Revistas de Investigación UNHEVAL (Universidad Nacional Hermilio Valdizán de Huánuco)
Not a member yet
1288 research outputs found
Sort by
Successful IgM-enriched immunoglobulin treatment in severe COVID-19 pneumonia: a case report
Get PDFCoronavirus disease (COVID-19) pandemic has turned into one of the most considerable challenges worldwide. The optimal treatment strategy, particularly in severely ill patients, is still unrecognized. IgM-enriched immunoglobulin (Pentaglobin®, Biotest AG, Dreieich, Germany) contains IgM, IgA and IgG against a variety of pathogens representing passive immune protection for affected individuals and it may be effective in the treatment of COVID-19. On March 16, 2020, a 32-year-old woman presented to Masih Daneshvari Hospital, Tehran, Iran. On admission, the peripheral oxygen saturation (O2 Sat) was 84%. Spiral chest computed tomography (CT) scan revealed bilateral ground-glass opacification (GGO) involvement. On March 19, 2020, the clinical condition was deteriorated, and her O2 Sat decreased to 70% in ambient air. Treatment with IgM-enriched immunoglobulin was immediately initiated over the course of three days (total dose for the patient was calculated to be 1500 ml). On the seventh day of hospitalization, the patient was discharged with satisfactory general condition, without any complaints, and with stable vital signs and O2 Sat of 95% on room air. In conclusion, IgM-enriched immunoglobulin could be considered as a potential option for the treatment of severely ill patients with COVID-19
Cutaneous histoplasmosis. A case report
Get PDFHistoplasmosis is an endemic infection of Ecuador, its forms of presentation can be varied and florid, especially in immunosuppressed patients, its lethality is high, hence its diagnosis and treatment should be based on both clinical and laboratory results. Cutaneous histoplasmosis is a form of disseminated Histoplasma capsulatum infection rarely described in HIV patients. The following is a description of the diagnosis and treatment of a patient with generalized papular skin lesions, heat stroke, diarrhea, attributed to adverse reaction of gastritis treatment of 10 days of evolution, this was associated with a recent diagnosis of HIV infection following his admission to hospital
Lactate as an important biomarker of cerebrospinal fluid in infectious diseases of the central nervous system: A comprehensive literature review
Get PDFCentral nervous system (CNS) infections are a group of diseases, where meningitis (associated or not to neurosurgical interventions) and bacterial ventriculitis have been studied for many years in order to establish early diagnosis methods through direct therapy to reduce morbidity and mortality in this population. Analysis of the cerebrospinal fluid (CSF) is an important source of information for diagnosis of neuroinfection. Lactate concentration in the cerebrospinal fluid has a value independent of plasma because it does not cross the blood-brain barrier, therefore, constitutes the end-product of the bacterial anaerobic glycolysis being the primary source of lactate in the CSF. Therefore, it has a great tool in the diagnostic approach of bacterial meningitis, however, reference values are not warranted. Objective: The authors present the latest scientific evidence on the use of lactate as a diagnostic method for two neurological pathologies with highest incidence on population, establishing a translational approach to clinical practice. Methods: A comprehensive literature review was carried out. We describe the results of a structured search based on keywords infection, meningitis, ventriculitis, bacterial, cerebrospinal fluid, and lactate, vía Medline, Scopus, WoS, EMBASE, and LATINDEX databases. Conclusion: Lactate in a CSF sample is useful to determine the bacterial etiology in patients with suspected meningitis. CSF lactate value equal or higher than 4 mmol/l could indicate bacterial meningitis about 90% of probability. Lactate value is identical in patients with ventriculitis; however, it cannot be established as neuroinfection, therefore, we should use another diagnostic method.
Objective: This work will present the updated scientific evidence regarding the use of lactate as a diagnostic method for two neurological entities with high incidence in our population, establishing a translational approach to our clinical practice.
Methods: A comprehensive literature review was carried out we wrote the results of a structured search with the keywords infection, meningitis, ventriculitis, bacterial, cerebrospinal fluid, and lactate, in both English and Spanish within the Medline, Scopus, WoS, EMBASE, and LATINDEX databases.
