Himalayan Journal of Health Sciences (HJHS)
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Pyridazine: A Magical Moiety
Get PDFIntroduction: A heterocyclic organic molecule having the chemical formula, C4H4N2. It is aromatic and has a 6-membered ring with two nearby nitrogen atoms. It has a specific heat of 208 °C and is an inert liquid. This paper presents a complete summary of the phytochemical and pharmacological activity of pyridazine as well as its derivatives published to date using new research findings and a wide variety of data.
For the study, authors' scientific journal articles on pyridazine as well as its derivatives were investigated.
The pharmacological properties of pyridazine as well as its derivatives include anti-cancer, anti-hypertensive, anti-allergic, anti-histaminic, eosinophil chemotaxis-inhibiting, anti-inflammatory, anti-PAF (thrombin factor), anti-HIV, and anti-histaminic effects.
Conclusion: Pyridazine and its derivatives are involved in many pharmaceutical procedures. Although researchers have highlighted the crucial roles pyridazines and its derivaives that fulfills, we emphasize that further laboratory studies should be conducted in order to broaden the breadth of this compound's possible applications
Clinical Significance and Biological Mechanism of “Netea Kriya Kalpa”
Get PDFAyurveda is conventional way of health management which prevents and treats many diseases. Ayurveda described approaches of healthy living and suggests approaches for restoring health of sense organs. As per Ayurveda eyes is most vital organs amongst the other sense organs. Eye as sense organ of body considered as most precious gift of god. The diseases related to the organs of Urdhwajatrugata sthana are described as Urdwajatrugata vyadhis which includes diseases of ear, eyes and nose, etc. The diseases of eye described as Netra-Roga and Ayurveda suggested many options for curing Netra-Roga and Kriyakalpa is one of them. Netra Kriyakalpa is therapeutic process for curing Netra rogas. Netra Kriyakalpa utilizes various cleaning and medicinal procedures for eye to maintain normal health status of eye. Netra Kriyakalpa helps to prevents and treat diseases of eye and can be practiced in routine life. Present article explored clinical significance and biological mechanism of “Netea Kriya Kalpa”
Myocardial Infarction
Get PDFMyocardial infarction (MI), commonly known as a heart attack is the disease of the blood vessels supplying the heart muscle (Myocardium) i.e. coronary heart disease. The area of heart muscle that has either zero flow or so little flow that it cannot sustain cardiac muscle function is said to be infracted and the overall process is called a myocardial infarction. MI are of two types; transmural and subendocardial. Mainly it is caused due to oxidative stress and atherosclerosis.Chest pain is the most common symptom of acute MI and is often described as a sensation of tightness, pressure, or squeezing. Other symptoms include diaphoresis (an excessive form of sweating), Shortness of breath (dyspnea), weakness, light-headedness, nausea, vomiting, and palpitations. The most common symptoms of MI in women include dyspnea, weakness, and fatigue, sleep disturbances. It can be treated by using blockers, diuretics, ACE inhibitors, calcium channel blockers and nitrates
Formulation and Evaluation of Itraconazole Nanocapsules
Get PDFAn objective of a present research has been able to prepare as well as analyze Itraconazole Nanocapsules through using emulsion solvent evaporation method. Itraconazole has been overfilled of ethyl cellulose & hydroxypropyl methylcellulose Nanocapsules and that was able to prepare through emulsion solvent evaporation technique. The outcomes like Fourier transform infrared implied a steady identity like Itraconazole Nanocapsules filled as for ethyl cellulose Nanocapsules and then also absence like drug - excipient interplay. Compatibility research findings like FTIR & differential scanning have been used to start investigating that there's no incompatability inside the composition. A morphometric size of the particles like Itraconazole Nanocapsules has been done through SEM. Nanocapsules has been analyzed such as total composition codes has been f1 to f8. A % yield has been obtained to be 73.22% to 88.91%. Drug content has been 65.9 to 98.4%. A size of the particles like Nanocapsules 80 µm to 22 µm, drug entrapment efficiency has been 54.3% to 91.3 %, a drug loading capabilities has been 97.8% to 56.9%. A swellability studies has been 0.6 sec to 1.6 sec. in vitro dissolution studies like best formulation f8 has been did find of being 61.78%. An In-vitro drug dissolution obtained data has been equipped to numerous mathematical equations such like zero order, 1st order, higuchi matrix & korsmeyer peppas model. Itraconazole Nanocapsules continues to follow model having r2 value has been 0.937, 0.399, 0.899, 0.785 & m value has been 1593, 0.061, 11409, 2.560. The discharge of drug out from Nanocapsules increased up of about 45 mints. Itraconazole loaded as for ethyl cellulose & HPMC Nanocapsules have been able to prepare below optimum condition and it display great discharge characteristic features
Ayurveda Concept of Immunity and Biological Factors Associated with Immunity
Get PDFThe term immunity stands for the power which protects from the diseases, the immune system acts as defense mechanism against many common diseases including infections. The Ayurveda described term Vyadhikshamatva for inherent defense mechanism. There are many drugs especially Rasayana herbs which improves immunity, Bala and Agni. Vyadhikshamatva varies person to person depending upon their Prakriti therefore some person possess good immunity while others deprived the same. The other factors such as diet, environmental factor, genetic predisposition, mental status and life style, etc. also affect Vyadhiksamatwa of individual. Bala and Ojas also associated with inherent immunity, Ojas or Bala helps to prevents manifestations of common infections thus restore normal health status. Ayurveda ways of daily regimen, balanced diet and Yoga can help to improves Vyadhikshamatva. Natural drugs like Guduchi, Ginger, Tulsi, Turmeric and Amalaki, etc. are well known for their immune boosting effects. Present article explores Ayurveda concept of immunity
Ayurveda Concept of Dravyaguna w.s.r. to Significance of Guna and Rasa: A Review
Get PDFThe Ayurveda philosophy of Dravyaguna Vigyan mainly talks about properties of substances which are responsible for specific pharmacological and biological responses. This science deals around Namajnana, Gunajnana, Yuktijnana and Rupajnana, etc. The Dravyaguna means properties materials which includes drugs as well as dietary substances. As per Ayurveda Rasa, Guna, Virya, Vipak and Prabhav are inherent characters of substances that contributed towards some biological and therapeutic responses. In this regards different types of Guna (quality) and Rasa (taste) play major role for the specific action of substances. Considering this aspect present article summarizes Ayurveda concept of Dravyaguna W.S.R. to clinical significance of Guna and Rasa
Importance of Kala Vichar, Pathya and Apathya in Pancha Karma
Get PDFThe Ayurveda mentioned several principles and practices related to the human health and signify role of Kala (time) for therapeutic procedure. Similarly the consideration of concept of Pathya and Apathya also play important role towards the health benefits of Ayurveda therapy like Panchakarma. The Panchakarma is considered as Kaya Shodhana which meant for detoxification or purification of body. The Panchakarma therapy offers maximum health benefits when it performs properly after the consideration of Kala, Ahara and Vihara. The Kala plays important role in promoting therapeutic values of Panchakarma. It is stated that Panchakarma pacifies Dosha, potentiates Agni and Bala if performed at appropriate time by following the rules of Pathya and Apathya. Kala (time) greatly affects Vyadhi and effects of Oushadhas and Shodhana Chikitsa. The effects of Panchakarma therapy merely depends upon Sharira Avastha, Sharira bala, Roga bala and Kaala of therapy. Considering these all aspects present article explains therapeutic application of Kaala, concept of Pathya and Apathya with reference to Panchakarma therapy
Ayurveda view on Fissure-in-Ano and its management through Ayurveda w.s.r. to role of Jatyadi Taila Matra Basti
Get PDFAcharya Sushruta has explained many diseases of Guda-Roga and Anal fissure is one of them, which is categorizes as painful Anorectal conditions. Ayurveda described fissure-in-ano as Parikartika which possess symptom of Kartanwat Vedana in anal region. Sharp cutting pain, bleeding, discharge, itching and burning sensation, etc. are common symptoms of fissure. Ayurveda described many therapeutic options for treating such types of conditions including uses of medicated Ghruta, Yastimadhu ghruta, Jatyadi ghruta and Swedan, etc. The Matra Basti of Taila also recommended treating fissure, in this regard Matra Basti of Jatyadi taila play remarkable role to suppress symptoms of disease. Matra Basti of Jatyadi taila helps to sooth affected area, remove slough and reduces pain, etc. Jatyadi taila Matra Basti known to controls discharge in case of ano-rectal problem. Jatyadi taila itself offers Shodhan and Ropan effects thus helps to heal anal wound and relieves Shotha by virtue of its Snigdha Guna. Present article described patho-physiology of fissure in ano and its management through Ayurveda W.S.R. to role of Jatyadi taila Matra Basti
Development, Validation and simultaneous estimation of Sulfamethoxazole and Trimethoprim by RP-HPLC Method
Get PDFThe straightforward, precise, accurate approach has been established for such simultaneous determination of a Sulfamethoxazole as well as Trimethoprim through oral dosage form. Chromatogram has been operate via inertsil ODS C185µm (4.6 x 250mm). Mobile phase comprising phosphate - buffered as well as acetonitrile with in proportion like 30:70 has been fired up thru section at such a rate of flow like 1ml/min. Buffer in use at pH 4.6, temperature has been retained there as ambient. Optimization frequency range such as Sulfamethoxazole as well as Trimethoprim has been 249nm. Time of retention like Sulfamethoxazole as well as trimethoprim have been did find of being 2.327min as well as 4.342min. A % purification like Sulfamethoxazole as well as Trimethoprim has been did find of being 100.6% as well as 101.3% including both. a stability studies parametric such as Sulfamethoxazole as well as Trimethoprim like theoretical plates as well as tailing element have been did find of being 1.3, 5117.5.as well as 1.4, 3877.3 a resolution has been did find of being 4.1.a linear relationship research such as Sulfamethoxazole as well as Trimethoprim has been present in range of concentrations like 20 ppm-100 ppm but also 10 ppm-50 ppm as well as coefficient of correlation (r2) has been did find of being 0.9999 as well as 0.9998, % average retrieval has been did find of about 99.96% as well as 99.75%, % RSD such as reproducibility was 0.31 as well as 0.38, % RSD such as medium precision has been 0.12 but also 0.15 including both. A precision research was accurate, robust as well as reproducible. LOD valuation has been 0.48 as well as 0.55, but also LOQ valuation has been 0.95 but also 1.10 including both
Ayurveda and Modern considerations on Pathogenesis and Prognosis of Diabetes
Get PDFPrameha is a condition described in traditional Ayurveda texts and this disease associated with other conditions including obesity, stress and other metabolic syndrome. Indulgence in the Nidanas (causes) leads disturbances in Kapha associated with Pitta. The imbalance of Kapha and Pitta increases Kleda in body and these all consequences initiates pathogenesis of Prameha. Modern science described disease as diabetes and mentioned several pathological events associated with disease including disturbed metabolic and hormonal regulations, etc. This article emphasizes ayurveda and modern considerations related to the pathogenesis and prognosis of diabetes