Repositorio de la Asociación Española de Neuropsiquiatría
Not a member yet
6227 research outputs found
Sort by
Testing multi-factor financial asset pricing models on participation indices
No full textFinansal piyasalarda, hisse senedi getirilerini etkileyen faktörler her dönem ilgi görmüştür. Son dönemlerde özellikle çok faktörlü finansal varlık fiyatlama modellerinin geliştirilmesiyle bu ilgi daha da artmıştır. Bu çalışmada çok faktörlü finansal varlık fiyatlama modellerinin Katılım 30 endeksi özelinde test edilmesi amaçlanmıştır. Bu amaçla literatürde yaygın olarak kullanılan beş model test edilmiştir. Bu modeller, Zamanlararası Varlık Fiyatlama Modeli (ZVFM), Fama-French Üç Faktör Modeli (FF3F), Carhart Dört Faktör Modeli, Fama-French Beş Faktör Modeli (FF5F) ve Q-Faktör modelidir. Çalışmanın odak noktalarından biri de hangi modelin Katılım 30 endeksinin hisse senedi getirilerini açıklamada en iyi performansa sahip olduğunun tespit edilmesidir. Çalışmada, Katılım 30 endeksinde yer alan ve kesintisiz verilerine ulaşılabilen 18 firmanın 2011-2023 dönemi arasındaki mali tablolarından elde edilen çeyrek dönemlik verileri kullanılmıştır. Çalışmada, modellere ait değişkenler hesaplanma yöntemlerine uygun bir biçimde hazırlanarak analize uygun hale getirilmiştir. Veriler, Eviews 10 paket programı kullanılarak ARDL Sınır Testi ile analiz edilmiştir. Elde edilen sonuçlara göre, modeller içerisinde Katılım 30 endeksi açısından hisse senedi getirilerini en iyi açıklayan modelin FF3F modeli olduğu kanısına varılmıştır. Modelde yer alan RMRKT (Pazar getirisi), SMB (Büyüklük) ve HML (Defter Değeri/Piyasa Değeri) faktörlerinin hepsinin istatistiki açıdan anlamlı olduğu ve katsayılarının da teoriyle uyumlu olduğu görülmüştür. Ayrıca Carhart Dört Faktör ve Q-Faktör modellerinin sonuçlarına bakıldığında istatistiki açıdan anlamlı ve katsayıları teoriyle uyumlu olan faktörlerin olduğu görülmüştür. Söz konusu iki modelin de Katılım 30 endeksinde uygulanabilir olduğu düşünülmektedir. Ayrıca ZVFM ve FF5F modellerinin de analiz sonuçlarına göre Katılım 30 endeksinde uygulanabilir oldukları söylenebilmektedir
Investigation of the effect of variable-sized energy dissipating blocks on sluice gate performance
No full textThe present research used a combination of experimental and numerical methods to investigate energy dissipation blocks of different heights placed downstream of a sluice gate in an open channel flow. Numerical model simulations were performed using a 3D computational fluid dynamics (CFD) technique, using the Reynolds-averaged Navier-Stokes (RANS) equations with the volume of fluid (VOF) and k-epsilon turbulence models. The accuracy of the numerical model and the grid sensitivity was assessed according to a recommended procedure in the literature. Different hydraulic and geometry conditions were investigated to understand the energy dissipation behaviour of the blocks. The hydrodynamic effects of different block spacings, heights and configurations were analysed by means of CFD simulations. The results show that the variable size blocks have a high energy dissipation efficiency in sluice gate flows, particularly at high Froude numbers. The energy dissipation efficiency of the blocks downstream of a sluice gate can reach up to 55% for high discharges (Q = 35 L/s). Interestingly, the energy dissipation performance of small gate openings exceeds that of large gate openings, reaching a peak efficiency of 40% for the same discharge. In addition, the block spacing has a minimal effect on the energy dissipation, while smaller block spacing results in a smoother water surface profile
Some physiological and biochemical responses to Ag nanoparticle and epibrassinolid treatment against drought stress in Helianthus annuus L.
