Bezmialem Vakıf Üniversitesi Kurumsal Akademik Arşiv
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Çocuklar için Yaşam Kalitesi Ölçeği Nöromusküler Modulü Türkçe Versiyonu'nun 2-4 Yaşları Arasındaki Spinal Musküler Atrofili Çocuklarda Geçerlilik ve Güvenilirliği
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Farklı Cerrahi Flep Geciktirme Yöntemlerinin Etkinliği ve Sistemik Toksisiteleri
No full textIntroduction: The surgical flap delaying has been shown to be effective in preventing partial flap loss or in preparing larger flaps. However, there is no gold standard flap delay method in the literature. In this study, the authors aimed to compare 3 types of surgical delay methods to determine which model would increase more flap survival. The authors also investigated the effect of delay methods on circulating mononuclear leukocytes as a parameter of DNA damage. Materials and Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups. All subjects had a 10 × 3 cm modified McFarlane flap. Surface area measurements, biopsies, and blood samples were taken on the day of sacrification; 7th day for the control group and 14th day for delay groups. Results: Between incisional surgery delay groups, a significant difference was found in necrosis and apoptosis in the bipedicled group, and only necrosis in the tripedicled group compared to the control. In terms of DNA damage, it was found higher in all experimental groups than in the control group. Conclusions: Both incisional surgical delay procedures’ results were meaningfully effective when only incisions were made without the elevation of flaps. In conclusion, bipedicled incisional surgical delay seems to be the most effective method in McFarlane experimental flap model whereas two-staged surgeries may increase the risk of systemic toxicit
Comparing The Effects Of Telmisartan, Perindopril, And Nebivolol On Neuroprotection In LPS-Induced Neuron Like Cells
No full textKonjenital ve edinsel subglottik stenoz
No full textSubglottik stenoz (SGS), çocukluk çağında kronik üst solunum yolu obstrüksiyonunun en sık nedenlerinden biridir. Konjenital veya edinsel nedenlerle oluşabilir. En sık endotrakeal tüp veya trakeostominin oluşturduğu hasara bağlı anormal yara iyileşmesi sonucu oluşmaktadır. Bu nedenle; tanısında ayrıntılı anamnez önemlidir. Risk faktörleri varlığında SGS araştırılmalıdır. Stridor en sık semptomdur ancak diğer solunum sistemi bulguları ile de karşımıza çıkabilir. Tanıda öncelikle laringoskop ile değerlendirilme önerilmektedir. Laringoskopi ile tanı koyulamadığında bronkoskopi ikinci basamak tanı yöntemi olarak tercih edilmelidir. Darlığın şiddetine göre farklı tedavi protokolleri uygulanır. Hafif darlığı olan vakaların çoğunda konservatif yaklaşım yeterli iken, orta ve şiddetli subglottik stenoz tedavisinde genellikle cerrahi gereklidir. Pediatrik hastalarda subglottik stenozun (SGS) değerlendirilmesi ve yönetimi karmaşık ve teknik olarak zor olduğundan uzmanlaşmış bir ekip ile multidisipliner yaklaşım gerektirir.Subglottic stenosis (SGS) is one of the most common causes of chronic upper airway obstruction in childhood. It can occur due to congenital or acquired reasons. It most commonly occurs as a result of abnormal wound healing due to damage to the endotracheal tube or tracheostomy. Therefore, detailed anamnesis is important in the diagnosis. In the presence of risk factors, SGS should be investigated. Stridor is the most common symptom, but it may also present with other respiratory system findings. In the diagnosis, it is recommended to evaluate with laryngoscope first. When the diagnosis cannot be made by laryngoscopy, bronchoscopy should be preferred as a second-line diagnostic method. Different treatment protocols are applied according to the severity of the stenosis. While the conservative approach is sufficient in most cases with mild stenosis, surgery is usually required for the treatment of moderate to severe subglottic stenosis. The assessment and management of subglottic stenosis (SGS) in pediatric patients is complex and technically challenging, requiring a multidisciplinary approach with a specialized team
