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Frequency of Gynecological Malignancies in a Tertiary Care Centre in Karachi, Pakistan
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Reflections of an Earliest Established Screening and Testing Facility for COVID-19 in the Largest Metropolis, Pakistan
Get PDFAs the world struggles to deal with the COVID-19 pandemic, this article talks about the experience and findings of the first COVID-19 screening facility in a tertiary care hospital in Karachi, Pakistan. Department of Family Medicine at Aga Khan University (AKU) took initiative where COVID-19 screening of stable patients first began in a dedicated area. Since testing kits were limited and community spread had not started, nurses would screen every walk-in patient based on the presence of fever, cough, travel history and exposure to COVID-19 positive patient in the last 14 days, and advise swab testing if indicated. Out of 742-screened patients, approximately 66% were males and 34% were females. 38% of patients reported fever and 54% of patients reported cough. 8% (65) patients checked all three screening criteria of cough, fever and international travel exposure whereas 35% were asymptomatic. The majority had clinical exposure (38.3%) followed by public exposure (33.4%) and international travel exposure (19.8%)
Plitidepsin under Clinical Trial for COVID-19
Get PDFOur team wants to draw attention to the clinical trial of drug Plitidepsin for COVID 19 treatment. SARS-CoV-2 has caused a catastrophe worldwide devastatingly of over 208 million confirmed cases and more than 4.4 million deaths reported worldwide as of early September 2021 according to WHO. Remdesivir despite being the only approved antiviral drug for the specific treatment of COVID- 19, has limited efficacy against the virus [1]. Because of very limited options for treatment of viral infection, the scientist has to work really hard to find out more treatment options so that we can protect humanity from next pandemic.
SARS-CoV-2 encounters many proteins in the human body. After hijacking many of these proteins SARS-CoV-2 starts replicating inside the human cells. These proteins and their inhibition can be the target in clinical studies to exploring the therapeutically potential of any antiviral drug. One such host protein is Eukaryotic elongation factor-1A (eEF1A) whose inhibitor Plitidepsin has come under the significant interest of researchers as Plitidepsin [2]. The antiviral activity of Plitidepsin is mediated through its inhibition of Eukaryotic Elongation Factor 1A (eEF1A) [3]. It has a cytostatic impact on cell proliferation and strongly inhibits nucleocapsid protein expression, thus inhibiting the cytoplasmic replication stage [4]. Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium Albicans
Health Inequalities Among Women in Developing Countries
Get PDFDisparities or variations in the achievement of a person or a group in terms of health can be defined as health inequalities. Access to quality health services is restricted by gender inequality resulting in preventable morbidity and mortality in women. This paper will highlight the health inequalities among women in developing countries by analyzing the results of selected abstracts through scoping review. It will develop an understanding of how health services are prioritized and utilized by females in developing countries. In the developing world, men seek medical advice more often than women who prefer either self-management or delay seeking formal treatment only when their symptoms get worse. The efforts taken to reduce these inequalities and in addressing health-related issues are not sufficient and require more efforts by the implementers and policymakers. Investment in education and improving women in making their own decisions about health can support a reduction in inequality in health by changing the cultural and social environment of a country
Uses of Antidepressant as Adjunct Treatment of Very Severe Atopic Dermatitis
Get PDFThis is a case of severe atopic dermatitis in a young married male age 37 years. This patient was very anxious and frustrated. The patient was using all the standard treatments for severe atopic dermatitis for e.g azathioprine, cyclosporine, tab deltacortril, applying emollients with clobetasol in it but he was not getting better. By chance the patient's family dragged him to visit a psychiatrist and the patient was advised to start venlafaxine and within 15 days the patient started getting better miraculously. Atopic Dermatitis is a very frustrating disease and patients face severe depression and bouts of severe itching exacerbated by exposure to dust, stress, sweating, changing and wearing clothes, etc. The use of antidepressants is not common practice in treating atopic dermatitis. Most general practitioners and dermatologists don't pay attention to how much a patient is suffering not only physically but also mentally and because of this, they don't suggest antidepressants. The role of antidepressants as an anti-inflammatory is still needed to be educated among physicians. This is a vicious cycle. The stress causes the exacerbation of this disease in which patients start itching all over the body and because of itching, lesions all over the body start getting infected as during itching staphylococcus aureus which resides under the nail enter in the lesion and cause infection and because of infection patients have a fever, lethargy, and weakness. The use of antidepressants is a game-changer in the management of atopic eczema
Practices and Attitude of General Physicians in Pakistan Regarding Post-Traumatic Stress Disorder: A Cross-Sectional Study
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End- of- Life Care: Beneficence Undermines Patient’s Autonomy
Get PDFEnd-of-life care is a decision-making process in which health care providers, patients, and their families play a crucial role in easing the suffering of the patients and their families. Usually, end-of-life decision-making takes place in a critical situation of the patient; therefore, health care providers, particularly, physicians and nurses play a major role in making a decision for the patient’s life with regards to updated knowledge and practice. In this view, health care providers face many challenges in end-of-life decision-making due to controversy among equally unfavorable solutions; particularly between two ethical principles i.e., patient autonomy and beneficence. Health care providers often overweigh beneficence over autonomy regarding less suffering for the patient and his/her family. This approach of health care providers raises a question for undermining patients' autonomy and violating the basic ethical right of a patient. To overcome these kinds of ethical challenges, it is imperative to equip health care providers with updated knowledge of advance directives for patients. In addition, patients and their families should be well informed from the beginning to the end stage of the patient stay in the hospital. Besides, each hospital should have an ethical expert committee including nurses to analyze the entire situation and to make the decision in the best interest of the patient and his/her family
Experience of Endoscopic Ultrasound Fine Needle Aspiration in Tertiary Care Hospital
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Adermatoglyphia (Loss of Fingerprints) in Young Female Patient Having the Conditions of Hyperhidrosis and Atopic Dermatitis
Get PDFThis is a case of Adermatoglyphia or simply a loss of fingerprints in a young female patient in her 20s having a condition of hyperhidrosis and atopic dermatitis. At a young age, this condition can be very frustrating and give the patient a red flag in his/her carrier and during international travel. The patient faces problems in unlocking smartphones and electronic devices. The patient has to keep a medical certificate from a certified Dermatologist all the time for proof of this condition. Adermatoglyphia is not recognized as a problem in society and law enforcement agencies are not aware of this condition in detail, all over the world
