Repositorio de la Asociación Española de Neuropsiquiatría
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Forensic evaluation of occupational accident cases admitted to İnönü University Faculty of Medicine Turgut Özal Medical Center
No full textAmaç: İş kazaları sonucu meydana yaralanmalarda, kaza türü, iş kolu, yaralanma bölgesi, kemik kırıkları, organ hasarlarını, yaralanmalar sonucu yapılan adli değerlendirme sonucu, ölüm gerçekleşen olgularda ölüm sebebi faktörleri tespit etmektir. Gereç ve Yöntem: Hastanemize 01.01.2016-31.12.2020 tarihleri arası 5 yıllık sürede başvuran iş kazası olguları çalışmaya dahil edildi. Çalışmada kazaya karışmış kişilerin; yaşı, cinsiyeti, yaralanmaları, yaralanma bölgeleri, kaza saati, günü, mevsimi, ölüm halinde ölüm sebebi, taburculuk şekilleri, yattığı bölüm, yaralanmanın basit tıbbi müdahale ile giderilip giderilemeyeceği, yaşamsal tehlikeye neden olup olmadığı, kan alkol testi yapılıp yapılmadığı, sigortasının olup olmadığı, kazanın oluş şekli ve meslek kolu açısından değerlendirildi. Veriler SPSS 26.00 programında analiz edildi. Bulgular: Çalışmamızdaki olgularda erkeklerin kadınlara göre daha fazla iş kazası geçirdiğini ve bu kazalar sonucu daha fazla yaşamlarını kaybettikleri görülmüştür. İş kazalarının genç yaş gurubunda daha sık görüldüğü tespite edilmiştir. İş kazalarının en sık sonbahar mevsiminde ve nisan ayında görüldüğü saptanmıştır. İş kazalarının gün içinde en sık görüldüğü zaman dilimi öğleden önce, en sık görüldüğü günlerin çarşamba ve cuma günü olduğu görülmüştür. Vücutta en sık yaralanan bölge üst ekstremite en sık görülen lezyon tipi kemik kırığı olarak tespit edilmiştir. Sonuç: İş kazalarının hemen hepsi önlenebilecek sebeplerden ötürü meydana gelmektedir. Çalışanlara rutin aralıklara eğitim verilmesi, sağlık kontrollerinin sağlanması, kişisel koruyucu ekipmanların bakımlarının yapılması, işyerindeki risklerin minimuma indirilmesi iş kazalarının önlenmesi açısından önemli olacaktır
Design of laccase-metal-organic framework hybrid constructs for biocatalytic removal of textile dyes
No full textThis study aims to present a simple and effective carrier matrix to immobilize laccase as opposed to complex and tedious immobilization processes and also to use it in the removal of textile dyes. For this purpose, Cobalt (Co) and Copper (Cu) based metal-organic frameworks (MOFs) were prepared and laccase was immobilized on two different MOFs via encapsulation. The characterization outcomes showed that laccase was well immobilized into MOF supports. Optimum pH and temperature were found for Lac/Co-MOF (pH 4.5 at 50 degrees C) and Lac/Cu-MOF (pH 5.0 at 50 degrees C). The Km (0.03 mM) and Vmax (97.4 mu mol/min) values of Lac/Cu-MOF were lower than those of Lac/Co-MOF (Km = 0.13 mM, Vmax = 230.7 mu mol/min). The immobilized laccases showed good reusability as well as improved resistance to temperature denaturation and high storage stability. For instance, the Lac/Co-MOF and Lac/Cu-MOF retained more than 58% activity after 4 weeks of storage at room temperature. Meanwhile, Lac/Co-MOF and Lac/Cu-MOF maintained 56.5% and 55.8% of their initial activity, respectively, after 12 reuse cycles. Moreover, thermal deactivation kinetic studies of immobilized laccases displayed lower k value, higher t1/2, and enhancement of thermodynamic parameters, which means better thermostability. Finally, the decolorization activities for the Lac/Co-MOF were 78% and 61% at the 5th cycle for Reactive Blue 171 an
Effects of curcumin on arginase enzyme activity, ornithine and nitric oxide levels in experimental breast cancer model
No full textBreast cancer accounts for almost 30% of all cancer types, making it the most common type of tumor among women in the world. Arginase, an essential enzyme of the urea cycle, leads to the formation of urea and ornithine from L-arginine using the same substrate as nitric oxide synthase (NOS). Arginase has been reported to be higher in cancer patients and can be used as a useful biomarker. In this study, we aimed to investigate the effects of curcumin, an anticarcinogenic agent, on arginase enzyme activity, ornithine, and nitric oxide (NO) levels in experimental breast cancer model in mice. 43 male Balb/c mice were used, and Erhlich acid tumor model was created in the study. Mice were divided into five groups as healthy control group, curcumin treatment before tumor formation, curcumin treatment after tumor formation and cancer control groups. 