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Evaluation of Trabecular Changes Using Fractal Analysis After Orthodontic Treatment for Congenital Maxillary Lateral Incisor Missing with Space Opening and Closure Methods
No full textAim: The aim of the study was to compare the trabecular changes in alveolar bone structure after the treatment of congenital maxillary lateral incisor missing (CMLIM) with space-opening and -closure meth- ods by fractal dimension (FD) analysis. Material and Methods: The study included 48 patients and three groups were formed: control (Group 1), space-opening (Group 2), and space-closure groups (Group 3). FD analysis was performed on panoramic images taken before (T0) and after (T1) treatment in the area of interest of trabecular alveolar bone determined in the distal apical region of the maxillary central incisor. For inter-group comparisons, the Kruskal-Wallis test was employed, while the Wilcoxon test was utilized for intra-group comparisons. The statistical significance was determined as p0.05). In Group 2, a significant decrease in FD values was observed during the T1 period compared to T0, whereas Group 3 showed a significant increase (p<0.05). Conclusion: It was observed that the alveolar bone trabeculation after orthodontic treatment for CMLIM was similar to the bone structure in patients who did not receive orthodontic treatment with both methods. It has also been concluded that in order to increase stability in space-opening cases, a consolidation period is needed for the mineralization of the alveolar structures before implant surgery, or, if possible, a space-closure method that eliminates the need for these should be preferred
Evitar la guerra, trabajar por la paz: Jorge Luis Tizón, La guerra como campo de batalla. Deconstruyendo mitos y símbolos.
No full textSiempre que me he interesado por un tema más o menos relacionado con la profesión, por original que me pareciera, me he encontrado con que Jorge Luis Tizón ya se había acercado a él y había escrito un texto –que generalmente me parecía el más certero y exhaustivo– sobre este. De memoria, recuerdo que me pasó con la epistemología, la psicoterapia, la psico(pato)logía, la atención primaria, la emigración, el duelo, el humor, la situación asistencial, la política o las relaciones de poder
Türk edebiyatında musammatlar (Bentlerden oluşan nazım biçimleri)
No full textSosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim Dalı, Eski Türk Dili Bilim DalıMusammat, her bendi en az üç mısradan müteşekkil nazım birimlerinin ortak adıdır. Bu çalışmada klasik Türk edebiyatında yazılan musammatlar incelendi. Bir nazım şeklinin tesmiyesi için gerekli olan en az üç bent kaidesiyle hareket edildi. Fakat tasmitlerin (zemin zamime ilişkisi olan nazım şekilleri terbi, tahmis, tesdis, tesbi, tesmin, tetsi, ta'şir… için) üçten az bentli olanları da değerlendirmeye dâhil edildi. Zira bu nazım şekillerinde şiirin kaç mısraya tamamlandığı esası, kabul edildi. Taştir, Terkib-bend ve Terci-bendi "Mısra Sayısı Değişen Musammatlar" başlığı altında ele alındı. Her ana başlık beş alt başlık altında değerlendirildi. Daha önce çalışılmış olan murabba, muhammes ve müseddes çalışmada detaya girilmeden bu nazım şekillerinin kısa değerlendirmeleri yapılıp genel dökümleri verilmekle yetinildi. Bu çalışmada, ulaşılabilen bütün divanlarda yer alan musammatlar tespit edilerek nazım şekilleri, şairleri, sayıları bakımından yüzyıllara göre tasnif edildi, şekil ve muhteva özellikleri açısından incelendi. Türk Edebiyatında Musammatlar adlı çalışma ile elde edilen musammat nazım şekilleri 10 ana başlıkta (Üç Mısralık Musammatlar, Dört Mısralık Musammatlar, Beş Mısralık Musammatlar, Altı Mısralık Musammatlar, Yedi Mısralık Musammatlar, Sekiz Mısralık Musammatlar, Dokuz Mısralık Musammatlar, On Mısralık Musammatlar, Bentleri On Mısradan Uzun Gazel Tipi Musammatlar, Mısra Sayısı Değişen Musammatlar) ve bu başlıklara bağlı 30 alt başlıkta (Müselles, Teslis, Murabba, Terbi, Muhammes, Tahmis, Tardiye, Müseddes, Tesdis, Müsebba, Tesbi, Müsemmen, Tesmin, Mütessa, Tetsi, Muaşşer, Ta'şir, Onbirli, Onbirleme, Onikili, Onikileme, Onüçlü, Ondörtlü, Onbeşli, Onaltılı, Yirmili, Yirmiikili, Taştir, Terkib-Bend, Terci-bend) ele alındı. Bu başlıkların her biri de beş alt başlıkta değerlendirildi: Birinci başlık altında kafiye çeşitleri incelenerek örnekler