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Diabetic Self-Management Programs as an Intervention to Decrease A1c Levels
Get PDFThis paper discusses and examines the impact of a technology-integrated diabetes self-management program on HbA1c levels in adults with Type 2 diabetes, compared to traditional diabetic care and education methods. Utilizing a theoretical framework of Social Cognitive Theory, which would be applied to this project, the research would investigate whether integrating technological tools, such as mobile applications and online platforms, into diabetes self-management can provide better glycemic control. A randomized controlled trialis proposed that would involve 200 adult participants with Type 2 diabetes, divided into two groups: one receiving the technology-integrated program and the other following conventional care protocols. Over six months, HbA1c levels would be measured and compared between the two groups. This research could have the potential benefits of incorporating modern technology into chronic disease management and underscores the need for healthcare systems to adapt to evolving patient care methods. Further studies are recommended to explore long-term effects and optimize program implementation strategies
Mission Log: Implementing and Integrating RapidILL to Automate Existing ILL Workflows as a New Systems Librarian
No full textRoseman Univserity of Health Sciences Library evaualted the existing Interlibrary Loan practices, Clio and Docline, and determined the need for a more automated system. After an evauation of needs we agreed on implementing RapidILL into our workflow to hopfully reduce manual intervention and patron wait times
Accessibility of Pharmacists Who Can Prescribe Hormonal Contraceptives Can Lessen the Burden Felt by the Increasing Shortage of OB-GYNs in Major Metropolitan Areas
No full textAcross the nation, shortages of Obstetricians and Gynecologists (OB-GYNs) and changes in legislation have resulted in decreased access to reproductive healthcare.1 Previous research2,3 identified the 33 US states in which pharmacists receive training and education to safely provide hormonal birth control to eligible patients in community pharmacies and clinics, thus providing a resource to patients who may otherwise be unable to access contraceptives. This study aimed to build upon research by more closely identifying the metropolitan areas with the greatest OBGYN shortages where pharmacists can help fill the gap
Enhancing Orthodontic Retraction: A Randomized Controlled Trial on Injectable Platelet-Rich Fibrin\u27s Impact on Tooth Movement
Get PDFIntroduction: Accelerated orthodontics aims to shorten treatment duration while improving patient comfort. Injectable platelet-rich fibrin (i-PRF) has been proposed to enhance orthodontic tooth movement (OTM) by stimulating bone remodeling. This study evaluates the effect of i-PRF on space closure rates, anchor loss, and salivary biomarkers (ALP, AST, and LDH) during orthodontic retraction.
Materials and Methods: Twenty-four participants requiring extractions and space closure were divided into two groups (n = 12 each). Group A (experimental) received i-PRF, while Group B (control) did not. Space closure, anchor loss, and salivary enzyme activity were measured at T0 (baseline), T1 (3 weeks), T2 (6 weeks), and T3 (9 weeks). Statistical analysis included the Mann-Whitney and independent t-tests.
Results: Eight participants remained in each group after follow-up losses. In the maxillary arch, Group A had a space closure rate of 1.4 ± 1.9 mm at T3 (T0: 10.8 ± 3.01 mm), while Group B reduced from 11.1 ± 2.0 mm at T0 to 4.9 ± 1.5 mm at T3. In the mandibular arch, Group A had a closure rate of 2.6 ± 2.0 mm at T3 (T0: 9.5 ± 2.5 mm), while Group B decreased from 10.0 ± 2.7 mm at T0 to 4.7 ± 2.3 mm at T3. Anchor loss was not significantly different between groups.
Conclusion: i-PRF accelerated space closure, with statistical significance in the maxilla at T2 and T3 and the mandible at T2, without affecting anchorage stability.
Clinical Significance: i-PRF may be a safe and effective adjunct in orthodontic treatment, reducing treatment duration without compromising anchorage
Efficacy of Concentrated Growth Factor Membrane versus Collagen Membrane in Treating Gingival Recession
No full textCreating a beautiful smile has always been a cornerstone of dental practice. Gingival recession, characterized by a downward shift of the gum line, causing uneven gum margins and an unattractive appearance.
The Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique, introduced by Zadeh in 2011, offers an innovative solution for root coverage. Concentrated Growth Factor Membrane (CGF) further enhances dental repair
DNA Extraction Method Development for Ocular Tissues
Get PDFPurpose: DNA extraction kits are traditionally developed to work with liquid tissues such as blood, saliva, and swabs, but some have been proposed to work with solid tissues. Somatic variation in cancers can be important for tumor subtyping and treatment guidance, including ocular tumors. Additionally, epigenetic marks such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are tissue-specific and change in disease states, particularly evident in diabetic retinopathy and age-related macular degeneration. Commercial DNA extraction kits are available from several vendors, but the various kits have different strengths and weaknesses, and the removal of PCR inhibitors will vary with each kit. This project investigates the yield and purity of DNA from ocular tissues using commercial DNA extraction kits.
Methods: Cornea, neural retina, RPE/choroid layer, optic nerve, and capsular bag were collected and aliquoted into 15 mg aliquots. Extractions were performed using the following kits: DNEasy Blood and Tissue Kit (Qiagen;), GeneJET Genomic DNA Purification Kit (ThermoFisher Scientific), Monarch HMW DNA Extraction Kit for Tissue (New England Biosciences), and genomicPrep Mini Spin Kit (Cytiva). DNA was quantified using the Qubit Fluorometer and molecular weight was checked by agarose gel. Several more kits are currently being tested.
Results: All four kits yielded high molecular weight DNA (above 20 kbp). The Monarch HMW kit yielded DNA with significantly higher molecular weights. The DNA yields per milligram of tissue were highest using the DNEasy Blood and Tissue Kit for optic nerve, neural retina, and RPE/choroid. The yield was highest for the cornea using the genomicPrep Mini Spin Kit. Only the genomicPrep Mini Spin Kit yielded sufficient DNA for quantification from the capsular bag, and total yields were minimal (600 ng or less). Additional kits are currently being tested, but initial results indicate that several commercial kits will be sufficient for DNA extraction of ocular tissues. Further work is needed to purify epithelial cells and stem cells from the intraocular lens.
Conclusions: Of the kits tested, all are sufficient to obtain significant amounts of DNA from all ocular tissues aside from the capsular bag. The Monarch HMW yielded the highest molecular weight, but significantly lower quantities of DNA than the other kits, indicating that it may not be ideal for most purposes. Protocol development for the capsular bag is still underway
Implications and Types of Artefacts in Oral Histopathology Tissue Processing
Get PDFThere is a scarcity of information regarding the occurrence and appearance of artefacts in the literature studies observed till date. This study aims to provide a more a comprehensive approach on identifying the different types of artefacts and also attempts to provide with description regarding their relation to the parent slide and the remedies in order to prevent misinterpretation. This study aimed to prepare a comprehensive report of the commonly occurring artefacts in archival collection of pathology laboratory
CORRELATION BETWEEN SALIVARY LEVELS AND TISSUE EXPRESSION STATUS OF HER2 IN BREAST CANCER PATIENTS - A CROSS-SECTIONAL STUDY
Get PDFThe study aims to investigate if soluble salivary human epidermal growth factor receptor-2 (HER2) would play a role in the diagnosis of breast cancer patients and also to find out the influence of demographic and hormonal factors on the salivary HER2 levels in breast cancer
Implementation of best practice when collecting blood cultures in the emergency department (ED)
Get PDFThe purpose of this study is to compare blood culture contamination rates in the ED before and after educational in-services on best practice
Influence of Sleep Pattern and Oral Hydration on Academic Performance among Undergraduate Dental Students-A Pilot Study
Get PDFSound sleep is important for preserving good physical, mental, and emotional health. An association with learning skills, critical decision making and thinking is also observed [1]. Poor hydration is associated with several health outcomes including poor oral health and academic performance. Timely assessment of oral hydration of students holds a potential to improve their oral health and academic performance [1, 2]. This study is designed to investigate the influence of oral hydration status and sleep deprivation on academic achievements of dental college undergraduate