9300 research outputs found
Sort by
Resultado funcional en reimplantes de miembro superior y calidad de vida
No full textLas reimplantaciones de miembros superiores ofrecen la posibilidad de recuperar parte de la
funcionalidad perdida. Esta intervención pretende, además de la preservación de la extremidad,
la mejora en la calidad de vida del paciente, permitiéndole recuperar una mayor autonomía en
sus actividades cotidianas.
Con el objetivo de identificar los factores asociados a la funcionalidad tras el reimplante, así
como los procesos de tratamiento y mejora de la cicatrización tras la intervención, se realizaron
sendas búsquedas sistemáticas de acuerdo con las recomendaciones de la Declaración PRISMA.
Se aborda también un estudio trasversal, descriptivo e inferencial en pacientes intervenidos de
reimplante de miembro superior en el Hospital Universitario de Burgos. Para la recogida de
datos se elaboró un cuestionario que incorpora diferentes escalas -test de Russel; DASH; SF12;
así como variables sociodemográficas y médicas. Los resultados informan sobre tasas de
ocupación tras la intervención, calidad de vida, satisfacción y funcionalidad tras la intervención.This thesis provides information about quality of life and functioning after upper limb
replantation, crucial aspects to patient satisfaction and prognosis after surgery.
Significant occupancy rates were found after replantation, reflecting an improvement in
quality of life, functionality and overall satisfaction. However, significant gaps in public
rehabilitation service provision are identified.Doctorado en Avances en Ciencia y Biotecnología Alimentaria
Naturaleza de STEM: marco teórico, diseño instrumental y propuesta didáctica integrada
No full textEn los últimos años, se ha detectado en el ámbito educativo una profunda
necesidad de una enseñanza más contextualizada y orientada a la resolución de
problemas reales y alienada con los retos del siglo XXI. Así, se han establecido
internacionalmente reformas curriculares que impulsan enfoques
competenciales y conectados con la realidad. En este contexto, la competencia
STEM ha emergido como una herramienta esencial para afrontar los grandes
retos contemporáneos. Sin embargo, persisten tensiones en su abordaje, como
la fragmentación del conocimiento, una visión tecnocrática centrada en la
empleabilidad, la escasa atención a las dimensiones críticas del saber científico
y una creciente desconfianza social hacia la ciencia que refuerzan la urgencia de
una alfabetización científica crítica e integrada.
En primer lugar, esta investigación avanza en el concepto de Naturaleza de
STEM, empleándolo como una perspectiva para repensar la enseñanza de las
ciencias en contextos educativos contemporáneos. Esta perspectiva auna
aportes del enfoque Ciencia-Tecnología-Sociedad, la Naturaleza de la Ciencia
y la educación STEM integrada. En segundo lugar, se desarrolla un itinerario
metodológico orientado al diseño, validación y aplicación de dos instrumentos
mixtos de evaluación bajo la perspectiva NoSTEM. Este proceso se materializa
en dos herramientas complementarias, EPISTEMIK-Fire y EPISTEMIKMeteo, que permiten explorar las concepciones del alumnado sobre
problemáticas sociocientíficas reales. Finalmente, se diseña, implementa y
evalúa una propuesta didáctica integrada basada en la ecología del fuego,
mostrando avances significativos en las concepciones sobre la NoSTEM del
grupo experimental.
Esta investigación contribuye al desrrollo de la educación STEM integrada para
la enseñanza de las ciencias contemporánea, ofreciendo aportes teóricos,
metodológicos y prácticos que responden a las exigencias de la alfabetización
científica actual.In recent years, a deep need has been identified within the educational field for
a more contextualized form of teaching, oriented toward real-world problem
solving and aligned with the challenges of the 21st century. As a result,
international curricular reforms have been established to promote competencybased approaches that are connected to reality. In this context, STEM
competence has emerged as an essential tool for addressing major
contemporary challenges. However, tensions persist in its implementation,
such as the fragmentation of knowledge, a technocratic vision focused on
employability, limited attention to the critical dimensions of scientific
knowledge, and a growing public distrust in science. These issues reinforce the
urgency of fostering a critical and integrated scientific literacy.
