Repositorio de la Asociación Española de Neuropsiquiatría
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Erken Çocukluk Dönemi Problem Çözme Becerilerine Yönelik Yapılan Eğitimsel Uygulamaların Etkililiği: Bir Meta-analiz Çalışması
No full textThe aim of this study is to determine the effect of educational practices designed in experimental research on children’s problem solving skills for the children aged 3-6 years attending pre-school education. In this context, a total of 1012 master’s/doctorate theses, of which 321 with the original scans and 691 supplementary scans, were examined between 1987-2021 (October) in Turkey. When the studies were examined according to the criteria, it was determined that 27 theses were suitable for meta-analysis.In the study, descriptive statistics data, publication bias, heterogeneity and effect sizes were analyzed with the Comprehensive Meta-Analysis Version 2 program. It was concluded in the analyzes that there was no publication bias and that the effect sizes of the studies had a heterogeneous distribution.When the effect of experimental education practices on children’s problem solving skills was analyzed in the random effects model, it was found that the effect size value was in favor of the experimental group. The obtained value shows that the educational practices designed in the experimental research for children aged 3-6 in preschool education have a higher level of effect on children’s problem solving skills compared to the Cohen d classification. When the moderator analysis results are examined, for the overall effect size; while reaching the conclusions that the age group of the children and the type of preschool education institution they attend, the type of thesis study, the department and university in which the thesis was made, the year the thesis was made, was’nt moderator; The institute where the thesis was made was found as a moderator variable for the overall effect size. © 2023,Milli Egitim.All Rights Reserved
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-? reveals anticancer effect in breast cancer
No full textBackground: Platelet derived growth factors (PDGF)-D and the expression of its receptor increase in neoplastic progression of cancer. Co-silencing of growth factor and receptor can be suggested as an important strategy for effective cancer therapy. In the present study, we hypothesized that suppression of PDGF-D signaling pathway with small interfering RNAs (siRNAs) targeting both PDGF-D and PDGF receptor (PDGFR)-beta is a promising strategy for anticancer therapy. Methods: Chitosan nanoplexes containing dual and single siRNA were prepared at different weight ratios and controlled by gel retardation assay. Characterization, cellular uptake, gene silencing and invasion studies were performed. The effect of nanoplexes on breast tumor growth, PDGF expression and apoptosis was investigated. Results: We have shown that downregulation of PDGF-D and PDGFR-beta with chitosan/siRNA nanoplex formulations reduced proliferation and invasion in breast cancer cells. In the in vivo breast tumor model, it was determined that the intratumoral administration of chitosan/siPDGF-D/siPDGFR-beta nanoplexes markedly decreased the tumor volume and PDGF-D and PDGFR-beta mRNA and protein expression levels and increased apoptosis. Conclusions: According to the results obtained, we evaluated the effect of PDGF-D and PDGFR-beta on breast tumor development and showed that RNAi-mediated inhibition of this pathway formulated with chitosan nanoplexes can be considered as a new breast cancer therapy strategy.Marmara University Scientific Research Projects Association; [SAG-B-110412-0075]ACKNOWLEDGEMENTS This study was supported by Marmara University Scientific Research Projects Association (grant number SAG-B-110412-0075)
Efficacy of antiviral therapy in the treatment of peripheral facial paralysis: A tertiary institution experience
