Repositorio de la Asociación Española de Neuropsiquiatría
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Enhancing high sensitive hydrogen detection of Bi2O3 nanoparticle decorated TiO2 nanotubes
No full textAn electrochemical anodization technique was used to create a hydrogen gas sensor based on TiO2 nanotubes decorated with bismuth oxide (Bi2O3). Bismuth nitrate pentahydrate (Bi(NO3)3 center dot 5H2O) was employed as the source material for Bi2O3. The resulting nanotubes were annealed at 500 degrees C, revealing an amorphous structure with a mixed phase of rutile and anatase. Platinum (Pt) electrodes, with a thickness of 100 nm, were coated onto the Bi2O3@TiO2/Ti and TiO2/Ti structures for sensor testing. Energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and field emission scanning electron microscopy (FESEM) were used to examine the structural, morphological, and surface properties of the Bi2O3@TiO2 and TiO2 nanotubes. The hydrogen sensing properties of the Pt/Bi2O3@TiO2/Ti and Pt/TiO2/Ti devices were evaluated at room temperature, with hydrogen concentrations ranging from 1000 ppm to 10 %. The I-V characterization of the sensor devices under 1 % H2 exhibited typical Schottky-type behavior. Remarkably, the Pt/Bi2O3@TiO2/Ti structure demonstrated a sensor response 1 x 107 times higher than that of in a dry air environment when the same voltage was applied under up to 1 % H2 conditions. The uniform dispersion of Bi2O3 nanoparticles throughout the structure contributed to the enhanced sensor response in the presence of H2.Malatya Turgut Ozal University Scientific Research Unit of Turkey (BAP) [2022/06]This study was funded by Malatya Turgut Ozal University Scientific Research Unit of Turkey (BAP, Project Number: 2022/06)
Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach
No full textThe proposed expert opinion aimed to address the current knowledge on conceptual, clinical, and therapeutic aspects of diabetic peripheral neuropathy (DPN) and to provide a guidance document to assist clinicians for the best practice in DPN care. The participating experts consider the suspicion of the disease by clinicians as a key factor in early recognition and diagnosis, emphasizing an improved awareness of the disease by the first-admission or referring physicians. The proposed screening and diagnostic algorithm involves the consideration of DPN in a patient with prediabetes or diabetes who presents with neuropathic symptoms and/or signs of neuropathy in the presence of DPN risk factors, with careful consideration of laboratory testing to rule out other causes of distal symmetric peripheral neuropathy and referral for a detailed neurological work-up for a confirmative test of either small or large nerve fiber dysfunction in atypical cases. Although, the first-line interventions for DPN are currently represented by optimized glycemic control (mainly for type 1 diabetes) and multifactorial intervention (mainly for type 2 diabetes), there is a need for individualized pathogenesis-directed treatment approaches for DPN. Alpha-lipoic acid (ALA) seems to be an important first-line pathogenesis-directed agent, given that it is a direct and indirect antioxidant that works with a strategy targeted directly against reactive oxygen species and indirectly in favor of endogenous antioxidant capacity for improving DPN conditions. There is still a gap in existing research in the field, necessitating well-designed, robust, multicenter clinical trials with sensitive endpoints and standardized protocols to facilitate the diagnosis of DPN via a simple and effective algorithm and to track progression of disease and treatment response. Identification of biomarkers/predictors that would allow an individualized approach from a potentially disease-modifying perspective may provide opportunities for novel treatments that would be efficacious in early stages of DPN, and may modify the natural course of the disease. This expert opinion document is expected to increase awareness among physicians about conceptual, clinical, and therapeutic aspects of DPN and to assist them in timely recognition of DPN and translating this information into their clinical practice for best practice in the management of patients with DPN.Abdi Ibrahim Pharmaceuticals TurkeyThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study was supported by Abdi Ibrahim Pharmaceuticals Turkey which played a role in organization of expert panel meetings including invitation of participants and compensation for the time and transport expenses of the experts. Abdi Ibrahim Pharmaceuticals Turkey had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study was supported by Abdi Ibrahim Pharmaceuticals Turkey which played a role in organization of expert panel meetings including invitation of participants and compensation for the time and transport expenses of the experts. Abdi Ibrahim Pharmaceuticals Turkey had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
