ankara, 2021. This descriptive study was conducted to determine the factors affecting the health of working women who had children before and after the Covid-19 pandemic process. The study was conducted between 06.01.2021 and 10.05.2021 to 165 mothers working at the Nuclear Regulatory Authority (NDK), Turkish Energy Nuclear and Mining Research Institute (TENMAK) and Hacettepe University Adult Hospital. The data collection form was prepared by the researcher with a literature review, and data were collected face-to-face and online. Analyzes were made using the IBM SPSS Statistics 26.0 package program. While evaluating the study data; Frequencies (number, percentage) are given for categorical variables, and descriptive statistics (mean, standard deviation) are given for numerical variables. Normality assumptions of numerical variables were examined with the Kolmogorov Smirnov Normality test and it was seen that the variables were normally distributed. For this reason, parametric statistical methods were used in the study. Relationships between two independent categorical variables were analyzed by Chi-Square, and differences between two dependent categorical variables were analyzed by McNemar analysis.Statistical significance was interpreted at the 0.05 level in the analyzes. The fact that the traditional roles attributed to women by society have to continue with their working life can cause women to experience difficulties. Compulsory changes in lifestyles due to the COVID-19 pandemic process, which has affected the whole world, have caused effects at different levels in the individual, family and society. This thesis was conducted to examine the effect of this process on women's health. When the work and domestic workloads of women were examined, it was found that there was an increase after the pandemic. In the pre-pandemic period, the rate of those who went to the health institution to be examined decreased after the pandemic. It was observed that the rate of those who communicated effectively before the pandemic decreased after the pandemic, and the positive evaluation levels of women's psychology decreased significantly after the pandemic. During the pandemic process, the rate of women spending quality time with their children has decreased. The rate of those who have changed their hygiene habits after the pandemic has increased significantly compared to the pre-pandemic period. As a result of the research, it was determined that the COVID-19 process has a negative effect on women's health
Clinical characteristics and growth hormone treatment in patients with prader-willi syndrome
Get PDFObjective: To investigate clinical characteristics and response to growth hormone (GH) treatment in patients with Prader-Willi syndrome
(PWS) in Turkey.
Methods: The data of 52 PWS patients from ten centers was retrospectively analyzed. A nation-wide, web-based data system was used
for data collection. Demographic, clinical, genetic, and laboratory data and follow-up information of the patients were evaluated.
Results: The median age of patients at presentation was 1.5 years, and 50% were females. Genetic analysis showed microdeletion in
69.2%, uniparental disomy in 11.5%, imprinting defect in 1.9% and methylation abnormality in 17.3%. Hypotonia (55.7%), feeding
difficulties (36.5%) and obesity (30.7%) were the most common complaints. Cryptorchidism and micropenis were present in 69.2%
and 15.3% of males, respectively. At presentation, 25% had short stature, 44.2% were obese, 9.6% were overweight and 17.3% were
underweight. Median age of obese patients was significantly higher than underweight patients. Central hypothyroidism and adrenal insufficiency were present in 30.7% and 4.7%, respectively. Hypogonadism was present in 75% at normal age of puberty. GH treatment
was started in 40% at a mean age of 4.7±2.7 years. After two years of GH treatment, a significant increase in height SDS was observed.
However, body mass index (BMI) standard deviation (SDS) remained unchanged.
Conclusion: The most frequent complaints were hypotonia and feeding difficulty at first presentation. Obesity was the initial finding
in 44.2%. GH treatment was started in less than half of the patients. While GH treatment significantly increased height SDS, BMI SDS
remained unchanged, possibly due to the relatively older age at GH start.
