Repositorio de la Asociación Española de Neuropsiquiatría
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Taşkın Yayılım Haritalarında Arazi Kullanım Türü Ve Yüzeysel Akış Etkilerinin Değerlendirilmesi: Malatya İli Örneği
No full textDünya genelinde kentleşme artmaktadır ve buna bağlı olarak kentsel nüfus da artmaktadır. Hızlı kentsel nüfus artışının sonucu olarak yetersiz drenaj sistemleri nedeniyle taşkın yağışı durumunda, binaların bodrum katlarını su basması, ulaşım yollarının kapanması gibi can ve mal kaybına neden olabilecek hasarlar meydana gelmektedir. Bu çalışmada, Malatya ili için arazi kullanım türü ve sızma durumlarına bağlı üç farklı senaryo kapsamında taşkın yayılım haritaları oluşturulmuştur. Bu senaryolar, modelde; arazi kullanım türünün olmadığı, arazi kullanım türünün olduğu ve arazi kullanım türü ile yüzeysel akış değerlerinin birlikte olduğu durumuna dayanmaktadır. Çalışmanın, hidrolojik veya hidrodinamik modellerde arazi kullanımı ve yüzeysel akış verilerinin kullanımı hakkında detaylar sunması amaçlanmıştır. Bu kapsamda, InfoWorks ICM yazılımı kullanılarak oluşturulan modeller, model doğruluğunu arttırması için sayısal yükseklik modeli, bina konum verileri, arazi kullanım türü ve gelecekte meydana gelebilecek yağış yükseklikleri verileriyle desteklenmiştir. Sonuçlar, arazi kullanım türü ile yüzeysel akış değerlerinin birlikte kullanıldığı modele dayalı senaryo da diğer iki senaryoya göre havza genelinde daha az akış kollarının oluştuğunu göstermiştir
KARABUĞDAY (Fagopyrum esculentum) UNU İLE ZENGİNLEŞTİRİLMİŞ DUT PESTİLLERİNİN BAZI FİZİKO-KİMYASAL, RENK, BİYOAKTİF VE DUYUSAL ÖZELLİKLERİNİN ARAŞTIRILMASI
No full textBu çalışmanın amacı farklı konsantrasyonlarda (0-12 g/100g) karabuğday unları (Fagopyrum esculentum) ile zenginleştirilmiş dut pestillerin bazı fiziko-kimyasal, renk, biyoaktif ve duyusal özelliklerini araştırmaktır. Dut pestillerin protein içerikleri 5.87-6.89 g/100g aralığında değişmiş ve karabuğday unu ilavesiyle anlamlı bir artma bulunmuştur (P<0.01). Karabuğday unu ilavesiyle dut pestillerinin viskozite içerikleri anlamlı oranda artmıştır (P<0.01). Örneklerin hidroksimetilfurfural (HMF) değerleri 3.95 ile 4.81 mg/kg aralığında tespit edilmiş ve karabuğday unu ilavesiyle anlamlı bir artma saptanmıştır (P<0.01). Maksimum toplam fenolik madde içeriği E kodlu örnekte (1622.56 mg GAE/kg) bulunurken minimumu toplam fenolik madde içeriği ise A kodlu örnekte (936.22 mg GAE/kg) tespit edilmiştir. Genel olarak karabuğday ilavesi ile örneklerin duyusal skorlarında anlamlı bir artış belirlenmiştir (P<0.01). B Kodlu çalışma dizaynı (10 g/100g karabuğday unu içeren) panelistler tarafından en beğenilen deneme tasarımı olarak tespit edilmiştir. Bu çalışmada karabuğday unu kullanılarak çölyak hastalarına uygun, genel kabul görmüş ve alternatif bir pestil üretilmiştir
PATULİNİN KARACİĞER VE AKCİĞER KANSERİ HÜCRE HATLARI ÜZERİNDEKİ İN VİTRO ANTİTÜMÖR AKTİVİTESİ
No full textObjective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity. Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways. Material and Method: HEP3B and A549 cell lines were used to determine the efficacy of patulin in the treatment of liver and lung cancers. Cell lines were exposed to increasing concentrations of patulin (1, 2.5, 5, 10, 25, 50, and 100 µM), followed by determination of cell viability, cell migration, and apoptosis by MTS assay, wound healing assay, and RT-PCR assays. Result and Discussion: Patulin caused a dose-dependent significant decrease in cell viability and cell migration in both cancer cell lines. It also promoted the induction of apoptosis in both cell lines. Our results showed that patulin can significantly reduce tumor growth in human liver and lung cancer cells in vitro. © 2022 University of Ankara. All rights reserved
Prediction of Breast Cancer Distant Metastasis by Artificial Intelligence Methods from an Epidemiological Perspective
