Complejo Hospitalario Universitario de Santiago
Repositorio Institucional da Universidade de Santiago de CompostelaNot a member yet
32415 research outputs found
Sort by
Análise xenética-poboacional da variabilidade na gravidade da COVID-19
Get PDFA enfermidade da COVID-19 mostra unha gran variabilidade fenotípica entre os
individuos, podendo manifestarse na forma asintomática ou progresar ata un estado crítico.
Algúns dos factores de risco máis relevantes son o sexo, a idade e a presencia de antecedentes
clínicos. Non obstante, parte desta variación tamén pode atribuírse á base xenética dos
hóspedes, influíndo tanto na susceptibilidade á infección como na resposta do sistema inmune.
Ademais, a arquitectura xenética da enfermidade podería ser variable entre as poboacións. Os
obxectivos desta tese foron abordar esas cuestións. No marco do proxecto SCOURGE,
establecido en 2020, recolléronse datos clínicos e xenéticos de máis de 10.000 pacientes de
España e Latino-América. Por unha banda, buscouse investigar e identificar os determinantes
xenéticos que actúan na predisposición á COVID-19 grave a través de estudos de asociación de
xenoma completo (GWAS) en ambas as poboacións. Ademais de confirmar a asociación de
xenes xa coñecidos, identificáronse asociacións novas en xenes como AQP3, UPK1A, DDIAS
ou BAZ2B. Posteriormente, construíronse índices de risco polixénico (PRS) e avaliouse a súa
capacidade para predicir a hospitalización por COVID-19, prestando especial atención á
xeneralización a poboacións non europeas e a unha potencial aplicación clínica
Detection of Frank's sign in the dental setting: A population‐based cohort study
Get PDFBackground: In 1973, Saunders T. Frank described the diagonal earlobe crease (DELC) as a potential marker of cardiovascular disease. However, this anatomical finding is not routinely examined. The aim of this study was to assess the presence of this crease in the general population attending a dental setting and describe its anatomical variations to be able to categorize it as a physical sign.
Methodology: A study group of 1050 white adults were selected, as participants in the framework of the "A Estrada Study of Glycation and Inflammation" (AEGIS), a cross-sectional, population-based descriptive study of a representative sample of the general adult population of the municipality of A Estrada (Pontevedra, Spain). Each participant's age, sex, and preferred head position when sleeping were recorded. Both earlobes were visually inspected and the anatomical variables of the crease were recorded (unilateral or bilateral, length, depth, and presence of secondary creases). The relationship between the study variables was analyzed using the chi-squared test, Student's t-test, the analysis of variance (ANOVA), and the nonparametric tests of Mann-Whitney and Kruskal-Wallis.
Results: The DELC was observed in 65.2% of the participants. In 71.5% of the cases, the sign was complete (occupying the space from the tragus to the posterior edge of the earlobe); in 56.9% of the cases, the sign was bilateral; in 45.1% of the cases it was deep; and in the 43.6% of the cases, accessory creases were identified. Neither sex nor the habitual head position when sleeping were related to the prevalence or characteristics of the DELC. The prevalence, extent and depth of Frank's sign increased significantly with age (p < .001).
Conclusion: The prevalence of the DELC increases significantly with age, and its morphological characteristics are accentuated. This finding, therefore, gains special relevance as a marker of potential cardiovascular disease when observed in young adultsThe A Estrada Glycation and Inflammation Study (AEGIS) group would like to acknowledge the participants’ efforts and thank them for participatingS
Agenda mediática y encuadres en el contexto de la crisis sanitaria del COVID-19 en el Cono Sur de América. Cobertura informativa en prensa y en Twitter en Argentina, Chile y Uruguay (2020-2022)
Get PDFEl surgimiento del brote epidémico del COVID-19 a finales del
2019, su rápida propagación y el aumento de casos a nivel
global propició su reconocimiento por la OMS como una
pandemia que en los últimos años trastocó, distintos espacios.
Uno de ellos, la agenda de los medios de comunicación, dado su
posicionamiento como el tema hegemónico en su cobertura;
mismo que aplica, de forma generalizada, a la agenda de los
jefes de Estado del globo. Este hecho ha tendido grandes
repercusiones políticas, sociales y económicas; por lo que, sin
dejar de lado el potencial rol de los medios en la política, esta
tesis doctoral analiza la articulación (dentro del espacio
informativo) de actores, hechos y audiencias
Antecedents, moderators, and consequences of co-creation: A research in the field of open-source software development
Get PDFService-Dominant Logic (SDL) in marketing challenges conventional definitions of goods
and services by redefining service as the application of specialized competencies and
resources for the benefit of others. It emphasizes that all firms essentially act as service
providers using goods as a means to deliver services. SDL shifts the perspective towards
viewing customers as active participants in the value creation process, rather than mere
recipients of goods and services.