No full textAim: For the treatment of peripheral facial paralysis, the superiority of the use of steroid alone and the use of steroid + antiviral over each other has not been clarified in the liter ature. In this study, the efficacy of using steroid treatment alone and using a combination of steroid+antiviral treatment in patients we followed up with peripheral facial paralysis in our clinic was questioned retrospectively. It was aimed to clarify the efficacy and su periority of steroid alone and steroid+antiviral therapy in patients with peripheral facial paralysis. Materials and Methods: One hundred and ten patients who received only steroids and 62 patients who received combination therapy were included in the study. Age, gender, regular drug use, smoking, previous history of facial paralysis, comorbid diseases, initial stage of the disease (House-Brackman/HB staging), treatment protocol and response to treatment were recorded from the files examined. Patients with HB stage ?2 at the 6th month follow-up were considered to have responded well or completely to the treatment. Results: When the group receiving only steroid treatment and the group receiving steroid + antiviral treatment were compared in terms of age, chronic drug use, gender, and previous facial paralysis, no statistically significant difference was observed. The groups were compared in terms of response to treatment, 88.2% improvement was observed in the steroid group (HB stage ?2), and 91.9% improvement was observed in the combined treatment group. No statistically significant difference was observed (p=0.605). Conclusion: For the treatment of peripheral facial paralysis, the superiority of steroid use alone and combined antiviral + steroid use has not been proven. In the light of the literature, it is recommended that the patient be treated with steroids at the earliest stage
Determining the awareness levels of social study teachers on ecological literacy
No full textBu çalışma ile Sosyal Bilgiler branşında lisans eğitimi alan öğretmen adaylarının ekolojik okuryazarlığa ilişkin farkındalık düzeylerinin belirlenmesi amaçlanmıştır. Çalışmada Sosyal Bilgiler öğretmen adaylarının ekolojik okuryazarlıkları, cinsiyet, bulunulan sınıf ve devam edilen üniversitenin bulunduğu il ile yaşanılan yerleşim birimi değişkenleri açısından değerlendirilip anlamlı farkların oluşup oluşmadığı incelenmiştir. İnsanın dünya üzerindeki varlığının devamı için doğa ve çevresi ile uyum içinde yaşaması esastır. Buda ancak doğanın koyduğu kurallara uygun ve sürdürülebilir bir yaşam tarzı ile mümkündür. İnsanın doğası ile sürdürülebilir bir yaşam kurmasının yolu eğitimden geçmektedir. Bu konudaki en büyük sorumluluk öncelikle kişinin kendisine, çevresine ve ailesine düşmektedir. Ek olarak hayatının büyük bölümü eğitim ortamlarında geçen yeni neslin çevre bilinci kazanması sürecinde, öğretmenlerimiz çok önemli sorumluluklar yüklenmektedir. Dolayısıyla öğretmenlerin yüklendikleri sorumluluk gereği üniversitede aldıkları eğitim ve konu ile ilgili takındıkları tutumlar da büyük öneme haizdir. Öğretmenlik eğitiminin devam ettiği süreçte bu durumun tespiti, yapılacakların ortaya çıkarılması ve farkındalık düzeyinin artırılması adına bu türden çalışmaların yapılması ve sayısal olarak artırılması gerekmektedir. Çalışmada nicel araştırma yöntemi ve betimsel desen kullanılmıştır. Çalışmanın evrenini 2022-2023 eğitim-öğretim yılında Türkiye'de öğrenim gören Sosyal Bilgiler öğretmen adayları oluşturmuştur. Araştırmada, "Ekolojik Okuryazarlık Ölçeği" kullanılmıştır. Çalışma sürecinde elde edilen verilerin analizi ve yapılan değerlendirmelerle Sosyal Bilgiler branşında eğitim alan aday öğretmenlerin ekolojik okuryazarlığa ilişkin farkındalık düzeylerinin çeşitli değişkenler açısından farklılık gösterip göstermediği belirlenmiştir.With this study, it was aimed to determine the awareness levels of pre-service teachers who received undergraduate education in the branch of Social Studies about ecological literacy. In the study, the ecological literacy of the Social Studies teacher candidates was evaluated in terms of gender, class, the province where the university attended and the place of residence were evaluated and whether there were any significant differences. It is essential for man to live in harmony with nature and his environment for the continuation of his existence on earth. This is only possible with a sustainable lifestyle in accordance with the rules set by nature. The way to establish a sustainable life with human nature is through education. The greatest responsibility in this matter falls primarily on the person himself, his environment and his family. In addition, our teachers take on very important responsibilities in the process of gaining environmental awareness of the new generation, who spend most of their lives in educational environments. Therefore, due to the responsibilities of teachers, the education they receive at the university and the attitudes they take on the subject are also of great importance. In the process of continuing teacher education, it is necessary to carry out such studies and increase them numerically in order to determine this situation, to reveal what to do and to increase the level of awareness. Quantitative research method and descriptive design were used in the study. The population of the study consisted of Social Studies teacher candidates studying in Turkey in the 2022-2023 academic year. In the research, "Ecological Literacy Scale" was used. With the analysis of the data obtained during the study and the evaluations made, it was determined whether the awareness levels of the novice teachers studying in the branch of Social Studies differ in terms of various variables