The relationship between perceived principal management style and organizational support perception in special education schools
No full textEğitim Bilimleri Enstitüsü, Eğitim Bilimleri Ana Bilim Dalı, Eğitim Yönetimi Bilim DalıBu çalışmanın temel amacı özel eğitim okullarında görev yapan öğretmenlerin algıladıkları müdür yönetim tarzı ile örgütsel destek algıları arasındaki ilişkiyi incelemektir. Araştırmanın alt amaçları ise cinsiyet, branş, mesleki kıdem ve görev yapılan okuldaki hizmet süresi değişkenlerinin özel eğitim okullarında görev yapan öğretmenlerin algıladıkları müdür yönetim tarzı ile örgütsel destek algılarına göre anlamlı fark gösterip göstermediğini belirlemektir. Araştırmanın evrenini 2023-2024 eğitim öğretim yılında Malatya ilinde bulunan özel eğitim okullarında görev yapmakta olan 270 öğretmen oluşturmaktadır. Araştırmada evrenin tamamına ulaşılmaya çalışıldığı için örneklem alımına gidilmemiştir. Araştırma nicel araştırma yöntemlerinden ilişkisel tarama modeline göre tasarlanmıştır. Araştırmada veri toplama aracı olarak Algılanan Müdür Yönetim Tarzı ölçeği ve Örgütsel Destek Ölçeği kullanılmıştır. Elde edilen veriler istatistik paket programı kullanılarak analiz edilmiştir. Analizde betimsel istatistik, çarpıklık ve basıklık katsayıları, ikili bağımsız grup ortalamalarının karşılaştırılmasında t-testi, ikiden fazla bağımsız grup ortalamalarının karşılaştırılmasında tek yönlü varyans analizi kullanılmıştır. Grup karşılaştırmalarında ortaya çıkan anlamlı farklılığın hangi gruplar arasında olduğunu belirlemek için LSD testi, grup karşılaştırmalarında belirlenen anlamlı farklılığın derecesini/ölçüsünü belirlemek için etakare testleri kullanılmıştır. Araştırma sonuçlarına göre özel eğitim okullarında görev yapan öğretmenlerin algılarına göre özel eğitim okulu müdürlerinin en çok işbirlikli müdür yönetim davranışını sergiledikleri, en az ise ilgisiz yönetim tarzı davranışlarını sergiledikleri belirlenmiştir. Özel eğitim okullarında görev yapan öğretmenlerin müdür yönetim tarzına yönelik algılarının cinsiyet ve branş değişkenleri açısından anlamlı bir farklılık göstermediği, mesleki kıdemleri ve görev yapılan okuldaki hizmet süresi değişkenleri açısından ise anlamlı farklılık gösterdiği bulunmuştur. Özel eğitim okullarında görev yapan öğretmenlerin algılarına göre okul müdürleri öğretmenleri en çok örgütsel adalet ve iş koşulları boyutunda desteklediği, en az yönetim desteği boyutunda desteklediği görülmüştür. Özel eğitim okullarında görev yapan öğretmenlerin örgütsel desteğe yönelik algılarında ise cinsiyet, branş, mesleki kıdem ve görev yapılan okuldaki hizmet süresi değişkenine göre anlamlı farklılık göstermemektedir. Müdür yönetim tarzında anlamlı farklılık çıkan değişkenlerin etki büyüklüğü incelendiğinde, çıkan anlamlı farklılığın etki derecesinin düşük olduğu görülmüştür. Özel eğitim okullarında görev yapan öğretmenlerin algıladıkları müdür yönetim tarzı ile örgütsel destek algıları arasında anlamlı bir ilişki bulunmamaktadır. Boyutlar arası korelasyona bakıldığında algılanan müdür yönetim tarzının otoriter yönetim tarzı boyutu ile örgütsel desteğin yönetim desteği boyutu arasında anlamlı bir ilişki bulunmamaktadır. İşbirlikli yönetim tarzı boyutu ile örgütsel adalet, örgütsel ödüller ve iş koşulları boyutları arasında pozitif yönde yüksek ilişki, yönetim desteği boyutu ile pozitif yönde orta düzeyde ilişki bulunmaktadır. Otoriter yönetim tarzı boyutu ile örgütsel adalet, örgütsel ödüller ve iş koşulları boyutları arasında negatif yönde zayıf düzeyde ilişki bulunmaktadır. İlgisiz yönetim tarzı ile örgütsel adalet, örgütsel ödüller ve iş koşulları boyutları arasında negatif yönde orta düzeyde ilişki, yönetim desteği boyutu arasında negatif yönde zayıf düzeyde ilişki bulunmaktadır. Karşı koyucu yönetim tarzı boyutu ile örgütsel adalet, örgütsel ödüller ve iş koşulları ile yönetim desteği boyutları arasında ise negatif yönde orta düzeyde ilişki bulunmaktadır.The main purpose of this study is to examine the relationship between the principal management style perceived by teachers working in special education schools and their perceptions of organizational support. The sub-objectives of the study are to