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Correlation of Serum Prostate Specific Antigen and Gleason Grade with Bone Metastases in Patients with Prostate Cancer; An Experience at a Tertiary Care Hospital
Get PDFBackground: Prostate cancer (PCa) is the second most frequent cancer in the world and its incidence in Asian countries is on the rise. A lot of research work has been done in the Western world for the better understanding and treatment of the disease but the Western data may not be relevant to the data from Asian countries.
Objective: To find out the association of serum prostate-specific antigen level and Gleason grade to the incidence of positive bone scan disease in our prostate cancer patient population.
Methods: A four-year retrospective study that comprised 32 Prostate cancer (PCa) patients who were seen at The Indus Hospital and Health Network (IHHN) from October 2017 to December 2021. Recorded data were serum PSA value, histopathological examination of prostate tissue, and bone scan results. Histopathological examination of PCa was confirmed on biopsy with well-documented Gleason grade groups and scores.
Results: Thirty-two patients with prostate cancer with a median age of 72.5 years (68-76.7), median PSA was 74 (12.4-100) ng/mL, and median GS was 9 (7-9) were included. Patients were segregated into four groups following their serum PSA levels ranging from ≤10 ng/ml (n=7; 21.8%), >10-≤20 ng/ml (n=4; 12.5%), > 20-≤100 ng/ml (n=14; 43.7%) and >100 ng/ml (n=7; 21.8%). Levels of PSA showed a significant association with BM (p=0.002). Similarly, in cancers with low Gleason grade, no bone metastasis was found (p=0.02).
Conclusion: Raised PSA and high Gleason grade are associated with increased occurrence of bone metastasis in patients with carcinoma of the prostate and can be used as predictors of disease severity and progression
Role and Importance of Integrating Physiotherapy in the Management of Patients with Gynaecological Cancers
Get PDFWe highlight the role and importance of physiotherapy in the integrated management of gynecological cancers. Various symptoms, complications of treatment and obesity are amenable to physiotherapy interventions. Physiotherapists should be included in the decision-making process and represented in tumor board
Exploring the Perspectives on Home-Based Palliative Care: A Systematic Literature Review
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An Overview of The Literature on Patient Safety Culture
Get PDFThe prevention of errors and negative consequences on patients associated with health care is referred to as patient safety. Healthcare has become more complex as new technologies, drugs, and treatments have become more widely available. Every year, 134 million adverse events occur in hospitals in low- and middle-income countries (LMICs), resulting in 2.6 million deaths worldwide. Many medical practices and healthcare risks are emerging as critical issues for patient safety, significantly increasing the burden of harm caused by unsafe care. There are numerous predictors, including safety and risk management, medication errors, fall risks, unsafe surgical care procedures, diagnostic errors, hospital-acquired infections, and diagnostic errors, all of which pose a risk to patient safety measures. The role of a nurse surrounds the complete analysis of the solemn issue associated with the well-being and safety culture. Nurses contribute to patient safety by remaining at patients' bedsides and interacting with their families and other healthcare professionals
Neurological and Urological Malformations in Infant of Diabetic Mother at Tertiary Care Hospital; a Single Center Experience
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Hypertension Research Productivity from Saudi Arabia: A Scientometric Analysis for the Last Two Decades (2001-2020)
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Pyogenic Granuloma-like Amelanotic Melanoma of the Fingernail
Get PDFAmelanotic melanoma is an atypical melanoma that presents without pigmentation and can thus be misdiagnosed as benign neoplasm. Ungual trauma can induce amelanotic melanoma of the fingernail as well as pyogenic granuloma (PG). We present the case of a patient in his 60s with a PG-like lesion on his third nail plate that was preceded by ungual trauma one year ago. A shave biopsy revealed an ulcerated nodule composed of epitheloid cells with melanocytic atypia, extending 1.7 mm. Features were consistent with melanoma, confirmed with SOX10, S100, MART-1, and HMB45 immunostaining. This case demonstrates the integral role of histopathology and immunostaining in differentiating a benign PG from amelanotic melanoma, and thereby, preventing metastasis. We present this case to improve clinicians’ ability to recognize atypical melanomas and to emphasize the importance of biopsy in such cases to ensure timely treatment and patient outcomes
Road Safety Practices While Driving among Non-Medical University Students in Karachi
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Our Experience with Tension-Free Urethral Reconstruction with Urethral Plate Dorsal Slit Technique
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ChatGPT for the Standardized Operative Notes in Plastic Surgery
Get PDFChatGPT (Open AI, San Francisco, CA, USA) was released on November 30, 2022. It is a conversational AI model developed by OpenAI. It is based on the GPT (Generative Pretrained Transformed) architecture that respond in conversational manner to all human text inputs. (1) This powerful tool is being explored to be used in full capacity in various fields of life. In medical field, it can not only enhance medical practice by improving communication, but also it can potentially be used for writing medical documents of medicolegal significance (e.g. discharge summaries etc.). (2) Good quality operative notes with adequate details are important information to maintain continuity of care between medical teams, serves as a source of information for future reference, for medical reimbursement, and above all, this document has legal implications