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Navigating the Future: The Integration of Artificial Intelligence in Primary Care Medicine in Pakistan
Get PDFThe recent past has witnessed a paradigm shift with the usage of artificial intelligence (AI) within a variety of healthcare services. This transition of incorporating AI has brought about multiple favours for enhancing current services and a lot of promising results in the primary care setup of Pakistan. Primary care has diverse and sophisticated provisions hence the challenges are complicated too. The authors examine the existing practices as well as future options for incorporating AI in primary care in Pakistan
An Analytical Study of Risk of Depression in Adult Population With Hearing Impairment
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A Narrative Review on Current Development and Future Prospects for the Treatment of Dengue Virus Infection
Get PDFIncidences of dengue-virus infection are increasing globally. Around 3.90 billion population is at high risk of infection. There is no cure/prevention available. Hence aim of the current review was the evaluation of current development and prospects for the production of safe anti-dengue drugs. The data of review was synthesized by PRISMA. Grading of Recommendation Assessment, Development, and Evaluation criteria were employed to establish the quality of the literature. Many drugs/compounds have shown promising prospects. Target site of these drugs on dengue virus were inhibition of replication (N-sulfonyl peptide-hybrids, milk-exosomes, sunitinib, schisandrin-A, cavinafungin, minocycline, 4-hydroxyphenyl retinamide, Goniothalamus umbrosus, Dryopteris crassirhizoma, Morus alba, statins), protease-enzyme (Thiazolidinone-peptide, nelfinavir, carnosine, 1,2-benzisothiazol-3(2H)- one and 1,3,4-oxadiazole), capsid-protein (Juglanin and silymarin), NS4B-gene (Desatinib), entry-in-host-cell (Duramycin, glycodendrimers, curdlan sulfate), RNA-capping (Lanatoside-C), fusion (Chloroquine) and NS3-helicase (Suramina). Many compounds/drugs are found effective by targeting the structural proteins of the dengue virus to use as a therapy in the future
Role of Single Nucleotide Polymorphisms in BRCA1 and BRCA2 Genes Relative to Previous Studies in Pakistan in the Prognosis of Breast Cancer
Get PDFBreast cancer is a complex disease characterized by a myriad of genetic alterations. Single nucleotide polymorphisms are particularly relevant due to small allelic variations. BRCA1 and BRCA2 genes are notably associated with inherited breast and ovarian cancers. Alterations in other genes were also identified. Mutations in BRCA1 and BRCA2 tumor suppressor genes play a significant role in development. Studies in the Pakistani population revealed significant differences in gene mutations. In 31 families, 8 had male and 23 had female breast cancer, substantial findings were observed. The analysis encompassed full coding sites of these genetic variations. Among eight families with male BC, changes were detected in 2 BRCA1 and 4 BRCA2 genes. Additionally, eight alterations were noted in 23 females from site-specific families, with 4 in BRCA1 and 4 in BRCA2. These findings underscore the importance of genetic variations, especially in the BRCA1 and BRCA2 genes, in the context of breast cancer susceptibility within diverse populations
Reducing the Burden of Diabetes Mellitus: Is it Achievable?
Get PDFDiabetes mellitus is rapidly on the rise globally, particularly in low- and middle-income countries. Pakistan has emerged with the highest prevalence of diabetes by percentage according to recent estimates. Evidence is available for different strategies to reduce this burden. Screening high-risk individuals can reduce burden of undiagnosed diabetes and improve outcomes. Although prediabetes can progress to type 2 diabetes, it has the potential to regress to normoglycaemia as well. Interventions like lifestyle modifications and metformin in high-risk individuals can reduce the risk of progression to diabetes. Furthermore, there is a potential to reverse diabetes in some individuals in the early years after diagnosis with a low-calorie diet, carbohydrate restriction or bariatric surgery
