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BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells
No full textCircadian oscillations of gene transcripts rely on a negative feedback loop executed by the activating BMAL1-CLOCK heterodimer and its negative regulators PER and CRY. Although circadian rhythms and CLOCK protein are mostly absent during embryogenesis, the lack of BMAL1 during prenatal development causes an early aging phenotype during adulthood, suggesting that BMAL1 performs an unknown non-circadian function during organism development that is fundamental for healthy adult life. Here, we show that BMAL1 interacts with TRIM28 and facilitates H3K9me3-mediated repression of transposable elements in naïve pluripotent cells, and that the loss of BMAL1 function induces a widespread transcriptional activation of MERVL elements, 3D genome reorganization and the acquisition of totipotency-associated molecular and cellular features. We propose that during embryogenesis, BMAL1 is redeployed as a transcriptional repressor of transposons in a CLOCK-independent way, and the activity of BMAL1-TRIM28 during prenatal life might protect mammalian organisms from premature aging during adulthood
What faculty already do: Universal Design for Learning strategies to support autistic students at university
No full textUniversal Design for Learning (UDL) is increasingly being considered in the different educational stages to embrace student diversity. However, more research is needed on how this paradigm can support the participation and learning of autistic students, integrating the perspectives of both faculty and these students. Conducted at University Jaume I in Spain, the research adopted a phenomenological framework, holding focus groups with 15 faculty members and individual interviews with 12 autistic students. Data analysis, guided by a phenomenographic approach, revealed that faculty members implement UDL principles, such as offering choice in content exploration and using seminars to clarify concepts, although unconsciously. The study concluded the importance of raising awareness on the strategies being developed within the UDL framework, as well as proving its benefits from the students' voice, aiming at providing a more constructive view that encourages faculty to continue innovating their practice from a more inclusive perspective.El Diseño Universal para el Aprendizaje (DUA) está cada vez más presente en las distintas etapas educativas para responder a la diversidad de estudiantes. Sin embargo, se necesita más investigación sobre cómo este paradigma puede apoyar la participación y el aprendizaje de estudiantes universitarios autistas, integrando las perspectivas tanto del profesorado como de estos estudiantes. Este estudio se realizó en la Universidad Jaume I (Castellón, España) y adoptó un enfoque fenomenográfico. Se llevaron a cabo grupos focales con 15 docentes y entrevistas individuales con 12 estudiantes autistas. El análisis de datos, guiado por el enfoque fenomenográfico, reveló que los docentes implementan principios del DUA, por ejemplo, ofreciendo opciones en la exploración de contenidos y utilizando seminarios para aclarar conceptos. Sin embargo, implementan sus principios de forma inconsciente. Las conclusiones apuntan que es importante aumentar la conciencia sobre las estrategias desarrolladas dentro del marco del DUA, así como demostrar sus beneficios desde la perspectiva de los estudiantes. Esto busca proporcionar una visión más constructiva que motive al profesorado a seguir innovando en su práctica desde una perspectiva más inclusiva
Social capital and tourism entrepreneurship in rural areas.An approach from a territorial perspective
No full textEl presente artículo pretende analizar la relación entre capital social, emprendimiento y territorio, mediante una revisión y análisis de la literatura existente de estas categorías; en aras de develar posibles relaciones que contribuyan al desarrollo y consolidación de emprendimientos turísticos en zonas rurales. Partiendo de los diferentes aportes teóricos del capital social, se analiza el constructo desde las dimensiones estructural, cognitiva y relacional. El emprendimiento y la figura del emprendedor se abordandesde sus concepciones teóricas como elemento clave en procesos de desarrollo territorial, teniendo en cuenta los elementos que caracterizan a las personas emprendedoras; y el territorio desde sus componentes territoriales, como herramienta para el estudio y la comprensión de las dinámicas socio económicas y la gestión territorial. Finalmente, se relaciona el trinomio capital social-emprendimiento-territorio, para aportar análisis más completos que contribuyan a mejorar la gestión y el desarrollo de la actividad emprendedora turística en zonas rurales.This article aims to analyze the relationship between social capital, entrepreneurship and territory, through areview and analysis of the existing literature on these categories, in order to unveil possible relationships that contribute to the development and consolidation of tourism enterprises in rural areas. Based on the different theoretical contributions of social capital, the construct is analyzed from the structural, cognitive and relational dimensions. Entrepreneurship and the figure of the entrepreneur is approached from its theoretical conceptions as a key element in territorial development processes, taking into account the elements that characterize entrepreneurs; and the territory from its territorial components, as a tool for the study and understanding of socioeconomic dynamics and territorial management. Finally, the trinomial social capital-entrepreneurship-territory is related to provide more complete analyses that contribute to improve the management and development of tourism entrepreneurship in rural area
Raising Awareness of Gender-Based Violence Through Messages Based on Ethical Witnessing: A Spain-Based Study
