Biosight journal
Not a member yet
88 research outputs found
Sort by
Effect of Ocimum sanctum (Basil) leaf in high-fat-diet induced hyperlipidemic rat
Full text linkDyslipidemia mediated atherosclerosis is the key pathogenesis of several cardiovascular diseases. Present study aimed to evaluate the therapeutic potential of Ocimum sanctum leaf consumption against high-fat-diet induced hyperlipidemia in rat model.
A total of 18 Wistar albino rats (200-215 g) were randomly divided as control, HFD (hyperlipidemic) and OS-treated groups. HFD-group received high fat diet (HFD) for 15 days, OS-treated group administered with Ocimum sanctum leaf powder (200 mg / kg of bodyweight / day) together with HFD diet for 15 days. Blood samples were analyzed for changes in plasma total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein. Plasma atherogenic index was also calculated.
HFD administration significantly increase plasma lipid levels and atherogenic index in HFD-group. Ocimum sanctum supplementation significantly reduce decrease plasma total cholesterol, triglyceride, lipoproteins and atherogenic index in OS-treated rats.
15 days Ocimum sanctum leaf (powder) supplementation at dose of 200 mg / kg of bodyweight / day effectively attenuates dyslipidemia in hyperlipidemic rats
Life Long Physiological Distress Due To Excessive Use of Social Media – A Damnation Disguised
Full text linkIntroduction: Social media is a forum that helps to interact between people by which they are provided the opportunity to share their ideas, pictures and much more over the internet. Now-a-days social media is being used excessively, influencing, modernizing and becoming a useful source of communication especially among university level students. Although social media is a proven opportunity for students but on a closer look it seems negatively affecting the way of thinking, lifestyle, health and relations as well. The impetus behind this study was to assess the influence of social media on the mental and physical well-being of young generation. Objective: To find out the cause of excessive indulgence in social media and its impact on students. Materials & Method: This study was carried out using close-ended questionnaires, which were distributed randomly among students. The survey was conducted for about four months, starting from May 2019 to August 2019. The analysis was carried out by simple cumulative statistical function. Result: The study pointed out some important negative aspects of social media among which weakened relationships, irregular sleeping patterns, increased stress and unstable emotions are a few to mention. Conclusion: Social media negatively influences the students both mentally and physically
The Effect Of Garlic Consumption With Prescribed Anti-Platelet Medicines On Platelet Count Of Cardiovascular Patients
Full text linkBackgroung: Garlic (A. sativum) is in use as a traditional medicine for millions of years. It is already establish that A. sativum is nature's best antibacterial, antiviral, antifungal, antiparasitic agent. Its helpful effects for Cardiovascular system, Blood, Immune system, Central Nervous system, Respiratory system, Anti-cancer, Anti-Inflammatory and Antidiabetic properties have already been studied. In this study, we will evaluate the effects of garlic consumption on platelets count of MI Patients along with other blood-thinning medicines. Materials & Methods: This is a cross sectional study, 500 patients were interviewed. Interview questions included demographic information, diet plan, lifestyle, garlic consumption. Results: 412 (82.45%), patients stated that they are using or have used garlic for more than 6 months in raw form to reduce the symptoms of hypertension, along with prescribed medicines such as aspirin and clopidogrel. Platelet count of all patients of the study has been monitored and results showed 22.4% of them had thrombocytopenia with less than 150,000 mcL platelet count while only 2.19% showed thrombocytosis high levels of platelets count inPatients reported symptoms of excessive fatigues, unexplained vaginal bleeding, easy bruising, extreme headache, fluctuating blood pressure and other related symptoms. Conclusion: Garlic has a really impressive and wide range of pharmacological properties including antimicrobial, anticancer, cardiovascular disease An amazing pharmacological agent like A. sativum may affect adversely if taken without precaution. High dosage of garlic results in intoxication and disturbance of platelet count. However, a careful measure should be taken before garlic consumption especially with other blood-thinning medicines
Demographic Factors Associated with Acceptance of COVID-19 Vaccination: An Online Survey-Based Study from Hyderabad Sindh
Full text linkBackground: COVID19 is a major threat to global health. World health organization has proposed use of vaccines against COVID19 to end the pandemic. Due to low literacy rate in many developing countries and disinformation, the population is reluctant for COVID19 vaccination. To explore the demographic factors associated with acceptance of COVID19 vaccination, we set up an online cross-sectional study. Methods: The online survey-based cross-sectional study was conducted to understand the demographic factors of residents of Hyderabad city associated with vaccine acceptance. The questionnaire was divided into sections to get sociodemographic characters and other information related with willingness of vaccination. This questionnaire was sent to 300 people from which 205 people participated. Results: The result showed that 28.8% of the participants were not sure to get vaccination of COVID-19, while 41.5% participants were willing to get vaccine if available; rest of the people (29.8%) were not willing be vaccinated at all. The main reason behind this denial was due to belief on conspiracies against COVID-19 vaccine. Many participants either denied (42%) for any disinformation or were not sure (12%) on this account. Conclusion: The study was based on demographic factors of residents of Hyderabad associated with acceptance of COVID-19 vaccine. Among the studied population only 41.5% showed willingness to get vaccinated which indicate the necessity to effectively educate the population about COVID-19 vaccines
The Association Of Socioeconomic Status With Preeclampsia In Pakistani Females
No full textIntroduction: To identify whether there is an association between maternal socioeconomic status as in living style, and preeclampsia in women from Pakistan, and if so, to what extent it increases the risk of developing preeclampsia.