No full textBu araştırmada, kuraklık stresi altındaki Helianthus annuus L. tohumlarına uygulanan Ag nanopartikülü (Ag NP) ve Epibrassinolide (EBL) karşı verilen cevaplar araştırıldı. Çimlenme öncesi tohumlara ayrı ayrı EBL (0.5 nM) ve Ag NP (10 nm)'nin uygulandığı deney gruplarına 2.95 bar ve 4.91 bar PEG içeren dozlarda kuraklık uygulaması yapıldı. Bu gruplarda; fotosentetik pigment sistemi, antioksidan enzim aktivitelerinden POD, APX, SOD, CAT, askorbik asit ile H2O2, MDA, prolin ve oransal su içeriği (OSİ) üzerindeki değişimler günlere bağlı olarak değerlendirildi.PEG'in 2.95 bar ve 4.91 bar uygulandığı EBL gruplarında Kl a ve toplam Kl miktarı 5. günlerde artarken, Kl b ve karotenoid miktarında önemli bir değişim gözlenmedi. POD, APX ve SOD seviyelerinde 3. ve 5. günlerde, katalaz seviyesinde ise 3. günde artış gözlendi. Askorbik asit, H2O2, MDA ve prolin miktarında 3. ve 5. günlerde artış gözlendi. OSİ miktarı ise 3. günde 2.95 bar'da artıp, 4.91 bar'da azalma gösterdi. PEG'in 2.95 bar ve 4.91 bar uygulandığı Ag NP gruplarında Kl a, Kl b, toplam Kl ve karotenoid miktarları 3. günlerde artmakla birlikte 5. günlerde azalma saptandı. POD, APX ve SOD seviyeleri 3. ve 5. günlerde artış gösterirken katalaz seviyesinde ilerleyen günlerde azalma gözlendi. Askorbik asit, H2O2 ve prolin seviyesi de günlere bağlı olarak artış gösterdi. MDA ve OSİ miktarları ise 3. günde 2.95 bar'da artarken 4.91 bar'da azalma gösterdi. Bulgularımız kuraklık stresi altındaki H. annuus L. bitkisine uygulanan EBL ve Ag NP'nin kuraklığa karşı toleransda etkili olduğunu göstermektedir.In this study, the responses of Helianthus annuus L. seeds to epibrassinolide (EBL) and Ag nanoparticles (Ag NP) on drought stress were investigated. The experimental groups in which EBL (0.5 nM) and Ag NP (10 nm) were applied to the seeds separately before germination were subjected to drought treatment at 2.95 bar and 4.91 bar PEG containing doses. Changes in photosynthetic pigment system, antioxidant enzyme activities such as POD, APX, SOD, CAT, ascorbic acid, H2O2, MDA, proline and relative water content (RWC) were evaluated in these groups depending on days. In EBL groups in which PEG was applied at 2.95 bar and 4.91 bar, Kl a and total Kl levels increased on day 5th, while no significant change was observed in Kl b and carotenoid levels. POD, APX and SOD levels increased on days 3rd and 5th and catalase level increased on day 3rd. Ascorbic acid, H2O2, MDA and proline levels increased on days 3rd and 5th. OSI increased at 2.95 bar and decreased at 4.91 bar on day 3rd. In Ag NP groups in which PEG was applied at 2.95 bar and 4.91 bar, Kl a, Kl b, total Kl and carotenoid amounts increased on the 3rd day but decreased on the 5th day. POD, APX and SOD levels increased on days 3 and 5, while catalase level decreased on the following days. Ascorbic acid, H2O2 and proline levels also increased depending on the days. MDA and OSI levels increased on day 3rd at 2.95 bar and decreased at 4.91 bar. Our findings indicate that EBL and Ag NP applied to H. annuus L. plants under drought stress were effective in drought tolerance
Investigation of the Relationship Between Science Motivation and the 21st Century Skill Levels of Secondary School Students
No full textThis study aimed to comprehensively examine the relationship between science motivation and the 21st-century skill levels of secondary school students. The study was conducted according to the quantitative methodology using the correlational survey method. The convenience sampling approach was adopted in the study. The study group was analyzed in terms of gender and grade level variables. Additionally, the measurement models created for middle school students' Science Motivation (SM) and 21st-Century Skills (21st-CS), as well as the theoretical structural model was created. The study included 507 secondary school students (252 females, 255 