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Enhanced photocatalytic performance of Pr and Co co-doped bismuth ferrite nanomaterials for water purification
No full textRoad testing confirms diesel cars now match gasoline vehicles in nitrogen oxide and black carbon emissions
No full textCharacterisation of ▫▫- and ▫▫-based nanocomposites by photothermal techniques for potential application as photocatalysts for water purification purposes
No full textOrganic dye-, pharmaceutical-, and heavy metal-contaminated water are emerging envi
ronmental issues, and thus there is a requirement for the development of efficient and
sustainable purification methods. Semiconductor (SmC) material-based photocatalysis us
ing TiO2 andFe2O3 nanostructuresisconsideredapromisingfieldforpollutantdegradation
due to its chemical stability, nontoxicity, and ability to perform photocatalytic degradation
using light irradiation. Understanding the thermal, optical, and charge transport properties
governing their photocatalytic activity requires advanced characterisation methods. In this
context, photothermal (PT) techniques provide powerful tools for probing non-radiative
processes and energy transport in photocatalytic materials. The photocatalytic activity
of these materials strongly depends on their structural, optical, thermal, and electronic
properties. These properties can be enhanced through several modification strategies, in
cluding metal and non-metal doping (e.g., C, N, Cu, Ag, Au), surface modification, forming
a complex with SiO2, and the formation of Fe2O3–TiO2 heterostructure nanocomposites. In
this review, a comprehensive overview is provided of TiO2 and Fe2O3-based nanocompos
ites with a specific focus on characterisation techniques for photothermal characterisation
techniques, including thermal lens spectroscopy (TLS), beam deflection spectrometry (BDS),
and photoacoustic spectroscopy (PAS), for determining thermal diffusivity, thermal con
ductivity, bandgap energy, carrier lifetime, surface roughness, porosity, etc., which are
related to photocatalytic activity. The properties of these nanocomposites are correlated
with photocatalytic activity for pollutant degradation using these nanocomposites. The
challenges faced while using these nanocomposites for pollutant degradation are also
discussed, along with future prospects for designing efficient photocatalysts for water
purification applications
Development and characterization of CR101-ADC, a fully-human anti-claudin18.2 monoclonal antibody-drug conjugate
No full textClaudin18.2 (CLDN18.2) is a stomach-specific tight junction protein aberrantly exposed in multiple cancers, particularly gastric and pancreatic malignancies, making it an attractive therapeutic target. Here, we developed CR101-ADC, a novel antibody-drug conjugate (ADC) constructed from a fully human anti-CLDN18.2 monoclonal antibody conjugated to the microtubule inhibitor MMAE via a cleavable linker. The CR101 antibody exhibits high affinity and specificity for claudin18.2, demonstrating superior tumor cell-killing efficiency compared to IMAB362. Additionally, CR101 shows cross-species reactivity in humans, mice, and monkeys, simplifying pre-clinical pharmacology and efficacy studies.
In vitro pharmacodynamic studies confirmed that CR101-ADC effectively induces targeted cytotoxicity, while multiple tumor models demonstrated its potent anti-tumor activity and favorable safety profile with minimal toxicity. Transcriptomic analysis revealed that CR101-ADC primarily affects cytoskeletal, inflammatory, and stress pathways and represents a promising candidate for the treatment of gastrointestinal malignancies. Collectively, these findings demonstrate that CR101-ADC combines high specificity, potent intracellular drug delivery, and favorable safety, representing a promising next-generation therapeutic candidate for CLDN18.2- positive gastrointestinal cancers
Bralni dnevnik
No full textBralni dnevnik (interaktivna učna enota) je namenjen učenkam in učencem v 5. razredu osnovne šole