Rumah Jurnal Universitas Majalengka
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Estimating permeability of carbonate rocks from porosity and vp ∕ vs
No full textWe present a method for predicting permeability from sonic and density data. The method removes the porosity effect on the ratio [Formula: see text] of dry rock, and it addresses the specific surface as an indirect measure of permeability. We look at ultrasonic data, porosity, and the permeability of 114 carbonate core plugs. In doing so, we establish an empirical relationship between the specific surface of the solid phase (as calculated by Kozeny’s equation) and [Formula: see text] (linearly transformed to remove the porosity effect). One must view the specific surface derived by using Kozeny’s equation as an effective specific surface because Kozeny’s equation only holds for homogeneous rock with interconnected pores. The ratio [Formula: see text] of dry rocks, on the other hand, seems to be controlled by the true specific surface, pointing to an inherent limitation in the method. The 114 carbonate plugs originate in three geological settings and comprise 83 calcitic and 31 dolomitic samples. Their depositional texture varies from mud-dominated to grain-dominated and recrystallized types. Our research applies the relationship to 137 carbonate samples from two different depositional settings. We find a reasonable match between predicted and measured permeability. The match is better for samples with carbonate mud-filled depositional textures than for carbonate mud-poor depositional textures. Diagenetic factors such as vuggy porosity decrease the predictability of permeability
Recruiting Intergenerational African American Males for Biomedical Research Studies: A Major Research Challenge
No full textThe health and well-being of all individuals, independent of race, ethnicity, or gender, is a significant public health concern. Despite many improvements in the status of minority health, African American males continue to have the highest age-adjusted mortality rate of any race-sex group in the United States. Such disparities are accounted for by deaths from a number of diseases such as diabetes, human immunodeficiency virus (HIV), cancer, and cardiovascular disease, as well as by many historical and present social and cultural constructs that present as obstacles to better health outcomes. Distrust of the medical community, inadequate education, low socioeconomic status, social deprivation, and underutilized primary health care services all contribute to disproportionate health and health care outcomes among African Americans compared to their Caucasian counterparts. Results of clinical research on diseases that disproportionately affect African American males are often limited in their reliability due to common sampling errors existing in the majority of biomedical research studies and clinical trials. There are many reasons for underrepresentation of African American males in clinical trials, including their common recollection and interpretation of relevant historical of biomedical events where minorities were abused or exposed to racial discrimination or racist provocation.1In addition, African American males continue to be less educated and more disenfranchised from the majority in society than Caucasian males and females and their African American female counterparts. As such, understanding their perceptions, even in early developmental years, about health and obstacles to involvement in research is important. In an effort to understand perspectives about their level of participation, motivation for participation, impact of education, and engagement in research, this study was designed to explore factors that impact their willingness to participate. Our research suggests that: (1) African American males across all ages are willing to participate in several types of research studies, even those that require human samples; (2) their level of participation is significantly influenced by education level; and (3) their decision to participate in research studies is motivated by civic duty, monetary compensation, and whether they or a relative has had the disease of interest. However, African American males, across all age groups, continue to report a lack of trust as a primary reason for their unwillingness to participate in biomedical research. There is an ongoing need to continue to seek advice, improve communication, and design research studies that garner trust and improve participation among African American males as a targeted underrepresented population. Such communication and dialogues should occur at all age levels of research development to assess current attitudes and behaviors of African American males around participation
Effects of fenbendazole on routine immune response parameters of BALB/c mice
No full textFenbendazole (FBZ) is an anthelmintic drug widely used to treat and prevent pinworm outbreaks in laboratory rodents. Although data in nonrodent species indicate possible effects of fenbendazole on the bone marrow and lymphocyte proliferation and function, little has been reported regarding possible effects on the rodent immune system. The purpose of the current study was to determine the effects of a therapeutic regimen of FBZ on immune parameters in BALB/c mice. Both 9-wk on-off and 5-wk continuous medicated feed protocols were assessed. No significant differences between normal and FBZ diet treated mice were observed in the following parameters: complete blood count, blood chemistry, quantitation of major T and B cell markers in spleen, quantitation of T cell markers in the thymus, spleen cell proliferation to T and B cell mitogens, bone marrow colony-forming cell assays, skin graft rejection, and primary and secondary humoral immune responses. These data indicate that FBZ treatment does not affect many standard broad measures of immune function