males). Based on the results of the study, reviewing SM scale and its sub-dimensions, there was no significant difference between genders in the dimensions except for Intrinsic Motivation. In addition, a significant difference was found between the grade levels in terms of (SM) level. There was no significant difference in the different sub-dimensions of the 21st-CS according to gender; however, a significant difference was found in terms of grade levels. Generally, positive correlations were found between the sub-dimensions of the SM scale and the sub-dimensions of the 21st-CS levels. Additionally, there is a statistically significant relationship between science motivation and cognitive skill, affective skill, and socio-cultural skill. These findings emphasize that science education and motivation in this field may play a significant role in the development of 21st-CS
Exploring the quadriceps muscle architecture variations in various sports disciplines: a comparative analysis of football, taekwondo, and athletics
No full textBACKGROUND: The purpose of this study was to comprehensively investigate and compare the architecture of the quadriceps muscle in football, taekwondo, and athletics, shedding light on potential differences and providing valuable insights for athletic training and performance enhancement. METHODS: Thirty-five athletes (football[N.]=14. [7 women, 7 men]; taekwondo [N.]=11. [6 women, 5 men]; athletics [N.]=10. [5 women, 5 men]) aged 17-21 years participated in the study. After participant demographic data were collected, 2D real-time B -mode ultrasound (USG) and right (R) and left (L) leg quadriceps muscle group rectus femoris (RF), vastus intermedius (VI), vastus lateralis, pennation angle (PA), RF cross-sectional area (CSA), and subcutaneous fat thickness were determined. RESULTS: In the study, in female athletes, R-RF+VI (P=0.04, ES:4.34), R -VI (P=0.01, ES: 6.1), R-RF: (P=0.009, ES: 7.9), R-CSA (P=0.04, ES: 5.2), L-RF (P=0.002, ES: 10.4) and L-CSA (P=0.007, ES: 7.7) significant differences were found in favor of the Football group. In male athletes, R-CSA (P=0.004, ES: 9.05), L-RF (P=0.05, ES: 3.5) and L-SFT (P=0.00, ES: 13.6), there was a significant difference in favor of the Football group. L -PA (P=0.009, ES: 6.2). L -PA (P=0.009, ES: 6.2) was significantly higher in the male Taekwondo group. CONCLUSIONS: Our research findings show that there is a significant relationship between the type of exercise performed and the structural differences observed in the quadriceps muscle. Consequently, it is highly recommended to consider the outcomes of our study for enhancing the efficacy of training programs in the domains of football, taekwondo, and athletics
Association of BK and CMV positivity with magnesium levels in renal transplant recipients
No full textTıp Fakültesi, İç Hastalıkları Ana Bilim DalıGiriş ve Amaç: Renal transplant alıcılarında hipomagnezemi, BK polyomavirus (BKV) ve sitomegalovirus (CMV) enfeksiyonları nakil sonrası görülebilen önemli komplikasyonlardandır. Biz de çalışmamızda Mg düzeyi ile BKV ve CMV pozitifliği arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya İnönü Üniversitesi Turgut Özal Tıp Merkezinde 01 Ocak 2000 ile 31 Ocak 2023 tarihleri arasında renal transplantı gerçekleşmiş veya bu tarihler arasında dış merkezlerde nakil olup renal transplant alıcısı olarak nefroloji polikliniğinde en az üç ay süreyle takipli, 18 yaşından büyük 527 (359 erkek,168 kadın) hasta dahil edilmiştir. Hasta verilerinin incelenmesi hasta dosyaları ve ENLİL bilgisayar otomasyon sistemi kullanılarak retrospektif olarak yapılmıştır. Bulgular: Çalışmaya alınan 527 hastanın 359 (%68,1)'u erkek 168 (%32,9)'i kadındı. Hastaların yaş ortalaması 45.4 +12,1 (22-83) yıl idi. Hastaların 306'sında (%58) hipomagnezemi görüldü. Hipomagnezemi olanlarda BKV PCR pozitif olanların oranında yüzdesel olarak artış olduğu görülse de