determine whether the variables of gender, branch, professional seniority and length of service in the school show a significant difference according to the perceptions of principal management style and organisational support perceptions of teachers working in special education schools. The population of the study consists of 270 teachers working in special education schools in Malatya in the 2023-2024 academic year. Since the entire population was tried to be reached in the study, sampling was not used. The research was designed according to the relational screening model, one of the quantitative research methods. Perceived Principal Management Style scale and Organizational Support Scale were used as data collection tools in the study. The data obtained were analysed using the statistical package programme. In the analyses, descriptive statistics, skewness and kurtosis coefficients, t-test for comparing the mean of two independent groups, one-way analysis of variance for comparing the mean of more than two independent groups were used. LSD test was used to determine between which groups there was a significant difference in the group comparisons, and the eta-square tests were used to determine the degree/measure of the significant difference in the group comparisons. According to the results of the research, according to the perceptions of the teachers working in special education schools, it was determined that special education school principals exhibited the most cooperative principal management behaviour and the least indifferent management style behaviours. It was found that the perceptions of teachers working in special education schools towards principal management style did not show a significant difference in terms of gender and branch variables, but showed a significant difference in terms of professional seniority and length of service in the school. According to the perceptions of teachers working in special education schools, school principals support teachers mostly in the dimensions of organizational justice and working conditions, and least in the dimension of management support. There is no significant difference in the perceptions of teachers working in special education schools towards organizational support according to gender, branch, professional seniority and length of service in the school. When the effect size of the variables with a significant difference in principal management style was analysed, it was seen that the effect size of the significant difference was low. There is no significant relationship between the principal management style perceived by teachers working in special education schools and their perceptions of organizational support. When the correlation between the dimensions is examined, there is no significant relationship between the authoritarian management style dimension of the perceived principal management style and the management support dimension of organizational support. There is a high positive relationship between the collaborative management style dimension and the dimensions of organizational justice, organizational rewards and working conditions, and a moderate positive relationship with the dimension of management support. There is a weak negative relationship between authoritarian management style dimension and organizational justice, organizational rewards and working conditions dimensions. There is a moderate negative relationship between the indifferent management style and the dimensions of organizational justice, organizational rewards and working conditions, and a weak negative relationship between the dimensions of management support. There is a moderate negative relationship between the dimension of confrontational management style and the dimensions of organizational justice, organizational rewards and working conditions and management support
The Impact of Bridge21 model applications on students' mathematical problem-solving skills, perceptions of 21st century skills and sociomathematical norms
