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Constitution and evaluation of a long - lived - productive rabbit line
No full textEmbargado hasta 01-01-2100An evaluation of a new maternal line (LP) of rabbits was carried out. This new line was founded following a scheme similar to that applied in the selection for hyperprolificacy in rabbits or pigs. In this case, the selection criteria were hyperlongevity and an independent culling level near the average for prolificacy. Evaluation was carried out by comparison of the reproductive and longevity performance of the LP line with another maternal line recognized for good reproductive performance and standard longevity (V line). The results indicate that the LP line could be a valuable resource for inclusion in the current 3-way cross schema used in rabbit production, because females showed better survival ability and nearly the same prolificacy as the well-reputed V line. A V doe was 1.3 times more likely to leave the herd than an LP doe, and the probability of the differences in prolificacy between lines being greater than 0 was not extreme (no more than 0.22). Differences in relative performance of the lines were observed across farms for prolificacy, longevity, cumulative production, and fertility; however, based on deviance information criterion results, the data supported the hypothesis of only these differences being generated under a genotype × environment interaction for prolificacy traits. The longer productive life of LP females could partially be understood as an indication of success of the selection procedure during the foundation of this line
Alumnado indígena brasileño: relatos de vida sobre una experiencia de internacionalización universitaria
No full textEmbargado hasta 01/01/2100
Unbiased estimation in the multivariate natural exponential family with simple quadratic variance function
No full textEmbargado hasta 01/01/2100.We give expansions for the unbiased estimator of a parametric function of the mean vector in a multivariate natural exponential family with simple quadratic variance function. This expansion is given in terms of a system of multivariate orthogonal polynomials with respect to the density of the sample mean. We study some limit properties of the system of orthogonal polynomials. We show that these properties are useful to establish the limit distribution of unbiased estimators
La introducción de actividades en el aula de infantil mediante herramientas de expresión emocional. Estrategia inclusiva de innovación
No full textEmbargado hasta 01/01/2100.La elaboración de este proyecto surge de la necesidad impulsar la inclusión del alumnado con Necesidades Específicas de Apoyo Educativo (en adelante, NEAE) en el aula de Educación Infantil. Se trata de priorizar y construir un aula inclusiva donde la diversidad y la igualdad entre los infantes se entienda como norma general de trabajo en el día a día. Conseguir una educación inclusiva es esencial para que el desarrollo de los infantes en su proceso de enseñanza-aprendizaje, sea óptimo
Percepción de riesgo como factor de riesgo de consumo de alcohol en adolescentes de la provincia de Córdoba
No full textEmbargado hasta 01/01/210
Lipoprotein(a) Levels in Familial Hypercholesterolemia An Important Predictor of Cardiovascular Disease Independent of the Type of LDL Receptor Mutation
No full textEmbargado hasta 01-01-2100Objectives:
The aim of this study was to determine the relationship between lipoprotein(a) [Lp(a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous familial hypercholesterolemia (FH).
Background:
Lp(a) is considered a cardiovascular risk factor. Nevertheless, the role of Lp(a) as a predictor of CVD in patients with FH has been a controversial issue.
Methods
A cross-sectional analysis of 1,960 patients with FH and 957 non-FH relatives recruited for SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study), a long-term observational cohort study of a molecularly well-defined FH study group, was performed. Lp(a) concentrations were measured in plasma using an immunoturbidimetric method.
Results:
Patients with FH, especially those with CVD, had higher Lp(a) plasma levels compared with their unaffected relatives (p 50 mg/dl showed the highest cardiovascular risk compared with patients carrying the same mutations and Lp(a) levels <50 mg/dl.
Conclusions:
Lp(a) is an independent predictor of CVD in men and women with FH. The risk of CVD is higher in those patients with an Lp(a) level >50 mg/dl and carrying a receptor-negative mutation in the LDLR gene compared with other less severe mutations
Interleukin 1B Variant -1473G/C (rs1143623) Influences Triglyceride and Interleukin 6 Metabolism
No full textEmbargado hasta 01/01/2100Context: IL1b (IL1B or IL1 ), a key modulator of the immune response, exerts its functions mainly via IL6 regulation. Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility.
Objective: We evaluated the influence of a genetic variant located in the promoter region of IL1B (-1473G/C) on fasting and postprandial lipids and IL6.
Design, Setting, and Participants: A total of 477 people over age 65 yr were genotyped for IL1B -1473G/C, and we evaluated fasting lipids depending on genotype. Then, 88 healthy young men were also genotyped and were fed a saturated fatty acid-rich meal. Serial blood samples were drawn for 11 h after the meal, and lipid fractions and IL6 were assayed.
Main Outcome and Interventions: Fasting lipids were studied in the aged persons. Fasting and postprandial measurements of lipids and IL6 were performed in the healthy young men.
Results: In the aged persons, CC subjects (minor allele homozygotes) showed higher triglyceride (P 0.002) and cholesterol (P 0.011) levels. Healthy young male carriers of the minor C allele showed higher postprandial triglycerides (P 0.037), and those carried into large triglyceride-rich lipoproteins (P 0.004). In addition, they showed higher postprandial IL6 concentrations (P 0.008).
