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Proyecto de gestión de calidad y mejora para la disminución de los errores en el manejo de los citostáticos
No full textLos fármacos citostáticos están formados por diversas sustancias químicas que se utilizan como terapia única o combinada para el tratamiento de enfermedades neoplásicas (1,2). La eficacia que se ha conseguido alcanzar en el tratamiento de este tipo de patologías con este tipo de fármacos ha incrementado el empleo de estos durante los últimos años. Sin embargo, a pesar de que son altamente beneficiosos, también conllevan una serie de riesgos, que pueden ser letales (2,3). Especialmente porque tienen un estrecho margen terapéutico, por lo que un pequeño error puede generar una alta toxicidad en los pacientes (4).
Las consecuencias para los pacientes pueden ser diversas. Algunos estudios han clasificado la severidad de los efectos adversos, como incidentes sin daño (50%), daños potenciales (41% )o incluso el fallecimiento (9%) (3)
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No full textContiene: Cuaderno docente, cuaderno de actividades en español, cuaderno de actividades en inglés y librillo conceptual docenteEste material se ha desarrollado dentro del proyecto Prototipos Curriculares Integrados e Inclusivos e incluye guías para profesores, cuadernos de actividades para estudiantes, y un curso de formación en línea para el personal docente y familias. Su objetivo es contribuir a la enseñanza en educación primaria, promoviendo el desarrollo competencial integral del alumnado a través de proyectos que aborden temas de sostenibilidad utilizando el currículo español de manera integrada. El material, que ha sido desarrollado y evaluado en contextos reales, está pensado para ser usado de forma flexible, con actividades y pautas variadas para que cada docente lo adapte a sus necesidades, de acuerdo con el nivel educativo y las características de su clase.Esta obra es parte de los trabajos científicos pertenecientes al proyecto Convocatoria «Pruebas de Concepto» 2021: Prototipos Curriculares Integrados e Inclusivos para propuestas STEAM, Referencia PDC2021-121498-I0
Dataset of the work "High-performance aramids with intrinsic bactericide activity"
No full textThe dataset contains all raw data of the work "High-performance aramids with intrinsic bactericide activity"This work was supported by the Regional Government of Castilla y León (Junta de Castilla y León), the Ministry of Science and Innovation MICIN and the European Union NextGenerationEU / PRTR, and the Spanish Agencia Estatal de Investigación (State Research Agency). We also are gratefully acknowledged to the financial support provided by Fondo Europeo de Desarrollo Regional-European Regional Development Fund (FEDER, ERDF) and Regional Government of Castilla y León-Consejería de Educación, Junta de Castilla y León (BU025P23). Author M. Trigo-López received grant PID2019-108583RJ-I00 and author J. M. García received grant PID2020-113264RB-I00, both funded by MCIN/AEI/ 10.13039/501100011033. Ana Arnaiz and Álvaro Miguel received funding from Ministerio de Universidades-European Union in the frame of NextGenerationEU RD 289/2021 (Universidad Politécnica de Madrid) and (CA1/RSUE/2021-00409) by the Universidad Autónoma de Madrid, respectively
Otras unidades organizativas de la Universidad de Burgos a 1/1/2023
No full textDatos institucionales en abierto sobre otras unidades organizativas (además de Facultades y escuelas universitarias) de la Universidad de Burgos que imparten docencia o tienen personal investigador. Datos actualizados a 1 de enero de 2023. Codificaciones de acuerdo con el Sistema Integrado de Información Universitaria (SIIU)
Las Guerras Cántabras. Asedio al castro de La Loma (Santibáñez de la Peña -Palencia)
Get PDFEn tiempos de Augusto, en el periodo comprendido entre el 29-16 a .C, y en base a su política expansionista del Imperio para avanzar con los limites naturales, se producirá un conflicto bélico entre Roma y parte de los habitantes del norte de Hispania, entre ellos los cántabros y los astures, conocido como Guerras Cántabras. El Castro de la Loma ubicado en Santibáñez de la Peña, (Palencia), comprenderá uno de esos episodios bélicos como lugar de asedio romano y formando un eslabón más como componente de la victoria romana sobre Hispania. En este contexto el Castro de la Loma será un lugar de cerco militar, en el que se ha desarrollado labores de estudio e investigación derivando en la localización de un gran número de materiales encontrados.In the time of Augustus, in the period between 29-16 BC, and based on his expansionist policy of the Empire to advance with the natural limits, a war will occur between Rome and part of the inhabitants of northern Hispania, among them the Cantabrians and the Asturians, known as the Cantabrian Wars. The La Loma fort located in Santibáñez de la Peña, (Palencia), will include one of those war episodes as a site of a Roman siege and forming another link as a component of the Roman victory over Hispania. In this context, the La Loma fort will be a place of military siege, in which study and research work has been carried out, resulting in the location of many materials found