No full textIntroduction: Despite significant advances in breast cancer (BC) management, the prognosis for most patients with distant metastasis remains poor. We predicted distant metastasis in BC patients with artificial intelligence (AI) methods based on genomic biomarkers. Methods: The dataset used in the study included 97 patients with BC, of whom 46 (47%) developed distant metastases, and 51 (53%) did not develop distant metastases, and the expression level of 24,481 genes of these patients. An approach combining Boruta + LASSO methods was applied to identify biomarker genes associated with BC distant metastasis. Mann-Whitney U test was used to examine the difference between groups in terms of gene expression levels in statistical analyses, and Cohen d effect sizes and odds ratios were calculated. AdaBoost and XGBoost algorithms, which are tree-based methods, were used for BC distant metastasis prediction, and the results were compared by evaluating comprehensive performance criteria. Results: After Boruta + LASSO methods, 14 biomarker candidate genes were identified. These predictive genes were PIB5PA, OR1F1, ALDH4A1, FGF18, WISP1, PRAME, CEGP1, AL080059, NMU, ATP5E, SMARCE1, FGD6, and 5LC37A1. In effect size results; in particular, show that the AL080059 (Cohen's D: 1.318) gene is clinically predictive of BC Metastasis. The accuracy, F1-score, positive predictive value, sensitivity, and area under the ROC Curve (AUC) values obtained with the AdaBoost algorithm for BC metastasis prediction was 95%, 96.3%,100%, 92.6%, and 98.8%, respectively. The model created with the XGBoost algorithm, on the other hand, obtained 90%, 92.9%, 92.9%, 92.9%, 97.6% accuracy, F1-score, positive predictive value, sensitivity, and AUC values, respectively. Conclusion: Identifying genes that successfully predict BC distant metastasis with AI methods in the study may be decisive for future therapeutic targets and help clinicians better adapt adjuvant chemotherapy to their patients. Additionally, the AdaBoost prediction model created can discriminate patients at risk of BC distant metastases
Investigation of protective effect of ellagic acid in phthalates-induced reproductive damage
No full textPhthalates that people are exposed to every day are toxic carcinogenic chemicals with proven harmful effects on growth and reproduction. Ellagic acid (EA) is a polyphenol derivative known for its antioxidant properties. We hypothesized that the possible reproductive damage mechanism of phthalates is oxidative attack and ellagic acid could have a protective effect against radical forms in the body through its antioxidant properties. Thirty-two male rats were randomly divided into 4 groups, with 8 rats in each. Phthalate (DBP) was administered intraperitoneally and EA acid through gastric oral gavage (phthalate group 500 mg/kg/day DBP; EA group 2 mg/kg/day ellagic acid; the treatment group 500 mg/kg/day DBP and 2 mg/kg/day EA). The vehicle of DBP and EA, carboxymethyl cellulose was administered to control group. At the end of 4 weeks the testis tissue samples were taken under mild anesthesia. Tissue malondialdehyde, antioxidant parameters, sperm motility, sperm density and abnormal spermatozoon ratios were determined. Analysis was performed with One Way ANOVA test using SPSS 12.0 program. As a result; it has been shown that DBP causes oxidative damage by increasing the malondialdehyde level and decreasing antioxidant parameters, increased abnormal sperm rate and decreased sperm motility and concentration and histopathological damage so this damage is inhibited by the antioxidant activity of ellagic acid.Turkiye Bilimsel ve Teknolojik Arastirma KurumuThe present research was financially supported by Turkiye Bilimsel ve Teknolojik Arastirma Kurumu
Türkiye’de Vergilendirmede Dijital Dönüşüm
No full textAim: It is aimed to evaluate the effect of reflux time in primary VUR in terms of predicting endoscopic treatment success and treatment timing in VUR management. Vesicoureteral reflux (VUR) is an important cause of urinary tract infection and chronic renal disease. Voiding cystourethrography (VCUG) is the gold standard diagnostic test in the diagnosis of VUR. In recent years, new parameters related to VCUG have been more objectively studied to evaluate the clinical prognosis. Materials and Methods: In our study, the records and imaging findings of children with primary VUR who underwent VCUG examination between 2012 and 2019, who were treated with endoscopic injections, were