verildi. Farklı kafiye düzeninde yazılmış dikkate şayan musammatlar nazarlara sunuldu. İkinci başlıkta musammatlarda kullanılan bütün vezinler tasnif edilip en çok kullanılan vezinler tespit edildi. Musammatlarda en çok tercih edilen vezinlerin şiir örneklerine çalışmada yer verildi. Üçüncü başlıkta musammatların bent sayısı tespit edildi. Bu başlık altında en az üç bendi olan manzumeler değerlendirmeye alındı. Fakat asgari bent sayısı olan üç bent mevzusu tasmitlerde dikkate alınmayıp bu musammatlarda tamamlandığı mısra sayısı esas alındı. Bent sayısına göre musammatlar tasnif edildi. En çok musammatın kaç mısralık bentler halinde yazıldığı tespit edildi. Dördüncü başlık altında konu tespit edildi. Musammatlarda konu tespit edilirken hâkim konu esası dikkate alındı. Zira klasik Türk edebiyatında bir şiirde birden fazla konu ele alınabiliyor. Özellikle kaside, terci-bende ve terkib-bend gibi uzun şiirlerde tevhid ile Münacaat, içtimaî mevzularda yazılan manzumelerde eleştiri ile nasihat iç içe girmiştir. Bundan dolayı konu tespit edilirken hâkim konu esası nazara alındı. Konular tasnif edildikten sonra örnekler ile desteklendi. Bunun yanında mersiye ve methiyelerin kime yazıldıkları da belirtildi. Beşinci başlık altında musammatlarda mahlasın kullanılıp kullunılmadığı tespit edildi. Mahlaslı olan ve mahlaslı olmayan musammatlar tespit edildi. Mahlas kulanmama sebepleri irdelendi. Bu beş ana başlık dışında; farklı özellikleri ile dikkat çeken musammatlar, her nazım şekli için en çok musammat yazan şair ve yazdığı musammat sayısı, zamimeli şiirlerde zemin olarak en çok tercih edilen şair, en çok tercih edilen şiir vb. hususlar tespit edilerek dikkatlere sunuldu. Her yüzyılda yazılan musammatların genel dökümü, bent sayıları ile beraber verildi. Musammatı bulunan divan şairlerinin isim, doğum ve ölüm tarihleri ile doğdukları yerler tablo halinde verildi. Bunun yanı sıra musammat sayısı, yüzyıllara göre grafikler şeklinde de gösterildi.Musammat is the common name of verse units each clause of which consists of at least three lines. In this study, the musammats written in classical Turkish literature were examined. It was acted on the principle that at least three clauses are required for the description of a verse. However, Tasmits with fewer than three clauses (for the verse forms with a base and extension relationship such as terbi, tahmis, tesdis, tesbi, tesmin, tetsi, ta'şir, etc.) were also included in the evaluation. Because in these verse forms, the basis of how many lines the poem is completed in is accepted. Taştir, Terkib-bend and Terci-bendi were discussed under the title of "Musammats with Changing Number of Verses". Each main heading was evaluated under five subheadings. Murabba, muhammes and müseddes, which were studied on before, were examined and described in general terms in this study. In this study, the musammats in all accessible divans were identified, classified according to centuries in terms of verse forms, poets, numbers, and examined in terms of form and content characteristics. The identified musammat verse forms are divided into 10 main headings (Musammats of Three Lines, Musammats of Four Lines, Musammats of Five Lines, Musammats of Six Lines, Musammats of Seven Lines, Musammats of Eight Lines, Musammats of Nine Lines, Musammats of Ten Lines, Ghazal Type with Verses Longer than Ten Lines, Musammats with Varied Numbers of Lines) and 30 subheadings related to these headings (Müselles, Teslis, Murabba, Terbi, Muhammes, Tahmis, Tardiye, Müseddes, Tesdis, Müsebba, Tesbi, Müsemmen, Tesmin, Mütessa, Tetsi, Muaşşer, Ta'şir, Eleventh, Twelfth, Thirteenth, Fourteenth, Fifteenth, Sixteenth, Twentieth, Twenty-second, Taştir, Terkib-Bend, Terci-bend) were discussed. Each of these headings was evaluated under five subheadings: Under the first heading, rhyme types were examined, and examples were given. Remarkable musammats written in different rhyme schemes were presented. Under the second heading, all the meters used in musammats were classified and the most used meters were determined. Poem samples of the most preferred meters in Musammats were included in the study. In the third heading, the number of clauses (stanzas consisting of 3 or 5 lines) of musammats was determined. However, the principle of three clauses, which is the minimum number of clauses, was not taken into consideration in tasmits