Quantitative Analysis of Vernacular Residential Building Typologies and Bioclimatic Strategies in the Warm-Summer Mediterranean Climate: The Montesinho Natural Park as a Case Study
No full textVernacular architecture embodies a lasting connection between communities, climates, and topographic landscapes, providing basic shelter needs for centuries. Adopting Montesinho Natural Park as a case study, this paper explores the essence of vernacular architecture, highlighting its adaptation and dynamic relationships with local climates, geographical features, and scarce resources. This paper firstly provides a quantitative characterisation of residential vernacular building typologies in several villages of the park based on field-collected data, using photography and videography for data reliability. The building typologies were then categorised according to their prominent architectural features, prioritising the access to the upper floor and door’s relative location and their integration within the landscape’s topography. The collected data were analysed by averaging each typology percentage across the villages and calculating dependency probabilities between each typology and the villages, aiming to identify the most frequent typologies and their dependency relationships with villages. This paper’s outcome entails the Protruding Staircase typology as the most common typology in the selected villages. Despite modern interventions, traditional features endure, emphasising practicality and resource efficiency. Among them, several bioclimatic strategies were identified and analysed qualitatively based on their potential contribution to energy efficiency and savings, highlighting their relationships with the local context and the typologies presented. The findings are important in supporting decision-making related to vernacular heritage in Northeastern Portugal. The bioclimatic construction strategies identified may be used as preliminary references to incorporate into rehabilitation projects and sustainable architecture practices, enhancing inhabitants’ thermal comfort and living conditions.This research was funded by the Portuguese Foundation for the Science and Technology (FCT) through the R&D project “Sustainability led approaches for the rehabilitation and revitalization of the cultural built heritage of Montesinho Natural Park” (INHAVIT) with reference MTS/BRB/0086/2020 (https://doi.org/10.54499/MTS/BRB/0086/2020). This work was also partly financed by FCT/MCTES through national funds (PIDDAC) under the R&D Unit Institute for Sustainability and Innovation in Structural Engineering (ISISE), under reference UIDB/04029/2020 (https://doi.org/10.54499/UIDB/04029/2020), and under the Associate Laboratory Advanced Production and Intelligent Systems ARISE under reference LA/P/0112/2020
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death
No full textDue to the relevance of lactic acidosis in cancer, several therapeutic strategies have been developed targeting its production and/or regulation. In this matter, inhibition approaches of key proteins such as lactate dehydrogenase or monocarboxylate transporters have showed promising results, however, metabolic plasticity and tumor heterogeneity limits their efficacy. In this study, we explored the anticancer potential of a new strategy based on disturbing lactate permeability independently of monocarboxylate transporters activity using a small molecule ionophore named Lactrans-1. Derived from click-tambjamines, Lactrans-1 facilitates transmembrane lactate transportation in liposome models and reduces cancer cell viability. The results showed that Lactrans-1 triggered both apoptosis and necrosis depending on the cell line tested, displaying a synergistic effect in combination with first-line standard chemotherapeutic cisplatin. The ability of this compound to transport outward lactate anions