No full textBu çalışmanın amacı Bridge21 öğrenme modelinin 8. sınıf öğrencilerinin matematiksel problem çözme becerilerine, matematik öğreniminde 21. yüzyıl beceri algılarına ve sosyomatematiksel normlarına etkisini incelemektir. Bu amaçlar doğrultusunda araştırma; bir ortaokulda seçmeli derste işbirlikli, proje tabanlı ve teknoloji aracılı Bridge21 öğrenme modeli çerçevesinde, problem çözme ve etkinlik yapma süreçleri boyunca hem öğretim hem de araştırma süreci yürütülerek gerçekleştirilmiştir. 2023-2024 eğitim-öğretim yılı güz döneminde gerçekleştirilen çalışmanın katılımcıları; amaçlı örnekleme yöntemine göre seçilmiş 8. sınıf öğrencileridir. İç içe (gömülü) karma desenin kullanıldığı çalışmada nitel aşamayı oluşturan ve ikincil yöntem olan durum çalışması, nicel aşamayı oluşturan ve baskın yöntem olan ön test son test kontrol gruplu yarı deneysel yöntemin içerisine iç içe geçirilmiştir. Böylece nitel aşamanın nicel aşamayı açıklaması sağlanmıştır. Nicel veriler araştırmacı tarafından geliştirilen "21. Yüzyıl Becerileri Algı Ölçekleri" ve "Matematiksel Problem Çözme Becerileri Testi" ile nitel veriler ise araştırmacı gözlemleri, yarı yapılandırılmış görüşmeler, etkinlik çalışma kâğıtları ve öğrenci günlüğü kullanılarak toplanmıştır. Araştırmanın uygulama aşaması araştırmacı tarafından geliştirilen günlük yaşam durumlarına ait matematiksel problem içeren 7 etkinlikle gerçekleştirilmiştir. Nitel verilerin analizinde betimsel analiz ve içerik analizi, nicel verilerin analizinde ise betimsel ve çıkarımsal istatistiksel analizler kullanılmıştır. Araştırmanın bulguları doğrultusunda Bridge21 öğrenme modelinin 8. sınıf öğrencilerinde matematiksel problem çözme becerilerinin ve problem çözme sürecindeki sosyomatematiksel normlarının gelişiminde etkili olduğu sonucuna ulaşılmıştır. Bununla birlikte modelin, 21. yüzyıl becerilerinden iletişim ve işbirliği ile insiyatif ve girişimcilik becerileri algısı üzerinde anlamlı bir etkisi bulunurken analitik beceriler ile bilgi işleme becerileri algısı üzerinde anlamlı bir etkisi bulunmadığı sonucuna ulaşılmıştır. Araştırmadan elde edilen sonuçlara göre çeşitli önerilerde bulunulmuştur.The aim of this study is to investigate the effect of the Bridge21 learning model on the 8th-grade students' mathematical problem-solving skills, perceptions of 21st-century skills in mathematics learning, and sociomathematical norms. In line with these objectives, the research was carried out in a middle school as part of an elective course, within the framework of the collaborative, project-based, and technology-assisted Bridge21 learning model, during both the teaching and research processes throughout problem-solving and activity completion. The participants of the study conducted in the fall semester of the 2023-2024 academic year were 8th-grade students selected through purposeful sampling. The study used an embedded mixed design, where the qualitative phase, consisting of a case study as the secondary method, was embedded within the quantitative phase, which was the dominant method using a pre-test and post-test control group quasi-experimental design. This ensured that the qualitative phase helped explain the quantitative phase. Quantitative data were collected using the "21st Century Skills Perception Scales" and the "Mathematical Problem Solving Skills Test," which were developed by the researcher. Qualitative data were gathered through researcher observations, semi-structured interviews, activity worksheets, and student diaries. The implementation phase of the research was carried out with 7 activities containing mathematical problems from real-life situations, developed by the researcher. Descriptive analysis and content analysis were used for the analysis of qualitative data, while descriptive and inferential statistical analyses were employed for the quantitative data. Based on the findings of the research, it was concluded that the Bridge21 learning model was effective in the development of mathematical problem-solving skills and sociomathematical norms during the problem-solving process of 8th-grade students. Furthermore, the model was found to have a significant effect on the perception of communication and collaboration, as well as initiative and entrepreneurship skills, while it did not have a significant effect on the perception of analytical skills and information processing skills. Based on the results of the study, various recommendations were made
The mediating role of psychological flexibility in the relationship between psychotic symptom severity and depression in individuals diagnosed with schizophrenia