The effects of strength training with the TRX resistance band on selected motor performance parameters of adolescent basketball players
No full textAmaç: Güncel antrenman ekipmanları ve metodolojilerinin atletik performans üzerindeki etkilerinin araştırılmasının önemli olduğu düşünülmektedir. Bu araştırmanın amacı, süspansiyon antrenman temelli merkezi sütun kuvvet antrenmanlarının adölesan dönemdeki basketbolcuların seçilmiş motor becerileri üzerine etkisini belirlemektir. Materyal ve Metot: Araştırmaya, 22 adölesan erkek basketbolcu dahil edildi. Basketbolcular kontrol ve süspansiyon antrenman grubu olarak iki farklı gruba randomize yöntem ile ayrıldı ve süspansiyon antrenman grubu 16 birimden (8 hafta x 2 gün) oluşan antrenman sürecine dâhil edildi. Antrenmanlar öncesi ve sonrasında uygulanan doğrusal sprint, çeviklik, aktif dikey sıçrama, durarak uzun atlama, el kavrama kuvveti ve sağlık topu göğüs atış değerlerinin karşılaştırılmasında iki yönlü tekrarlı ölçümlerde varyans analizi ve bağımlı gruplarda t testi analizi kullanıldı. Bulgular: Araştırmaya dâhil edilen gruplar arasında antrenman öncesi demografik ve vücut kompozisyonu açısından anlamlılık farklılık tespit edilmedi (p>0.05). Araştırmada antrenman öncesinde gruplar arasında hiçbir test performansı açısından anlamlı farklılığa rastlanmadı (p>0.05). Ön test ve son test performans skorları incelendiğinde süspansiyon antrenman grubunun tüm doğrusal sprint ve çeviklik performansları (% ? = 3.4 – 4.9) ile kuvvet ve sıçrama performansları açısından (%? = 4.6 – 13.4) son testler lehine istatistiksel olarak gelişim olduğu tespit edildi (p 0.05). There was no significant difference between the groups in the study in terms of test performance before training (p > 0.05). When examining performance outcomes before and after training, the suspension training group was found to have an advantage (p < 0.05) in all linear sprint and agility performance (? = 3.4 - 4.9%) and strength and jumping performance (? = 4.6 - 13.4%). A statistical improvement was observed. Furthermore, with regard to the training method used, there were changes in favour of the training group in the effect of group, time and group x time interaction (effect size range = ?p2 = 0.334 – 0.841, p < 0.05). Conclusion: Regular suspension exercises are thought to provide significant benefits for basketball players in the adolescent developmental category who are sensitive to external stimuli
In vitro effects of neopterin on invasion, metastasis and proliferation of hepatocellular cancer cell lines
No full textJoint International Congress of the ILTS, ELITA and LICAGE -- MAY 03-04, 2023 -- Rotterdam, NETHERLANDS[Abstract Not Available]Int Liver Transplantat So
An investigation of mothers' early maladaptive schemas and their self-perceptions of parental roles (Explanatory mixed design)
No full textBu araştırmanın amacı, annelerin erken dönem uyumsuz şemaları ile ebeveyn rollerine ilişkin kendilik algılarını çeşitli değişkenler açısından incelemek ve annelerin bu konudaki görüşlerini derinlemesine araştırmaktır. Araştırmanın modeli karma yöntem araştırmalarından açıklayıcı karma desendir. Araştırmanın evreni Malatya ilinde yaşayan en az bir çocuğu olan kadınlardır. Araştırmanın nicel boyutunda annelerin erken dönem uyumsuz şemaları ile ebeveyn rollerine ilişkin kendilik algılarını tespit etmek için ilişkisel tarama modeli kullanılmıştır. Araştırmanın nitel boyutunda ise fenomenolojik araştırma yöntemi kullanılmıştır. Araştırmanın nicel kısmındaki veriler Young Şema Ölçeği Kısa Form-3, Ebeveyn Rolüne İlişkin Kendilik Algısı Ölçeği ve Kişisel Bilgi Formu ile toplanmıştır. Araştırmanın nitel kısmındaki veriler ise yarı yapılandırılmış görüşme formu ile toplanmıştır. Araştırmanın nicel kısmında 484 anne ile nitel kısmında ise 32 anne ile çalışılmıştır. Araştırmanın nicel verilerinde normallik ölçütünü sağlayanlarda t-Testi, Tek Yönlü Varyans Analizi ANOVA ve Pearson Moment Çarpım Korelasyon Katsayısı kullanılırken; normallik ölçütünü