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Contribuciones en osteonecrosis maxilar secundaria al consumo de antiresortivos: prevención y biomarcadores
No full textIntrodución e obxectivos: De acordo coa definición de consenso proposta pola American Association of Oral and Maxillofacial Surgeons (AAOMS), considérase que un paciente ten osteonecrose dos maxilares asociada a fármacos (ONM) se está a recibir ou recibiu tratamento con medicamentos antiresortivos ou antiangiogénicos, presenta óso exposto ou fistulación intraoral ou extraoral na rexión maxilofacial que se comunica co óso, e persiste por máis de 8 semanas, sen antecedentes de radioterapia orofacial ou evidencias de enfermidade metastásica maxilar. Aínda non se chegou a un consenso sobre diversos temas en relación con esta patoloxía, especialmente en termos de prevención. Neste sentido, dous dos pilares preventivos para esta patoloxía pasan polo coñecemento exhaustivo dos seus factores de risco e a identificación de biomarcadores de utilidade con valor predictivo ou pronóstico
A sisterhood of constructions? A structural priming approach to modelling links in the network of Objoid Constructions
Get PDFNota: Material adicional no DOI secundarioA central aim of Construction Grammar is to model links within the construct-i-con. This paper investigates three constructions that share one property: an atypical element in the object slot. The constructions are therefore not prototypically transitive. Structural priming (implemented with an automatic maze variant of self-paced reading) is used to test hypotheses on the relation among the Reaction Objoid (She smiled her thanks), the Cognate Objoid (She smiled a sweet smile or He told a sly tale), and the Superlative Objoid (She smiled her sweetest) Construction, and between two variants of the latter (They worked (at) their hardest). Results support transitivity as gradient: intransitive COCs prime the ROC and the SOC, whereas COCs with transitives only prime the ROC. For variants of the SOC, we find evidence of asymmetric priming with the bare SOC priming the at-SOC. Within-construction priming effects in the SOC are of greater magnitude than those with the at-SOC and the latter are weaker than those of the COC and of a rather different nature than those from the ROC. This suggests that speakers, rather than creating a constructeme between the bare and the at-SOC, store distinct but closely related constructions on a cline of transitivity.Collaborative work on this paper was supported by the Swiss National Research Foundation (grant IZSEZ0_213179), the Universitat de les Illes Balears – Oficina de Suport a la Recerca (UIB-OSR) (grant
number AAC33/2023), the Spanish State Research Agency (grant number PID2020-114604GB-I00), and the Consellería de Cultura, Educación, Formación Profesional e Universidades of the Regional Government of Galicia, Spain (grant number ED431B 2023/03).S
Insights on the production of volatile fatty acids from saline wastewater
Get PDFThis work investigates how several marine salt levels typical of canning industry wastewaters (0, 10, 15, 20, and 35 g salt/L), mainly composed of proteins and sugars, impact the production of volatile fatty acids (VFAs), their selectivity and the acidogenic microbiome. Mixed-culture fermenters were operated in continuous (25 °C, pH =7; HRT 1.5 d) and batch (25 °C, pH = 7, substrate-to-inoculum ratio 20 g COD/g VSS) regime. Low salinity levels (0–10 g/L) led to high VFA yields (74 %, COD basis), dropping to 46 % at higher salt concentrations. Acetic acid was always the main product (> 67 % molar basis), and butyric and valeric acid concentrations were negatively affected by high salinities (20–35 g/L). Salinity changes were also reflected in the microbial population: Clostridia was the dominant class in the whole salinity range although Actinobacteria increased its relative abundance as salinity increased. The experimental results were consistent with salt-in osmoregulation at low and medium salinities (0–15 g/L) while the compatible solutes strategy appears as more likely at high salinities (20–35 g salt/L). Given the needs for compatible solute strategy, these results enable the selection of co-substrates complementing wastewaters at the high salinity range to enhance the VFA production.This research is part of CONSERVAL project, co-financed by the European Regional Development Funds through Interreg V-A Spain-Portugal Program (POCTEP) 2014-2020. The authors belong to a Galician Competitive Research Group (ED431C-2021/37).S
Does ESG implementation influence performance and risk in SMEs?