100 mg/kg curcumin were given orally. Serum and tissue arginase enzyme activities, NO levels and tissue ornithine levels were determined spectrophotometrically. Increased serum arginase activity decreased with curcumin treatment, but this difference was not statistically significant. On the other hand, decreased NO levels were increased with curcumin treatment. In tumor tissue, arginase activity and ornithine levels decreased significantly with curcumin treatment and tissue NO levels increased significantly with curcumin treatment. In our study, we show that curcumin may have a protective effect on the development of breast cancer by inhibiting arginase enzyme activity and ornithine levels, which are the precursors of polyamines, as well as inducing NO production via NOS. As a promising anticancer agent, the net effects of curcumin in this mechanism should be supported by more advanced studies and new parameters. © 2022 Ondokuz Mayis Universitesi. All rights reserved.Trakya ÜniversitesiFunding: The authors declared that this study has received financial support from Trakya University Research Project (TUBAP)
Beta-glucan effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in liver and brain
No full text2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a common environmental contaminant that is toxic to brain, heart, kidney and liver. TCDD toxicity is due to free radical formation. Beta-glucan is an antioxidant that exhibits beneficial effects on health. We investigated the effects of beta-glucan on brain and liver tissues of rats with TCDD induced toxicity. We used female rats divided into four groups: control, TCDD group treated with TCDD 2 mu g/kg/week, beta-glucan group treated with 50 mg/kg/day beta-glucan for 3 weeks, TCDD + beta-glucan group treated with 2 mu g/kg/week TCDD and 50 mg/kg/day beta-glucan together for 3 weeks. We found that the thiobarbituric acid reactive substance (TBARS) levels were increased significantly in the TCDD group compared to the other groups. Glutathione (GSH) levels, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were reduced in the TCDD group compared to the control group. SOD, CAT, GPx activities and GSH levels were increased in the TCDD + beta-glucan group. Histopathological observations were consistent with our biochemical findings. The oxidative stress and histopathology caused by TCDD were ameliorated by beta-glucan treatment. Beta-glucan should be explored for preventing brain and liver damage caused by TCDD toxicity
The success of the Cystic Fibrosis Registry of Turkey for improvement of patient care
No full textBackground Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. Methods Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data. Results There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in 1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively). Conclusions The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF
The relationship between institutional quality and economic growth: A review on BRICS-T countries
No full textEkonomi tarihi, ülkeler arasındaki gelişmişlik farklarının nedenlerini açıklamaya çalışan birçok yaklaşıma tanık olmuştur. Bu yaklaşımların başında 1950'li yıllarda R. Solow tarafından öne sürülen fiziki sermaye ve teknolojik ilerleme farkları gelmektedir. Fakat bu iki değişken, neden bazı ülkelerin daha zengin bazılarının daha fakir olduklarını açıklamada yetersiz kalmıştır. Tam da bu noktada fiziki sermayenin arttırılması, teknolojik altyapının oluşturulması, üretim kapasitesinin arttırılması vb. olayların kurumların işleyişi ile alakalı olabileceği konusu gündeme gelmiştir. Kurumların, sosyal ve ekonomik yaşamı düzenleyen yapılar olduğu ve sürdürülebilir ekonomik büyümenin temeli olduğu konusunda geniş bir literatür mevcuttur. Kurumların ve kurumsal kalitenin ülkelerin ekonomik performanslarına ne kadar etkisi olduğu sorusuna cevap bulmak adına çalışmada özdeş ekonomik yapılara sahip Brezilya, Rusya, Hindistan, Çin, Güney Afrika ve Türkiye (BRICS-T) ülkeleri incelenmiştir. 