sağlamayanlarda ise Mann-Whitney U Testi, Kruskal Wallis-H Testi ve Spearman Sıra Farkları Korelasyonu kullanılmıştır. Araştırmanın nitel verilerinde içerik analizi yöntemi kullanılmıştır. Araştırmanın nicel verilerinin analizinde annelerin erken dönem uyumsuz şemalarının yaşa, ilk kez anne olma yaşına, öğrenim durumlarına göre farklılaştığı bulunmuştur. Annelerin ebeveyn rollerine ilişkin kendilik algıları ile ilk kez anne olma yaşı arasında bir ilişki olduğu; ebeveyn rollerine ilişkin kendilik algıları öğrenim durumlarına göre farklılaştığı bulunmuştur. Annelerin erken dönem uyumsuz şemaları ile ebeveyn rollerine ilişkin kendilik algıları arasında pozitif yönde bir ilişki olduğu tespit edilmiştir. Araştırmanın nitel verilerinin analizinde üç tema tespit edilmiştir: Bir kavram olarak annelik, annelik süreçleri ve çocukluk dönemine ilişkin algılar. Araştırmanın nicel ve nitel bulgularına ilişkin alanyazında destekleyici bulgulara ulaşılmıştır. Araştırmanın sonuçları doğrultusunda alan çalışanlarına, ilgili kurum ve kuruluşlara, araştırmacılara önerilerde bulunulmuştur.The aim of this study is to examine mothers' early maladaptive schemas and self-perceptions of parental roles in terms of various variables and to investigate mothers' views on this issue in depth. The model of the research is explanatory mixed design from mixed method research. The population of the study is women with at least one child living in Malatya province. In the quantitative dimension of the study, the relational screening model was used to determine mothers' early maladaptive schemas and their self-perceptions of parental roles. In the qualitative dimension of the study, phenomenological research method was used. The data in the quantitative part of the study were collected with Young Schema Scale Short Form-3, Self-Perception of Parental Role Scale and Personal Information Form. The data in the qualitative part of the study were collected with a semi-structured interview form. In the quantitative part of the study, 484 mothers and in the qualitative part, 32 mothers were studied. In the quantitative data of the study, t-Test, One-Way Analysis of Variance ANOVA and Pearson Product Moment Correlation Coefficient were used for those who met the normality criterion; Mann-Whitney U Test, Kruskal Wallis-H Test and Spearman Rank Differences Correlation were used for those who did not meet the normality criterion. Content analysis method was used in the qualitative data of the study. In the analysis of the quantitative data of the study, it was found that mothers' early maladaptive schemas differed according to age, age of first-time motherhood, and education level. It was found that there was a relationship between mothers' self-perceptions of parental roles and the age of becoming a mother for the first time; self-perceptions of parental roles differed according to their education level. It was found that there was a positive relationship between mothers' early maladaptive schemas and their self-perceptions of parental roles. Three themes were identified in the analysis of the qualitative data of the study: Motherhood as a concept, motherhood processes and perceptions of childhood. Supportive findings were found in the literature regarding the quantitative and qualitative findings of the study. In line with the results of the research, suggestions were made to the field workers, related institutions and organisations, and researchers
Mercy in Schopenhauer's moral philosophy
No full textBu çalışma Schopenhauer'un ahlak felsefesini ve ahlak felsefesinin temeline yerleştirdiği merhamet düşüncesini içermektedir. Filozof için insan dünyaya geldiği ilk andan itibaren, bireyselleşmesinin bir sonucu olarak bencilce davranır. İnsan bencilliğini yok edemezse eğer, bütün canlıları kendisi için bir rakip olarak görüp onların acı çekmesi için çabalar. Bundan dolayı filozof, ahlakın temeli olarak gördüğü merhamet ile insanın acı ve ıstırabını yok edip diğer canlılara acı çektirmesinin önüne geçer. Merhamet, insanı içine düştüğü ıstırap ve bencillikten kurtararak erdemli davranmaya iter. İnsanı var oluşun aldatıcılığından kurtararak, bütün canlılara karşı insaflı ve adaletli davranmasını sağlayan duygu merhamettir. Çünkü insan, bütün canlılara karşı içinde bencilce duyguları barındırdığı zaman, merhamet hissedip ahlaki davranamaz. İnsanın davranışlarının ahlaki olabilmesi için, bencillikten uzak durması gerekir. Dolayısıyla insanın hem kendi cinsine hem de diğer canlılara karşı, ahlaki davranmasını sağlayan temel duygu merhamettir. Merhamet