and the number of completed verses was taken as basis in these musammats. Musammats were classified according to the number of clauses. It was determined in which clauses the most musammat were written. The subject was identified under the fourth heading. While determining the topic in musammats, the dominant topic principle was taken into consideration. Because in classical Turkish literature, more than one subject can be discussed in a poem. Especially in long poems such as qasida, terci-bende and tekib-bend, monotheism and munacat are intertwined, and in poems written on social issues, criticism and advice are intertwined. Therefore, when determining the subject, the dominant subject matter was taken into consideration. After the topics were classified, they were supported with examples. In addition, it was also stated to whom the elegies and eulogies were written. Under the fifth heading, it was determined whether the pseudonym was used in the musammats. Pseudonymous and pseudonymous musammats were identified. The reasons for not using pseudonyms were examined. Apart from these five main headings; issues such as musammats that attract attention with their different features, the poet who wrote the most musammats for each verse form and the number of musammats he wrote, the poet most preferred as a background in poems with pronouns, the most preferred poem, etc. were identified and brought to attention. The general list of musammats written in each century is given together with the number of clauses. The names, birth and death dates, and birthplaces of the divan poets who have musammats were given in a table. In addition, the number of musammats was also shown in graphs according to centuries
The relationship between serum adropin levels and erectile dysfunction
No full textErectile dysfunction (ED) is associated with endothelial damage, especially atherosclerosis. The search for biomarkers that can predict ED still continues. Adropin is known to affect nitric oxide (NO) bioavailability and energy homeostasis. In our study, we have aimed to investigate the relationship between serum adropin levels and ED. Male patients with and without ED between 40-60 years of age, who presented to the outpatient clinics of urology between November 2019-February 2020, were prospectively included in the study. Biochemical values measured at the time of admission to the outpatient clinic. According to the International Index of Erectile Function -5 (IIEF-5) scores which range between 5 and 25 points, patients with a score <= 21 were considered to have ED. The patients were divided into two groups: as ED and non -ED control groups. Laboratory values obtained at admission to outpatient clinics of urology were compared between groups. Patients with (n: 40), and without (n: 40) ED were included in the study. The mean age (50.2 +/- 5.7 years), average body mass index (BMI) (29.7 +/- 2.5 kg/m(2)), IIEF score (15.8 +/- 6 pts), serum adropin (584.8 +/- 172 pg/mL), and total testosterone (396.4 +/- 91.7 ng/dL) levels were recorded. Serum adropin and testosterone levels were statistically significantly higher in the non -ED group than in the ED group (712.3 +/- 222 pg/mL vs. 511.1 +/- 145 pg/mL, p < 0.001 and 420.5 +/- 56 ng/dL vs. 374.3 +/- 98 ng/dL, respectively p = 0.032). Whereas fasting blood glucose (FBG) values were found to be statistically significantly higher in the ED group (100.2 +/- 14 mg/dL vs. 143.8 +/- 78 mg/dL, p = 0.001). According to the results of our study, serum levels of adropin which improves endothelial functions were comparatively lower in ED patients, as expected.Erzincan University [TSA-2020-671]This research was funded by Erzincan University scientific research projects as project number TSA-2020-671
Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax/Bcl-xL, Caspase-3/9, and Akt/NF-?B pathways