Methods: This is a case-control study, consisting of 74 normal pregnant and 76 already diagnosed preeclamptic Pakistani females, recruited from various hospitals in Karachi. Their socioeconomic status was assessed through the standard of living index (SLI) using the National Family Health Surveys (NFHS) criteria, which considers different living facilities as an indicator of socioeconomic status. Odds ratios of preeclampsia were calculated for low, middle and high socioeconomic status and other maternal anthropometric parameters.
Results: Based on their groups, it appeared that the highest percentage of preeclamptic females (n= 65; 43.3%) and the lowest of control patients (n=14; 9.3%) lie in lower socioeconomic groups and the results were highly significantly different. Study observed that having lower socioeconomic status (P<0.001) significantly increase risk of having preeclampsia by 9% and middle socioeconomic status has no role in prevalence of preeclampsia shown by 0.0 odds ratio. In addition, odds ratio of age and PreBMI for the preeclamptic females were found as 1.37 (P<0.001) and 1.55 (P<0.001) respectively, which shows that each year increase in age, increases risk of preeclampsia by 1.37 times and 1.55 times with each increased in BMI.
Conclusion: Living facilities are indications of socioeconomic status and are strong risk factors of preeclampsi
Bacteriological profile and antimicrobial susceptibility patterns of symptomatic bloodstream infection in Dhaka City
Full text linkINTRODUCTION: Bacteremia, is regarded as a significant reason in all over the world for morbidity and mortality in mainly sick patients. Invasion by microorganisms in blood constitutes the critical issues in infectious disease. The aims and objectives are to find out the pathogenic agents infecting males and females in blood of different age groups and naturally used antimicrobial sensitivity profiles. METHODS: All the blood samples were collected aseptically and tested in Popular Diagnostic Centre, Dhaka, Bangladesh between May, 2020 and October, 2020. Total 305 blood specimens from both sexes of different age groups were collected. Cultural analysis was performed by Gram staining, phenotypic examination, biochemical and serological analysis. Finally, antibiotic susceptibility test was done against commonly used antibiotics. RESULTS: 96 (31.47%) samples yielded a positive culture with predominant isolate being Salmonella typhi (41.66%) though Salmonella spp., Salmonella typhi, Staphylococcus spp and Pseudomonas spp. were also detected. Like most of previous reports, Salmonella spp was predominant, this corroborates this study. But the profile of antimicrobial susceptibility of the detected organisms varied comparing studies which were done in the past. The isolates were found mostly resistant to nalidixic acid. Most of the pathogens showed tremendous susceptibility against ceftriaxone, cefixime, ceftazidime etc.
CONCLUSION: The antibiotic selection for the treatment of bacteraemia in patients should always be serious concern due to multidrug resistant (MRD) bacterial isolates. For proper treatment of anti-bacterial resistance and critical mortality and morbidity should be related with the sickness. For validating more reliability, this research requires further work
Prevalence of Various Sign and Symptoms of Diabetic Peripheral Neuropathy
Full text linkBACKGROUND: Diabetes mellitus (DM) is a chronic metabolic syndrome marked by hyperglycemia due to absolute or relative deficiency of insulin hormone. Diabetic neuropathy is a complication of both type 1 and type 2 diabetes. Although pain is one of the most dominant symptoms of diabetic neuropathy, its pathophysiological mechanisms yet unknown. Toxic effects of high glucose levels play an important role in the development of this complication.