Preferential uptake of restriction fragments from a gonococcal cryptic plasmid by competent Neisseria gonorrhoeae
No full textFactors involved in the specificity of DNA uptake by competent Neisseria gonorrhoeae were examined. Host-controlled modification did not affect uptake. Certain restriction fragments of the 4.2 kb gonococcal cryptic plasmid pFA1 and of the replicative form of the bacteriophage M13 were taken up in preference to others, independent of differences in fragment size. A 600 bp fragment from the 4.2 kb plasmid was cloned into pLES2, a gonococcal-Escherichia coli shuttle vector; the 600 bp fragment was taken up into a DNAase-I-resistant state in preference to the vector fragment. A second 370 bp fragment in pFA1 was also taken up preferentially. The 600 bp and 370 bp fragments share a 10 bp sequence, which is found in pFA1 only on fragments that were taken up readily. However, a fragment from M13 which was efficiently taken up did not contain this 10 bp sequence. In addition, this sequence was not sufficient to direct preferential DNA uptake by gonococci, since a recombinant plasmid containing this 10 bp sequence was not taken up appreciably better than the vector plasmid or another recombinant plasmid containing an unrelated 10 bp sequence. Sequence comparisons of the three restriction fragments which were preferentially taken up did not yield any consensus sequences greater than 7 bp. Although it is likely that efficient uptake of DNA by gonococci is determined by DNA structure, a single short sequence could not be found that accounted for specific uptake
Myocarditis simulating acute transmural myocardial infarction
No full textA patient with cardiogenic shock had typical electrocardiographic findings of acute anterior transmural myocardial infarction. Cardiac catheterization revealed normal coronary arteries and severe biventricular failure. Postmorten examination confirmed normal coronary arteries; acute myocarditis, but no evidence for infarction, was found. Electrocardiographic changes of myocarditis may be indistinguishable from acute transmural infarction. In suspected cases, cardiac catheterization should be considered prior to thrombolytic therapy
The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts
No full text4-hydroxy-4-androstene-3,17-dione (4-OHA) has been shown to be a potent inhibitor of aromatase activity. It is effective in the control of estrogen-dependent processes in female subjects and may potentially be useful in the treatment of estrogen-dependent processes in men. Human foreskin fibroblasts grown in cell culture provide a model to investigate the effects of 4-OHA on extraglandular aromatase activity as well as the ability of the compound to influence androgen receptor binding and the 5α-reduction of testosterone (T). Initial experiments were carried out to determine the potency of 4-OHA in genital skin fibroblasts by incubating cells with 4-OHA over a range of concentrations. When aromatase activity was determined at a substrate concentration close to the apparent
K
m of the enzyme, a 44% inhibition of enzyme activity occurred at a mean concentration of 5 nM 4-OHA. Enzyme kinetic studies analyzed by Eadie-Hofstee plots demonstrated competitive inhibition by 4-OHA with a mean apparent
K
i of 2.7 nM. When 5α-reductase activity was determined in the presence of 200 nM [
3H]T, in the absence or presence of 4-OHA, a 50% inhibition of enzyme activity occurred at an inhibitor concentration of 3 μM. In androgen receptor binding studies, 4-OHA possessed 1% of the affinity of dihydrotestosterone (DHT) for [
3H]DHT binding sites. In summary: 4-OHA is a potent and specific inhibitor of aromatase activity in human genital skin fibroblasts, the affinity of the enzyme for 4-OHA being greater than its affinity for the substrate, adrenostenedione. The influence of 4-OHA on 5α-reductase activity and androgen receptor binding is minimal
Major depressive disorder and impulsive reactivity to emotion: toward a dual-process view of depression
No full textDual-process theories of behaviour have been used to suggest that vulnerability to depression involves elevated reactivity to emotions. This study tests that idea, examining self-reported reactivity.
Comparison between persons with at least one lifetime episode of major depressive disorder (lifetime MDD) and those without this diagnosis, controlling for symptoms of alcohol use (a potential externalizing confound) and current symptoms of depression (a potential state-dependent confound).
Undergraduates (N = 120) completed a clinical interview to diagnose lifetime MDD and a series of self-reports bearing on diverse aspects of self-control, including reactivity to emotion. Thirty-four people were diagnosed with lifetime MDD; 86 did not meet criteria for MDD. The groups were then compared on three factors underlying the scales assessing self-control.
The MDD group had higher scores than controls on the two factors that reflect impulsive reactivity to diverse emotions, including emotions that are positive in valence. These effects were not explained by associations with either externalizing symptoms or current depressive symptoms.
Reflexive reactivity to emotions characterizes depression, in addition to some externalizing problems, and it may deserve study as a potential trans-diagnostic feature.
Reflexive reactivity to emotions characterizes persons diagnosed with major depressive disorder. Findings suggest desirability of focusing treatment partly on management of reflexive reactions to emotions.