No full textChronic tobacco use can lead to liver damage and inflammation due to the accumulation of various toxins in the body. This study aimed to investigate the correlation between the molecular mechanisms of nicotine-induced liver injury, the caspase cascade, and the Akt/NF-kappa B signaling pathway, as well as the protective effects of dexpanthenol (DEX). Male rats were subjected to intraperitoneal injections of nicotine at a concentration of 0.5 mg/kg/day and/or DEX at a concentration of 500 mg/kg/day for 8 weeks. After the treatment period, liver function tests were conducted on serum samples, and tissue samples were analyzed for protein levels of Akt, NF-kappa B, Bax, Bcl-xL, Caspase-3, and Caspase-9, along with histopathological changes. Additionally, assessments of oxidative stress markers and proinflammatory cytokines were carried out. Nicotine administration led to elevated levels of IL-6, IL-1 beta, MDA, TOS, and oxidative stress index, accompanied by decreased TAS levels. Moreover, nicotine exposure reduced the p-Akt/Akt ratio, increased NF-kappa B, Bax, Caspase-3, and Caspase-9 protein levels, and decreased the antiapoptotic protein Bcl-xL levels. DEX treatment significantly mitigated these effects, restoring the parameters to levels comparable to those of the control group. Nicotine-induced liver injury resulted in oxidative stress, inflammation, and apoptosis, mediated by Bax/Bcl-xL, Caspase-3, Caspase-9, and Akt/NF-kappa B pathways. Conversely, DEX effectively attenuated nicotine-induced liver injury by modulating apoptosis through NF-kappa B, Caspase-3, Caspase-9, Bax inhibition, and Bcl-xL activation. Chronic nicotine exposure led to oxidative stress, inflammation, and apoptosis, as evidenced by altered protein levels in Bax/Bcl-xL, Caspase-3/9, and Akt/NF-kappa B pathways. Dexpanthenol treatment effectively countered these effects, highlighting its potential as a therapeutic agent for nicotine-related liver injury.imag
Evil in İhsan Oktay Anar's works
No full textSosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim DalıKötülük, tarih boyunca birçok düşünür ve araştırmacının üzerinde durduğu karmaşık bir kavramdır. İnsanlar, kötülüğün ne olduğu ve kaynağının ne olabileceği konusunda çeşitli teoriler geliştirmiştir. Kötülük, tek başına insan eylemlerini sınıflandırmakta yetersiz kalmış ve bu nedenle farklı kategorilere ayrılarak incelenmiştir. Kötülük, insan doğasının ve toplumsal dinamiklerin merkezinde yer almış, birçok sanat alanında işlenmiştir. Edebiyatta da sıkça işlenen bu tema, estetik bir boyut kazanmış, dini ve mitolojik anlatılarda iyi ile kötünün mücadelesi olarak yansıtılmıştır. Edebiyatımızda da özellikle günümüz yazarları arasında kötülüğün işlenişi çeşitli şekillerde görülmektedir. Edebiyat dünyasında, özellikle günümüz yazarlarından İhsan Oktay Anar, eserlerinde kötülüğü hem karakterler düzleminde hem de sembolik düzeyde işleyerek bu kavrama farklı bir perspektif sunmaktadır. Anar'ın romanlarında kötülük, bazen bireylerin içsel çatışmalarında, bazen de toplumsal yapının eleştirisinde kendini göstermektedir. Bu bağlamda, İhsan Oktay Anar'ın eserleri, kötülüğün edebî bir motif olarak nasıl kullanıldığını ve bu kavramın edebiyatta nasıl bir işlev üstlendiğini anlamak için önemli bir kaynaktır.Evil is a complex concept that has been a focal point for many thinkers and researchers throughout history. Various theories have been developed about what evil is and what its source might be. Evil, insufficient on its own to classify human actions, has thus been examined by dividing it into different categories. It has occupied a central place in human nature and social dynamics, and has been depicted in many forms of art. This theme, frequently explored in literature, has gained an aesthetic dimension, reflected as the struggle between good and evil in religious and mythological narratives. In our literature, particularly among contemporary writers, the treatment of evil appears in various ways. In the literary world, such as İhsan Oktay Anar present a different perspective on this concept by addressing evil both on the level of characters and symbolically. In Anar's novels, evil sometimes manifests in the internal conflicts of individuals, and sometimes in the critique of social structures. In this context, İhsan Oktay Anar's works are significant sources for understanding how evil is used as a literary motif and what function this concept serves in literature
Transformation in the civil service regime and human resources office in the Presidential government system