Conclusion: Measuring lactate in a CSF sample is useful to determine the bacterial etiology in patients with suspected meningitis, a CSF lactate value greater than or equal to 4 mmol / l means that a patient will have bacterial meningitis with certainty greater than 90% However, the lactate value is the same in a patient with ventriculitis, it cannot be established with total certainty that it is a neuroinfection, therefore, we should use some other diagnostic metho
Factor humano y condiciones de trabajo en el sector hotelero, provincia de Leoncio Prado, Huánuco
Get PDFThe human factor is the fundamental resource to achieve the success of a company, however, few investigations indicate its influence on working conditions. The objective of the study was to analyze the human factor and decent work conditions in 110 housekeeping and reception workers, distributed in 34 lodging establishments in the province of Leoncio Prado. The research is explanatory, transversal and was based on the concept of decent work proposed by the international labor organization. For data collection, a survey was applied, using a questionnaire of 15 questions, with a content validity of equal to 0.997 and a reliability of Cronbach\u27s alpha equal to 0.80. In the results it was found that 51.95% of the workers are in regular basic education, 57.5% work for up to one year and 62% have not received any type of training. Through the multinominal probit model, it is concluded that the human factor indicators: years of studies, experience and job training increase the probability of having decent working conditions by 9.34%, 11.1% and 86.7% respectively.El factor humano es el recurso fundamental para lograr el éxito de una empresa; sin embargo, pocas investigaciones señalan sobre su influencia en las condiciones de trabajo. El objetivo de estudio fue analizar el factor humano y las condiciones de trabajo decente en 110 trabajadores en limpieza y recepción, distribuidos en 34 establecimientos de hospedaje de la provincia de Leoncio Prado. La investigación es explicativa, transversal y se basó en el concepto de trabajo decente propuesto por la organización internacional de trabajo. Para la recolección datos, se aplicó una encuesta, utilizando un cuestionario de 15 preguntas, con una validez de contenido de igual a 0.997 y una confiabilidad de alfa de Cronbach igual 0,80. En los resultados se encontró que en ambas ocupaciones el 51.95% de los trabajadores se encuentra en educación básica regular, el 57.5% trabajó hasta un año y el 62% no ha recibido algún tipo de capacitación. A través del modelo probit multinominal, se concluye que los indicadores del factor humano: años de estudios, experiencia y capacitación laboral aumentan la probabilidad de tener condiciones de trabajo decente en 9,34%, 11.1% y 86.7%, respectivamente
Exportación de conservas de pescado: revisión sistemática de la literatura científica (2001-2021)
Get PDFObjective. To show experiences and export plans of canned fish in South America presented in ScienceDirect, Redalyc, Scielo, Doaj, Econbiz, Sisbib, La Referencia and Fedesarrollo, between the years 2001 and 2021. In addition, the specific objectives were to identify the countries from which these experiences and export plans originate, to which countries they are oriented, their logistic methods, conclusions and recommendations. Method. A systematic review was conducted in which 1,069,944 records were identified, which, after application of exclusion and inclusion criteria, were reduced to 10 final records for analysis. Results. Data was extracted referring to the authors\u27 names, the year of publication, the title of the record, the type of document (thesis, scientific article or technical report), the export product, exporting and importing country, logistic method and conclusions of the original authors. Conclusion. Of the selected records, most of the exports come from Ecuador (4 cases), the most used logistical method is maritime transport and their main destination is the U.S. market (5 cases), which concentrates the greatest demand for canned fish from the region, especially of Ecuadorian origin.Objetivo. Evidenciar experiencias y planes de exportación de conservas de pescado en Sudamérica presentadas en ScienceDirect, Redalyc, Scielo, Doaj, Econbiz, Sisbib, La Referencia y Fedesarrollo, entre los años 2001 y 2021. Además, se tuvo como objetivos específicos identificar de qué países provienen dichas experiencias y planes de exportación, a qué países se orientan, sus métodos logísticos, conclusiones y recomendaciones. Método. Se condujo una revisión sistemática en la que se identificaron 1 069 944 registros, los cuales, luego de la aplicación de criterios de exclusión e inclusión, se redujeron a 10 registros finales para el análisis. Resultados. Se extrajo data alusiva a los nombres de los autores, el año de publicación, el título del registro, el tipo de documento (tesis, artículo científico o informe técnico), el producto de exportación, país exportador e importador, método logístico y conclusiones de los autores originales. Conclusión. De los registros seleccionados, la mayoría de las exportaciones proviene de Ecuador (4 casos), el método logístico más utilizado es el transporte marítimo y tienen como destino principal el mercado estadounidense (5 casos) que concentra la mayor demanda por conservas de pescado de la región, especialmente de origen ecuatoriano
El rol de la literacidad crítica en la formación ciudadana
Get PDFThe present text analyzes the connection between critical literacy and citizenship education. Its objective is to describe the theoretical concepts found in the rol it has in citizen education. It was found that the critical literacy approach should be considered in order to foster responsible participation and social transformation since it allows students to have a toolbox to confront social inequities. Furthermore, educational proposals have been put forward to take the theory to the praxis. Lastly, it is essential to bear in mind this information so as to prepare students for the challenges in the 21st century and provide education for social change.El presente texto analiza la relación entre la literacidad crítica y la formación ciudadana. Se plantea como objetivo describir la conceptualización teórica encontrada sobre el rol de la literacidad crítica en la formación ciudadana. Se evidenció que para tener una educación que incentive la participación responsable y transformación social, se debe considerar al enfoque de la literacidad crítica en las escuelas, pues permite que los estudiantes tengan herramientas para hacerle frente a las desigualdades sociales. Asimismo, se dieron a conocer propuestas pedagógicas para llevar este enfoque de la teoría a la práctica. Finalmente, es imprescindible tener presente estas pautas para formar a estudiantes preparados para los desafíos del siglo XXI y brindar una educación para el cambio social
