eCommons at Roseman University
Not a member yet
635 research outputs found
Sort by
ONCE UPON A LIME: A TALE OF PEDIATRIC PHYTOPHOTODERMATITIS
Get PDFPhytophotodermatitis is a blistering skin condition caused by photoactivation of furocoumarins in certain plants including limes, carrots, and parsnips. High clinical suspicion based on the presentation and distribution of a patient’s findings, followed by thorough history-taking and identification of an exposure, were enough to diagnose this condition in an otherwise healthy child
Evidence of Prostate Cancer Progression in Transgender Women After Hormone Replacement Therapy - Scoping Review Protocol
Get PDFThis scoping review aims to determine the extent and quality of evidence regarding prostate cancer progression outcomes in transgender women who have undergone hormone replacement therapy. Notably, transgender females undergoing hormone replacement therapy as a component of the gender affirmation treatment commonly have their prostate, rendering them vulnerable to developing prostate cancer. There is no current agreement about the likelihood of transgender women developing prostate cancer or the impact of hormone replacement therapy on oncogenic molecular pathways. Unfortunately, due to a lack of scientific data and inadequate trust and awareness in the medical community, transgender women are often not provided with the essential information needed to make informed decisions regarding their prostate health. This puts them at risk for a delayed diagnosis. Understanding PC development in transgender women is critical, and addressing this gap in scientific knowledge necessitates highlighting this issue
An Immunohistochemical Panel for The Accurate Differentiation Between Mucoepidermoid Carcinoma and Pleomorphic Adenoma
Get PDFSalivary Gland Tumors (SGTs) are a diverse group of neoplasms, with a wide range of histological subtypes, some of which can exhibit overlapping features. Amongst this group of tumors, Pleomorphic Adenoma (PA) and Mucoepidermoid Carcinoma (MEC) stand out as prevalent entities originating from the salivary glands. The accurate differentiation between these two entities is crucial for treatment planning, as it influences decisions regarding the extent of surgical resection. Because of the overlapping histopathological features, it is difficult to differentiate these two lesions with the help of conventional Hematoxylin & Eosin (H& E). The evaluation of Immunohistochemical (IHC) markers holds pivotal importance in diagnosing salivary gland tumors, offering valuable insights into their molecular and cellular characteristics. The application of IHC markers assumes paramount importance in the precise diagnosis of MEC and PA within the context of salivary gland tumors. The study aimed to assess the effectiveness of immunobiomarkers in differentiation between mucoepidermoid carcinoma and pleomorphic adenoma
Harm Reduction Measures in Substance Use Disorder (SUD)
Get PDFThis literature review aims to comprehensively analyze harm reduction strategies employed in addressing Substance Use Disorder (SUD). Focusing on key interventions such as fentanyl testing strips, naloxone distribution, syringe exchange programs, and methadone/buprenorphine clinics, the study seeks to evaluate the effectiveness of these approaches in reducing the associated harms of substance misuse
Parental anxiety associated with children undergoing dental treatment-pulpectomy procedure under LA
Get PDFThe aim of this study was to evaluate the anxiety felt by parents of children undergoing dental treatment- pulpectomy procedure under LA
Targeting CYP51 in the treatment of Acanthamoeba keratitis
Get PDFAcanthamoeba castellanii causes a rare but serious ocular infection called Acanthamoeba keratitis. Risk factors for infection include contact with contaminated water and poor hygiene of contact lenses. The first-line treatment is comprised of a months-long schedule of antibiotics. However, in cases where pharmacological interventions fail to address the infection, surgery may be necessary, with the continued risk of potential vision loss. Consequently, new treatments are needed, whether new pharmacological agents or new combination therapies with current agents. As an aerobic parasite, Acanthamoeba synthesizes ergosterol as a cell membrane insert, and ergosterol biosynthesis inhibitors (EBIs), common in antifungal pharmaceuticals, could potentially fill that gap. The most common EBIs are of the azole drug class, which inhibit CYP51 (sterol 14α-demethylase). This study reviews the clinical usage of azole inhibitors of CYP51 in the management of Acanthamoeba keratitis.
Keywords:
Amoebic keratitis, Cornea, Ergosterol biosynthesis inhibitors, Eukaryotic pathogen, Eye infectio
Brushing and staining influence on esthetic properties of attachment composites
Get PDFThe aim of this study was to evaluate the brushing and staining influence on esthetic and surface properties of resin composites indicated for aligner attachment
Euglycemic diabetic ketoacidosis secondary to Sodium Glucose 2 Transport Inhibitor: a case report
Get PDFThe purpose of this case report is to highlight the emergence of a rare adverse drug reaction (ADR), euglycemic diabetic ketoacidosis (EDKA), associated with the use of sodium glucose transport 2 (SGLT2) inhibitors.EDKA is a rare and often misdiagnosed condition, due to the absence of hyperglycemia, but represents a life-threatening emergency. We present a unique case of a 35-year-old female patient with a past medical history of diabetes and recent diagnosis of Hashimoto’s thyroiditis. The primary objective is to provide valuable insights and education to the medical community regarding this infrequent yet significant complication. Ultimately, the goal is to enhance future patient care by improving awareness and promoting informed decision-making in EDKA cases involving SGLT2 inhibitors
Influence of intraradicular restoration technique on the biomechanical behavior of upper canines
Get PDFThis study assessed the stress distribution in endodontically treated upper canines subjected to the cementation of two types of intraradicular retainers
Interplay of Periodontal Bacterial Metabolites in the Progression of Coronary Artery Disease: A System Biological Approach
Get PDFPurpose:
The purpose of this study is to investigate the intricate relationship between periodontal disease (PD) and coronary artery disease (CAD), as evidenced by epidemiological associations. Metalloproteinase inhibitor (TIMP1) plays a pivotal role in cellular signaling, differentiation, cell death, and migration by binding to target metalloproteinases, forming complexes with other molecules (collagenases) to inactivate them. However, the expression of TIMP1 is reduced in both PD and CAD, leading to an upregulation of other metalloproteinases. This research explores the hypothesis that metabolites released from (Porphyromonas gingivalis), a prevalent bacterium in atherosclerotic patients, may inhibit TIMP1, thereby influencing CAD progression.
Methods:
This research utilized a series of computational techniques, encompassing data mining, protein network analysis, molecular modeling, molecular docking, and molecular dynamics simulation. In the initial phase, metabolites from Porphyromonas gingivalis were retrieved from the Virtual Metabolic Human (VMH) database. The proteins associated with the TIMP1 were identified through the construction of a protein interaction network in Cytoscape. Subsequently, the TIMP1 underwent modeling using the Swiss-Model web server and was docked with bacterial metabolites. Furthermore, the structural stability of both the protein and metabolite was evaluated over a 100 ns simulation period.
Results:
In total, 370 metabolites from Porphyromonas gingivalis were obtained from the database. Notably, the network analysis revealed that MMP1, MMP9, and MMP14 were closely associated with TIMP1. Molecular docking outcomes demonstrated that Malonyl CoA displayed a binding affinity of -8.82 kcal/mol at the active sites of TIMP1. Additionally, a stable complex between TIMP1 and Malonyl CoA was observed throughout the simulation period, potentially influencing the activity of TIMP1.
Conclusion:
This investigation underscores the potential implications of Porphyromonas gingivalis metabolites as a risk factor in the development of CAD. The computational analysis suggests that these metabolites may disrupt the function of TIMP1, thereby contributing to the elevated levels of metalloproteinases observed in CAD patients. This emphasizes the critical need for further research to delve into the intricate mechanisms and exploring potential therapeutic interventions