hipomagnezemi ile BKV PCR pozitifliği arasında istatistiksel olarak anlamlı ilişki saptanmadı (p>0,05). Hipomagnezemi ile CMV PCR pozitifliği arasında da istatistiksel olarak anlamlı ilişki saptanmadı (p>0,05). BKV ve CMV PCR sonrası negatiflikte Mg desteği ile hipomagnezemi arasındaki ilişki incelendiğinde istatiksel olarak anlamlı ilişki saptanmadı (p>0,05). Sonuç: Renal transplant alıcılarında her ne kadar BKV ve CMV PCR pozitiflikleri ile hipomagnezemi arasında anlamlı ilişki saptanmasa da yüzde olarak bakıldığında BKV enfeksiyonunun hipomagnezemisi olan hastalarda daha fazla görülmesi böbrek nakli hastalarında enfeksiyondan korunmak için Mg düzeyinin göz önünde bulundurulması gerektiğini düşündürmektedir. Anahtar Kelimeler: Renal transplant, hipomagnezemi, BKV CMV PCRIntroduction and purpose: Hypomagnesemia, BK polyomavirus (BKV) and cytomegalovirus (CMV) infections are important post-transplant complications in renal transplant recipients. In our study, we aimed to investigate the relationship between Mg levels and BKV and CMV positivity. Materials and methods: The study included 527 patients (359 males, 168 females) older than 18 years of age who had undergone renal transplantation at Inönü University Turgut Özal Medical Center between January 1, 2000 and January 31, 2023 or who had received renal transplantation in foreign centers between these dates and were followed up in the nephrology outpatient clinic for at least three months as renal transplant recipients. Patient data were analyzed using patient files and ENLIL computer automation system. Results: Of the 527 patients included in the study, 359 (68.1%) were male and 168 (32.9%) were female. The mean age of the patients was 45.4 +12.1 (22-83) years. Hypomagnesemia was observed in 306 patients (58%). Although there was an increase in the percentage of BKV PCR positive patients in those with hypomagnesemia, there was no statistically significant relationship between hypomagnesemia and BKV PCR positivity (p>0.05). There was no statistically significant relationship between hypomagnesemia and CMV PCR positivity (p>0.05). When the relationship between Mg supplementation and hypomagnesemia in BKV and CMV PCR negativity was analyzed, no statistically significant relationship was found (p>0.05). Conclusion: Although no significant correlation was found between BKV and CMV PCR positivity and hypomagnesemia in renal transplant recipients, the fact that BKV infection is more common in patients with hypomagnesemia suggests that Mg level should be taken into consideration to prevent infection in renal transplant patients. Key Words: Renal transplant, hypomagnesemia, BKV CMV PC
Effects of core stabilization exercises on sexual function, pain, sleep and quality of life in women with fibromyalgia
No full textSağlık Bilimleri Enstitüsü, Fizyoterapi ve Rehabilitasyon Ana Bilim DalıAmaç: Çalışmanın amacı fibromiyaljili kadınlarda core stabilizasyon egzersizlerinin cinsel fonksiyon, ağrı, uyku ve yaşam kalitesi üzerine etkilerinin incelenmesidir. Materyal Metod: 25-60 yaş aralığında, fibromiyalji tanılı 48 hasta randomizasyonla takipli ev egzersizi ya da core stabilizasyon egzersiz gruplarından birine atandı. Program 8 hafta, haftanın 2 günü her seans 30 dakika olarak verildi. Hastaların demografik bilgileri alındı. Ağrı VAS; hastalık şiddeti RFEA; pelvik taban semptomlarının yaşam kalitesine etkisi PTEA-7; cinsel fonksiyon KCİÖ; uyku kalitesi PUKİ ile; yaşam kalitesi ise Kısa Form SF-36 ile değerlendirildi. Bulgular: Grup içi karşılaştırmada her iki grupta da ağrı skorlarında, RFEA skorunda, PTEA-7'nın, KCİÖ'nün, PUKİ'nin ve SF-36 tüm alt skorlarında anlamlı fark bulundu (p<0.05). Gruplar arası karşılaştırma da RFEA skoru, KCİÖ'nün tüm alt parametrelerinde ve SF-36'nın emosyonel rol, fiziksel fonksiyon, zindelik/yorgunluk, fiziksel rol, sosyal fonksiyon ve ağrı parametrelerinde core stabilizasyon