Firstly, this research advances the concept of the Nature of STEM, using it as
a perspective that rethinks science education in contemporary educational
contexts. This perspective integrates contributions from the ScienceTechnology-Society (STS) approach, the Nature of Science (NOS), and
integrated STEM education. Secondly, a methodological pathway is developed
for the design, validation, and application of two mixed-method assessment
instruments based on the NoSTEM perspective. This process results in two
complementary tools, EPISTEMIK-Fire and EPISTEMIK-Meteo, which
allow for the exploration of students’ conceptions regarding real socioscientific issues. Finally, an integrated didactic proposal based on fire ecology
is designed, implemented, and evaluated, showing significant improvements in
the NoSTEM-related conceptions of the experimental group.
This research contributes to the development of integrated STEM education
for contemporary science teaching by offering theoretical, methodological, and
practical contributions that respond to the current demands of scientific
literacyDoctorado en Didácticas Específica
Bioaccessible Bread Melanoidins Modulate Oxidative Stress, Reduce Inflammation and Suppress Adhesion of Helicobacter pylori to Caco-2 Cells
No full textBackground/Objectives: Helicobacter pylori is a major contributor to gastric infections; it is prevalent in humans and associated with gastrointestinal diseases. In recent years, the increase in antimicrobial resistance has contributed to the need for alternative approaches, prompting interest in natural products with antimicrobial and antivirulence properties. This study investigated the effect of bioaccessible melanoidins from common and soft bread crust against H. pylori infection. Methods: Melanoidins were extracted using dead-end ultrafiltration, and bioaccessible fractions were obtained through in vitro digestion. The bactericidal effect of melanoidins was assessed at 2% and 4% concentrations over 24 and 48 h. The effect on H. pylori adhesion of 100 μg/mL and 200 μg/mL of gastric and intestinal bioaccessible fractions of melanoidins was evaluated in Caco-2 cells. Results: The bactericidal effect of melanoidins revealed significant efficacy, with a greater effect for soft bread melanoidins. The gastric fractions exhibited a higher inhibitory effect, which is crucial for gastric mucosa, the primary site of H. pylori infection. Both bioaccessible fractions showed anti-inflammatory and antioxidant effects against H. pylori-induced inflammation, particularly in the gastric fractions. This was evidenced by a reduction in interleukin-6 and interleukin-8 release and an enhancement in interleukin-10 release. The observed reduction in reactive oxygen species (ROS) and the maintenance of glutathione levels indicate an improved redox status. Conclusions: This study emphasizes the potential of melanoidins, especially from soft bread, as bioactive compounds against H. pylori, offering insights for future functional food development.This research was funded by the Autonomous Government of Castilla y León and FEDER (JCyL/FEDER), grant number BU243P18
Towards Intelligent and Immersive Healthcare: Edge-AI, IoMT, and Digital Twins in the Metaverse
No full textTrabajo presentado en: International Conference on Intelligent Data Engineering and Automated Learning 2025, realizado del 13 al 15 de noviembre de 2025, en Jaén (España)The integration of emerging technologies such as Virtual Reality (VR), Artificial Intelligence (AI), and the Internet of Medical Things (IoMT) is transforming personalized healthcare. This work presents an innovative system that leverages the concept of digital health twins, IoMT devices, and immersive VR environments to enable real-time remote monitoring of biomedical signals (ECG, PPG, blood pressure, oxygen saturation, among others). Captured data is transmitted to centralized servers where neural networks analyze health parameters, allowing early anomaly detection and dynamic adjustment of treatment plans. The system also incorporates a cloud-connected assistant based on embedded hardware, enhancing continuous patient monitoring and interaction within both physical and virtual environments. To safeguard sensitive medical data, robust cybersecurity measures are integrated, including encrypted communications, authentication protocols, and local storage failover in case of connectivity loss. This multi-layered approach ensures patient confidentiality and system resilience. By improving diagnostic accuracy, optimizing patient experiences, and extending healthcare access to remote areas, this solution contributes to reducing overcrowding in medical facilities and enabling more equitable healthcare delivery.This work is supported by PID2022-136627NB-I00 project funded by MCIN/AEI/10.13039/501100011033/FEDER and by Fundación Mutua Madrileña through the 2025 Call for Medical Research Grants (AP-22016/2025)
