Complejo Hospitalario Universitario de Santiago

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    Skyrme Neutron Stars

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    The present thesis aims to develop a realistic description of highly dense nuclear matter and neutron stars within the Skyrme model. For this purpose, the properties of neutron stars and the problem of ultra-dense nuclear matter are introduced. The main features of the Skyrme model and the previous attempts to reproduce neutron stars are reviewed to introduce a physically motivated generalization of the model that yields remarkable results for the neutron stars observables. We establish the basis for a consistent description of infinite nuclear matter at each range of densities and perform the standard quantization procedure to account for the isospinasymmetric effects. Finally, we consider the kaon condensation in the neutron star cores, and we include ρ mesons as a viable solution to the compression modulus problem

    Cuestionario Proust

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    Inclúe un retrato múltiple de Carmen Blanco pintado e un retrato gravado por Sara Lama

    Presence of gastrointestinal and bronchopulmonary parasites in Cantabrian brown bears

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    The Cantabrian brown bear (Ursus arctos) population is threatened although in a constant process of recovery during the last 20 years. Since data on the parasitological status of this bear is still limited, the objective of the present study was to assess the diversity and prevalence of parasites in this population. Thus, 111 bear faecal samples were collected in north-western Spain and analysed for estimating the occurrence of gastrointestinal and bronchopulmonary parasites. Samples were processed by flotation in saline and sucrose solution, sedimentation and Baermann-Wetzel techniques. In addition, a commercial immunofluorescent assay was performed for detecting Giardia duodenalis and Cryptosporidium spp. Dicrocoelium dendriticum was the most prevalent parasite (58.6%), followed by Baylisascaris transfuga (43.2%) and nematodes of the Suborder Strongylida (18.9%) and Spirurida (2.7%). Mixed infections were detected in the 41.4% of the samples. The presence of D. dendriticum was significantly highest in bears from the autonomous region of Castile and León as well as in those in which grass or nuts/acorns were the predominant food item. Moreover, the risk of being positive to B. transfuga was significantly higher during autumn–winter, and in those, faecal samples were mainly composed of fleshy fruit. Some of the parasites detected could infect other wildlife and even humans, and therefore, the risk of pathogen transmission deserves further investigation. Since the impact of endoparasites in the health status of bears is poorly understood, the establishment of a disease surveillance protocol is strongly recommended in order to assess the potential risk of these infections for bearsOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study has received funding from the Ministry of Ecological Transition and Demographic Challenge of Spain. It was also funded by the Program for consolidating and structuring competitive research groups (ED431C2023/16, Xunta de Galicia, Spain). J.V. López-Bao was additionally supported by the Spanish Ministry of Economy, Industry, and Competitiveness (CGL2017-87528-R AEI/FEDER EU) and a GRUPIN grant IDI/2021/000075 (Asturias Government)S

    Cuidado e inclusión social. Análisis de las necesidades formativas y propuestas de mejora en los estudios de Grado de Enfermería de Galicia

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    Esta tesis doctoral se sitúa en el ámbito de la educación universitaria y aspira a contribuir a la innovación de la propuesta formativa en los estudios iniciales de Enfermería de Galicia desde la perspectiva de la inclusión social. Se desarrolló una investigación documental en dos etapas, que consistió en una revisión crítica de la literatura especializada y un análisis conceptual que derivó en un libro de categorías utilizado para el análisis de contenido de 250 guías docentes. Se identificó que el enfoque de “cuidado inclusivo” planteado es minoritario, especialmente en términos de accesibilidad y sostenibilidad. Se propone un currículum para el Grado en Enfermería más amplio, que combine las habilidades clínicas con la comprensión ética y sociopolítica del cuidado

    Assessing The Adoption of EHealth Technology in The Jordan Healthcare System: An Extension of The UTAUT Model

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    The healthcare industry has been impacted by technological advancements, leading to the emergence of eHealth. However, patients are hesitant to embrace medical treatments through eHealth applications, which has caused a delay in the worldwide adoption of such applications. This empirical study aims to develop and validate an eHealth adoption model that focuses on patients' viewpoints and enables quantitative survey research. The study identifies strategies to enhance adoption, including addressing privacy concerns, empowering patients, promoting social support, ensuring eHealth justice, and upholding ethical standards. Overall, this study contributes valuable insights into eHealth adoption, paving the way for more effective healthcare technologies

    Towards stronger tobacco control policies to curb the smoking epidemic in Spain

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    Smoking and exposure to secondhand smoke pose a significant risk to the health of populations. Although this evidence is not new, the commitment of countries to implement laws aimed at controlling consumption and eliminating exposure to secondhand smoke is uneven. Thus, in North America or in Europe, locations like California or Ireland, are pioneers in establishing policies aimed at protecting the population against smoking and secondhand smoke. Identifying measures that have worked would help control this important Public Health problem in other countries that are further behind in tobacco control policies. In Spain, there has been almost 15 years of little political action in legislation oriented to control the tobacco epidemic. If we want to achieve the tobacco endgame, new legislative measures must be implemented. In this paper, we have elucidated tobacco control policies that could be implemented and show how different countries have done soOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study has been funded by the Instituto de Salud Carlos III (ISCIII) through project “PI22/00727” and co-financed by the European UnionS

    Intrastromal Corneal Ring Segment in Moderate to Severe Keratoconus: Refractive, Topographic and Aberrometric Changes