retrospectively reviewed. Forty-one children (67 renal units) were included in our study. Patients with preoperative VCUG, urinary ultrasonography, dimercaptosuccinic acid (DMSA) renal scan, and post-operative control VCUG were included in this study. Results: Patients with preoperative VUR grade 1-2 were divided into two groups as “low grade” and patients with stage 3-4-5 as “high grade”. In the general patient pop- ulation, endoscopic success rates in terms of renal unit deficit were found to be 46.3% (31/67). When the subgroup was analyzed, the endoscopic treatment success rate was 72.2% (13/18) in the low-grade group, versus 36.7% (18/49) in the high-grade group (p = 0.010). In the multivariate logistic regression analysis performed to identify indepen- dent predictors of scarring, reflux degree and reflux time were found to be independent predictors of scarring. Conclusion: In our study, we found that in VCUG evaluated preoperatively, VUR time as well as VUR grade were effective on endoscopic success rate and scar development. Based on these results, it could be thought that VUR time may be effective in selecting the best candidates for surgery and in the management and timing of treatment of VUR patients
ÇİN KARAKTERİSTİĞİYLE DÜNYA DÜZENİ: GEÇMİŞTEN GÜNÜMÜZE HARAÇÇI SİSTEM
No full textÇin’in yükselişi veya düşüşü Doğu Asya bölgesel düzenin hemen her zaman belirleyici faktörü olmuştur. 21. Yüzyılda Çin’in yeniden büyük bir güç olarak tarih sahnesine çıkması, bölgesel ve küresel düzenin nasıl şekilleneceğine yönelik tartışmaları hızlandırmaktadır. Çin’in ekonomik ve askeri gücü, birçok aktörle Çin lehine olan asimetrik bir bağımlılık ilişkisine yol açmaktadır. Çin ile diğer ülkeler arasındaki ekonomik ve askeri eşitsizliğin haraççı sistemde olduğu gibi hiyerarşik bir düzene yol açıp açmayacağı merak konusudur. Bu çalışmada, yükselmekte olan Çin’in nasıl bir düzen arayışında olacağı, tarihsel deneyimlerden yola çıkarak analiz edilmiştir. Çalışma, ekonomik ve askeri olarak güçlü bir Çin’in dış işlerini nasıl bir çerçevede yürüteceği sorusuna yanıt vermeyi amaçlamaktadır. Çin ve diğer ülkeler arasındaki ekonomik ve askeri asimetrinin haraççı sistemde olduğu gibi, Çin’in bazı ülkelerle olan ilişkilerinin eşitsiz bir temelde yürütülmesine olanak sağlayacağı savunulmaktadır
Comparison of pregnant women's anxiety, depression and birth satisfaction based, on their traumatic childbirth perceptions
No full textThis study was conducted to identify and compare pregnant women's anxiety, depression, and birth satisfaction levels based on their traumatic childbirth perceptions. This study used a cross-sectional design. The data were collected at two stages, namely, the prenatal and postpartum stages. First, the Traumatic Childbirth Perception Scale, the Beck Anxiety Inventory, and the Beck Depression Inventory were applied to the pregnant women. Next, in the postpartum period, the Childbirth Information Form and the Birth Satisfaction Scale-Revised were applied. It was found that the participants with high levels of traumatic childbirth perception had higher mean anxiety and depressive symptom scores (26.13 +/- 11.30 and 16.16 +/- 9.02, respectively), whereas the participants with low levels of traumatic childbirth perception had a higher mean birth satisfaction score (17.50 +/- 4.91). The findings indicated that high levels of traumatic childbirth perception may lead to have anxiety and depression, while low levels of traumatic childbirth perception may enhance their birth satisfaction. IMPACT STATEMENT What is already known on this subject? In the literature, it is stated that the perception of a traumatic birth can lead to permanent or long-term negative consequences in women's lives, negatively affecting their future health, subsequent birth experiences, and family relationships. What do the results of this study add? In this study, 37.7% of the participants were found to have high levels of traumatic childbirth perception. It was determined that the anxiety and depression levels of the participants with high levels of perception of traumatic birth were higher, and the levels of birth satisfaction were higher in the pregnant women with low levels of perception of traumatic birth. The results indicated that severe depressive symptoms, severe anxiety, and low levels of birth satisfaction were likely to raise traumatic childbirth perception levels in pregnant women. What are the implications of these findings for clinical practice and/or further research? The care to be given under the leadership of midwifery professionals is important in terms of reducing pregnant women's perceptions of a traumatic birth, anxiety, and depression levels and increasing their levels of birth satisfaction