How do teachers understand TPSR to promote social justice and health? Teaching experiences in Spanish public schools
No full textThe aim of this research is to analyse the perception of Physical Education (PE) teachers on the influence of Teaching Personal and Social Responsibility (TPSR) in the generation of social justice and the practice of healthy physical activity. Semi-structured interviews in thirteen PE teachers were used as a data collection technique. The data generated were structured into three categories of analysis: (1) Potential of TPSR in PE; (2) Connection between TPSR and social justice; (3) Connection between TPSR and health. The results showed how PE teachers understand TPSR model suitable to apply in PE classes, as it allows for teaching diverse content. Furthermore, they highlight the importance of linking health and physical activity approaches through the promotion of an optimal social climate that fosters inclusion. This awareness and commitment to social justice through PE classes, while recognising structural limitations, offers a perspective of great importance for the future of TPSR. Unlike most studies that assess TPSR’s impact from the students’ perspective, this research contributes to the field by exploring teachers’ views and experiences, providing valuable insights into pedagogical, social, and health implications of sustained TPSR model implementation in schools
The influence of social media in the training on physical activity and health of future physical sports educators
No full textFor years, social networks have become a powerful means of information for young people. In the specific case of health, in recent years there has been a large increase in content associated with physical activity on social networks that directly affects young people and future professionals in the field. A qualitative study is proposed with the new students of the Degree of Physical Activity and Sport Sciences, to know what are the perspectives and uses around social networks in the field of health associated with physical activity with which they begin their initial training. The results reflect the value and use that future physical-sports educators give to social networks, as well as the influence that their access to the Degree has. We conclude the importance of this work for the effective inclusion of social networks in the initial training of future physical-sports educators
Genome-Wide association study to identify genetic markers associated with Campylobacter jejuni motility
No full textThe ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen.This work was supported by “La Caixa” Foundation and Caja Burgos Foundation [LCF/PR/PR18/51130007], and the Ministry of Education of the Government of Castilla y León [BU064P20]. Ortega-Sanz I received a predoctoral grant from the Junta de Castilla y León, cofinanced by the Ministry of Education of the Government of Castilla y León and the European Social Fund
Proyecto de intervención. Educación en salud para disminuir la transmisión de enfermedades diarreicas en la población infantil del distrito de Wakiso, Uganda
No full textIntroducción: La reducción de la tasa de mortalidad infantil, a pesar de su notable
disminución a nivel mundial, continúa siendo uno de los propósitos de las agendas
internacionales. En España, la mortalidad infantil es de 3 defunciones por cada 1.000
nacidos vivos. En cambio, en países del África Subsahariana como Uganda, la tasa
asciende a 40 muertes. Entre los principales agentes causantes de la muerte infantil, se
encuentran las enfermedades diarreicas. La OMS, como medidas preventivas, establece: el
acceso a agua potable, saneamiento adecuado, el lavado de manos con agua y jabón, una
higiene personal y alimentaria apropiadas, la lactancia materna exclusiva, educación para la
salud y la vacunación.
Objetivos: El diseño de una propuesta de intervención de educación en salud, para la
reducción de la transmisión de enfermedades diarreicas en Entebbe, Uganda.