Conclusions: Our work shows that inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL gene variant have altered lipid metabolism. To reinforce these gene-phenotype findings, IL6 (the natural effector of IL1B) was increased in these persons
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
No full textBackground: The regulatory function of the endothelium is al- tered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a central role in the development of atheroscle- rosis.
Objective: To determine whether endothelial function in hyper- cholesterolemic patients is affected by replacing a saturated fat– enriched diet with a low-fat, low–saturated fat diet (the U.S. National Cholesterol Education Program stage 1 [NCEP-1] diet) or a diet rich in monounsaturated fat (such as that common in Mediterranean countries).
Design: Intervention dietary study with a baseline phase and two randomized crossover dietary periods.
Setting: Hospital Universitario Reina Sof ́ıa, Co ́rdoba, Spain. Patients: 22 hypercholesterolemic men.
Intervention: Patients followed a diet high in saturated fat, then were assigned in a crossover design to the NCEP-1 diet or a Mediterranean diet. Each dietary period lasted 28 days.
Measurements: Plasma P-selectin levels, lipid concentrations, and endothelial function.
Results: Compared with the saturated fat diet, flow-mediated dilatation increased during the Mediterranean diet but not during the NCEP-1 diet. In addition, levels of plasma cholesterol, low- density lipoprotein cholesterol, apolipoprotein B, and P-selectin decreased during the NCEP-1 and Mediterranean diets.
Conclusion: In hypercholesterolemic men, diets low in fat (especially saturated fat) and diets rich in monounsaturated fats improve endothelial function
Preventing Progression of Renal Disease: A New Method for Monitoring Body Fat Percentage in Predialysis Chronic Kidney Disease Patients
No full textEmbargado hasta 01/01/2100Background and aims: Chronic kidney disease (CKD) is a progressive condition affecting metabolic pathways and physiological mechanisms. In Spain, CKD prevalence has risen, increasing patients requiring renal replacement therapy (RRT). Managing nutritional status in advanced CKD (ACKD) patients is crucial as it influences disease progression and quality of life. This study aims to describe the nutritional status of predialysis patients at University Hospital Reina Sofia, Cordoba, Spain, and develop a quick and easy model for estimating body fat percentage without bioimpedance.
Methods and results: This cross-sectional study, conducted from February to May 2023, involved 106 patients from the ACKD consultation at the University Hospital Reina Sofia. Inclusion criteria were stage 3 or 4 CKD patients who consented to participate. Data included demographic and anthropometric variables, with body composition assessed using a Tanita BC-545N bioimpedance analyzer. The sample included 32 females (30.5%) and 73 males (69.5%), with an average BMI of 30.31 (SD 5.48). Significant findings were higher body fat percentage in women (37.82%) than men (27.86%; P < 0.001) and notable differences in waist circumference and waist-to-hip ratio between sexes. Multiple linear regression showed waist circumference, height, and sex as significant predictors of body fat percentage, with an intraclass correlation coefficient of 0.71 (95% CI = 0.59-0.79).
Conclusion: Accurately assessing body composition in CKD patients is crucial as traditional measures like BMI may not capture health risks effectively. The developed model offers a practical alternative to bioimpedance for estimating body fat percentage, potentially improving CKD management and patient outcomes. Further validation in diverse populations and integration with lifestyle interventions is needed
El turismo indígena como estrategia de valoración del patrimonio cultural inmaterial mapuche. Un estudio de caso en el área costera de La Araucanía (Chile)
No full textEmbargado hasta 01-01-2100El turismo indígena es un instrumento potencialmente útil para los pueblos originarios en la medida en que estos se involucren y se empoderen en todo el proceso de implementación de la actividad turística en sus territorios, ya sea porque la gestionen directamente (turismo comunitario indígena) o porque su cultura y patrimonio en general sea el centro de la oferta turística partiendo de principios básicos de sostenibilidad. Este tipo de turismo goza, de hecho, de una creciente popularidad en Latinoamérica, alentado por los gobiernos nacionales como fórmula de mitigación de una situación de pobreza material que agobia a muchos pueblos indígenas, de manera que algunas de sus comunidades han visto en la actividad turística una alternativa de desarrollo socioeconómico. Se trata, asimismo, de una opción vinculada con nuevas formas de turismo contemporáneo, donde la inclusión del patrimonio cultural inmaterial de las poblaciones anfitrionas en la oferta turística abre un debate no solo sobre la autenticidad patrimonial de los productos turísticos ofertados, sino también respecto al rol que tienen los pueblos originarios en el control de la actividad turística y su capacidad de situarse simbólicamente en un plano de igualdad respecto a la cultura occidental. En este trabajo presentamos un análisis de dos emprendimientos turísticos en comunidades indígenas “mapuches” de la costa de la Región de La Araucanía, en Chile. Para ello, utilizamos una metodología de estudio de carácter cualitativo para atender nuestros objetivos de describir las estrategias de turismo desplegadas en la zona y detallar los procesos de participación de los indígenas en éstas. Concluye este trabajo en que las comunidades mapuches estudiadas ofertan un patrimonio cultural muy auténtico, en el marco de una actividad turística experiencial e intercultural que les permite visibilizar su cultura en un plano positivo de valoración simbólica, lo que favorece finalmente el reconocimiento de una sociedad originaria como la mapuche, durante muchos años invisibilizada y postergada dentro de la sociedad chilena