Eureka Herba Indonesia (EHI - E-Journal)
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Potential Combination of Tinospora crispa, Andrographis paniculata, Cinnamomum burmanii, Syzygium polyanthum, and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus
Get PDFDiabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. This disorder is characterized by a decrease in the ability of body cells to intake glucose into cells. Due to the failure of cells in glucose intake, glucose buildup occurs in the extracellular, namely in the plasma. These medicinal plants contain quite varied secondary metabolites, and these plants are rich in flavonoids, alkaloids, terpenes, and glycosides. The content of these secondary metabolite compounds is believed to be rich in antioxidant effects so that it has the effect of being able to suppress various oxidative stress conditions that cause damage to various organs due to blood sugar dysregulation. The effect of Tinospora crispa, Andrographis paniculata, Cinnamomum burmanii, Syzygium polyanthum and Momordica charantia extract on blood sugar levels and GLUT4 protein expression in muscle tissue shows the potential of the test extract's ability to improve blood glucose intake to cells so as to maintain blood sugar regulation
Antibacterial and Antifungal Activity of Clove Extract (Syzygium Aromaticum): Review
Get PDFCloves is one of the native Indonesian plants and is used in many aspects of life. Cloves are used in multiple industries and as detergents, soaps, perfumes, food seasonings, aromatherapy, etc. Cloves are mainly used for ingredients in kretek cigarettes in Indonesia. Various studies of cloves reported they have good pharmacological and therapeutic effects. The main compounds of clove extract are eugenol and β-caryophyllene, which are powerful antibacterial and antifungal agents. The clove ethanolic extract showed the activity to inhibit Gram-positive and negative bacteria such as B. cereus, S. aureus, E. coli, P. aeruginosa, S. pneumonia, S. aureus,S. epidermidis, A. hydrophila, K. pneumoniae, P. gingivalis, and P. mirabilis . Clove essential oil has shown the ability to inhibit the growth of V. inaequalis, C. Albicans, C. glabrata, and C. tropicalis. Cloves extract can be used as an essential ingredient in various medicines. However, it requires further research and trials
The Potency of Cinnamomum Zeylanicum to Prevent Diseases: A Review
Get PDFPlants are an important source of traditional medicines that can be used to improve health. Cinnamon (Cinnamomum zeylanicum) has long been recognized to have many benefits. Cinnamon was used traditionally as a remedy for arthritis, diarrhea, allergies, and ulcers. This literature review aimed to identify the bioactive compounds and bioactivity of cinnamon. Literature searches used PubMed and Google Scholar. A total of 55 full-text articles met the inclusion criteria of the review. The extract or essential oil of cinnamon contains many bioactive compounds, such as eugenol, cinnamic acid, linalool, β-caryophyllene, coumarin, and trans cinnamyl acetate, and 1.8 cineole. These compounds have several bioactivities including anti-cancer, anti-arrhythmia, anti-inflammatory, anti-diabetic, anti-atherosclerosis, anti-cholinesterase, and anti-lipid oxidation. Cinnamon extract has excellent potential as an antioxidant and antidiabetic agent. Its potential and unique taste have contributed to its wide use in herbal remedies
Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in Rat Muscle Tissue Induced Aloxan
Get PDFDiabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. Bay leaves contain entirely various secondary metabolites, and this plant is rich in flavonoids, alkaloids, terpenes, and glycosides. This study aims to assess the effect of bay leaf extract (Syzygium polyanthum) on blood sugar levels and the expression of GLUT4 protein in muscle tissue. A total of 30 white rats (Rattus norvegicus) Wistar strains were obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 – and 250 grams. Bay leaf Simplicia was obtained from the Tawangmangu Herbal Research Center, Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) and diabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly even though they had not reached the target blood glucose target of less than 200 mg / dL. The treatment with bay leaf extract was able to reduce blood sugar levels significantly. The administration of metformin drugs or bay leaf extract showed the ability to increase the level of GLUT4 protein. In conclusion, bay leaf extract affects reducing blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues
The Effect of Bay Leaf Extract (Syzygium polianthum) Against Cholesterol Regulation in Hypercholesterolemic Rats
Get PDFCholesterol is an important precursor that plays a role in the production and regulation of various sterol group compounds, especially steroid hormone compounds, androgen hormone compounds, cortisol compounds, and estrogen compounds. This herb is known to have the effect of improving glucose regulation by increasing glucose intake into cells and tissues. Its ability to improve cell and tissue metabolism is mediated by the content of secondary metabolite compounds. This ability is believed to have the potential to improve cholesterol regulation. Bay leaf extract is effective in lowering cholesterol levels through regulation of Acetyl CoA production
The Utilization of Pasak Bumi Plants (Eurycoma longifolia Jack.) as Traditional Medicine and Its Bioactivity