Metodología: El proyecto está diseñado bajo la Metodología de Marco Lógico, a través del
cual se analizó el problema y sus involucrados. Posteriormente, se creó un árbol de
objetivos y se diseñó una matriz de planificación con diferentes intervenciones.
Conclusiones: Las enfermedades diarreicas continúan siendo un problema potencial con
relación a la mortalidad infantil, sobre todo en aquellos países en vías de desarrollo.
Impulsar proyectos que fomenten la educación para la salud, dirigidos a la promoción y
prevención de estas enfermedades, reducirá el número de infecciones y mejorará la salud
de la comunidad local.Introduction: Reducing the infant mortality rate, despite its significant global decline, remains one of the goals of international agendas. In Spain, the infant mortality rate is 3 deaths per 1,000 live births. In contrast, in sub-Saharan African countries like Uganda, the rate rises to 40 deaths. Among the main causes of infant death are diarrhoeal diseases. The WHO, as preventive measures, recommends: access to safe drinking water, adequate sanitation, handwashing with soap and water, proper personal and food hygiene, exclusive breastfeeding, health education, and vaccination. Objectives: Design of a health education intervention proposal to reduce the transmission of diarrhoeal diseases in Entebbe, Uganda. Methodology: The project was developed using the Logical Framework Approach (LFA), which involved analysing the problem and identifying the stakeholders involved. Subsequently, an objective tree was constructed, leading to the design of a planning matrix that outlines various proposals and interventions. Conclusions: Diarrhoeal diseases continue to pose a significant threat to child mortality, particularly in developing countries. Implementing health education initiatives aimed at promoting and preventing these diseases can substantially reduce infection rates and enhance the health of local communities
Dataset of the work "VALPECTIN_Research Article JECE_2024_12(6)_114845"
No full textThe dataset contains data used in the work "Biorefinery approach for the development of an integrated extraction and purification process for the recovery of pectin derived compounds and flavonoids from onion peels"This work was supported by the Agencia Estatal de Investigación (AEI) through projects PID2020-116716RJ-I00/ AEI / 10.13039/501100011033, PID2019-104950RB-I00 / AEI / 10.13039/501100011033 and TED2021-129311B-I00
Membrane fractionation of hydrolysates of the water-soluble protein from tuna fish meal obtained by subcritical water and enzymatic treatments. Comparison of physical and chemical properties
Get PDFTwo different hydrolysates of the water-soluble protein (WSP) fraction from tuna fish meal were obtained by subcritical water-CO2 (subW-CO2) and Alcalase® treatments. Hydrolysates showed different chemical composition regarding their free amino acid (FAA) profile and molecular weight distribution of the peptides generated. Consequently, different strategies were proposed by using a stirred dead-end filtration system equipped with flat sheet membranes. Two nanofiltration (NF) consecutive steps were proposed for fractionation of subW-CO2 hydrolysates with polyamide membranes (800–600 Da and 300–150 Da) yielding a first retentate where 79% of the protein fraction was retained, while 92% of FAA were retained in the second step with a purity index of 29%. Alcalase® hydrolysates were fractionated by ultrafiltration (UF, 10 kDa) followed by NF (1–1.1 kDa) with polyethersulfone membranes obtaining a first retentate with more than 65% of protein fraction retention with a purity index of 50%. A relatively wide molecular weight distribution was observed in all streams, with high antioxidant and iron-chelating capacities in the retentate fractions.This work was supported by the Agencia Estatal de Investigación [Grant numbers PID2022-136385OB-I00, PDC2022-133443-I00] and the Junta de Castilla y León (JCyL) and the European Regional Development Fund (ERDF) [Grant number BU027P23]. P. Barea pre-doctoral contract was funded by JCyL and the European Social Fund (ESF) [ORDEN EDU/1868/2022]. A. E. Illera postdoctoral contract was funded by BU027P23. H. Candela-Gil contract was funded by PDC2022-133443-I00. R. Melgosa contract was funded by a Beatriz Galindo Research Fellowship [BG20/00182]