was confirmed in A549 and HeLa cells, two cancer cell lines having distinct rates of lactate production. In addition, through cell viability reversion experiments it was possible to establish a correlation between the amount of lactate transported and the cytotoxic effect exhibited. The movement of lactate anions was accompanied with intracellular pH disturbances that included basification of lysosomes and acidification of the cytosol and mitochondria. We also observed mitochondrial swelling, increased ROS production and activation of oxidative stress signaling pathways p38-MAPK and JNK/SAPK. Our findings provide evidence that enhancement of lactate permeability is critical for cellular pH homeostasis and effective to trigger cancer cell death, suggesting that Lactrans-1 may be a promising anticancer therapy.This work was supported by Consejería de Educación de la Junta de Castilla y León [Project BU067P20] and Ministerio de Ciencia e Innovación [Project PID2020-117610RB-100]. A.A.-B. thanks to PFCHA/Becas Chile (Folio #72200156) for his pre-doctoral scholarship. P.F., D.A.-C. and I.C.-B. thank Consejería de Educación de la Junta de Castilla y León, European Regional Development Fund (ERDF) and European Social Fund (ESF) for their post-doctoral (P.F. and I.C.-B.) and pre-doctoral (D.A.-C.) contracts
Potential of Subcritical Water Hydrolysis to Valorize Low-Valued Ray-Finned Fish (Labeobarbus nedgia): Effects of Hydrolysis Temperature and Pressurization Agent
Get PDFSubcritical water (SCW) hydrolysis was applied to valorize the low-valued ray-finned fish (Labeobarbus nedgia) into valuable protein hydrolysates, employing N2 and CO2 as pressurization agents at varying temperatures (140, 160, 180, and 200 °C). The degree of hydrolysis (DH) and total free amino acid content increased with temperature for both pressurizing agents. The highest DH (54.5 ± 0.4%) and total free amino acid content (210 ± 1 mg/gprot) were observed at 200 °C when CO2 gas was used as the pressurizing agent. Predominantly, glycine and alanine were released for both pressurizing agents. The antioxidant activity, evaluated through three different assays, increased with temperature and was found to be the highest at 200 °C. This study illustrated the advantages of the intensified SCW technology by using CO2 as a pressurization agent in valorizing low-valued ray-finned fish (Labeobarbus nedgia), as animal residue rich in proteins, for the production of valuable protein hydrolysates with a high fraction of valuable free amino acids, which could offer potential applications as a functional ingredient in the food industry.This work was funded by the Agencia Estatal de Investigación (AEI) and Ministerio de Ciencia e Innovación (MICINN) [grant number PID2022-136385OB-I00], by the AEI, MICINN, UE NextGenerationEU (Plan de Recuperación, Transformación y Resiliencia) [grant numbers TED2021-129311B-I00 and PDC2022-133443-I00] and by the Junta de Castilla y León (JCyL) and the European Regional Development Fund (ERDF) [grant number BU027P23]. The Pedro Barea predoctoral contract was funded by JCyL and the European Social Fund (ESF) by ORDEN EDU/1868/2022, de 19 de diciembre. Alba Ester Illera post-doctoral contracts were funded by JCyL and ERDF through project BU027P23. Rodrigo Melgosa contract was funded by a Beatriz Galindo Research Fellowship [BG20/00182]
Quantum revivals in HgTe/CdTe quantum wells and topological phase transitions
Get PDFThe time evolution of a wave packet is a tool to detect topological phase transitions in two-dimensional Dirac materials, such as graphene and silicene. Here we extend the analysis to HgTe/CdTe quantum wells and study the evolution of their electron current wave packet, using 2D effective Dirac Hamiltonians and different layer thicknesses. We show that the two different periodicities that appear in this temporal evolution reach a minimum near the critical thickness, where the system goes from normal to inverted regime. Moreover, the maximum of the electron current amplitude changes with the layer thickness, identifying that current maxima reach their higher value at the critical thickness. Thus, we can characterize the topological phase transitions in terms of the periodicity and amplitude of the electron currents.We thank the support of Spanish MICIU through the project PID2022- 138144NB-I00. AM thanks the Spanish MIU for the FPU19/06376 predoctoral fellowship. OC is on sabbatical leave at Granada University, Spain, since the 1st of September 2023. OC thanks support from the program PASPA from DGAPA-UNAM