Keywords: Prader-Willi syndrome, endocrine dysfunction, growth hormone treatment, body compositio
Transition from the personnel management to human resources management: The sample of Bingöl municipiality
No full textBu amaç doğrultusunda Bingöl Belediyesi çalışanlarına uygulanmak üzere bir anket düzenlenmiş ve Bingöl Belediyesi'nin 94 çalışanına uygulanmıştır. Anket sonuçlarının analizi bilgisayar ortamında, SPSS programı kullanılarak analiz edilmiştir. İnsan kaynakları yönetimine geçişin belediye personeli üzerindeki etkisini değişkenlere bağlı olarak analiz edebilmek için ki-kare analizi yapılmıştır. Bu bağlamda birtakım demografik değişkenlerin, personelin belediyedeki değişime olan tepkisiyle bağlantılı olup olmadığı incelenmiştir. Bununla birlikte katılımcıların değişkenlere bağlı olarak verdikleri cevapların oranları da ki-kare test sonuçlarıyla birlikte değerlendirilmiştir. Araştırma sonucunda; Bingöl Belediyesi'nde personel yönetiminden insan kaynaklarına geçişte yaşanan Değişikliklere belediye personelinin tepkileri ölçülmüştür. Yapılan bu değişiklikte insan kaynakları yönetimine geçişten belediye personelinin büyük oranda memnun olduğu ve değişiklikleri fark ettiği görülmüştür. Bu bağlamda, çalışmanın 3. bölümünde de açıklanacağı üzere yapılan SPSS analizinde katılımcıların bazı demografik değişkenlerinin anket sonucuna verdikleri yanıtı etkilediği görülmüştür.This construction purpose: In the transition from public administration management to human resources management, it is to determine the continuing clothing and the impact this printer has on the printer. For this purpose, a survey has been prepared to be applied to Bingöl Municipality employees and applied to Bingöl Municipality's employees. In order to analyze this, the questionnaire was applied to 94 employees of Bingöl Municipality. Analysis of the survey results was programmed in the computer environment, SPSS program. A chi-square analysis has been conducted to analyze the transition to human resources management depending on the responsibilities turned into municipal officials. In this context, it was analyzed whether certain demographic variables are individually related to the changing response with their response. In addition, the answers given by the participants depending on the variables were analyzed together with the chi-square test results. About the research, In Bingöl Municipality, rotary transformations in the transition from personal management to human resources were measured. With this change, it has been observed that the municipality personnel are mostly satisfied with the transition to human resources management and the change has been made. In this context, it was observed that some demographic variables of the SPSS participants, which will be carried out as explained in section 3, affect their response to the results of the questionnaire
The effect of folate on ischemia/reperfusion injury in a rat adnexal torsion model
Get PDFPurpose The ischemia/reperfusion (I/R) injury of ovaries in adnexal torsion may have inadvertent consequences. Many agents have been studied in terms of their ability to prevent reperfusion damage to ovaries in suspected cases. In this study, folic acid, known to have antioxidative properties, was investigated to determine whether it played a role in the prevention of I/R damage in a rat ovarian torsion model.Methods In this experimental study, 40 female adult Wistar-Albino rats were randomly divided into fve groups as control, ischemia, I/R, Fol2 (2 mg/kg folic acid), and Fol4 (4 mg/kg folic acid). In the Fol2 and Fol4 groups, folic acid was intra peritonelly administered 30 min before reperfusion. Blood samples were obtained from the tails of each rat at the second hour of reperfusion.Results The total oxidant status (TOS), total antioxidant status, cystatin C and folic acid levels of the fve groups were investigated. Folic acid in 2 mg/kg dose could moderately increase the serum folic acid concentration (15.75–19.95 ng/ml, p0.05), although there was no statistical diference in TOS levels (p=0.07). Folic acid in 4 mg/kg dose, could signifcantly increase the serum folic acid concentration (15.75–37.65 ng/ml). However, it did not signifcantly reduce the level of cystatin C (0.18–0.19 µg/L, p>0.05), and did not improve oxidative stress injury (76.05–130.58, p>0.05).Conclusion Folic acid in 2 mg/kg dose might improve the ovarian I/R injury though this was not statistically signifcant. Further studies are required to reach a defnitive conclusion about the protective efect of folic acid in I/R injury