2002-2020 dönemine ait yıllık verilerin kullanıldığı çalışmada Panel Veri Analiz yöntemleri kullanılmıştır. Çalışmada kurumsal kalite göstergeleri olarak, Dünya Yönetişim Göstergelerinden (World Govarnance Indicators- WGI) alınan hükümetin etkinliği(GE), politik istikrar ve şiddetin olmaması(PS), hukukun üstünlüğü(RL), düzenleme kalitesi(RQ), ifade özgürlüğü ve hesap verilebilirlik(VA) ve yolsuzluğun kontrolü(CC) kullanılmıştır. Çalışmada, PVECM (Uzun Dönem) nedensellik test sonuçlarına göre uzun dönemde kurumsal kalite faktörlerinden ekonomik büyümeye doğru nedensellik ilişkisi bulunmuştur. Emirmahmutoğlu ve Köse (2011) panel nedensellik test sonuçlarına göre her ülkede farklı bir kurumsal kalite faktöründen büyümeye nedensellik ilişkisi mevcuttur. Genel olarak politik istikrar ve şiddetin olmaması(PS), ifade özgürlüğü ve hesap verilebilirlik(VA) ve düzenleme kalitesinden(RQ) büyümeye doğru nedensellik olduğu yönünde bulgulara ulaşılmıştır. Son olarak ülkelerin ekonomik büyümelerini pozitif etkileyen kurumsal kalite faktörleri, düzenleme kalitesi(RQ), yolsuzluğun kontrolü (CC) ve hukukun üstünlüğü(RL) olarak bulunmuştur.Economic history has witnessed many approaches that try to explain the reasons for development differences between countries. At the beginning of these approaches are the differences in physical capital and technological progress put forward by R. Solow in the 1950s. But these two variables fell short of explaining why some countries are richer and some poorer. At this point, it is necessary to increase the physical capital, create the technological infrastructure, increase the production capacity, etc. The issue that events may be related to the functioning of institutions has come to the fore. There is a large literature on the subject that institutions are the structures that regulate social and economic life and that they are the basis of sustainable economic growth. In order to find an answer to the question of how institutions and institutional quality affect the economic performance of countries, Brazil, Russia, India, China, South Africa and Turkey (BRICS-T) countries with identical economic structures were examined in the study. Panel Data Analysis methods were used in the study, in which annual data for the 2002-2020 period were used. The institutional quality indicators in the study, taken from the World Governance Indicators, are government effectiveness (GE), political stability and non-violence (PS), rule of law (RL), regulatory quality (RQ), freedom of expression and accountability (VA) and corruption control (CC). In the study, according to the PVECM (Long Term) causality test results, a causal relationship was found from institutional quality factors to economic growth in the long run. According to Emirmahmutoğlu and Köse (2011) panel causality test results, there is a causality relationship from a different institutional quality factor to growth in each country. In general, we found that there is causality running from political stability and non-violence (PS), freedom of expression and accountability (VA) and regulatory quality (RQ) to growth. Finally, institutional quality factors that positively affect the economic growth of countries were found to be regulatory quality (RQ), corruption control (CC) and rule of law (RL)
The comparison of radiologic measurements of the hip parameters between girls and boys
No full textAim: This study aimed to compare the radiologic measurement of hip parameters between girls and boys aged 3,5 to 4 years. Material and Methods: This retrospective study included 112 healthy children (n:57 girls, n: 55 boys) aged 3,5 to 4 years who required radiological images due to examination. Radiological images from Inonu University, Faculty of Medicine, Department of Orthopedia were used in the study. The measurements taken from the children were right and left femur head ossification, acetabular index and femur inclination angle. Results: In girls, median right femur head ossification was 16.80 mm, median left femur head ossification was 15.30 mm, median right acetabular index was 24.10(0), median left acetabular index was 23.80(0), median right femur inclination angle was 147.40(0), median left femur inclination angle was 147.50 degrees. In boys, median right femur head ossification was 18.40 mm, median left femur head ossification was 19.50 mm, the median right acetabular index was 17.40 degrees, the median left acetabular index was 17.50 degrees, median right femur inclination angle was 147.50 degrees, and median left femur inclination angle was 148.70 degrees. Discussion: A statistically significant difference was found between girls and boys regarding right and left femur head ossification and acetabular index. This contributes to the determination of gender differentiation, gold standard values of hip parameters for diagnosis, evaluation and prognosis of hip diseases in children aged 3,5 to 4 years