No full textWhat is known about the subject? Psychotic symptoms and depression are common problems in people diagnosed with schizophrenia. Psychological flexibility is a skill that facilitates coping with difficulties. There is limited research on the role of psychological flexibility in the relationship between psychotic symptoms and depression in people diagnosed with schizophrenia.What does the article add to existing knowledge? This article investigates the role of psychological flexibility in the link between psychotic symptom severity and depression in people diagnosed with schizophrenia. The article shows that psychological flexibility partially mediates the relationship between psychotic symptom severity and depression. The article suggests that interventions aimed at improving psychological flexibility may be beneficial in reducing depressive symptoms in people diagnosed with schizophrenia.What are the implications for practice? Mental health nurses should consider psychotic symptom severity and psychological flexibility when assessing and intervening for depressive symptoms in people diagnosed with schizophrenia. Mental health nurses should receive training to improve psychological flexibility and pass this skill on to their patients. Mental health nurses should continue to research the effectiveness and outcomes of interventions aimed at improving psychological flexibility.IntroductionPsychological flexibility may help people diagnosed with schizophrenia (PWS) cope with their psychotic symptoms and reduce their depressive symptoms, but the mechanism of this effect is unclear.AimTo investigate whether psychological flexibility mediates the relationship between psychotic symptom severity and depression in PWS.MethodA cross-sectional study was conducted, in which a total of 111 PWS were assessed with DSM-5 Clinician-Rated Dimensions of Psychosis Symptom Severity, Calgary Depression Scale for Schizophrenia and Acceptance and Action Questionnaire. Data analysis was performed using SPSS 25 and PROCESS macro.ResultsSignificant correlations were found between psychotic symptoms, depression and psychological flexibility. Psychological flexibility partially mediated the relationship between psychotic symptom severity and depression.DiscussionPsychological flexibility could weaken the impact of psychotic symptom severity on depression in PWS. Higher psychotic symptoms were associated with lower psychological flexibility and higher depression.Implications for PracticeInterventions to improve psychological flexibility may prevent depressive symptoms in PWS. Psychiatric nurses can use psychological flexibility as a goal for evaluation and intervention
Evaluation of right ventricle functions using advanced ecocardiographic methods before and after the procedure in bone marrow transplant patients
No full textGiriş ve Amaç: Bu çalışmada kemik iliği transplantasyonu (KİT) öncesi ve sonrasında transtorasik ekokardiyografik değerlendirme ile, KİT sonrası erken dönemde ortaya çıkabilecek pulmoner vasküler değişikliklere bağlı olarak subklinik/klinik sağ ventrikül fonksiyon bozukluğunun tespit edilmesini amaçladık. Konvansiyonel ekokardiyografik yöntemlere ek olarak 4 boyutlu ejeksiyon fraksiyonu, speckle tracking imaging ve pulmoner arteriyel sertlik değerlendirmesi yapıldı. Metod: Çalışmaya 18-65 yaş arası allojenik veya otolog 45 kemik iliği nakil (KİT) yapılan hasta ve 45 sağlıklı kontrol grubu dahil edildi, ayrıca KİT yapılan hastaların 1. ay verileri de değerlendirmeye alındı. Her iki grubun sosyo-demografik özellikleri, laboratuvar verileri ve ekokardiyografik değerleri incelendi. Konvansiyonel ekokardiyografik incelemede, sağ ve sol ventrikül sistolik, diyastolik fonksiyonları ve sağ miyokardiyal performans indeksi (MPİ), tahmini sistolik pulmoner arter basıncı, pulmoner arter sertliği (PAS) ölçümleri değerlendirildi. 4 boyutlu ekokardiyografi ile sağ ventrikül ejeksiyon fraksiyonu, sağ ventriküler fraksiyonel alan değişimi değerlendirildi. Ayrıca Strain ekokardiyografi tekniği ile sağ ventrikül fonksiyonları değerlendirildi. Bulgular: Çalışmamızda Sağ ventrikül global (SaV GS) (-19,242±8,713'e karşı -22,33±1,638 p = 0,022) ve serbest duvar strain (SaV SDS) (-25,956±2,836'ya karşı - 28,211±2,103 p <0,001) KİT sonrası grupta kontrol grubuna göre anlamlı düşüktü. Ayrıca KİT yapılan grupta, kontrol grubuna göre 4B ekokardiyografi ile değerlendirilen sağ ventrikül ejeksiyon fraksiyonu (SaV EF) (52,311±2,465'e karşı 56,601±5,548 p<0,001), sağ ventriküler fraksiyonel alan değişimi (SaV FAD) (46,27±2,57'ye karşı 51,42±4,56 p <0,001) değerleri daha düşüktü. Sonuç: Bu çalışma ile KİT uygulanan hastalarda sağ kalp sistolik ve diyastolik fonksiyonlarının ve pulmoner arter sertliğinin etkilenebileceğini gösterdik. Bu açıdan KİT tedavisi ve hazırlık rejimi ilişkili kardiyotoksisite gelişme riski olan hastalarda koruyucu ve tedavi edici yaklaşımlara başlanması için, ileri ekokardiyografik tekniklerle değerlendirilmesinin gerekliliğine inanıyoruz. Anahtar Kelimeler: Kemik iliği nakil, Hematolojik hastalık, 4B Ekokardiyografi Strain, transtorasik