Bezmialem Vakıf Üniversitesi Kurumsal Akademik Arşiv
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İnsan İmmun Yetmezlik Virüsü (HIV) Tanı, Tedavi ve Epidemiyolojisinde Moleküler Yöntemlerin Kullanımı
No full textFrom Social Sustainability to Social Entrepreneurship: A Path for Social Value Creation
No full textDespite the discussion of social sustainability, which has been a crucial component of sustainable development for decades, unfortunately, the desired successful outcomes have not been realized in practice. This failure caused the need to examine the concept of social sustainability differently than ever before. Social entrepreneurship is a valuable tool to meet this need. Concordantly, this chapter purposes to evaluate the relations between social sustainability and social entrepreneurship by comprehensively analyzing them. Discussing this relationship and proposing a new perspective will support overcome theoretical dilemmas and practical struggles. Therefore, the concept of sustainability was explained in detail through a wide literature review, and then the concept of social entrepreneurship was examined, and links, similarities, and gaps were revealed between the two concepts. As a result, the effective implementation of social sustainability policies depends on the social impact and value created by social entrepreneurship
Primer Özefagus Squamöz Hücreli Karsinomundan Renal Metastazı Olan Hastanın Olgu Sunumu
No full textPrimer Özefagus Squamöz Hücreli Karsinomundan Renal Metastazı Olan Hastanın Olgu Sunum
Tümörün Mesanedeki Lokalizasyonu İle Tümörün Progresyon Derecesi İle Olan İlişkisi
No full textTümörün Mesanedeki Lokalizasyonu İle Tümörün Progresyon Derecesi İle Olan İlişkis
Preclinical studies evaluating the therapeutic efficacy of novel natural compound olean-12-en-28-ol, 3β pentacosanoate for multiple sclerosis
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Evaluation of the Immunomodulatory Effects of C-Vx on the Innate and Adaptive\"Immune\" System:Preliminary Results
No full textObjectives: In this preliminary study, the in vitro effect of C-Vx in human PBMCs and the in vivo effect of C-Vx in rats were investigated. Methods: The human part was analyzed in PBMCs isolated from healthy subjects. Apoptotic index, cytotoxic activity of CD8+ T and NK cells, and cell proliferation of CD3+, CD4+, CD8+ T and NK cells in response to different doses of C-Vx were investigated. Also the hematological and biochemical parameters of the rats administered subcutaneously in three different doses of C-Vx were monitored for 14-days. Results: Increased CD107a expression in response to C-Vx on NK cells but not on CD8+ T cells support the increasing of NK cell cytotoxicity. C-Vx alone was capable of triggering proliferation of T and NK cells. The PHA-induced proliferation of CD3+ and CD4+ T cells was diminished in response to C-Vx, while PHA-induced CD8+ T cell proliferation was up-regulated. PHA-triggered proliferation of total NK cells was enhanced with the existence of C-Vx. C-Vx was well tolerated in rats with no serious adverse effects or mortality (death) after 14-days of follow-up. Biochemical-parameters (creatinine, blood urea nitrogen, etc.) were not significantly different among treated and control groups. The levels of white blood cells and lymphocytes were increased up to two-folds in the C-Vx group (especially 0.25 ml/day) as compared to the control group. Conclusion: Taken together, these preliminary findings support the immunomodulatory effects of C-Vx. But these findings should cautiously be evaluated due to the low numbers of subjects in both human and experimental arms
Gebelerde Farklı Trimesterlerde Görülebilen Problemlerin İncelenmesi
No full textAMAÇ: Çalışmamızda, gebelikte görülebilen bel ağrısı, üriner inkontinans, konstipasyon ve sistit gibi problemlerin farklı trimesterlerdeki görülme sıklığının incelenmesi amaçlanmaktadır.YÖNTEM: Gebelerin değerlendirilmesinde, bel ağrısı için Revize Oswestry Skalası, konstipasyon için Konstipasyon Ciddiyet Ölçeği, üriner inkontinans için İnkontinans Şiddet Ölçeği ve sistit için İnterstisyel Sistit Semptom İndeksi kullanıldı.BULGULAR: Bel ağrısı; 1. trimesterdeki gebelerin %13,3’ünde şiddetli iken, 2. trimesterdeki gebelerin %7,3’ünde şiddetli olup 3. trimesterdaki gebelerin %16,9’unda şiddetlidir. Konstipasyon; 1. trimesterdeki gebelerin %86,7’sinde, 2. trimesterdeki gebelerin %87,8’inde ve 3.trimesterdeki gebelerin %86,4’ünde görülmektedir.Üriner inkontinans; 1. trimesterdeki gebelerin %13,3’ünde, 2. trimesterdeki gebelerin %56,1’inde ve 3.trimesterdeki gebelerin %45,8’inde görülmektedir.Sistit; 1. trimesterdeki gebelerin %46,7’sinde, 2. trimesterdeki gebelerin %43,9’unda ve 3.trimesterdeki gebelerin %57,6’sında görülmektedir. Fakat trimesterler arasında istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0.05).SONUÇ: Gebeliğin tüm trimesterlerinde bel ağrısı, üriner inkontinans, konstipasyon ve sistit problemleri görülmekte olup, gebeliğin haftası ilerledikçe şikayetlerin görülme sıklığında artış olduğu bulunmuştur.OBJECTIVE: In our study, it is aimed to examine the incidence of problems such as low back pain, urinary incontinence, constipation and cystitis that can be seen during pregnancy in different trimesters.METHODS: Revised Oswestry Scale for low back pain, Constipation Severity Scale for constipation, Incontinence Severity Scale for urinary incontinence, and Interstitial Cystitis Symptom Index for cystitis were used in the evaluation of pregnant women.RESULTS: Low back pain; while it is severe in 13.3% of the pregnants in the 1st trimester, it is severe in 7.3% of the pregnants in the 2nd trimester and severe in 16.9% of the pregnants in the 3rd trimester. Constipation; it is seen in 86.7% of the pregnants in the 1st trimester, 87.8% of the pregnants in the 2nd trimester and 86.4% of the pregnants in the 3rd trimester. Urinary incontinence; it is seen in 13.3% of the pregnants in the 1st trimester, 56.1% of the pregnants in the 2nd trimester and 45.8% of the pregnants in the 3rd trimester. Cystitis; it is seen in 46.7% of the pregnants in the 1st trimester, 43.9% of the pregnants in the 2nd trimester and 57.6% of the pregnants in the 3rd trimester. However, there was no statistically significant difference between trimesters (p>0.05).CONCLUSION: Low back pain, urinary incontinence, constipation and cystitis problems are seen in all trimesters of pregnancy, and it has been found that the frequency of complaints increases as the week of pregnancy progresses