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Polymorphisms of Methyltetrahydrofolate Genes among Patients with Diffuse Large B Cell Lymphoma in Oman
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Frequency of Functional Gastrointestinal Disorders in Children with Recurrent Abdominal Pain
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Thrombocytopenia in Dengue Fever and Its Correlation with Serum Vitamin B12 Level
Get PDFBackground: The most prevalent and significant arboviral disease affecting humans is dengue. It is spread by the Aedes genus of mosquitoes, which are common in tropical and subtropical regions of the world. Thrombocytopenia occurs commonly among patients suffering from dengue fever, making them more prone to hemorrhagic complications. The predisposing factors leading to thrombocytopenia and bleeding manifestations after dengue infection are not well-known
Objective: We attempted to determine the frequency of thrombocytopenia and its co-relation with serum vitamin B12 levels among dengue patients.
Methods: This Cross-sectional study after taking approval from the hospital ethical committee was carried out at the Department of Medicine PNS Rahat Hospital from 01/06/2022 to 30/11/2022 over six months. A total of 145 diagnosed patients suffering from dengue fever fulfilling the inclusion criteria were enrolled. Patients with concomitant sepsis, malignancy, autoimmune disorder, hematological disorder, and drugs causing thrombocytopenia were not included in the study. Precise history and bio data were entered in the Pro forma. Patients were investigated for CBC, VIT B12 LEVEL, and other routine investigations. SPSS v27 was used for data analysis. P-value≤0.05 was considered as significant.
Results: Out of a total of 145 patients, 78 (53.8%) were males and 64 (46.2%) were females With a mean age of 38.22±15.93 years.139 patients (95%) had thrombocytopenia with variable severity, and platelet count is positively correlated with serum vitamin B12 Level (p=0.000).
Conclusion: Dengue fever patients with thrombocytopenia were found to have vitamin B12 deficiency. Thrombocytopenic patients may require more platelet transfusion and longer hospitalizations
Community-acquired Methicillin-resistant Staphylococcus Aureus Pneumonia: A Diagnostic Challenge
Get PDFDespite the fact that methicillin-safe Staphylococcus aureus (MRSA) has been known to be related with nosocomial pneumonia, a few reports have likewise depicted instances of community-acquired pneumonia (CAP) among healthy individuals that was brought about by MRSA. The assessed rate of community-acquired MRSA (CA-MRSA) pneumonia is 0.51 to 0.64 cases per 100,000[1].A worldwide study revealed that out of 3193 CAP patients ,MRSA was positive among 3% of cases only[2].MRSA can cause serious CAP, which prompts basic sickness and at times demise. Patients with CA-MRSA pneumonia had more extreme clinical outcomes than those with pneumococcal CAP, including emergency unit and in-patient mortality [3]. Studies have shown that the mortality of CA-MRSA pneumonia is pretty much as high as 56% to 63%[4,5]. CAP caused by MRSA conveying the PVL quality can proceed as broad lung damage, multilobular infiltrates, leucopenia, hemoptysis, and sepsis, prompting a higher mortality rate[6,7].
Thus, we present an intense case of CAP brought about by MRSA with impending respiratory failure in a 19-year-old male with no co morbid and insignificant past medical history. Through this case, we intend to increase awareness about prompt initiation of therapy for CA-MRSA whenever it is suspected, to enhance better clinical outcomes
Assessment of Sodium Disturbances in Chronic Liver Disease Suffering from Diarrhea with Dehydration
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Chronic liver disease (CLD) significantly impacts global health, affecting nearly 1.5 billion individuals. Sodium disturbances are common in CLD and can lead to severe systemic effects. However, the relationship between these disturbances and CLD-related complications such as diarrhea and dehydration is complex and not fully understood.
Objective: To assess the sodium disturbances in chronic liver disease patients suffering from diarrhea with dehydration presenting at a tertiary care hospital, in Karachi, Pakistan.
Methodology: A cross-sectional study was conducted from October 2022 to July 2023, including individuals aged >18 years diagnosed with CLD, experiencing diarrhea and dehydration, and on diuretic therapy. The blood sample was collected from all of the participants and sent to a laboratory for analysis. The blood is then tested to measure the concentration of sodium in milliequivalents per liter (meq/L). The normal range for sodium levels in the blood typically falls between 135 to 145 meq/L. Levels below or above this range can indicate sodium imbalances. Descriptive statistics and inferential statistics were performed on SPSS.
Results: The mean age of the participants was 33.35 years, with a standard deviation of 8.01. Of 126 patients, 38.1% were male, 27% had hypertension, and 15.1% had diabetes. The mean sodium concentration was found as 132.17±14.23 meq/L, with 42.9% of CLD patients experiencing diarrhea and dehydration having sodium levels <135 meq/L. Diabetic CLD patients showed a significant association with low sodium levels (73.7% with sodium <135 meq/L).
Conclusion: A high prevalence of sodium imbalances among CLD patients suffering from diarrhea and dehydration, with diabetes being a significant contributing factor
Diversity of Diseases-Causing Neonatal Jaundice - Experience of Pediatric Surgery Unit in Saidu Group of Teaching Hospital, Swat
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Diagnosis of Celiac Disease in a Patient with Isolated Refractory Dyspepsia and GERD: A Case Report
Get PDFCeliac disease is a chronic autoimmune illness that develops in genetically susceptible persons who consume gluten that causes damage to the small intestine. The average global prevalence of CD is between 0.5 and 1%, despite regional variations in the disease's frequency.
In this report, we present a 34-year-old patient with a complaint of epigastric pain and burning with a history of nausea and vomiting. She complained of severe gastric pain, bloating, discomfort, burning, and digestive problems.
Endoscopy and colonoscopy were performed due to her lower abdominal pain and it showed that the asymptomatic with isolated dyspepsia patient was diagnosed with celiac disease. Every six months, anti-TCG, IgG, and IgA levels were monitored and they improved at the same time that the patient's symptoms did. Endoscopy must be performed in young patients, who have no signs of celiac disease and have a positive laboratory test
An Insight into Surgical Site Marking Introducing Infection
Get PDFPreoperative marking of the surgical site is necessary to prevent surgical site errors. In numerous plastic and reconstructive surgeries, tissue marking is performed preoperatively and intraoperatively using surgical markers. It enables the surgeon to create a map prior to surgery, which is essential for a successful outcome. Intraoperative marking is likewise essential. Despite its positive effects, it is not entirely devoid of flaws. When sterility is compromised, it is known to cause surgical site infections
Bridging the Gap between the Students and Faculty Members
Get PDFThe "student-teacher gap" is the term used to describe the disconnect or differences between learners and their educators in many facets of a learning environment. It's critical to remember that this disparity does not necessarily signal a problem; rather, it draws attention to the unique roles, backgrounds, and perspectives that students and teachers bring to the classroom. A happier and more cooperative intellectual community enhanced educational outcomes, and increased student involvement can all result from enhanced interaction and comprehension between the two sectors.
Nowadays, it is observed that the gap between students and teachers is minimized. People think the credit goes to information technology which has invented different strategies for teaching and learning. According to the people's opinion, there should be no gap between students and teachers so that they can communicate with each other easily without any hesitation or fear. As students close the distance between their present abilities and the anticipated level of competency, positive feedback is essential. Good communication and collaboration is also necessary to bridge this gap