Measures were self-reports, rather than behavioural responses to emotions
Traktor Modern Berbasis pH dan NPK Sensors Guna Meningkatkan Produktivitas dan Kualitas Tanaman di Desa Madiredo Kabupaten Malang
No full textAgriculture is a crucial sector in supporting food security and the national economy. However, the limited use of modern technology remains a barrier to increasing farmer productivity. The partner for this community service activity is the HARAPAN Farmers Group in Sobo Hamlet, Madiredo Village, Pujon District, Malang Regency, which manages approximately 0.5 hectares of land with an average yield of 30 tons of vegetables per harvest. The partner's main problems include the use of time-consuming conventional tools, suboptimal soil quality, and harvests that do not meet market standards. The solution offered is the implementation of a modern tractor based on pH and NPK sensors integrated with the NANDUR application. This application functions to monitor soil conditions, provide suggestions for suitable plant types, and display information related to cultivation. The implementation of this technology has been proven to increase work efficiency by speeding up the land processing process from 10 hours to 5 hours and helping farmers understand land conditions for appropriate decision-making. This activity is expected to increase productivity, the quality of agricultural products, and the welfare of farmers in a sustainable manner
PENDAMPINGAN DALAM RANGKA TRANSFORMASI KAFE JAMU SUKOHARJO SEBAGAI DESTINASI EDUWISATA BERBASIS KEARIFAN LOKAL
No full textSukoharjo dikenal sebagai kota jamu yang memiliki peranan penting dalam sentra industri jamu di Indonesia. Jamu merupakan warisan tradisi budaya yang tidak dapat dipisahkan dari budaya masyarakat peraciknya. Kafe jamu Sukoharjo yang beralamatkan di Dusun II, Nguter, Kec. Nguter, Kabupaten Sukoharjo, Jawa Tengah, tepatnya berada di dalam Pasar Nguter. Permasalahan mitra yang diangkat dalam kegiatan ini adalah pengembangan destinasi wisata Kafe Jamu Sukoharjo menjadi eduwisata sehingga dapat meningkatkan ketertarikan pengunjung dan meningkatkan promosi Kafe Jamu Sukoharjo sebagai destinasi wisata. Tujuan Pelaksanaan Kegiatan ini adalah untuk meningkatkan daya guna Kafe Jamu Sukoharjo menjadi sebuah destinasi eduwisata yang tidak hanya menyajikan jamu sebagai minuman tradisional, tetapi juga memberikan pengalaman edukatif dan memperkenalkan kearifan lokal dalam bentuk pemanfaatan tanaman obat. Metode yang digunakan dalam kegiatan pendampingan ini adalah identifikasi masalah, perencanaan program, pelatihan, serta monitoring dan evaluasi. Hasil yang didapatkan selama program adalah tersusunnya paket workshop bagi pengunjung dalam bentuk booklet, pojok herbarium, papan informasi tanaman obat serta website Kafe Jamu Sukoharjo. Adanya pendampingan ini telah mendorong Kafe Jamu untuk melakukan beberapa perbaikan, diantaranya adalah perbaikan dalam menu serta tampilan sajian bagi pengunjung, dan selanjutnya yang akan dilakukan adalah perbaikan layout. Kegiatan pendampingan ini akan terus dilakukan untuk membantu kemajuan Kafe Jamu Sukoharjo
Inisiasi Knowledge-Based Collaboration Untuk Memperkuat Kapasitas Inovasi Dan Ketahanan Ekonomi Usaha Mikro Kecil Dan Menengah (UMKM) Di Desa Babakan Kecamatan Kertajati Kabupaten Majalengka
No full textKegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk memperkuat kapasitas inovasi dan ketahanan ekonomi pelaku Usaha Mikro, Kecil, dan Menengah (UMKM) di Desa Babakan, Kecamatan Kertajati, Kabupaten Majalengka melalui pendekatan knowledge-based collaboration. UMKM di wilayah ini memiliki potensi ekonomi yang besar, namun menghadapi berbagai kendala, terutama rendahnya literasi digital, keterbatasan pencatatan keuangan berbasis teknologi, dan minimnya kolaborasi antar pelaku usaha. Kegiatan dilaksanakan pada 12 Juni 2025 di Balai Desa Babakan dengan melibatkan 20 pelaku UMKM dari berbagai sektor usaha. Metode pelaksanaan menggunakan pendekatan partisipatif melalui pelatihan, pendampingan, dan praktik langsung, yang mencakup penggunaan aplikasi SIAPIK (Sistem Aplikasi Pencatatan Informasi Keuangan), penguatan konsep knowledge sharing, serta penyusunan business plan. Hasil kegiatan menunjukkan peningkatan pemahaman peserta terkait literasi digital, manajemen usaha, dan kolaborasi berbasis pengetahuan, dengan peningkatan skor post-test rata-rata sebesar 20% pada 85% peserta. Selain itu, terbentuk komunitas UMKM berbasis knowledge sharing yang berfungsi sebagai wadah kolaboratif untuk mendukung keberlanjutan usaha. Program ini sejalan dengan tujuan Sustainable Development Goals (SDGs), khususnya tujuan ke-8 (pekerjaan layak dan pertumbuhan ekonomi) serta tujuan ke-9 (industri, inovasi, dan infrastruktur), dan diharapkan dapat direplikasi di wilayah lain dengan karakteristik serupa