Get PDFPasak bumi (Eurycoma longifolia Jack.) is a species belonging to Simarobuaceae that has been long used as traditional medicine, which is known very well as an aphrodisiac. The studies have been conducted to reveal the benefits of E. longifolia through ethnobotany, phytochemical, and bio essay approaches, but the review articles on its utilization and bioactivity are limited. This article is based on scientific articles published online or offline, then synthesized so that to be information on the relationship between use and bioactivity. Ethnobotany of E. longifolia has been used as a medicine for fever, malaria, improved stamina, diabetes, cancer, aphrodisiac, and erectile dysfunction. The bioactivity of E. longifolia is antiosteoporotic, antimicrobial, aphrodisiac, anticancer, angiogenesis, and hepatoprotective. Eurycomanone is a secondary metabolite in E, longifolia has activity as an antimalaria, antipyretic, aphrodisiac, and cytotoxic. The quassinoids, coumarin, and glycosides of El have activity increase the production, quality, totality, synthesis, and release of spermatozoa. Eurycoma longifolia is very potential to be developed as an antiosteoporotic and a prosidiac drug, but until now most of it is harvested directly from the forest, so to preserve it, we need to study the cultivation method
Curcuma zedoaria (Christm.) Roscoe: Benefits and Bioactivity
Get PDFCurcuma zedoaria (Christm.) Roscoe or Temu Putih is a native plant in India and has been long cultivated in Indonesia. By the local communities in Java, it has been used as a component of the Jammu and the traditional medicine. This article is based on literature from offline and online media. Offline literature used the books, whereas online media used Web, Scopus, Pubmed, and scientific journals. Based on a study of ethnobotany Curcuma zedoaria was used as medicine and spices. The main secondary metabolites of Curcuma zedoaria rhizomes are terpenoids, especially sesquiterpenoids and monoterpenoids. Curcuma zedoaria have bioactivities as anticholesterol, anti-tumor/cancer, anti-inflammation, fever, antipyretic, analgesic dan anti-microbia
Indonesian Plants with Potential as Anti-diabetes Mellitus Agent
No full textDiabetes Mellitus (DM) is a degenerative disease that continues to increase in number in Indonesia and is a disease that is spread throughout the world due to unbalanced nutritional conditions. Treatment of diabetes mellitus is a chronic and lifelong treatment. Treatment of diabetes mellitus, such as the use of insulin and oral antihyperglycemia drugs, is relatively expensive, is used for a long time and can cause unwanted side effects. There are many plants that have potential as antihyperglycemia drugs. One of the active compounds that act as antihyperglycemia is flavonoids.Flavonoids derived from various types of plants studied are thought to act as antihyperglycemic agents. Flavonoids are known to have the ability to scavenge free radicals or act as natural antioxidants. The antioxidant activity of flavonoids is related to phenolic –OH groups which can capture or neutralize free radicals (such as ROS or RNS). Flavonoids can play a role in pancreatic tissue damage caused by DNA alkylation due to alloxan induction as a result of improving the morphology of the rat pancreas
Acute Toxicity Ethanol Extract of Bidara Leaves (Ziziphus spina-christi L.) Against Liver and Kidney Function of White Rats
Get PDFBidara plants have the efficacy as antioxidants, anti-inflammatory, antimicrobial, anti- fungal and prevents tumours. Bidara is efficacious to protect human DNA cells caused by damage from actinic radiation. This study aims to explore the acute toxicity test of the ethanol extract of Bidara leaves using white mice as experimental animals. A total of 30 white rats (Rattus norvegicus) Wistar strain obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams. After one week of adaptation, the mice were randomly divided into the following six groups, each containing five animals: Normal control group and Bidara extract group (50mg/kg BW; 150 mg/kg BW; 450 mg/kg BW; 1350 mg/kg BW; and 4050 mg/kg BW). This study shows that the extract of Bidara leaves has a relatively high toxic dose, namely at a dose of 4050 mg/kg BW. Bidara leaf extract at doses below 1500 mg/kg BW, shows no toxic effect on the liver. In conclusion, bidara leaf extract has a toxic dose above 4000 mg/kg BW in Wistar white rats
Effect of Noni Fruit Extract (Morinda citrifolia) on Glucose Intake to Diabetes Mellitus White Rat Muscle Tissue
Get PDFNoni fruit (Morinda citrifolia) is one of the most common plants in Indonesia. This plant is often found in various regions in Indonesia, where these plants are often in the form of shrubs or wild plants that grow in yards or plantations. This study aims to assess the effect of noni (Morinda citrifolia) fruit extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which shows the potential of the test extract's ability to improve blood glucose intake in cells so that it can maintain blood sugar regulation. This research was an experimental study that used white rats as research subjects. Induction of diabetes was done by injecting alloxan at a dose of 110 mg/kg BW intraperitoneally; then the white rats were given 10% glucose to drink. Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly. In white rats induced with diabetes mellitus, there was a decrease in GLUT4 levels in muscle tissue. The administration of metformin drugs or noni fruit extracts shows the ability to increase levels of GLUT4 protein. In conclusion, noni fruit extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues