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Dataset of the work “New screen-printed electrodes for Raman spectroelectrochemistry. Determination of p-aminosalicylic acid”
No full textBackground: The availability of new surface enhanced Raman scattering (SERS) substrates is essential to develop quantitative analytical methods. Electrochemistry is an easy, fast and reproducible methodology to prepare SERS substrates on screen-printed electrodes (SPEs).
Results: This work proposes new SPEs based on a three-electrode system all made of silver. Using the same ink for the whole electrode system facilitates the fabrication process, reduces production costs, and leads to excellent analytical performance. The results showed that Raman enhancement depends strongly on the type of silver ink. To demonstrate the capabilities of the new electrodes developed, 4-aminosalicylic acid was determined in complex matrices and in the presence of strong interfering compounds such as salicylic acid and acetylsalicylic acid. The proposed analytical method is based on the electrochemical surface oxidation enhanced Raman scattering (EC-SOERS) strategy. AgCl nanocrystals are generated on the working electrode surface, which amplify the Raman signal of 4-aminosalicylic acid. Good figures of merit were obtained both in the absence and in the presence of the interfering compounds, achieving a correct estimation of a 4-aminosalicylic test sample in complex matrices.
Significance: The new SPEs have been demonstrated to be very sensitive and reproducible which, together to the high specificity of the Raman signal, makes this methodology very attractive for chemical analysis.Open Access funding provided thanks to the CRUE-CSIC agreement with Elsevier B.V. Ministerio de Ciencia e Innovaci´on and Agencia Estatal de Investigacion (MCIN/AEI/10.13039/501100011033, PID2020-113154RB- C21, PID2020-113154RB-C22), Junta de Castilla y Leon and European Regional Development Fund (Grant number: BU036P23), Ministerio de Ciencia, Innovacion y Universidades (RED2022-134120-T) are fully acknowledged for funding this work. L.R. acknowledges Ministerio de Ciencia e Innovacion and Agencia Estatal de Investigacion (MCIN/ AEI/10.13039/501100011033, PIS2020-113154 GB-C21) for the doctoral contract. J.V. P.-R. acknowledges Ministerio de Universidades and NextGenerationEU for his Maria Zambrano fellowship
Estudio evolutivo del linaje de los osos de las cavernas en la Sierra de Atapuerca a partir del paleoproteoma del esmalte dental
No full textLa presente tesis doctoral, se centra en explorar la evolución de los úrsidos del linaje de
las cavernas a través del estudio de las proteínas conservadas en su esmalte dental.
Mediante el uso de técnicas avanzadas de paleoproteómica, se identificaron proteínas
clave en la formación del esmalte y polimorfismos de un solo aminoácido, algunos de
ellos descritos por primera vez, que permitieron realizar detalladas inferencias
filogenéticas. Este enfoque interdisciplinar integra biología molecular y paleontología,
para investigar las relaciones evolutivas entre los osos de las cavernas y algunas de las
especies actuales de úrsidos.
Basada en el excepcional registro fósil de la Sierra de Atapuerca y otros yacimientos del
suroeste europeo, esta investigación ofrece, desde una perspectiva proteómica, una
visión más profunda sobre cómo la evolución de este linaje pudo ser moldeada durante
el Pleistoceno, enriqueciendo nuestra comprensión de la interacción entre evolución y
ambiente en especies extintas.This doctoral thesis focuses on exploring the evolution of cave bear lineages through the
study of proteins preserved in the dental enamel of their fossils. Using advanced
paleoproteomic techniques, key proteins involved in enamel formation and single amino
acid polymorphisms, some described for the first time, were identified, enabling detailed
phylogenetic inferences. This interdisciplinary approach combines molecular biology and
paleontology to investigate the evolutionary relationships between cave bears and some
of the current bear species.
Based on the exceptional fossil record of the Sierra de Atapuerca and other sites in
southwestern Europe, this research provides, from a proteomic perspective, a deeper
understanding of how the evolution of this lineage was shaped during the Pleistocene,
enriching our knowledge of the interaction between evolution and environment in extinct
species.La presente Tesis Doctoral ha sido financiada por el programa de investigación e innovación Horizonte 2020 de la Unión Europea, bajo el acuerdo de subvención Marie Sklodowska-Curie No. 861389, como parte del Proyecto PUSHH (Palaeoproteomics to Unleash the Study of Human History). Además, este estudio forma parte del proyecto PID2021-122355NB-C33, titulado "El Pleistoceno y Holoceno de la Sierra de Atapuerca: Paleobiología de homínidos y patrones de asentamiento en Europa, cerebro y cognición, y marco geológico y geocronológico", financiado por el MCIN (Ministerio de Ciencia e Innovación) / AEI (Agencia Estatal de Investigación) / 0.13039/501100011033/FEDER (Fondo Europeo de Desarrollo Regional), UE. Adicionalmente, desde octubre de 2023, ha recibido apoyo de la “Ayuda a la Investigación Fundación REALE FOUNDATION”, dentro del Programa de Ayuda a la Investigación de la Fundación Atapuerca, destinada a la formación de jóvenes investigadores del Equipo de Investigación de Atapuerca (EIA) que aseguran la continuidad del Proyecto Atapuerca.Doctorado en Evolución Humana, Paleoecología del Cuaternario y Técnicas Geofísicas Aplicadas a la Investigación (Interuniversitario
La coordinación entre el Registro de la Propiedad y el Catastro Inmobiliario. La inscripción de la descripción georreferenciada de la finca en el Registro y su concordancia catastral
No full textSe analiza la coordinación entre el Registro de la Propiedad y el
Catastro Inmobiliario dentro del Ordenamiento Jurídico Español, teniendo en cuenta
la última gran reforma de la Ley Hipotecaria y la Ley del Catastro Inmobiliario, que
tiene como principal objetivo la coordinación entre ambas instituciones, y que ha sido
llevada a cabo mediante la Ley 13/2015, de 24 de junio.
Son analizadas las discordancias existentes entre ambas instituciones a la hora
de regular la información referente a la descripción de la finca, que es el elemento
común que las une, así como los métodos utilizados para rectificar esta discordancia,
con los cuales se puede llegar a una coordinación plena entre ambas instituciones,
haciendo especial referencia a la georreferenciación gráfica de la descripción de la
finca, como elemento esencial para llegar a la citada coordinación.
En el análisis de la reforma legal operada en dos mil quince, se destaca el gran
avance que ha supuesto la misma en la cooperación y coordinación entre ambas
instituciones, y a su vez, la potenciación de una mayor concordancia entre el Registro
de la Propiedad y la realidad física y jurídica extrarregistral, todo ello sin llegar aún a
una coordinación plena entre ambos organismos, siendo este el fin último al que tiene
que aspirar el legislador a la hora de regular esta materia.This doctoral thesis analyzes the coordination between the Property
Registry and the Real Estate Cadastre within the Spanish Legal System, taking into
account the last major reform of the Mortgage Law and the Real Estate Cadastre
Law, which has as its main objective coordination between both institutions, and
which has been carried out by Law 13/2015, of June 24.
The existing discrepancies between both institutions are analyzed when it comes
to regulating the information regarding the description of the property, which is the
common element that unites them, as well as the methods used to rectify this
discrepancy, with which a conclusion can be reached full coordination between both
institutions, making special reference to the graphic georeferencing of the description
of the property, as an essential element to reach said coordination.
In the analysis of the aforementioned legal reform, the great advance that it has
represented in the cooperation and coordination between both institutions is
highlighted, and in turn, the promotion of greater agreement between the Property
Registry and the physical and legal reality outside the registry, all without yet
reaching full coordination between both organizations, this being the ultimate goal
that the legislator must aspire to when regulating this matter.Doctorado en Ciencias Jurídicas, Económicas y Sociale
Dataset of multi-field functional electrical stimulation with Fesia Grasp for hand rehabilitation in Multiple Sclerosis: randomized controlled trial outcomes
No full textThis dataset contains anonymized data from a randomized controlled trial investigating the use of multi-field functional electrical stimulation (FES) with the Fesia Grasp device for hand rehabilitation in patients with Multiple Sclerosis (MS). The dataset includes baseline and post-intervention measures of hand strength, fine motor control, and activities of daily living. Data were collected during the rehabilitation program and analyzed to assess the effectiveness of the intervention.The APC was funded by Colegio Profesional de Terapeutas Ocupacionales de Castilla y León (COPTOCYL)
Statistical inference in games: Stability of pure equilibria
No full textWe consider sampling best response decision protocols with statistical inference in population games. Under these protocols, a revising agent observes the actions of k randomly sampled players in a population, estimates from the sample a probability distribution for the state of the population (using some inference method), and chooses a best response to the estimated distribution. We formulate deterministic approximation dynamics for these protocols. If the inference method is unbiased, strict Nash equilibria are rest points, but they may not be stable. We present tests for stability of pure equilibria under these dynamics. Focusing on maximum-likelihood estimation, we can define an index that measures the strength of each strict Nash equilibrium. In tacit coordination or weakest-link games, the stability of equilibria under sampling best response dynamics is consistent with experimental evidence, capturing the effect of strategic uncertainty and its sensitivity to the number of players and to the cost/benefit ratio.Financial support from the Spanish State Research Agency (PID2024-159461NB-I00/MICIU and PID2020-118906GBI00/MCIN, AEI/10.13039/501100011033/EU-FEDER), from the Regional Government of Castilla y León and the EU-FEDER program (CLU-2019-04 - BIOECOUVA Unit of Excellence Universidad de Valladolid), and from the Spanish Ministry of Universities (PRX22/00064 and PRX22/00065
Diseño mecánico del enhebrado del Producto 5 desde Cassette
No full textEste trabajo se integra en un proyecto global destinado a automatizar el aprovisionamiento de distintos productos en las máquinas de confección de neumáticos en la fábrica de Michelin de Aranda de Duero. En la actualidad, este procedimiento se realiza manualmente, implicando la colaboración de varios operarios o el uso de útiles de manutención, por lo que el objetivo principal de este estudio es implementar una solución que permita la automatización completa del suministro del producto a la máquina.
El proyecto se enfocará en el desarrollo mecánico de un sistema diseñado para facilitar la inserción del carro transportador de la bobina en la línea de confección, así como la soldadura entre el producto finalizado y el nuevo producto que se introduce.This work is part of a global project aimed at automating the supply of various products in the tire manufacturing machines at the Michelin plant in Aranda de Duero. Currently, this procedure is carried out manually, involving the collaboration of several operators or the use of handling equipment. Therefore, the main objective of this study is to implement a solution that allows for the complete automation of product supply to the machine.
The project will focus on the mechanical development of a system designed to facilitate the insertion of the transport cart for the coil into the fabrication line, as well as the welding between the finished product and the new product being introduced
A critical analysis of the curriculum development process for physical education in primary education in Spain: challenges, achievements and future proposals
No full textThis article offers a critical analysis of the curricular development of the physical education
(PE) area in primary education in the Balearic Islands. It examines the achievements and
challenges encountered during the adaptation of the national framework to regional needs,
emphasising teacher involvement, contextualisation, and the integration of local culture. It also
highlights the effects of political instability, tight deadlines, and the lack of coordination across
different educational levels. Finally, it proposes strategies for future curricular reforms aimed at
enhancing coherence, equity, quality, and educational innovation
Screening opportunities for high abilities through overexcitabilities, executive functions, perfectionism, and leadership
No full textThere is a lack of identification in high abilities, usually due to the lack of economic and temporal resources. One of the possibilities for addressing this issue is the creation of screening methods. This study explores the possibilities of a gender-neutral screening tool based on leadership, executive functions, overexcitability, and perfectionism. Using a quantitative methodology, the study examined differences among male and female highly able students and their non-identified peers. Results revealed no statistically significant differences across the groups, suggesting no difference in those abilities and limited screening possibilities. Logistic regression further indicated that the used tools lacked predictive power for identifying high abilities. These findings highlight the need for refined screening methods that address resource limitations, gender biases, and systemic barriers. Future research should focus on developing effective tools to identify highly able students and ensure equitable access to tailored educational support
The Dispositions for Culturally Responsive Pedagogy Scale (DCRPS): psychometric validation and results among Spanish teachers
No full textLas aulas educativas son un fiel reflejo de las sociedades cada vez más diversas y desiguales, es por ello que el profesorado precisa de una determinada disposición docente hacia sus estudiantes y su enseñanza que garantice una mayor justicia social. Este artículo describe una investigación instrumental centrada en la adaptación y validación en población española de la Disposition for Culturally Responsive Pedagogy Scale (Whitaker & Valtierra, 2018). El objetivo principal es analizar las características psicométricas de esta escala, que evalúa la disposición docente hacia la Educación Culturalmente Receptiva (ECR). No se conocen o no hemos hallado instrumentos específicos en castellano que analicen la disposición docente hacia esta pedagogía. Se ha utilizado una metodología de corte cuantitativo por medio de un método de encuestas administradas a profesores de diferentes niveles educativos y regiones de España (N = 538). El análisis factorial confirmatorio reveló un ajuste óptimo para una estructura de tres factores: praxis educativa, comunidad y justicia social, tras eliminar dos ítems originales. Los resultados del análisis de fiabilidad indican una consistencia interna adecuada, con índices de Alfa de Cronbach (α = .942) y Omega de McDonald (ω = .943) satisfactorios. Además, se encontraron diferencias estadísticamente significativas respecto a las disposiciones hacia la ECR según el sexo, nivel educativo y especialidad del profesorado, lo que sugiere la relevancia de considerar estas variables al evaluar la disposición docente hacia la ECR en diferentes contextos educativos. En conclusión, el estudio proporciona una primera herramienta válida y fiable para conocer la disposición del profesorado hacia la ECR, contribuyendo así a la mejora de una educación más inclusiva y equitativa.Educational classrooms are a true reflection of increasingly diverse and unequal societies; therefore, teachers require a specific pedagogical disposition towards their students and teaching that ensures greater social justice. This article describes an instrumental study focused on adapting and validating the Disposition for Culturally Responsive Pedagogy Scale (Whitaker and Valtierra, 2018) in the Spanish population. The main goal is to analyze the psychometric characteristics of this scale, which evaluates the disposition towards Culturally Responsive Education (CRE). There are no known or we have not found any specific instruments in Spanish that analyze teachers’ disposition towards this pedagogy. A quantitative methodology using surveys was administered to teachers at various educational levels and regions in Spain (N = 538). Confirmatory factor analysis revealed an optimal fit for a three-factor structure: educational praxis, community, and social justice, after removing two original items. Reliability analysis showed adequate internal consistency, with Cronbach’s Alpha (α = .942) and McDonald’s Omega (ω = .943). Significant differences in dispositions towards CRE were found based on sex, educational level, and specialty, suggesting the importance of considering these variables when evaluating dispositions towards CRE in different educational contexts. In conclusion, the study provides a first valid and reliable tool to assess teachers’ dispositions towards CRE, contributing to more inclusive and equitable education