Developing the socio-spatial integration of historical city centers with spatial strategies: the case of Gaziantep
No full textHistorical city centers are important places for cities in terms of their cultural, historical, economic, and social characteristics. Due to the rapid economic growth and excessive population increase experienced in the recent period, most cities have faced an uncontrolled growth. Because of the related pressures, historical city centers have been adversely affected in terms of their physical, functional, economic, and social structure. This study aims to develop spatial strategies to contribute to the solution of the problem mentioned above. It focuses on the spatial configuration of the study area and utilizes the space syntax method and parameters, as well as a comparative analysis of some key indicators. The study presents the results of the spatial strategy developed through the identification of points of special interest (SA), strategic priority areas (SPA), and urban sub-foci (USP). As a result of the analysis and the suggestions developed, it has been revealed that there is a significant increase in the socio-spatial characteristics of both the city area and the historical city center.Cukurova University [FDK-2016-7736]The study was funded by Cukurova University Research Projects Unit.Project No: FDK-2016-773
Evaluation of the efferent auditory system in COVID-19 adult patients
No full textBackground The short- and long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the medial olivocochlear reflex and outer hair cells in the cochlea remain largely unclear. Aims The aim of this study was to investigate the efferent auditory system effects in adult patients with COVID-19. Materials and methods The study included 18-50 years old 44 volunteers: 26 individuals (52 ears) with COVID-19 in the study group and 18 healthy individuals (36 ears) in the control group. Otolaryngological examination, immitancemetric evaluation, distortion product otoacoustic emission (DPOAE), contralateral acoustic stimulation with DPOAE, audiometric evaluation, and high frequency audiometric evaluation were performed in all individuals participating in the study. Results In our study, patients with COVID-19 had significantly lower DPOAE results with or without broadband noise at only 6 kHz frequency and contralateral suppression results at all frequencies compared to healthy individuals. A statistically significant difference was found between the study and control groups according to whether the participants had a response in the high frequency audiometry at 12 and 16 kHz frequencies. Conclusions COVID-19 affects many systems in the body. As a result of the findings obtained in the present study, it is shown that the auditory efferent system may also be affected
Türkiye’nin Akdeniz Bölgesine Adapte Edilen Bazı Tropikal Meyvelerin Biyoaktif Bileşenlerinin ve Antioksidan Kapasitelerinin Analizi
No full textTürkiye sahip olduğu ekolojik özellikleri sebebiyle birçok bitki türüne ev sahipliği yapmaktadır. Bununla birlikte Türkiye’nin farklı iklimsel özelliklere sahip olan farklı bölgelerinde yeni meyve türlerinin adaptasyon çalışmaları her geçen gün artmaktadır. Bu çalışmanın amacı Akdeniz Bölgesine adapte edilen Mango (Mangifera indica L.), beyaz (Hylocereus undatus Britton & Rose) ve kırmızı pitaya (Hylocereus lemairei (Hook.) Britton & Rose), guava (Psidium guajava L.) ve bölgede yaygın olarak yetişen mart inciri (Opuntia ficus-indica (L.) Mill.) meyvelerinin etinde toplam fenolik madde, toplam flavanoid madde, toplam askorbik asit ve antioksidan kapasitenin (ABTS, DPPH) belirlenmesidir. En yüksek toplam fenolik madde ve toplam flavanoid madde içeriği sırasıyla guava (80.1 mg 100g-1) ve mart inciri (4.68 mg 100g-1) meyvelerinde; en düşük mango (45.4 mg 100g-1) ve beyaz pitaya (0.95 mg 100g-1) meyvelerinde tespit edilmiştir. Kırmızı pitaya meyve etinde renk maddelerinin de içerisinde yer aldığı toplam flavanoid madde içeriği beyaz pitaya meyvelerinden daha yüksek bulunmuştur. Toplam askorbik asit içeriği en yüksek olan meyve mart inciri meyvesidir (5.38 mg 100g-1). ABTS ve DPPH radikal süpürücü aktiviteler ise guava meyvesinde en yüksek bulunurken, mart inciri meyvesinde en düşük olarak belirlenmiştir