METHODOLOGY: Data was collected through the questionnaire regarding Clinical findings, medical records, weight, age, family history, different habits, and psychogenic behavior. All the patients with the mentioned diseases are included in this study, excluding the mentally ill patients and the pregnant women.
RESULT: The result of the present study showed that diabetic neuropathy is the most common complication of diabetes mellitus. It has been observed that most of the patients due to lack of awareness are suspected to the elevated or extreme blood sugar level which leads to neuropathy. Due to the Diabetic Peripheral Neuropathy (DPN) most of the patients suffering from foot problems, foot ulcers and then amputations. Lack of awareness, lack of health management, obesity, blood pressure changes, less care plays a key role in increasing the chances of diabetic neuropathy. COCLUSION: Diabetic neuropathy had very bad influence on a person’s health and daily activities. The Patient education programs need to emphasize on large scale. The ultimate aim of this study is the foot care education for people with the diabetes and to prevent foot ulcers and amputation
The effect of fenugreek seeds (Trigonella foenum-Gracecum) supplementation on glycemic status, androgens, and lipid profile in letrozole induced polycystic ovarian syndrome (PCOS) model
Full text linkIntroduction: PCOS the most common endocrinopathy of reproductive-aged females is hallmarked by characteristics of polycystic ovary syndrome and biological hyperandrogenism and hyperinsulinism. Fenugreek seeds have proven to be beneficial in the treatment of PCOS because of their antiandrogenic and anti-hyperglycaemic effects. The present study was aimed to evaluate the effect of aqueous extract of fenugreek seed in PCOS rats. Materials and method: Twenty-four female Wistar rats were divided into two groups: Group 1 served as a (control group, n=10) received saline (0.9%NaCl) while Group 2 (PCOS control group, n=30) received letrozole (1mg/kg) to induce PCOS. After 21 days, PCOS-induced rats were divided into two groups. One group was treated with the aqueous extract of fenugreek seeds and another group was treated with metformin (300mg/Kg) for 21 consecutive days while the control group continued to receive saline. At the end of the experiment ovaries were removed for histological examination and blood collected for the estimation of Insulin, Testosterone, and Lipid profile. Result: Compared with the control group, Letrozole administration in rats exhibited significant alterations in serum testosterone, insulin activity, glucose and Lipid profile (P<0.001). Acyclicity of the estrus cycle with cysts were also detected. In Fenugreek and metformin groups restoration of normal ovarian stroma, normalization of estrous cycle with reduced levels of testosterone (P<0.001), insulin (P<0.001), glucose (P<0.001), and cholesterol (P<0.0001) were observed. Discussion: These findings suggest that aqueous extract of fenugreek showed better amelioration in the regulation of impaired insulin resistance, hyperandrogenaemia, and ovarian dysfunction in PCOS
The Prevalence of risk factors associated with ocular problems in males and females in type 1 & 2 diabetes
No full textBackground: The aim of current study was exploring the ocular abnormalities in individuals with Type 1 & 2 diabetes. Methods: Patients referred for diabetic ocular abnormalities (retinopathy, cataract, glaucoma and refractive error) on fundoscopy from LRBT eye hospital Korangi, Karachi were randomly included in the study. Retinopathy, cataract and refractive error were evaluated by slit lamp biomicroscope or indirect ophthalmoscope, & categorized into lacking, non-proliferative, proliferative retinopathy, maculopathy, capsular or sub capsular cataract, myopia and hypermetropia. While glaucoma was assessed by tonometry. Prevalence of eye complication has been seen in subjects. Outcome of substantial risk factors on the diverse phases of retinopathy, multivariate regression analysis was performed. Results: 200 diabetic subjects (106 males and 94 females) when the compared; diabetic subjects and subjects with hypertension; 28.0 % retinopathy, 9.75 % cataract, 7.31 % with glaucoma, and about 2.43% refractive error were found out among the diabetic males. 47.61 % retinopathy, 11.9% Cataract, 40.47% refractive error were found in females. In males with diabetes and hypertension were found 60.46 % retinopathy, 27.9 5% cataract, 11.62 % refractive error & in females 46.15% retinopathy, 19.23 % cataract, and 34.61 % with refractive error. Conclusions: This current study emphasizes screening of diabetic subjects regularly so as to distinguish ocular abnormalities and increasing public awareness