The concept of co-creation takes center stage within the realm of SDL, underlining the
significance of involving customers in the co-design and delivery of personalized services.
This study delves into co-creation, with a specific focus on two pivotal variables: co-creation
participation and co-creation experience.
The first segment investigates the antecedents and moderators of co-creation, including
influential factors such as the sense of community, platform identification, and
innovativeness, which drive active participation. The second part scrutinizes the outcomes of
co-creation, shedding light on the economic and relational benefits, alongside indirect effects
like satisfaction and its impact on future engagement and advocacy.
The study's data collection involved conducting an online survey distributed through
open-source community platforms dedicated to the development of the Linux operating
system, resulting in a commendable response rate of 41.10%.
The research accentuates the advantages of co-creation, encompassing both direct and
indirect benefits. Directly, it creates economic and relational value by fostering participants'
sense of connection and ownership, which in turn generates emotional and economic value,
nurtures trust, and cultivates loyalty. Additionally, it underscores the pivotal role of
satisfaction in shaping perceptions of product quality and influencing future participation.
In addition to these benefits, the study delves into the exploration of three key factors in
co-creation: platform identification, sense of community, and innovativeness. These elements
are identified as precursors to successful co-creation, playing a dual role with both direct and
moderating effects on the co-creation process.
Collectively, the research emphasizes the potent link between co-creation experience and
participation, underscoring how emotional bonds and a sense of accomplishment serve as
motivating factors for sustained involvement. This connection empowers participants,
enabling them to actively shape the development of products and services, potentially leading
to the formation of meaningful relationships and enduring connections with firm
Emotion Recognition Deficits in Children and Adolescents with Psychopathic Traits: A Systematic Review
Get PDFChildren and adolescents with psychopathic traits show deficits in emotion recognition, but there is no consensus as to the extent of their generalizability or about the variables that may be moderating the process. The present Systematic Review brings together the existing scientific corpus on the subject and attempts to answer these questions through an exhaustive review of the existing literature according to PRISMA 2020 statement. Results confirmed the existence of pervasive deficits in emotion recognition and, more specifically, on distress emotions (e.g., fear), a deficit that transcends all modalities of emotion presentation and all emotional stimuli used. Moreover, they supported the key role of attention to relevant areas that provide emotional cues (e.g., eye-region) and point out differences according to the presence of disruptive behavior and based on the psychopathy dimension examined. This evidence could advance the current knowledge on developmental models of psychopathic traits. Yet, homogenization of the conditions of research in this area should be prioritized to be able to draw more robust and generalizable conclusionsOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was supported by the Projects PID2019-107897RB-I00/ funded by MCIN/AEI/https://doi.org/10.13039/501100011033, and TED2021-130824B-C22, funded by MCIN/AEI/https://doi.org/10.13039/501100011033 and the European Union (EU) “NextGenerationEU”/PRTR. B. Díaz-Vázquez’s was supported by a predoctoral contract funded by bank Santander and the University of Santiago de Compostela L. López-Romero’s contribution was supported by the grant RYC2021-032890-I, funded by MCIN/AEI/https://doi.org/10.13039/501100011033 and the EU “NextGenerationEU”/PRTRS
Modelling tourists' decisionmaking from a cross-cultural perspective
No full textDecision-making models are widely used tools developed to
study how agents select their preferred features on conflictive
alternatives. Despite the importance given to individual
preferences in decision-making, cognitive biases, emotions or
psychological influences were not studied in the realm of
economics till the 70s, with rise of behavioural economics.
