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Low‐cost technologies in a rich ecological context: Hotel California open‐air site at Sierra de Atapuerca, Burgos, Spain
Get PDFHotel California is part of a network of open-air Neanderthal sites located in the Sierra de Atapuerca (Burgos, Spain). In this study, we examine the technology of the lithic assemblages recovered from this site's archaeological levels 3 to 7, which are characterised by the use of local raw materials, non-hierarchical centripetal exploitation systems, systematic production of flakes and few retouched items. This type of expedient technology is repeated throughout the entire sequence, which spans Marine Isotope Stages (MIS) 3 to 4. Through a comparison with the technocomplexes and occupation histories of surrounding sites – including a re-evaluation of the published chronology for the nearby site of Fuente Mudarra, which is now dated exclusively to MIS 5 – we examine whether the detected pattern is applicable to the rest of the Atapuerca Mousterian record and if this expedient behaviour has equivalents in other sites in the region. Our findings show that the lithic procurement, exploitation and configuration strategies employed at the Sierra de Atapuerca open-air sites were constant over broad time periods spanning MIS 5 to 3, in contrast to the technological sequences observed at other nearby sites on the Northern Iberian Plateau. The recurrent settlement of these open-air Neanderthal sites over tens of thousands of years and the consistent use of expedient technologies during different occupation periods is likely attributable to the rich ecological context of the Sierra de Atapuerca environs.This work was funded by the Spanish Ministry projects CGL2012-38434-C03-02, CGL2015-65387-C3-3-P and PGC2018-093925-B-C31. The field excavation work was funded by the Junta de Castilla y León and Fundación Atapuerca. Marta Santamaría has a predoctoral fellowship from the University of Burgos. Martina Demuro is supported by Australian Research Council Future Fellowship grant FT200100816. The excavation team has made this research possible. We would like to give special thanks to Hector de la Fuente and Pedro Alonso, colleagues of the Prehistory Laboratory of the UBU, for their constant support
El arte al servicio de la fiesta. La Casa de Misericordia y el cartel de la Feria del Toro (1959-2022)
No full textReseña del libro "El arte al servicio de la fiesta. La Casa de Misericordia y el cartel de la Feria del Toro (1959-2022)" de José Javier Aranza Lópe
Small molecule anion carriers facilitate lactate transport in model liposomes and cells
No full textAn excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of
anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate
carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier,
was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that 1 is
an active lactate transporter in living cells, confirming the results obtained in phospholipid vesicles. Moreover, an additive effect of compound 1 with cisplatin was observed in HeLa cells. Identification of active
lactate anionophores working in living cells opens up ways to exploit this class of compounds as molecular
tools and drugs addressing dysregulated lactate metabolism.This research has been financially supported by Consejería de Educación de la Junta de Castilla y León (project BU067P20) and Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00). D.A.-C., I.C.-B. and P.F. thank Consejería de Educación de la Junta de Castilla y León, European Regional Development Fund (ERDF) and European Social Fund (ESF) for their pre-doctoral (D.A.-C.) and post-doctoral (I.C.-B. and P.F.) contracts. A.A.-B. thanks to PFCHA/Becas Chile (Folio#72200156). The authors gratefully acknowledge Andrea Sancho-Medina for her contributions to transmembrane anion transport experiments
Finding the place of content and language integrated learning in physical education within the models-based practice framework
No full textAlthough the educational intentions of content and language integrated learning (CLIL) seem to be perspicuous, how to put them into practice in different subjects is not so clear-cut. In addition, critical voices within the physical education (PE) arena claim that CLIL may jeopardise the subject. Therefore, CLIL needs to be adjusted in order to remain on the PE agenda. Currently, PE specialists embrace the models-based practice framework, which may involve new educational objectives (e.g. language learning). This paper seeks to fill this gap by advocating CLIL as a pedagogical model within the models-based practice framework. In this sense, CLIL may benefit from the advantages of a well-established approach in PE, bridging the gap between the general theory of CLIL and the practice of PE. The article follows the structure of previous advocacies for pedagogical models in PE and presents criteria, theoretical tenets, teaching and learning implications, a specific teacher profile, essential elements and guiding principles of the CLIL in PE model, as well as research evidence and field-testing experiences. In conclusion, such a framework depicts the interdependence of learning, teaching, subject content, language and context, presenting a work that could become a turning point for PE specialists to see CLIL in a new light.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Generalitat Valenciana, Conselleria d’Innovació, Universitats, Ciència i Societat Digital (grant number CIGE/2021/019)
Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group
No full textIntroduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; = 0.012), being male (OR = 2.333; < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.COPPADIS and the present study were developed with the help of Fundacion Española de Ayuda a la Investigaci ´ on en ´ Enfermedades Neurodegenerativas y/o de Origen Genetico ´ (https://fundaciondegen.org/) and Alpha Bioresearch (https://www.alphabioresearch.com). Also, Te authors received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesion de subvenciones de Proyectos de Investigaci ´ on´ en Salud de la convocatoria 2020 de la Accion Estrat ´ egica en ´ Salud 2017–2020 por el proyecto “PROGRESION NO ´ MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project
Impact of new technologies on neurology in Spain. Review by the New Technologies Ad-Hoc Committee of the Spanish Society of Neurology
No full textIntroducción: Las nuevas tecnologías (NT) están cada vez más presentes en el ámbito biomédico. Utilizando la definición de consenso de NT del Comité Ad-Hoc de Nuevas Tecnologías de la Sociedad Española de Neurología (SEN), se evalúa su impacto en la neurología española a través de las comunicaciones de las reuniones anuales de la SEN.
