LNH-Journals
Not a member yet
521 research outputs found
Sort by
Pain Management in Cancer Patients
Get PDFPain is always a subjective experience that is influenced by behavioral, biological, and social factors. Timely assessment and proper treatment can significantly reduce the consequences associated with inadequate pain relief. The pathophysiology of the pain that is suffered by cancer patients is overly complex and is thought to be due to various mechanisms involved. It is thought that many of them complain of severe neuropathic pains, which may be due to the ongoing compression, ischemia, and inflammation. In addition to the pain of their metastatic disease, they also suffer from treatment-related pains and procedural/surgical pains. This review article highlights the pathophysiology, and assessment and particularly focuses on the management of pain in cancer patients with different modalities using Oncological, Pharmacological, Non-pharmacological, and Interventional techniques
Early detection of Cancer using Mammograms with Advanced Artificial Intelligence (AI) Algorithms for Breast lesions
Get PDFNot Availabl
Hospital Waste Management as an Emergent Public Health Concern in Pakistan
Get PDFHospital waste is very small in quantity but it carries a huge risk in the transmission of disease and injury. It is considered special type of waste due to its potency to infect the population. According to World Health Organization (WHO) The waste that is contagious, containing toxic metals, infected diagnostic material and decontaminators are said to be the hospital waste. (1) Poor and inappropriate management of waste material can cause very serious health outcomes and it may contribute substantial impact to the environment
A Literature Review on Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and its Complications
Get PDFStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are delayed-type hypersensitivity reactions to medications. Early signs of identification and proper management are critical for patients’ survival. The distinct features initially resemble influenza-like conditions, malaise, and fever with gradual pain and lesions in the oral, ocular, and genital areas along with other systemic symptoms. SJS/TEN can be differentiated: SJS by the degree of skin involvement and TEN by the degree of exfoliation. In SJS, skin involvement is 30%; overlapping among the two develops with 10–30% skin involvement. For the identification of culprit drugs, oral provocation tests, patch testing, and in vitro assay tests are used. The estimation of mortality rates for SJS/TEN has been performed by using SCORTEN- severity-of-illness score for toxic epidermal necrolysis. Sulfonamides, anti-epileptics, NSAIDs (oxicams), and allopurinol are some of the medications with a high risk of SJS/TEN development. Drug-mediated SJS/TEN is facilitated by genetic involvement particularly HLA antigens along with CYP450 genetic variants. Most frequent clinical features include mucosal involvement of nasopharyngeal, esophageal, and genital regions accompanying blisters and erosions. A multidisciplinary approach is required for the handling and treatment of SJS/TEN. It is mandatory to withdraw the contributing medicine followed by supportive therapy. Clinical management involves the use of corticosteroids, cyclosporine, and immunoglobulins
Laparoscopic Gastrectomy for Gastric Cancer – An Overview of the Current Perspectives
Get PDFDue to its favorable postoperative phase and outcomes, laparoscopic gastrectomy has become widely accepted as an alternative to an open surgical method for the treatment of early gastric cancer. The approach is being increasingly adopted to treat advanced gastric cancer, though concerns exist about oncological safety, technical feasibility, and long-term outcomes. This article presents a brief overview of the recent literature related to the adoption of a laparoscopic approach for the management of gastric cancer
Plummer-Vinson Syndrome: A Case Report
Get PDFPlummer-Vinson syndrome (PVS), also termed as sideropenic dysphagia or Paterson-Brown-Kelly syndrome, is an uncommon medical disorder characterised by three things: iron deficiency anaemia, dysphagia, and esophageal web(s), more often seen in middle-aged females. We present a case of a 45-year-old married lady who came to the medical outpatient department at Abbasi Shaheed Hospital with food swallowing difficulty, fatigue, and generalised body weakness for the past 7 months. Her hematological workup revealed microcytic hypochromic anaemia and barium studies showed smooth circumferential narrowing of the cervical esophagus at the level of the C5-C6 vertebrae (post-cricoid esophageal web). PVS was diagnosed. Endoscopic dilatation or balloon dilatation was advised to treat her dysphagia but was refused by the patient. Her iron deficiency anaemia was corrected with an intravenous iron sucrose supplementation. She was encouraged to eat an iron-rich, semi-solid diet. When she came for a follow-up after six weeks of oral iron supplementation, her condition was satisfactory, and dysphagia had improved
Medical and Dental Students’ Perception of Online Learning across Pakistan in the COVID Pandemic Era: A Review Article
Get PDFThe widespread lockdowns due to the COVID pandemic led to an abrupt shift in the medical education sector from a conventional to an online education system. The aim of this study was to determine the perception of medical and dental students regarding the acceptance of e-learning in Pakistan. A thorough literature search was conducted on PubMed and Google Scholar; six articles were included in this review.
Perceptions of students regarding online medical learning were compiled. These perceptions were related to both non-clinical subjects as well as the attainment of clinical skills through online education. This review also highlights online educational challenges such as the level of student-teacher interaction, internet connectivity issues, and perception of fairness in online assessments.
Online learning during COVID pandemic has not been a successful mode of learning for undergraduate medical and dental students across Pakistan. This specifically stands true for the learning of clinical and laboratory skills
Preferences and Practices of Face Mask to Halt the Spread of COVID-19: A Multi-Country Research on the New Normal
Get PDFNot Availabl
Revolutionary Immunotherapy for Merkel Cell Carcinoma: Retifanlimab-Dlwr (Zynyz) Receives FDA Approval
Get PDFApproval of Retifanlimab-dlwr (brand name Zynyz) represents a significant breakthrough in the field of dermatology, providing a promising treatment option for patients diagnosed with this highly aggressive and rare form of Merkel Cell Carcinoma (MCC). Traditionally, treatment options for MCC have been limited, with surgery, radiation, and chemotherapy are the mainstays.
Retifanlimab-dlwr debut will mark a milestone in the treatment of MCC. Clinical trials have shown impressive results, with a significant number of patients experiencing durable responses to the therapy. Retifanlimab-dlwr is a monoclonal antibody that targets the programmed cell death protein 1 (PD-1), which is expressed on immune cells and helps to reactivate the body's immune response against cancer cells.
The impending use of Retifanlimab-dlwr not only provides a groundbreaking treatment option for MCC but also paves the way for further advancements in immunotherapy and personalized medicine