insanın, diğer canlılarla arasındaki duvarı yıkıp onların acısını hissetmesine neden olur. Çünkü içinde merhamet hissetmeyen insan, acımasızlaşır. Acımasızlık ise, insanı nefrete götürerek bencilce davranmasına sebep olur. Merhamet duygusu, insanın içinde sevgi oluşturarak, bütün canlılara karşı acımasızca davranılmasının önüne geçtiği için çok önemlidir.This study includes the thinking of the schopenhauer's moral philosophy and the idea of mercy placed on the basis of the morality philosophy. In addition, the concepts of Schopenhauer with morality and mercy were examined. The philosopher reveals the philosophy of the philosophy as the emergence of the end of the struggle between people and the emergence of mercy. From the first moment the human is to the world, it treats as a result of its individualization. If human selflessness cannot destroy, if you see all its creatures as an opponent to himself and efforts to suffer. Therefore, it is in front of the pity that the philosopher has seen as the basis of the moral and the human suffering is not suffering and suffering to other creatures. The mercy person pushes to treat virtuous by recovering suffering and selfishness in which it falls into. The feeling is merciful by recovering the human being, the feeling of persistent and justice against all living things. Because human is unless selfless feelings in all living creatures, mercy feels mercy and behave moral. In order for man's behavior to become moral, he needs to stay away from selfishness. Therefore, the basic feeling of human being against both their own genus and other living things is the basic feeling. Thanks to the mercy of human, the phenomenal may not have the ruthlessness of the world and treat all living things. The mercy causes people to destroy the wall between other creatures and to feel their pain. Because the person who doesn't feel mercy is cruel. The ruthlessness causes the man to act selfishly by taking the human to hate. The feeling of mercy is very important to prevent love in human being in front of all living creatures. Therefore, we aim to explain the understanding of Schopenhauer and the sense of mercy where the morality and moral understanding of the morality is related to the concept of the morality
Treatment of Pneumocystis jirovecii Pneumonia with Caspofungin and Clindamycin: An HIV Patient and Literature Review
No full textThe first-line treatment for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim-sulfamethoxazole (TMP-SMZ). However, some cases require alternative agents due to the side effects of TMP-SMZ. Treatment with TMP-SMZ was initiated in an HIV-positive patient with microbiologically confirmed PCP, who presented with acute renal failure on admission. On the third day of treatment, TMP-SMZ was discontinued due to worsening renal function. Subsequently, clindamycin was initiated in combination with caspofungin. Although caspofungin-based therapies were shown to be effective against Pneumocystis in animal models, clinical experience in humans is limited. The patient was treated successfully with clindamycin combined with caspofungin
Mülteci Kadınlarda Üreme Sağlığı Problemleri
No full textFor centuries, people had to migrate due to wars, poverty, education, political, and religious reasons. Refugees need basic rights such as nutrition, shelter, education, and health in order to survive in the countries they go to. In our country, which has the largest immigrant population in the world with 4.9 million, the health problems of refugees greatly affect our health system. Refugee women, who are described as a special group due to the characteristics they have by nature, have problems especially in reproductive health. Women refugees, who make up the majority of refugees in the world, do not have adequate access to reproductive health services, and this may lead to an increased risk of sexually transmitted diseases, unwanted pregnancies, induced abortions, pregnancy complications, mother–infant illness, and death. However, refugee women experience health problems such as adolescent pregnancy, inadequate menstrual hygiene, menstrual irregularities, difficulties in accessing family planning methods, and insufficient time between pregnancies. Meeting the reproductive health needs of refugee women protects the health of refugee women in particular, while it protects the health of the society in general. The aim of this study is to compile the reproductive health problems of refugee women in the light of the literature. © 2023, AVES. All rights reserved