Material y métodos: Se define el concepto de NT en neurología como una tecnología novedosa o aplicación de una tecnología anterior, caracterizada por un cierto grado de coherencia persistente en el tiempo, con potencial de tener impacto en el presente y futuro de la neurología. Se plantea un estudio descriptivo tomando como fuente las comunicaciones de las reuniones de la SEN desde 2012 hasta 2018 y analizando los tipos de NT empleadas, la subespecialidad, así como su distribución territorial.
Resultados: De las 8.139 comunicaciones presentadas, 299 estaban relacionadas con NT (3,7%), incluyendo 120 pósteres y 179 comunicaciones orales, variando desde el 1,6% en 2012 hasta el 6,8% en 2018. Los tipos de tecnología mayormente representados fueron neuroimagen avanzada (24,7%), biosensores (17,1%), electrofisiología y neuroestimulación (14,7%) y telemedicina (13,7%). Las áreas neurológicas con mayor empleo de NT fueron trastornos del movimiento (18,4%), enfermedades cerebrovasculares (15,7%) y demencias (13,4%). Madrid fue la comunidad que presentó más comunicaciones (32,8%), seguida por Cataluña (26,8%) y Andalucía (9,0%).
Conclusiones: Las comunicaciones sobre NT siguen una tendencia creciente. El número de NT empleadas ha ido aumentando de manera paralela a la disponibilidad tecnológica. Se encontraron comunicaciones en todas las subespecialidades neurológicas, con una distribución geográfica heterogénea.Introduction: New technologies (NT) are increasingly widespread in biomedicine. Using the
consensus definition of NT established by the New Technologies Ad-Hoc Committee of the Spanish Society of Neurology (SEN), we evaluated the impact of these technologies on Spanish
neurology, based on communications presented at Annual Meetings of the SEN.
Material and methods: We defined the concept of NT in neurology as a novel technology or
novel application of an existing technology, characterised by a certain degree of coherence
persisting over time, with the potential to have an impact on the present and/or future of
neurology. We conducted a descriptive study of scientific communications presented at the
SEN’s annual meetings from 2012 to 2018, analysing the type of NT, the field of neurology, and
the geographical provenance of the studies.
Results: We identified 299 communications related with NT from a total of 8,139 (3.7%), including 120 posters and 179 oral communications, ranging from 1.6% of all communications in
2012 to 6.8% in 2018. The technologies most commonly addressed were advanced neuroimaging
(24.7%), biosensors (17.1%), electrophysiology and neurostimulation (14.7%), and telemedicine
(13.7%). The neurological fields where NT were most widely employed were movement disorders (18.4%), cerebrovascular diseases (15.7%), and dementia (13.4%). Madrid was the region
presenting the highest number of communications related to NT (32.8%), followed by Catalonia
(26.8%) and Andalusia (9.0%).