However, contextual factors like culture from the field of social
psychology were less studied in the area of economics. To
explore the influence of culture on decision-making, we use the
case of tourism, where the primary hypothesis is that culture
affects decision-making. Thus, the aim of the thesis is to merge
the knowledge from decision-making, behavioural economics
and social-psychology in a tourism context to check if culture
affect decision-making, and how.2025-03-1
Influence of haemolysis on blood biochemistry profiles in cattle
Get PDFAlthough haemolysis is the most common source of preanalytical error in clinical laboratories, its influence on cattle biochemistry remains poorly understood. The effect of haemolysis and its clinical relevance were investigated in 70 samples in which haemolysis was artificially induced (by spiking with increasing amounts of haemolysate, yielding 0.0%, 0.2%, 0.5%, 1.0%, 2.5%, 5.0% and 10% haemolysis degree (HD)), focusing on key parameters for bovine metabolic health assessment, including albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), blood urea nitrogen (BUN), calcium (Ca), cholesterol, creatinine, creatine kinase (CK), gamma-glutamyl transferase (GGT), globulins, magnesium (Mg), phosphorus (P), total bilirubin (TBIL) and total proteins (TP). Preanalytical haemolysis significantly affected most (8 of 14) of the biochemical parameters analysed, leading to significant increases in concentrations of albumin (starting at 5% HD), cholesterol (at 5% HD) and P (at 10% HD) and to significant decreases in Ca (at 2.5% HD), creatinine (at 5% HD), globulins (at 10% HD), TBIL (at 2.5% HD) and TP (at 10% HD). Comparison of the present and previous data indicated that, for each parameter, the HD required to produce significant bias and the clinical relevance of over- and underestimation are variable and appear to depend on the analytical technique used. Therefore, different laboratories should evaluate the influence of haemolysis in their analytical results and provide advice to clinicians accordingly. Affected parameters should be interpreted together with clinical signs and other analytical data to minimize misinterpretations (false or masked variations). Finally, due to the significant impact on numerous parameters and the limited potential for correction, we recommend rejection of samples with >10% HDThis work was supported by laboratory RAL S.A. Belén Larrán is in receipt of a FPU fellowship (Ref. FPU21/01742) from the Spanish Ministry of Education, Culture and Sports. Belén Larrán, Marta Miranda, Marta López-Alonso and Inmaculada Orjales belong to Grupo de Potencial Crecimiento financed by GAIN (Axencia Galega de Innovación; grant number ED431B 2023/008)S
Estudio de la actividad termogénica del tejido adiposo pardo en población con fenilcetonuria y controles sanos
Get PDFEn la presente tesis doctoral hemos estudiado la actividad del
tejido adiposo en pacientes con fenilcetonuria,
hiperfenilalaninemia moderada y controles sanos mediante
videotermografía infrarroja. Se investigaron las posibles
correlaciones entre la temperatura corporal y del tejido adiposo
pardo con parámetros metabólicos, hormonales,
antropométricos y dietéticos en los distintos grupos. Se observó
una correlación positiva entre el gradiente de
temperatura del tejido adiposo pardo y la temperatura corporal
periférica en los tres grupos, aunque los pacientes con
fenilcetonuria mantuvieron la temperatura corporal a expensas
de una mayor temperatura del tejido adiposo pardo.
Además, presentaron cifras más elevadas de triglicéridos,
FGF21 y diferentes proporciones de catecolaminas en relación
a la tirosina
As políticas públicas habitacionais e o processo de produção e reprodução do espaço urbano nas pequenas cidades do Território de Identidade do Sisal- Bahia-Brasil
No full textO objetivo central que fundamenta esta tese é analisar como a atuação do Estado, através da implantação de políticas públicas habitacionais, tem exercido influência sobre o processo de (re)produção do espaço urbano nas pequenas cidades da região do Território do Sisal- Bahia- Brasil. A pretensão basilar foi averiguar se essas ações são norteadas por princípios que visem assegurar a garantia de direitos sociais e uma maior justiça espacial ao viabilizar o acesso à moradia em áreas dotadas das estruturas básicas, ou se estão atreladas à reprodução das desigualdades sociais e exclusão que caracterizam o atual contexto de acumulação capitalista. Nesta investigação as análises estão centradas, porém não restritas, ao Programa Minha Casa Minha Vida (MCMV), Faixa 1, para a linha de ação direcionada, ao menos no discurso político-institucional, ao atendimento das demandas habitacionais para famílias pobres. Os procedimentos metodológicos adotados para a realização da investigação contemplaram levantamentos bibliográficos, documentais, cartográficos e dados secundários
The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging
Get PDFLiver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a). In rodents, LEAP-2 blunts ghrelin-induced feeding and its plasma levels are modulated in response to nutritional status, being decreased upon fasting and increased in high-fat diet (HFD) fed mice. Clinical data support the regulation of circulating LEAP-2 by nutrient availability in humans. In this work, our primary objective was to examine the chronic effects of ghrelin and LEAP-2 administration on food intake, adiposity, and energy expenditure in young mice subjected to standard and HFD at both room temperature and at thermoneutrality. Furthermore, we aimed to assess the impact of these two hormones on aging miceThis work has been supported by grants from Ministerio de Economía y Competitividad (ST: PID2020-116741RB-I00; CD: PID2020-116628GB-I00) Xunta de Galicia (RN:HR18-00100), Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds.
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer NatureS