Get PDFThe relationship between Environmental Social and Governance (ESG) activities and financial performance has been explored within large companies. The presence of these activities in Small and Medium Enterprises (SMEs) is still in its early stages in the literature, requiring further empirical evidence. Given the importance of SMEs in economy and based on Stakeholder Theory, a set of hypotheses regarding the influence of ESG on financial and risk performance has been tested using a sample of 538 Spanish SMEs. Specifically, an index has been developed to assess ESG at both global and individual levels. The study analyses the impact of these variables on corporate performance, taking into account factors such as the pandemic period, level of disclosure and the size effect. The results demonstrate the importance of developing and index tailored to measuring ESG within this type of company, as the methodology employed can impact the outcomes. Moreover, at the individual level, all dimensions reflect a significant relationship, but the overall ESG score does not. The social and labor dimensions prove to be the most beneficial indices for enhancing resilience during periods of crisis. Finally, the findings confirm that it is more difficult for SMEs to monetize the results of ESG investment and that disclosing these activities has a positive impact. This study contributes to existing knowledge by constructing a robust measure of the level of ESG implementation and quality, providing valuable insights for SMEs on how to effectively manage their ESG activitiesAgencia Estatal de Investigación. Grant Number: PID2021-124336OB-I0
Xunta de Galicia. Grant Number: ED431C 2020/18S
Insights into the application of the anodic oxidation process for the removal of per- and polyfluoroalkyl substances (PFAS) in water matrices
Get PDFThe current study aimed to investigate major knowledge gaps regarding the application of the anodic oxidation (AO) process with boron-doped diamond (BDD) anodes for the remediation of water matrices contaminated with per- and polyfluoroalkyl substances (PFAS). This included: (i) the degradation of ultrashort-chain (C1-C3) and long-chain (C9-C13) PFAS in addition to short- and medium-chain (C4-C8) PFAS, (ii) the application of multi-solute systems with different PFAS content (0.2 µg L−1 versus 2.0 µg L−1) and diversity (24 C1-C13 versus 8 C1-C8) in addition to single-solute systems, (iii) the use of real water matrices in addition to pure water, and (iv) the application of current densities (j) up to 250 mA cm−2 in addition to usual j (≤20 mA cm−2). C1-C4 PFAS with a sulfonated headgroup were the most recalcitrant compounds. By contrast, PFAS ≥ C9 with a sulfonated headgroup and PFAS ≥ C12 with a carboxylic headgroup were potentially instantaneously degraded. The content and diversity of PFAS mainly affected the degradation kinetics of PFEtS (C2), PFPrA (C3), and PFBA (C4). Four real water matrices were under focus: drinking water (DW), urban wastewater after secondary treatment (UWW), and nanofiltration concentrate (NF) and reverse osmosis concentrate (RO) from urban wastewater polishing step. PFAS degradation typically benefited from using real matrices primarily due to the presence of chloride ions and consequent electrogeneration of active chlorine species. However, for waters with a high organic content, namely a chemical oxygen demand (COD) of 319 mg O2 L−1, PFAS degradation was hindered. Furthermore, the removal of most PFAS benefited from the application of j > 20 mA cm−2, and some specific PFAS required the use of j ≥ 250 mA cm−2 to have maximized removal rates.This work was financially supported by (i) Xunta de Galicia (ED431C 2021/06), (ii) Agencia Estatal de Investigación MCIN/AEI/10.13039/501100011033 (ref. PID2020-117686RB-C32, and TED2021-129200B-C41 (co)funded by the EU through NextGenerationEU/PRTR funds), (iii) national funds through Fundação para a Ciência e a Tecnologia (FCT)/MCTES (PIDDAC) – LSRE-LCM, UIDB/50020/2020 (DOI: 10.54499/UIDB/50020/2020) and UIDP/50020/2020 (DOI: 10.54499/UIDP/50020/2020), and ALiCE, LA/P/0045/2020 (DOI: 10.54499/LA/P/0045/2020), and (iv) EU and Bundesministerium für Bildung und Forschung, Germany, Ministero dell'Università e della Ricerca, Italy, Agencia Estatal de Investigación, Spain, FCT, Portugal, Norges forskningsråd, Norway, and Water Research Commission, South Africa for funding, in the frame of the collaborative international consortium SERPIC financed under the ERA-NET AquaticPollutants Joint Transnational Call (GA N° 869178). This ERA-NET is an integral part of the activities developed by the Water, Oceans, and AMR Joint Programming Initiatives. Francisca C. Moreira and Vítor J.P. Vilar acknowledge the FCT Individual Call to Scientific Employment Stimulus 2017 – CEECIND/02196/2017 (DOI: 10.54499/CEECIND/02196/2017/CP1399/CT0013) and CEECIND/01317/2017 (DOI: 10.54499/CEECIND/01317/2017/CP1399/CT0010), respectively. Carla S. Santos acknowledges her PhD scholarship funded by FCT (2022.10796.BD)S
Simple thermal treatment to improve the MRI and magnetic hyperthermia performance of hybrid iron Oxide-Mesoporous silica nanocarriers