ekokardiyografiIntroduction and Objective: In this study, we aimed to measure pulmonary artery stiffness (PAS) before and after BMT and to evaluate the right ventricle with advanced echocardiographic methods to detect subclinical/clinical right ventricular dysfunction and pulmonary vascular changes that may develop after BMT. Method: 45 allogeneic or autologous bone marrow transplantation (BMT) patients between the ages of 18-65 and 45 healthy control groups were included in the study, and the 1st month data of the patients who underwent BMT were also evaluated. Socio-demographic characteristics, laboratory data and echocardiographic evaluations of both groups were analyzed. In conventional echocardiography, right and left ventricular systolic and diastolic diameters and right myocardial performance index (MPI), right ventricular diastolic function, estimated systolic pulmonary artery pressure and pulmonary artery stiffness (PAS) measurements were evaluated. With 4- dimensional echocardiography, right ventricular diastolic and systolic volumes, right ventricular ejection fraction, and right ventricular fractional area change were evaluated. In addition, right ventricular strain was evaluated by Strain echocardiography. Results: In our study, right ventricular global (SaV GS) (-19.242±8.713 vs.- 22.33±1.638 p = 0.022) and free wall strain (SaV FWS) (-25.956±2.836 vs.- 28.211±2.103 p <0.001) in the post-BMT group were significantly lower than the control group. In the BMT group, compared to the control group, right ventricular ejection fraction (RAV EF)(52.311±2.465 VS 56.601±5.548 p<0.001), right ventricular fractional area change (RAV FAC) (46.27±2.57 vs 51.42± 4.56 p<0.001) values were lower. Conclusion: In this study, we demonstrated that right heart systolic and diastolic functions and pulmonary artery stiffness may be affected in patients undergoing BMT. In this respect, we believe that patients at risk of developing cardiotoxicity associated with BMT treatment and preparation regimen should be evaluated with advanced echocardiographic techniques to initiate preventive and therapeutic approaches. Keywords: Bone marrow transplantation, Hematologic disease, 4B Echocardiography Strain, transthoracic echocardiograph
Deep phenotyping of miRNAs in exercise-induced cardiac hypertrophy and fibrosis
No full textCardiac hypertrophy (CH) is an adaptational enlargement of the myocardium, in exposure to altered stress conditions or in case of injury which can lead to heart failure and death. MicroRNAs (miRNAs) are non-coding RNAs that play a significant role in modulating gene expression. Here, we aimed to identify new miRNAs effective in an experimental CH model and to find an epigenetic biomarker that could demonstrate therapeutic targets responsible for the pathology of heart tissue and serum. In this study, Sprague-Dawley male rats were divided into the training group (TG, n=9) and the control group (CG, n=6). Systolic and diastolic dimensions of the left ventricle and myocardial wall thickness were measured by echocardiography to assess CH. After the exercise program of the rats, miRNA expression measurements and histological analyses were performed. The 25,000 genes in the rat genome were searched using microarray analysis. A total of 128 miRNAs were selected according to the fold change rates, and nine miRNAs were validated for expression analysis. The terminal deoxynucleotidyl transferase dUTP nick (TUNEL) method was used to detect apoptotic cells. Cell proliferation was evaluated by the proliferative cell nuclear antigen (PCNA) method. Necrosis, bleeding, and intercellular edema were detected in TG. The mean histopathological score was higher in TG (p=0.03). There were rarely positive cells for apoptosis of both groups in cardiomyocytes. In the receiver characteristic curve analysis (ROC), the heart tissue rno-miR-290 had an area under the curve (AUC) of 0.920 with 100% sensitivity and 89.90% specificity (p=0.045), rno-miR-194-5p had AUC of 0.940 with 83.33% sensitivity and 100% specificity (p=0.003), and the serum rno-miR-132-3p AUC was 0.880 with 66.67% sensitivity and 100% specificity (p=0.004) in TG. miR-194-5p was used as a therapeutic target for remodeling the cardiac process. While miR-290 contributes to CH as a negative regulator, miR-132 in serum is effective in the pathological and physiological cardiac remodeling process and is a candidate biomarker.Scientific Research Projects Unit of Istanbul University [48783]This work was supported by the Scientific Research Projects Unit of Istanbul University (Project No.: 48783)
