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Methodologie en richtlijnen voor de detectie van studentencapaciteiten voor educatieve inclusie
Get PDFDit document is het resultaat van het werk van verschillende professionals rond EURODDIP-e,
een project dat wordt medegefinancierd door het Europese Erasmus + -programmaEuropese Commissi
Méthodologie et orientations pour l'identification des capacités des élèves d'inclusion éducative
Get PDFLe présent document est le résultat du travail de différents professionnels à EURODDIP-e, projet
cofinancié par le programme européen Erasmus+.Commission européenn
Teacher's manual: manufacture of push buttons by 3D printing
Get PDFTrabajo realizado dentro del proyecto EURODDIP-e, cofinanciado por el programa europeo Erasmus+,European Commissio
Method operable design region obtained with a partial least squares model inversion in the determination of ten polycyclic aromatic hydrocarbons by liquid chromatography with fluorescence detection
Get PDFA chromatographic method with the Analytical Quality by Design (AQbD) methodology is developed for the simultaneous determination by HPLC-FLD of ten PAHs (naphthalene, phenanthrene, anthracene, flu- oranthene, pyrene, chrysene, benzo[a]anthracene, perylene, benzo[b]fluoranthene, and benzo[a]pyrene), widely spread in the environment. The construction of the Method Operable Design Region (MODR) is conducted, for the first time, via the inversion of a multiresponse Partial Least Squares (PLS2) model, which is needed to maintain the correlations among the Critical Method Parameters (CMP), among the Critical Quality Attributes (CQA), and the covariance between one another. The five CMP considered were the composition of the mobile phase (water, methanol, acetonitrile), flow rate, and column temperature. The eight CQA were linked to resolution between peaks recorded in the same emission wavelength (greater than 1.4) and the total time (less than 15 minutes). By systematic use of experimental design and parallel coordinates plots to explore the Pareto optimal front obtained with the PLS2 model inversion, the computed MODR is formed by convex combinations of eight specific settings of Critical Method Parameters that have a mobile phase with percentages of water between 37 and 38 %, of methanol from 13 and 22 %, and of acetonitrile between 41 and 49 %, together with a flow rate between 1.47 and 1.50 mL min −1 , and column temperature between 41.9 and 44.0 °C in their adequate combinations. All the chromatographic peaks are well resolved, with total time varying between 12.96 and 15.66 min inside the estimated MODR and the analytical method is accurate with CC βbetween 0.9 and 7.0 μg L −1 with probability of both false positive and false negative equal to 0.05.Research projects CTQ2017-88894-R and BU052P20, financed by the Spanish Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE) and Consejería de Educación de la Junta de Castilla y León, both cofinanced with European Development Funds. M.M. Arce wishes to thank Junta de Castilla y León for her postdoctoral contract through BU052P20 project
A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy†
Get PDFCancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (dmba = N,N-dimethylbenzylamine-κN,κC; L = 2-(benzo[d]oxazol-2-yl)-phenolato-κN,κO 1, 2-(benzo[d]thiazol-2-yl)-phenolato-κN,κO 2, and 2-(1-methyl-1H-benzo[d]imidazole-2-yl)phenolato-κN,κO 3) have been characterized and developed to potentially eliminate both resistant bacteria and lung cancer cells. The phototherapeutic effects of complex 2 have been evaluated using low doses of blue light irradiation. Complex 2 exerted promising photoactivity against pathogenic Gram-positive bacteria strains of clinical interest, displaying a phototoxic index (PI) of 15 for methicillin-resistant Staphylococcus aureus, one of the major microorganisms predominating lung infections. Likewise, the anticancer activity of 2 was also increased upon light irradiation in human lung A549 cancer cells (PI = 36). Further in vitro experiments with this platinum(II) complex suggest that ROS-generating photodynamic reactions were involved upon light irradiation, thus providing a reasonable mechanism for its dual anticancer and antibacterial activities.Spanish Ministerio de Ciencia e Innovación (MCI/AEI) and FEDER funds (Projects RTI2018-096891-B-I00, RTI2018-102040-B-100 and MultiMetDrugs network RED2018-102471-T), Consejería de Educación-Junta de Castilla y León-FEDER (BU042U16-BU305P18), “la Caixa” Banking Foundation (LCF/PR/PR12/11070003) and Fundación Séneca-Región de Murcia (Project 20857/PI/18). E.O. thanks AECC (PRDMU19003ORTE). Networking support by the COST Action CA1820
El aplazamiento de la deuda tributaria como medida fiscal adoptada en España para superar la crisis del COVID -19
No full textEn el trabajo se analiza y valora la figura del aplazamiento para el pago de las deudas tributarias, tanto en la regulación anterior a la pandemia del COVID-19 como a la que se dio durante la misma (para hacer frente a la falta de liquidez de las empresas en España). Además, desde un perspectiva modesta de un Trabajo de Fin de Grado. se expone tanto a la comunidad universitaria como a los especialistas en la materia. que se adopten medidas adicionales al aplazamiento dentro de la política fiscal elaborada por el Gobierno, sugiriendo así.mismo que ésta deba ser planificada . y muy seria. no sólo para poder superar esta crisis económica. sino también para otorgar credibilidad a la sostenibilidad del Estado español.The paper analyses and assesses the figure of deferral for the payment of tax debts, both in the regularisation prior to the COVID-1 9 pandemic and during the same (to address the lack of liquidity of companies in Spain). Furthermore , from the modest perspective of a final thesis, it is proposed to the university community and specialists in the field that additional measures be adopted to the postponement withi n the fiscal policy drawn up by the government, suggesting that this should be planned and very serious, not only to overcome .this economic crisis, bu1 also to lend . credibility to the sustainability of the Spanish state