Uso y duración de terapia antibiótica en la exacerbación pulmonar aguda de la fibrosis quística: un tema aún sin definir
Get PDFCystic fibrosis is a condition about which not much is yet known and remains a hot topic in translational and pulmonary medicine. Evidence on the management of exacerbations is limited, with few clinical trials and systematic reviews. For example, the use and duration of antibiotics in this condition is unknown. Considering that this is a disease that entails high health costs and substantially decreases the functional capacity of the affected person, it is necessary to quickly establish practical algorithms based on evidence. Based on the above, the objective of this narrative review is to synthesize evidence on the use and duration of antibiotic therapy in acute pulmonary exacerbations in patients with cystic fibrosis. For this, a bibliographic search was carried out in the search engines and databases PubMed, ScienceDirect, Embase, EBSCO and MEDLINE. It was defined that any article related to the evaluation of the use and duration of antibiotic therapy in acute pulmonary exacerbation in patients with cystic fibrosis would be included, giving priority to original studies and systematic reviews and meta-analyses. After the review of the title and the summary of all the results, 42 articles were finally included. It was found that antibiotic therapy 10 days after standard treatment, by intravenous route, either doxycycline or azithromycin plus colistimethate, allows greater recovery of lost pulmonary function, lengthens the time until the next exacerbation and resolves symptoms quickly.La fibrosis quística es una enfermedad sobre la que aún no se sabe mucho y sigue siendo un tema candente en la medicina traslacional y pulmonar. La evidencia sobre el manejo de las exacerbaciones es limitada, con pocos ensayos clínicos y revisiones sistemáticas. Por ejemplo, se desconoce el uso y la duración de los antibióticos en esta enfermedad. Teniendo en cuenta que se trata de una enfermedad que supone un elevado coste sanitario y que disminuye sustancialmente la capacidad funcional del afectado, es necesario establecer rápidamente algoritmos prácticos basados en la evidencia. En base a lo anterior, el objetivo de esta revisión narrativa es sintetizar evidencia sobre el uso y la duración del tratamiento antibiótico en las exacerbaciones pulmonares agudas en pacientes con fibrosis quística. Para esto, se llevó a cabo una búsqueda bibliográfica en los motores de búsqueda y bases de datos bases de datos PubMed, ScienceDirect, Embase, EBSCO y MEDLINE. Se definió que cualquier artículo relacionado con la evaluación del uso y duración de antibioticoterapia en la exacerbación aguda pulmonar del paciente con fibrosis quística, sería incluido, dando prioridad a los estudios originales y a las revisiones sistemáticas y meta-análisis. Posterior a la revisión del título y resumen de todos los resultados, se incluyeron 42 artículos. Se encontró que instaurar antibioticoterapia 10 días posterior al tratamiento estándar, por vía intravenosa, ya sea de doxiciclina o azitromicina más colistimetato, permite obtener mayor recuperación de la función pulmonar perdida, alargar el tiempo hasta la próxima exacerbación y solucionar sintomatología rápidamente
Aula virtual y cultura digital en estudiantes de posgrado de una universidad pública peruana
Get PDFThe present study aims to determine the relationship between the virtual classroom and digital culture in research and higher education master\u27s degree students at a Peruvian public university. Through a basic research, correlational level and non-experimental design of transectional type. With a total of 30 students selected through a non-probabilistic purposive sampling. The data were collected at two moments, using two questionnaires validated by judgment of 5 experts and with a reliability of cronbach\u27s alpha coefficient of α=0.869 and α=0.849 respectively. The results show that for the virtual classroom variable, 36,67% always put it into practice, 53,33% sometimes and 10% never. On the other hand, for the digital culture variable; 23,33% evidenced that it is always being updated, 53,33%, sometimes and 23,33%, never. A positive average relationship was verified through Spearman\u27s rank order correlation coefficient (Rho = 0.539; p = 0.002). It is concluded that the virtual classroom allows the development of a digital culture in graduate students; therefore, the training and development of digital competencies corresponds to all members of the academic community.El presente estudio tiene como objetivo determinar la relación entre el aula virtual y cultura digital en los maestristas de investigación y docencia superior de una universidad pública peruana. A través de una investigación de tipo básica, nivel correlacional y diseño no experimental de tipo transeccional. Con un total de 30 estudiantes seleccionados a través de un muestreo no probabilístico intencionado. Los datos fueron recolectados en dos momentos, utilizando dos cuestionarios validados por juicio de 5 expertos y con una confiabilidad del coeficiente alfa de cronbach de α=0,869 y α=0,849 respectivamente. Los resultados evidencian para la variable aula virtual; que el 36,67% siempre lo pone en práctica, el 53,33%, a veces y el 10%, nunca. Por otro lado, para la variable cultura digital; el 23,33% evidenció que siempre se está actualizando, el 53,33%, a veces y el 23,33%, nunca. Se comprobó una relación positiva media a través del coeficiente de correlación de orden por rangos de Spearman (Rho = 0,539; p = 0,002). Se concluye que el aula virtual permite el desarrollo de una cultura digital en los estudiantes de posgrado; por lo que la formación y desarrollo de competencias digitales corresponde a todos los miembros de la comunidad académica