Bulletin of Computer Science and Electrical Engineering (BCSEE)
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A large aerobic scope and complex regulatory abilities confer hypoxia tolerance in larval toadfish, Opsanus beta, across a wide thermal range
No full textDeconvolving mechanisms of particle flux attenuation using nitrogen isotope analyses of amino acids
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Endometrial Biopsy: Indications, Techniques and Recommendations. An Evidence-Based Guideline for Clinical Practice
No full textThis practice guideline provides updated evidence for the gynecologist who performs endometrial biopsy (EB) in gynecologic clinical practice.
An international committee of gynecology experts developed the recommendations according to AGREE Reporting Guideline.
An adequate tissue sampling is mandatory when performing an EB. Blind methods should not be first choice in patients with suspected endometrial malignancy. Hysteroscopy is the targeted-biopsy method with highest diagnostic accuracy and cost-effectiveness. Blind suction techniques are not reliable for the diagnosis of endometrial polyps. In low resources settings, and in absence of the capacity to perform office hysteroscopy, blind techniques could be used for EB. Hysteroscopic punch biopsy allows to collect only limited amount of endometrial tissue. grasp biopsy technique should be considered first choice in reproductive aged women, bipolar electrode chip biopsy should be preferred with hypotrophic or atrophic endometrium. EB is required for the final diagnosis of chronic endometritis. There is no consensus regarding which endometrial thickness cut-off should be used for recommending EB in asymptomatic postmenopausal women. EB should be offered to young women with abnormal uterine bleeding and risk factors for endometrial carcinoma. Endometrial pathology should be excluded with EB in nonobese women with unopposed hyperestrogenism. Hysteroscopy with EB is useful in patients with abnormal bleeding even without sonographic evidence of pathology. EB has high sensitivity for detecting intrauterine pathologies. In postmenopausal women with uterine bleeding, EB is recommended. Women with sonographic endometrial thickness > 4mm using tamoxifen should undergo hysteroscopic EB
Discussion of “Calibration of Stage–Discharge Relationship for Rectangular Flume with Central Cylindrical Contraction”
No full textVariations in germline gene mutations in women diagnosed with epithelial ovarian cancer (2159)
No full textThe Double Layer Sign is highly predictive of progression to exudation in Age-Related Macular Degeneration
No full textPURPOSEThe presence of a double layer sign (DLS) and a shallow irregular RPE elevation (SIRE) were investigated using spectral domain-optical coherence tomography (SD-OCT) imaging to determine their ability to predict progression to exudative macular neovascularization (eMNV) in the unaffected fellow eyes (study eye) of participants with Age-Related Macular Degeneration (AMD) with newly diagnosed unilateral eMNV. DESIGNRetrospective, re-analysis of SD-OCT scans of study eyes from the Early detection of Neovascular AMD (EDNA) study with 3 years follow-up (FU). PARTICIPANTSThe EDNA study repository of SD-OCT scans was assessed for inclusion. Cases with incomplete datasets, low quality scans or exhibiting other pathology were excluded, which resulted in 459 eligible cases. METHODSSD-OCT volume scans of study eyes were graded for irregular elevation of the RPE (IE), length and height measurements made on the most affected B-scan. Eyes with heterogeneous reflectivity within the IE were classified as exhibiting the DLS. Eyes with DLS where the length of separation between RPE and Bruch's was equal or exceeded 1000 μm in length and less than 100 μm in height were sub-classified as SIRE. MAIN OUTCOME MEASURESHazard of progression to eMNV for DLS and SIRE RESULTS: Of the 459 eyes, 268 had IE in which 101 were DLS-like and 51 of these also fulfilled criteria for SIRE. Over the 3 years FU period, 104 (23%) eyes progressed to eMNV. After a follow up of 18 months, a significantly higher proportion of study eyes (p<0.001) with IE, DLS and SIRE developed eMNV compared with those without these features (IE: 17% vs no IE 6.3%; DLS: 23% vs no DLS 9.9%; SIRE: 22% vs no SIRE 11%). In the adjusted Cox regression models, a significantly greater hazard of progression (p<0.001) was associated with the presence of IE (adjHR, 3.01, 95%CI 1.88, 4.82), DLS (adjHR, 3.41, 95%CI 2.26, 5.14) or SIRE (adjHR, 2.83, 95%CI 1.68, 4.75). CONCLUSIONThe DLS is a highly sensitive predictor of progression to eMNV and the use of SIRE does not improve predictability
Detection and isolation of infectious SARS-CoV-2 omicron subvariants collected from residential settings
No full textAbstract 594: E-selectin-Overexpressing Mesenchymal Stem Cell-based Therapy Augments Cutaneous Wound Healing In Ischemic Limbs
No full textAbstract only Objective: Tissue loss considerably worsens the risk of extremity amputation in patients with chronic limb-threatening ischemia (CLTI), and unmodified mesenchymal stem cell (MSC) therapies have failed to demonstrate more than minor clinical benefits for inducing therapeutic angiogenesis and wound healing. Here we describe the effects of MSCs engineered to overexpress E-selectin, a cell-adhesion molecule capable of stimulating neovascularization, using a translational murine model recapitulating hindlimb ischemia with cutaneous tissue loss. Methods: MSCs were harvested from bone marrow of 8-10-week-old FVB/Rosa26Sor mTmG donor mice and verified as CD44 + /CD73+/CD105 + /CD29 + /Sca-1 + by flow cytometry. MSCs underwent viral transduction with E-selectin-GFP/AAV or GFP/AAV. Femoral artery ligation was performed in 12-14-week-old recipient FVB mice followed by a 4 mm cutaneous wound in the ipsilateral limb and local injection of PBS or 1x10^6 donor GFP + /MSCs or E-selectin + /MSCs (E-sel + /MSC). Wounds were monitored daily for 7 days and then harvested. Results: Unmodified MSCs do not express E-selectin, and E-sel + /MSCs retained MSC phenotype. Mice receiving E-sel + /MSC treatment (n=10) demonstrated accelerated wound closure compared to both GFP + /MSCs (n=10) and PBS (n=10) treated mice at each post-operative day (POD) with the highest degree of difference observed at POD 5 (94 ± 3% vs. 79 ± 10% GFP vs. 72 ± 9% PBS, p<0.001) and 7 (98 ± 2% vs. 86 ± 8% GFP vs. 87 ± 6% PBS; p<0.010). Collagen deposition was greater in wounds treated with E-sel + /MSCs (21 ± 4% vs. 5 ± 1% GFP vs. 9 ± 1% PBS). DiI perfusion at POD 10 demonstrated greater vessel density in wounds treated with E-sel + /MSCs (76 ± 15% vs. 29 ± 7% GFP vs. 9 ± 5% PBS relative vascular density). E-sel + /MSCs demonstrated improved viability with more mTmG + -E-sel + /MSCs (13 ± 3 cells/high powered field (HPF) vs. GFP + /MSCs 3 ± 2 cells/HPF vs. PBS 0 ± 0 cells/HPF, p<0.010) at POD 7 on immunofluorescent microscopy. Conclusion: Cell therapy using E-selectin-overexpressing MSCs overcomes impairments in wound healing of ischemic limbs. These data exhibit the potential role for E-selectin-modified MSCs as a novel cell therapy in future clinical applications for delayed and non-healing wounds associated with CLTI
APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
No full textThis genetic association study assesses associations between apolipoprotein E and Alzheimer disease risk across age, sex, race and ethnicity, and global population ancestry