No full textDevletlerin geçmişten günümüze yaşadıkları deneyimler sonucunda personel çalışma düzenini en iyi hale getirmek ve bununla ilgili sorunları çözmek için çalıştıkları görülmektedir. Ülkemizde 23/07/1965 tarihli ve 12056 sayılı Resmi Gazete'de yayımlanan 657 sayılı Devlet Memurları Kanunu'nda memur ve diğer kamu görevlilerine dair düzenlemeler yer alırken; bu çerçevede devlet memurlarının; hizmet şartları, nitelikleri, atanma ve yerleştirme, terfi ve yükselme, devlet memurlarının görevleri, hakları, yükümlülükleri, sorumlulukları, maaşları memurların ödenekleri ve diğer özlük hakları düzenlenmiştir. Bu çalışmanın amacı, devlet memurları rejiminde liyakat, kariyer ve sınıflandırma ilkelerinin uygulanması temel esasları ortaya koymaktır. Bunun yanı sıra Cumhurbaşkanlığı Hükümet Sistemi ile İnsan Kaynakları Ofisi'nin devlet memurluğundaki değişim ve dönüşümlerinde güncel uygulamalar hakkındaki incelemelerde bulunarak bir ışık tutmaktır. Bu amaçla yürütülen üst düzey kamu yöneticisi olabilme şartları değerlendirilmiş ve hizmet süreleri ele alınmıştır. Üst düzey kamu yöneticilerinin siyasi iradenin etkileri üzerinde durulmuştur. Öte yandan Cumhurbaşkanlığı Hükümet Sistemi ile yeni kurulan sistemin memurlarla ilgili kararnamelere ilişkin açıklamalar ortaya konulmuştur. Bu araştırma, Cumhurbaşkanlığı hükümet sisteminde Devlet Memurları Kanunu'nun dönüşümü, Cumhurbaşkanlığı Hükümet Sistemi ve İnsan Kaynakları Ofis ile ilgili yayınlanan akademik çalışmalardan edindiğimiz bilgiler ile doküman analizi bilgileri kullanılarak gerçekleştirilmiştir. Anahtar Kelimeler: 657 sayılı Devlet Memurları Kanunu, Memur, Cumhurbaşkanlığı Hükümet sistemi, İnsan Kaynakları Ofisi, Liyakat, Kariyer, Sınıflandırma,As a result of their experiences from past to present, it is seen that states are working to optimize the personnel working order and solve related problems. In our country, the Civil Servants Law No. 657, published in the Official Gazette No. 12056 dated 23/07/1965, contains regulations regarding civil servants and other public officials; In this context, civil servants; Conditions of service, qualifications, appointment and placement, promotion and elevation, duties, rights, obligations, responsibilities, salaries, allowances and other personal rights of civil servants are regulated. The aim of this study is to reveal the basic principles of applying the principles of merit, career and classification in the civil servants regime. In addition, it is to shed light on the changes and transformations of the Presidential Government System and the Human Resources Office in the civil service by examining current practices. For this purpose, the conditions for becoming a senior public administrator have been evaluated and the length of service has been discussed. Emphasis was placed on the effects of political will of senior public administrators. On the other hand, explanations regarding the Presidential Government System and the decrees regarding civil servants of the newly established system have been put forward. This research was carried out using the information we obtained from published academic studies on the transformation of the Civil Servants Law in the Presidential government system, the Presidential Government System and the Human Resources Office, and document analysis information. Key Words: Civil Servants Law No. 657, Civil Servant, Presidential Government System, Human Resources Office, Merit, Career, Classificatio
Microbial synthesis of silver nanoparticles and determination of their antimicrobial properties
No full textFen Bilimleri Enstitüsü, Biyoloji Ana Bilim Dalıgümüş AgNP'ler biyolojik yöntemle, kolay, düşük maliyetli ve çevre dostu bir şekilde elde edilmiştir. Cladosporium cladosporioides'in AgNP'ler filtrat, üretimi amacıyla kullanılmıştır. Öncelikle fungal filtrat elde edilerek nanopartikül üretiminde kullanılmıştır. Nanopartikül üretiminin ilk göstergesi, metalik nanopartiküllerin yüzey plazmon rezonansına bağlı olarak meydana gelen renk değişimi ve karakteristik absorpsiyon bandıdır. Daha sonra, nanopartiküllerin karakterizasyonu yapılmış ve antimikrobiyal özellikleri test edilmiştir. Antimikrobiyal etkileri bulunan gümüş nanopartiküllerinin Cladosporium cladosporioides kullanılarak biyosentezi, SEM (taramalı elektron mikroskopisi) ve EDAX (enerji dağınımlı X-ışınları spektroskopisi) gibi analitik yöntemlerle karakterize edilmiştir.AgNPs were obtained through a biological method that is easy, low-cost, and environmentally friendly. The filtrates and extracts of Cladosporium cladosporioides were used for the production of silver nanoparticles. Initially, fungal filtrates and extracts were obtained and utilized in nanoparticle production. The first indication of nanoparticle production was the color change resulting from the surface plasmon resonance of the metallic nanoparticles and the characteristic absorption band. Subsequently, the characterization of the nanoparticles was performed, and their antimicrobial properties were tested. The biosynthesis of silver nanoparticles with antimicrobial effects using Cladosporium cladosporioides was characterized by analytical methods such as SEM (Scanning Electron Microscopy) and EDAX (Energy Dispersive X-ray Spectroscopy)