Get PDFThe design of multifunctional nanocomposites (NCs), incorporating a variety of controllable properties from nanostructured materials, spans their applicability as nanotools in biomedical applications. Santa Barbara Amorphous (SBA-15) mesoporous silica has showcased remarkable capabilities, ranging from bone regeneration to drug delivery. Its synergy with magnetic nanoparticles (MNPs) further broadens its scope as a theranostic agent, seamlessly integrating both therapeutic and diagnostic functions. However, efficiency issues arise due to MNP anchoring, necessitating novel solutions for optimization. This study focuses on enhancing the magnetic properties of hybrid iron oxide-SBA-15 mesoporous silica NCs through a simplified thermal procedure. The aim is to optimize their magnetic performance for dual functionality as contrast agents for magnetic resonance imaging (MRI) and as effective heaters in magnetic hyperthermia (MH) processes, while preserving the cylindrical mesoporous structure, high surface area, and high loading capacity compared to conventional ceramics. The investigation highlights that the impact of heat treatment on physicochemical properties varies depending on the compositions of the NCs. Specifically, the transversal relaxivity in MRI was doubled, accompanied by an enhanced Néel contribution in MH. This enhancement was achieved while maintaining the same biocompatibility as non-treated NCs, as demonstrated in evaluations with two cancer cell lines (HeLa and T-731 astrocytes), revealing low toxicity at concentrations up to 200 μg/mLThis work was supported by the European Commission under the BOW project (FETPROACT-EIC-05-2019, Grant 952183), CARTsol project (PLEC2022-009217 funded by MICINN/AEI /10.13039/501100011033 and NextGenerationEU/ PRTR) and partially supported by the Spanish Ministry of Science and Innovation (ref PID2020-112626RB-C21), Modalities «Research Challenges» and «Knowledge Generation» and the Regional Consellería de Innovación Program for the Grupos de Referencia Competitiva 2021 —GRC2021 project of Xunta de Galicia. Zulema Vargas gratefully acknowledges the financial support from the European Uniońs Horizon 2020 Research and Innovation Programme under grant agreement No 739566. R. Iglesias-Rey (CP22/00061) from the Miguel Servet Program of Instituto de Salud Carlos III and Co-financed by the EU. P.T. also thanks Agencia Estatal de Investigación (AEI) by project PID2019-109517RB-I00) and from Xunta de Galicia, project ED431C2022/18. European Regional Development Funds are also acknowledgedS
Impacto de la forestación de terrenos agrícolas sobre el carbono orgánico lábil y la actividad microbiana del suelo
Get PDFUno de los grandes retos que tiene la sociedad actual es cómo afrontar el cambio climático y
mitigar, en lo posible, los efectos que se estima que se producirán. En los años 90 del siglo
pasado (XX) un total de 84 países se adhirieron al Protocolo de Kioto. Si bien este protocolo ya
se ha visto superado por acuerdos posteriores, las normas que contiene son un instrumento de la
Convención Marco de las Naciones Unidas sobre el Cambio Climático (UNFCCC) para una
gestión ambiental que promueva el desarrollo sostenible, la reducción de las emisiones de gases
de efecto invernadero y la potenciación de actividades sumidero de estos gases.
Además del control en origen con la reducción de las emisiones de gases de efecto invernadero,
entre las estrategias promovidas para la mitigación y adaptación al cambio climático, una de las
más importantes es favorecer y potenciar la consolidación de zonas forestales con una biomasa
vegetal permanente, inmovilizando el carbono, lo que, además de favorecer la lucha contra el
efecto invernadero y la absorción de dióxido de carbono, contribuiría a mejorar a largo plazo los
recursos forestales y a realizar una gestión del espacio natural más compatible con el medio
ambiente
Association between serum mineral levels and reproductive performance in primiparous dairy cows during the peripartum period
Get PDFTo the best of the authors' knowledge, no study has previously investigated whether
the concentration of minerals is related to reproductive outcomes in primiparous
cows. For this reason, two objectives were set in the present study: (i) to assess serum
mineral levels, macrominerals, and trace elements during the transition period (period
of high nutritional requirements) in primiparous cows, considering reproductive efficiency, and (ii) to address if the serum mineral levels of primiparous cows are related
to reproductive efficiency. Blood samples were taken (i) one month before calving,
(ii) one week before calving, (iii) one week postpartum, and (iv) one month postpartum. At the beginning and the end of the study, a body condition score (BCS) was assigned to each lactating cow with no clinical signs of disease. The difference between
one month before and one month after calving was the body condition loss (ΔBCS).
Optimal prepartum concentrations of K and Cl were associated with fewer days open
and a shorter interval calving. Furthermore, macrominerals in the serum decreased
immediately after calving (one week) but recovered at one month postpartum. In contrast, the highest concentration of trace elements was found at one week postpartum. Primiparous cows with higher postpartum Se, Mn, Co, and Mo concentrations
exhibited better reproductive efficiency, and the concentrations of trace elements in
serum were correlated with interval calving and the number of inseminations. Finally,
primiparous cows with a greater ΔBCS (at least one point) in period 4 exhibited both
a longer calving interval and a greater number of days open. In summary, this study
showed, for the first time in primiparous cows, that the concentration of some serum
minerals not only plays a crucial role during the transition period but is also related to
crucial reproductive parameters, such as interval calving and days open.S
La sedición de lo sensible. Arte y filosofía en el Lyotard de los años setenta
No full textLa presente tesis doctoral aborda la relación entre arte y
filosofía en la vida y en la obra de Jean-François Lyotard,
privilegiando el estudio de los años comprendidos entre 1968 y
1978. La hipótesis que aquí se defiende es que el
pensamiento de Lyotard está constitutivamente atravesado por
la influencia recibida del mundo de las artes, por lo que
para entenderlo es imprescindible considerar sus escritos sobre
arte como una parte fundamental de su corpus teórico.
En este sentido, la relevancia de los años setenta es grande,
pues no solo fue en esta década cuando comenzó a escribir
sobre arte y a relacionarse activamente con los artistas, sino
que este también puede considerarse como su período de
mayor transformación intelectual.2025-05-0