Conclusions: The number of communications addressing NT follows an upward trend. The
number of NT used in neurology has increased in parallel with their availability. We found
scientific communications in all neurological subspecialties, with a heterogeneous geographical
distribution
El deudor comunitario en el régimen de la propiedad horizontal
No full textLa deuda en las comunidades de propietarios constituye un problema de cara al mantenimiento de éstas., así como un problema de convivencia. Se distingue entre el deudor contumaz e insolidario, de aquel que lo es de forma sobrevenida y fortuita. Es relevante la distinción de trato legislativo entre el deudor comunitario y el hipotecario en contextos de crisis. Se realiza un análisis de la obligación de contribuir al adecuado sostenimiento del inmueble, la formación del título de la misma, sujeto activo y pasivo de la obligación, las garantías de cobro, medidas disuasorias frente a la morosidad, consecuencias del incumplimiento y la reclamación judicial de la deuda. Todo ello, teniendo en cuenta los antecedentes históricos y su regulación en derecho comparado, tanto desde la óptica del derecho extranjero como del interno. Se concluye con la formulación de propuestas de reforma legislativa con el fin de mejorar la regulación legal actual
Evaluación de fortalezas y puntos débiles en procedimientos diagnósticos en neurofisiología: epilepsia, mielopatía cervicoartrósica y síndrome del túnel carpiano en el Hospital Universitario de Burgos. Propuestas de mejora
No full textIntroducción: En la asistencia sanitaria se llevan a cabo procesos diagnósticos y terapéuticos repetitivos en grupos consecutivos de pacientes sin que existan a menudo protocolos, o los que existen no son eficientes por no estar avalados por la evidencia científica. La deficiencia de los mencionados protocolos conlleva la derivación errática de los pacientes, la realización de pruebas complementarias innecesarias y la gestión poco eficiente en el empleo de recursos en patologías muy prevalentes o que requieren pruebas diagnósticas cuya realización consume mucho tiempo. Objetivos: Evaluar nuestra propia práctica clínica centrada en el Servicio de Neurofisiología Clínica del Hospital Universitario de Burgos (HUBU) incidiendo en la detección de los "puntos débiles" en una serie de procesos diagnósticos, utilizando como ejemplo patologías cuyo diagnóstico requiere técnicas neurofisiológicas tales como la vídeo electroencefalografía (V-EEG), la neurografía (ENG) y la estimulación magnética transcraneal (EMTC) y potenciales evocados somatosensoriales (PESS). Interés y aplicabilidad: La evaluación y reevaluación periódica de la práctica clínica permite mantener aquellas prácticas que demuestran ser eficientes y eliminar aquellas que no son útiles y cuya realización se lleva a cabo por inercia en la práctica clínica. La identificación de puntos débiles permite crear estrategias de corrección y la aplicación de estas modificaciones en la población venidera de pacientes del propio servicio, repercutiendo en un incremento de la calidad asistencial, en el ahorro de tiempo y recursos que se manifestarán, presumiblemente, en mejora de tiempos asistenciales. Campos de aplicación: Se seleccionan una serie de patologías en las cuales se llevan a cabo procedimientos diagnósticos que serán costosos, bien por la necesidad de tiempos prolongados para su realización, bien por la frecuencia con la que se llevan a cabo al ser requeridos en patologías muy prevalentes. Elegimos, como paradigma de patologías del primer grupo, la monitorización V-EEG de larga duración en pacientes con epilepsias farmacorresistentes y la realización de EMTC y PESS en pacientes con mielopatías compresivas secundarias a cervicoartrosis con indicación quirúrgica. Como ejemplo del segundo grupo seleccionamos la realización de ENG a pacientes con sospecha de síndrome del túnel carpiano.Introduction: In health care, repetitive diagnostic and therapeutic processes are carried out in consecutive groups of patients for whom, often, there are no protocols or those that do exist are not efficient because they are not based on any type of scientific evidence. The lack of protocols leads to erratic referral of patients, unnecessary complementary tests and inefficient management in the use of resources, either in highly prevalent pathologies or other that require time consuming tests for their evaluation. Goals: To evaluate our own clinical practice on the Neurophysiology Department of the University Hospital of Burgos, focusing on the detection of "weak points" in a series of diagnostic processes, using as examples pathologies whose diagnosis requires neurophysiological techniques such as such as video electroencephalography (V-EEG), neurography (ENG) and transcranial magnetic stimulation (TCMS) and somatosensory evoked potentials (SSEP). Interest and applicability: The periodic evaluation and reevaluation of clinical practice leads to maintain proven efficient practices and eliminate those that are not useful and whose performance is carried out by inertia in clinical practice. The identification of weak points allows correction strategies for these and their application in the coming population of patients from the Service itself, resulting in an increase in the quality of care, in saving time, and resources that will lead to reduction of care times. Fields of application: A series of pathologies are selected in which diagnostic procedures are carried out that will be costly, either because of the need for long periods of time for their performance, or because of the frequency with which they are carried out as they are required in very prevalent pathologies. We chose as a paradigm of pathologies in the first group, long-term V-EEG monitoring in patients with drug-resistant epilepsies and the performance of TCMS and SSEP in patients with compressive myelopathies secondary to cervicoarthrosis with surgical indication. As an example of the second group, we selected ENG in patients with carpal tunnel syndrome