Outcomes of 6 Human Leukocyte Antigen-Mismatched Living Donor Kidney Transplant: A Study With Biopsy Amendment
No full text17th Virtual Congress of the Middle-East-Society-for-Organ-Transplantation (MESOT) -- SEP 03-05, 2021 -- ELECTR NETWORKObjectives: In this study, we examined the graft and patient survival outcomes in patients with end-stage kidney disease who received 6 HLA-mismatched incompatible living donor kidney transplant. Materials and Methods: Patients who underwent living donor kidney transplant between January 2010 and March 2020 were evaluated retrospectively. Group A included kidney transplant recipients with 6 HLA mismatches, and group B included kidney transplant recipients with 0 to 5 HLA mismatches. Patients with <1 year of follow-up were excluded. All rejection episodes were diagnosed via Tru-Cut biopsy and histopathological evaluation. Results: There were 15 patients in group A and 176 patients in group B. The mean follow-up was 54.1 +/- 30 months. The number of patients who underwent pretransplant immune desensitization and received tacrolimus-based triple maintenance immunosuppression therapy was significantly higher in group A. In group A, there were 13 acute rejections seen in 9 patients (81%); in group B, there were 67 acute rejections seen in 51 patients (28.9%; P =.019). No differences were observed between the groups in terms of baseline glomerular filtration rate (60 +/- 16 vs 61.6 +/- 20 mL/min/1.72 m(2); P =.76), final control glomerular filtration rate (60.7 +/- 15 vs 58 +/- 19 mL/ min/1.72 m(2); P =.59), graft loss (0% vs 4%; P =.94), and mortality (6.6% vs 3%; P =.39). Conclusions: The presence of 6 HLA mismatches was associated with higher rates of biopsy-proven acute rejection. However, 6 HLA-mismatched incompatible living donor kidney transplant can be safely performed in centers where posttransplant followup is supported by indication and protocol biopsies and where there is a pathological infrastructure with extensive knowledge and experience.Middle E Soc Organ Transplanta
Analysis of posttraumatic embitterment disorders by machine learning: Could sullenness be a predictor of posttraumatic embitterment disorder?
No full textObjective: This study aimed to determine some fundamental factors specific to posttraumatic embitterment disorder (PTED) using deep machine learning (ML) and network analysis techniques. Method: Sociodemographic data form, Buss-Perry Aggression Questionnaire, Brief Symptom Inventory (BSI), PTED Self-Rating Scale (PTED Scale), and list of stressful life events were administered to 557 people who applied to the outpatient anxiety clinic. ML method and network analysis were applied with the 33 most significant variables. Results: PIED was found in urban areas (p=0.006), individual health problems (p=0.029), early separation from their families (p=0.040), previous trauma (p=0.021), describing childhood sexual abuse (p<0.001), and those with the illness for more than 10 years (p<0.001) were detected at a higher rate than those without. The PIED score was higher in those with an anxiety disorder (p=0.043) and a personality disorder (p<0.001). Almost all life stressors were higher in the PIED group. There was a statistically significant difference between the groups in all subscales of the BSI. When the ML procedure was applied, sullenness was identified as the main symptom of PIED. The factors most associated with sullenness were well-being, hopelessness, and painful event experience. Conclusion: The higher rate of chronic trauma in the group with PTED and the detection of sullenness as the main symptom have been important data for understanding the psychopathological process