Comparison of two different Nasal Interfaces used in Non-Invasive Respiratory support in terms of Neonate comfort
No full textBackground Non-Invasive Ventilation (NIV) is the first choice approach in neonates with sufficient respiratory effort that require respiratory support. The type of nasal interface used in NIV affects both efficacy and patient comfort. The aim of this study is to investigate the effects of different nasal interfaces used in NIV support on neonatal patient comfort. Methods Our study evaluated patients who received NIV support for 24 hours. The patients were randomly divided into two groups according to the type of nasal interface used, which were RAM cannula and short binasal prong (SBP). The patients’ demographic and clinical data were noted. Their sleep was monitored for 24 hours with an actigraphy device. Results A total of 82 patients were evaluated. The sleep efficiency in the RAM cannula group was significantly higher (respectively, 65.7% [10.22-95.25] vs. 57.81% [2.49-77], p=0.004). Although not statistically significant, the neonates in the RAM cannula group exhibited longer total sleep time (respectively, 10.4 ± 4.28 hours vs. 9.02 ± 3.73 hours, p=0.161). Comparison of heart rates and respiratory rates indicate that the patients in the RAM cannula group were more comfortable. Conclusions Our study found that infants who received NIV support through a RAM cannula experienced more efficient sleep. Holistic approaches in neonatal intensive care units are vital for better neurodevelopmental outcomes in newborns. Although non-invasive, the interface used in NIV should also be a part of this holistic approach. © 2024 Kamuzu University of Health Sciences
Protective Role of Pistacia palaestina Boiss. Fruit and Leaf Extracts in Isoproterenol-Induced Cardiac Ischemia
No full textMyocardial infarction (MI) is one of the leading causes of death worldwide. This study aimed to investigate the protective effects of Pistacia palaestina Boiss (PP) leaf and fruit extracts, which are thought to have antioxidant and anti-inflammatory activity, in isoproterenol (ISO)-induced MI. 80 Sprague-Dawley rats were divided into ten groups. The control group was given 0.9% isotonic sodium chloride saline. PP leaf and fruit extracts at doses of 250 mg/kg and 500 mg/ kg were administered by oral gavage for 21 days. ISO 100 mg/kg subcutaneously was administered to the MI and MI-treatment groups on the 17th and 18th days of the experiment. Thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were measured in heart tissue. In serum, troponin T, CK-MB; pro-inflammatory cytokine necrosis factor-alpha (TNF-?), interleukin-1? (IL-1?,) and IL-6; anti-inflammatory IL-10 levels were determined by the ELISA method. Heart tissue was examined by hematoxylin-eosin staining. While lipid peroxidation indicator TBARS activity increased in the MI group, antioxidant enzyme activities and GSH levels decreased. While troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels increased, anti-inflammatory IL-10 levels decreased. Low and high dose PP leaf and fruit extracts significantly decreased TBARS, troponin T, CK-MB, TNF-?, IL-1?, and IL-6 levels improved antioxidant enzyme activity, and GSH and IL-10 levels. PP ameliorated cardiac biomarkers and histopathological changes in ISO-induced MI by suppressing oxidative stress and inflammation. PP extracts may play an important cardioprotective role in the treatment of MI through their antioxidant and anti-inflammatory effects. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.TSA-2020-2146This study was supported by IUBAP (İnönü University Scientific Research Project Unit) numbered TSA-2020-2146. All authors would like to thank Prof. Dr. Turan Arabacı, who identified Pistacia palaestina Boiss. plant material