eCommons at Roseman University
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Mechanical behavior of premolars with incomplete rhizogenesis after apexification and revascularization a finite element study
Get PDFThe aim of this study was to evaluate the mechanical resistance of premolars with incomplete rhizogenesis using the FEA methodology, comparing apexification methods and regenerative endodontic procedures
MATLAB based phenotypic evaluation and gene expression of CD44 and CD133 biomarkers in the prediction of Oral Squamous Cell Carcinoma metastasis
Get PDFOral cancer accounts to 20–30% of all cancers in India. The major difficulty in managing carcinomas is due to failure in the control and detection of metastases (\u3e90% deaths). Cancer stem cells (CSCs) are tumor-initiating cells that survive even after extensive radiotherapy and chemotherapy. Recently, the use of computer-assisted quantification methods employing image processing is drawing attention wherein information can be automatically extracted from the immunostained digitized images. The aim of the study was to assess the metastatic risk of Oral Squamous Cell Carcinoma (OSCC) by the phenotypic evaluation and gene expression of CD44 and CD133 biomarkers with clinical correlation. The study also assessed the role of Cancer Stem Cells through phenotypic evaluation and gene expression of CD44 and CD133 in metastasis of OSCC
Modified Zero-Gravity Chair in the Management of Pain and Anxiety with Emphasis on Pre and Post Anesthesia for Surgical Procedures
Get PDFThe purpose of this research is the integration of a zero-gravity chair with planar vibration as a non-pharmaceutical approach to preoperative anxiety and postoperative pain management. The treatment plan involves preoperative familiarization with the chair\u27s vibrational patterns and postoperative use for pain relief. Integration of this approach holds promise in reshaping postoperative care paradigms, advocating for personalized, holistic interventions to enhance patient well-being and mitigate opioid-related risks
Exploring the Interconnected Role of the Oral Microbiome and Periodontal Disease in the Development and Progression of Oral Squamous Cell Carcinoma
Get PDFThis comprehensive review explores the complex linkage among the oral microbiome, periodontal disease, and the onset and progression of oral squamous cell carcinoma (OSCC)
Validity of digital cephalometric tracing: A systematic review
Get PDFAim of this systematic review was to assess the accuracy of digital cephalometric tracing with manual hand tracing
Evaluating the oral health-related quality of life among dental patients in South India - A Descriptive Study
Get PDFThis study aims to evaluate the oral health-related quality of life among dental patients in South India
Educational intervention for delirium assessment in intensive care units using the Confusion Assessment Method
Get PDFDelirium frequently occurs in severely ill adults, leading to worse outcomes and increased duration of intensive care unit (ICU) and hospital stays, along with higher associated expenses. The 2018 clinical practice guidelines for Pain, Agitation, Delirium, Immobility, and Sleep Disruption (PADIS) recommend that all adult ICU patients be regularly assessed for delirium. At Valley Hospital Medical Center, the utilization of Confusion Assessment Method for the ICU (CAM-ICU) for monitoring delirium is infrequent, typically taking place either after the adjustment of sedatives or in response to nursing reports of positive neurologic assessments indicating signs of delirium
Behind the Spine: Investigating the Role of Cervical Posture and Range of Motion on Mental Health
Get PDFThis research explores the correlation between abnormal forward head posture, cervical range of motion, and psychiatric disorders. Specifically, the study examines the relationships between the loss of cervical lordosis and anxiety, depression, and ADHD. Previous studies have demonstrated the beneficial effect of manipulative therapy on forward head posture and provided a link between postural alignment and cognitive function. This investigation aims to build on existing literature and enhance understanding of how loss of cervical lordosis impacts cervical and overall range of motion as well as its potential association with psychiatric conditions
Chromatin Pattern Quantification for the Differentiation of White Blood Cells
No full textNuclear chromatin patterns have been used historically to distinguish between different developmental stages and lineages of white blood cells. While it is common to characterize cells based on arbitrary ‘open’ or ‘closed’ chromatin patterns, quantification of chromatin data is lacking. By extracting nuclei from a database of white blood cells and running fractal analyses using TWOMBLI, we were able to produce meaningful data quantifying chromatin patterns. Our data were put through a random forest algorithm which grouped each point based on relationship probability. The algorithm compared immature and mature cell types as well as cells of similar maturity and differing lineage (i.e. mature monocytes, lymphocytes, neutrophils, etc.). The data were organized into tables in order to visualize the relationship between chromatin pattern, stage of maturity, and cell lineage. The random forest algorithm was able to distinguish immature cells (blasts) from mature cells with a success rate of 93.9%. It was able to distinguish mature cells from immature cells with a success rate of 96.9%. Promyelocytes were found to be the most unique among those in the blast category as they were correctly identified 99.1% of the time. Monocytes and neutrophils were the most unique in the mature category, being correctly identified 90.9% and 92.0% of the time, respectively. Most patterns were not accurately categorized when comparing cells of different lineages at equivalent stages of maturity. Cells from myeloid and lymphoid lineages did not show chromatin patterns unique enough to accurately distinguish between them. The data have shown that chromatin patterns alone can be used to distinguish between immature and mature white blood cells with a high level of accuracy. Comparing cells of similar maturity and differing lineage shows that chromatin patterns alone are not sufficient to accurately differentiate based on cell type. Cells from myeloid and lymphoid lineages did not show chromatin patterns unique enough to accurately distinguish between them. This suggests that more research needs be performed to determine other quantifiable factors that can be used to differentiate cells based on lineage
Neurocognitive Considerations and Impacts in Chronic Migraines
Get PDFMigraine, characterized by moderate-to-severe headache, may arise from neurological, psychological, orthopedic, metabolic, or endocrine origins. Pain associated with migraine, while commonly cited as the primary patient concern, only represents a small portion of short- and long-term effects caused by the condition. Many presenting cases include neuromuscular dysfunction, increased neuronal firing, inflammation, and cortical spreading depression. These effects can induce multiple symptoms such as pain, aura, brain fog, confusion, hangover, multiple hypersensitivities, and decreased memory capacity. These effects and symptoms can lead to neurocognitive and neuropsychological deficiencies in many patients. This study aims to investigate the relationship between migraines and neurocognitive function