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    Aim: This study evaluates the topographic and aberrometric changes induced by ICRS in patients with moderate and severe keratoconus and analyzes pre-operative factors affecting the refractive and visual outcomes. Methods: This retrospective, observational, nonrandomized, and single-center case series, included 21 keratoconic eyes of 21 patients implanted with Keraring ICRS (Mediphacos, Belo Horizonte, Brazil), using the manual tunnelization technique and vacuum device. All subjects were examined after 6 months following surgery, including the measurement of uncorrected visual acuity (UCVA), best-Corrected Distance Visual Acuity (CDVA), refractive data, pachymetry, corneal topography, and aberrometry. Results: The mean age of 21 patients was 31.14±10.65 years, eleven (52%) were male. Kerarings were successfully implanted in all eyes. After 6-month from implantation, significant increase was found in mean UCVA (P<0.01) and CDVA (P<0.01). There was a statistically significant reduction in refractive cylinder (P<0.01), corneal cylinder (P=0.020), Kmax (P<0.01) and BFS (P=0.02). Statistically significant differences were found in several aberrometric parameters for 6-mm pupil, RMS HOA (P=0.045), oblique astigmatism (P=0.009), vertical coma (P=0.02), and oblique trefoil (P=0.018). Conclusion: Analysis of the visual outcomes after Keraring ICRS implantation showed a significant postoperative corneal flattening with a subsequent increase in UCVA and CDVA. Visual, refractive, topographic and aberrometric parameters remarkably change in the 6-month period after Kerarings implantation. Kerarings in this sample have shown to provide a mild visual rehabilitation between 2 and 3 lines, particularly in more advanced cases. Furthermore, flattening of the anterior segment induced by the surgery might be beneficial for contact lens fitting.S

    Música e identidade galega. Do baile da gaita á muiñeira (S. XVII-XIX)

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    A muiñeira está recoñecida como unha das pezas musicais que mellor representa á música galega, como símbolo identitario de Galicia. Mais este recoñecemento non é froito dunha evolución natural e desinteresada, senón dun longo proceso que ten a súa orixe no século XVII, no baile da gaita galega, e que se consolida definitivamente no século XIX. Esta evolución fundaméntase na transformación do ideario colectivo, que pasa dunha percepción negativa do galego, consecuencia dunha visión centralista creada desde Castela e difundida a través do teatro e os vilancicos por toda a Península Ibérica, á xeración, a finais do século XVIII e principios do XIX, dunha imaxe positiva desenvolvida de forma interna –na propia Galicia– como inversión da heterodesignación proxectada desde o exterior, e na que a música xogará un papel fundamental. Neste sentido, o asentamento das ideas románticas e a influenza do pensamento galeguista nas súas diferentes etapas derivarán nun interese polos elementos folclóricos que representan as tradicións e costumes e potenciarán a busca e selección dos compoñentes culturais que sirvan de símbolos representativos de Galicia. Partindo destes principios, o presente traballo pretende indagar na historia da muiñeira, e do seu antecedente a gaita galega, para estudar e identificar cales son os feitos e as persoas que contribuíron en maior medida ao seu desenvolvemento. A investigación realizada baséase nun amplo traballo de arquivo no que se levou a cabo un baleirado de fontes documentais do período que recolle o presente estudo, que vai desde o século XVII ata o século XIX, pois, coa chegada do século XX o proceso xa estaba perfectamente consolidado, fixándose o canon da música galega na tríade formada por alalá, muiñeira e alborada. Aínda que se achega información sobre o proceso xeral de conformación da música popular galega, o obxectivo central é a muiñeira e as numerosas variantes da mesma en Galicia. Como resultado da investigación obsérvase que a narrativa creada polas historias de Galicia publicadas a partir dos anos trinta do século XIX foi determinante para xerar un discurso de base etnicitaria –marcado fundamentalmente polas ideas celtistas do momento– que puxo á música no centro dos elementos patrimoniais considerados propios da cultura popular. Esta tese preséntase, polo tanto, como unha achega ao estudo do papel da música no seo do proceso cultural coñecido como Rexurdimento

    Estimating illegal catches in data-poor S-fisheries: Insights from multispecies shellfish poaching in galician small scale fisheries

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    The opaque nature of illegal, unreported, and unregulated (IUU) fishing means that the data on catches are scarce or unreliable, making it difficult to estimate the volume of illegal fishing and the number of individuals who practice it. In this work, we develop the use of quantification methods for IUU fishing in data-poor fisheries and provide estimates for the main shellfish species exploited in S-fisheries in Galicia (NW Spain). To make the estimates, we use a model whose primary input is the Confiscations per unit of policing effort (CPUPE) index, which relates the sanctions imposed for poaching, estimated poaching, and confiscations carried out by the Enforcement Forces. The estimates for the period 2012–2020 are 660.2 t of illegal catches of different species and an average number of 1,766.2 poachers/year. These estimates provide evidence that makes it possible to analyse tendencies in illegal fishing, to establish assessment baselines and to highlight potential improvements in the fight against IUU fishing in small-scale fisheriesS

    New strategies for the prevention and treatment of complications associated with diabetes mellitus

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    Diabetes mellitus has emerged as one of the most prevalent chronic diseases of the 21st century with serious complications worsening its progression. This doctoral thesis is divided into four chapters focused on improving the treatment of complications associated with diabetes mellitus. In the first chapter, the subcutaneous administration of biopharmaceuticals is adressed as an effective and patientpreferred alternative to intravenous infusions. In the second chapter, supercritical foaming technology was utilised to manufacture PLGA implants loaded with dexamethasone and bevacizumab. The third chapter develops a drug delivery system to enhance the penetration of antifungal drugs into nails with onychomycosis. The fourth chapter develops an inert coating for in vitro testing with 3D printed devices.2025-03-0

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