Hepatoprotective effects of N-acetylcysteine on liver injury by irisin upregulation and oxidative stress reduction in diabetic rats
No full textBackgroundThe current study aimed to investigate the oxidative stress in rat liver with diabetes mellitus (DM) as well as the protective effects of N-acetylcysteine (NAC) on irisin expression.MethodsTwenty-eight male Wistar rats were divided into four groups, 7 rats in each group, and 30-day regimens of experimental or control groups. NAC-treated group is as follows: 100 mg/kg once daily was administered intraperitoneally (i.p.). Diabetes-induced group is as follows: single-dose intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) was used to induce DM in overnight fasting Wistar rats. By determining blood glucose concentration in STZ-induced rats 72 h after injection of STZ, DM was assessed. DM + NAC group is as follows: STZ-induced DM plus NAC is described previously. On the 30th day of the experiment, liver samples were collected after fasting and anesthesia. Biochemical analyses were performed to measure total antioxidant status (TAS), total oxidant status (TOS), and malondialdehyde (MDA) levels. Each liver sample was weighed and then prepared for histopathologic evaluation by light microscopy.ResultsThere was a statistically significant decrease in TAS levels and an increase in TOS and MDA levels in the DM group compared to the control group. In contrast, TOS and MDA levels were found significantly decreased, and TAS levels increased in the serum and liver tissues of the DM + NAC group compared to the DM group. Liver samples were also used for histopathological examination using hematoxylin-eosin and immunohistochemical staining. STZ-induced liver damage was detected as oxidative stress, increased irisin immunoreactivity, sinusoidal dilatation, and hepatocyte degeneration. In the DM + NAC group, it was observed that NAC significantly reduced the aforementioned histopathological changes due to STZ.ConclusionIn the early period of diabetes, due to the antioxidant properties of irisin related to the sudden response of liver tissue to oxidative stress, it is thought that the immunoreactivity in the tissue increases in the early period. As a result, NAC in diabetic rat liver tissue was found to suppress oxidative damage and irisin immunoreactivity
Can myocardial dysfunction be detected in patients with rheumatoid arthritis with no cardiac symptoms?
No full textOBJECTIVE: The aim of our study was to investigate the role of tissue Dop-pler and Myocardial Performance Index (MPI) in evaluating cardiac involvement in patients with rheumatoid arthritis (RA) with no cardi-ac symptoms, to determine whether these mea-surements differ between healthy controls and RA patients, and whether they can be used to determine the risk of cardiovascular disease and predict prognosis.PATIENTS AND METHODS: 50 RA patients fulfilling the 2010 American College of Rheuma-tology/European League Against Rheumatism (ACR/EULAR) RA criteria and 50 healthy volun-teering controls were included in the study. All patients and controls were assessed using elec-trocardiography (ECG), echocardiography, con-ventional Doppler echocardiography and tissue Doppler echocardiography. MPI values were cal-culated. In addition, RA patients were compared after being divided into two subgroups: sero-positive and seronegative RA. Disease activi-ty levels of the patients were determined based on Disease Activity Score in 28 Joints (DAS28).RESULTS: The control group and RA group were compared in terms of PR interval, left atrial diameter, E/A, E/e', and MPI values. Comparisons between the groups yielded statistically signifi-cant differences in left atrial diameter, E/A, E/e', and MPI values and no significant difference in PR intervals. These parameters were also com-pared between seropositive and seronegative pa-tients. Left atrial diameter was significantly high-er in seronegative patients than in seropositive patients. There was no significant difference in the other values. DAS28 scores had no correla-tion with cardiac parameters.CONCLUSIONS: Early detection of ventricu-lar dysfunction in RA may be useful in clinical practice when predicting prognosis and optimiz-ing treatment. The present study found that RA patients had impaired tissue Doppler measure-ments and MPI results compared to controls. MPI and tissue Doppler may be useful in early detection of ventricular dysfunction
Effects of Cerebral Glucagon Administration on Blood Glucose Homeostasis in Rats
No full text[Abstract Not Available