egzersizlerinin anlamlı olarak daha üstün olduğu bulundu (p<0.05). Sonuç: Fibromiyaljili hastalarda core stabilizasyon egzersizlerinin ve takipli ev egzersizlerinin ağrı ve hastalık şiddetini azaltmada, cinsel fonksiyon, uyku ve yaşam kalitesinin iyileştirilmesinde olumlu etkileri olduğu; ayrıca core stabilizasyon egzersizlerinin hastalık şiddetini azaltma, cinsel fonksiyon ve yaşam kalitesini iyileştirme açısından daha üstün etkileri olabileceği bulundu. Fibromiyalji, Core stabilizasyon egzersizleri, Ağrı, Cinsel fonksiyon, Yaşam kalitesiPurpose: The aim of the study was to investigate the effects of core stabilization exercises on sexual function, pain, sleep and quality of life in women with fibromyalgia. Material Method: 48 patients with fibromyalgia between the ages of 25-60 were randomly assigned to either home exercise or core stabilization exercise groups. The program was given for 8 weeks, 2 days a week, each session lasting 30 minutes. Demographic information of the patients was obtained. Pain was assessed using VAS; disease severity using FQIR; the effect of pelvic floor symptoms on quality of life using PFIQ-7; sexual function using FSFI; sleep quality using PSQI; and quality of life using Short Form SF-36. Results: In the intragroup comparison, significant differences were found in pain scores, FQIR scores, PFIQ-7, FSFI, PSQI and all subscores of SF-36 in both groups (p<0.05). In the comparison between the groups, it was found that core stabilization exercises were significantly superior in FQIR score, all subparameters of FSFI and emotional role, physical function, fitness/fatigue, physical role, social function and pain parameters of SF-36 (p<0.05). Conclusion: Core stabilization exercises and home exercises with follow-up have positive effects in reducing pain and disease severity, improving sexual function, sleep and quality of life in patients with fibromyalgia; it was also found that core stabilization exercises may have superior effects in terms of reducing disease severity, improving sexual dysfunction and quality of life. Keywords: Fibromyalgia, Core stabilization exercises, Pain, Sexual dysfunction, Quality of lif
Manipulating Local Chemistry and Coherent Structures for High-Rate and Long-Life Sodium-Ion Battery Cathodes
No full textLayered sodium transition-metal (TM) oxides generally suffer from severe capacity decay and poor rate performance during cycling, especially at a high state of charge (SoC). Herein, an insight into failure mechanisms within high-voltage layered cathodes is unveiled, while a two-in-one tactic of charge localization and coherent structures is devised to improve structural integrity and Na+ transport kinetics, elucidated by density functional theory calculations. Elevated Jahn-Teller [Mn3+O6] concentration on the particle surface during sodiation, coupled with intense interlayer repulsion and adverse oxygen instability, leads to irreversible damage to the near-surface structure, as demonstrated by X-ray absorption spectroscopy and in situ characterization techniques. It is further validated that the structural skeleton is substantially strengthened through the electronic structure modulation surrounding oxygen. Furthermore, optimized Na+ diffusion is effectively attainable via regulating intergrown structures, successfully achieved by the Zn2+ inducer. Greatly, good redox reversibility with an initial Coulombic efficiency of 92.6%, impressive rate capability (86.5 mAh g(-1) with 70.4% retention at 10C), and enhanced cycling stability (71.6% retention after 300 cycles at 5C) are exhibited in the P2/O3 biphasic cathode. It is believed that a profound comprehension of layered oxides will herald fresh perspectives to develop high-voltage cathode materials for sodium-ion batteries.National Natural Science Foundation of China [52325405, U21A20284, 52261135632]; National Natural Science Foundation of China [2023XQLH069, 2023XQLH070]; Postgraduate Innovative Project of Central South University; High-Performance Computing Center of Central South UniversityThis work was financially supported by the National Natural Science Foundation of China (52325405, U21A20284, 52261135632) and Postgraduate Innovative Project of Central South University (2023XQLH069, 2023XQLH070). The authors express gratitude for the technical assistance provided by the High-Performance Computing Center of Central South University. The soft XAS measurements were performed at the U19 station in the National Synchrotron Radiation Laboratory (NSRL). Additionally, the authors extend their appreciation to the Shiyanjia Lab (www.shiyanjia.com) for their support in characterizations
The Effect of Cognitive Behavioral Therapy-Based Psychoeducation on Anger Management and Death Anxiety in Individuals Receiving Chemotherapy: A Randomized Controlled Trial
No full textThis study was conducted to examine the effect of Cognitive Behavioral Therapy (CBT)-based psychoeducation on anger control and death anxiety in individuals receiving chemotherapy. The research was completed as a pretest-posttest experimental design with 80 individuals who received chemotherapy (40 control, 40 experimental). The data were collected using the Personal Information Form, the Controlled Anger Scale (CAR), and the Death Anxiety Scale (DAS). Individuals in the experimental group received eight sessions of CBT-based psychoeducation. We used percent distribution, chi-square test, and t test for dependent and independent groups were used to analyze the data. This study demonstrated that the gap among between the pretest and posttest total scores of the anger scale and death anxiety scale of the individuals in the CBT-based psychoeducation experimental group receiving chemotherapy was statistically significant (p < .05). CBT-based psychoeducation can be recommended as a professional psycho-oncology practice to improve the anger and anxiety in individuals with cancer
Clinical features, diagnosis and treatment outcomes of Cushing's disease in children: A multicenter study
No full textObjective: Since Cushing's disease (CD) is less common in the paediatric age group than in adults, data on this subject are relatively limited in children. Herein, we aim to share the clinical, diagnostic and therapeutic features of paediatric CD cases.Design: National, multicenter and retrospective study.Patients: All centres were asked to complete a form including questions regarding initial complaints, physical examination findings, diagnostic tests, treatment modalities and follow-up data of the children with CD between December 2015 and March 2017.Measurements: Diagnostic tests of CD and tumour size.Results: Thirty-four patients (M:F = 16:18) from 15 tertiary centres were enroled. The most frequent complaint and physical examination finding were rapid weight gain, and round face with plethora, respectively. Late-night serum cortisol level was the most sensitive test for the diagnosis of hypercortisolism and morning adrenocorticotropic hormone (ACTH) level to demonstrate the pituitary origin (100% and 96.8%, respectively). Adenoma was detected on magnetic resonance imaging (MRI) in 70.5% of the patients. Transsphenoidal adenomectomy (TSA) was the most preferred treatment (78.1%). At follow-up, 6 (24%) of the patients who underwent TSA were reoperated due to recurrence or surgical failure.Conclusions: Herein, national data of the clinical experience on paediatric CD have been presented. Our findings highlight that presenting complaints may be subtle in children, the sensitivities of the diagnostic tests are very variable and require a careful interpretation, and MRI fails to detect adenoma in approximately one-third of cases. Finally, clinicians should be aware of the recurrence of the disease during the follow-up after surgery