No full textThis study takes the perspective of the theory of ethical witnessing. We analyse whether there is a difference in a discourse transmitted in a frame of reference based on ethical witnessing versus a discourse transmitted in the frame of hegemonic discourse based on the hierarchical testimony. This study tests the hypothesis that discourses diverging from the communication hierarchy and, consequently, from the interpretation frame established about gender-based violence, transform the elaboration, comprehension, and structure of questioning the victim’s suffering. The sample comprised 300 individuals, 85 identifying as male and 215 identifying as female. This study adopted a two-factorial (2 × 2) design comparing the testimony of gender-based violence (ethical witnessing vs. hierarchical testimony) and familiarity with the victim’s testimony (Yes vs. No). The results show that communications based on the ethical witnessing format are more effective in transforming the perception of gender-based violence than those using a hierarchical format. This study adopts the framework of ethical witnessing to examine whether discourse differs when conveyed through this lens, compared to discourse shaped by a hegemonic, hierarchical testimony. We test the hypothesis that narratives which deviate from traditional communication hierarchies—and thus from dominant interpretative frameworks surrounding gender-based violence—significantly influence how the victim’s suffering is processed, understood, and questioned. The global resonance of the #MeToo movement exemplifies the transformative potential of ethical testimony, as it amplified the voices of survivors while challenging traditional hierarchies of credibility and authority in public discourse
Citar para engañar: citas falsas y deslegitimación política en las campañas de desinformación de base de la extrema derecha española
No full textThis paper focuses on the deliberate fabrication of quotations attributed to rival politicians by Spanish far right activists and their dissemination on social media (particularly Twitter/X). It argues that such practices can be viewed as attempts to undermine the credibility and legitimacy of political adversaries. The data were obtained from Al Descubierto (http://aldescubierto.org), an organization specializing in tracking disinformation spread in Spain by the far right. This study examines a collection of anti-government disinformation, specifically focusing on the content of fake quotes attributed to government officials or other left-leaning politicians. The analysis uncovers a calculated attempt to portray left-wing politicians as incompetent leaders, thereby undermining their legitimacy to govern the nation. Specifically, it shows that fake quotes can help present politicians as immoral and their policies as irrational. In short, these fabricated quotes are used to erode trust in governing institutions and delegitimize politicians and policy initiatives.
Este artículo estudia las citas falsas inventadas por activistas españoles de extrema derecha y su difusión en las redes sociales (especialmente en Twitter) con el objetivo de socavar la credibilidad y legitimidad de
los adversarios políticos. Los datos se obtuvieron de Al Descubierto (https://aldescubierto.org), una organización especializada en el rastreo de la desinformación difundida en España por la extrema derecha. Se estudian
ejemplos de desinformación antigubernamental, centrándonos específicamente en el contenido de citas falsas atribuidas a miembros del Gobierno o a otros políticos de izquierdas. El análisis muestra que hay un intento claro
de presentar a los políticos de izquierdas como incompetentes para gobernar el país, reduciendo su legitimidad. En concreto, el análisis muestra que las citas falsas contribuyen a presentar a los políticos como personas de
dudosa moralidad y a hacer que sus propuestas políticas parezcan irracionales. En resumen, estas citas inventadas se utilizan para erosionar la confianza en las instituciones, deslegitimar a los políticos rivales y despreciar
sus iniciativas políticas
Association Between Physical Activity Level and Training Volume in Adolescent Athletes
No full textOrganized sports are assumed to boost overall physical activity, but evidence suggests structured training does not always increase general activity outside formal sessions. This study explores the link between physical activity levels and weekly training hours in adolescent athletes across sports and competition levels. A total of 10,196 participants aged 11 to 19 were included in the analyses. Participants were classified into seven groups: inactive, somewhat active, non-competitive athletes, and athletes competing at the local, regional, national, or international level. They completed the Spanish version of the Physical Activity Questionnaire and answered questions regarding their performance level, training volume, and socioeconomic status. Girls exhibited lower physical activity levels than boys, even at higher competition levels where both sexes had comparable training hours. Competitive athletes reported the highest physical activity levels. In competitive athletes, physical activity levels decreased with age despite a substantial increase in weekly training hours. They were similar across athletes competing in different sports and at different levels, despite significant differences in training hours. Many athletes, including those at the national and international levels, displayed low physical activity levels, and no clear relationship was found between physical activity level and weekly training hours. The current study provides valuable insights into adolescent physical activity patterns by sex, age, sport, and competition level. Girls showed lower physical activity than boys, even with similar training hours. Physical activity levels declined with age despite increasing training volumes, and no strong association was observed between physical activity and weekly training hours. These results reveal a discrepancy between structured training and overall activity levels, challenging assumptions about the impact of sports participation on daily physical activit
Un mundo hecho por los hombres o nuestra cultura androcéntrica / Charlotte Perkins Gilman; Constanza Tobío Soler (ed.); Madrid: CIS, 2023 [Reseña]
No full textEs reseña de: Charlotte Perkins Gilman
(Constanza Tobío Soler (ed.), Madrid, CIS, 2023
Identification of risk factors for evisceration in open radical cystectomy
No full textIntroduction:
Abdominal wall closure defects (AWCD) represent a cause of morbidity and mortality in patients undergoing laparotomy.
Objective:
The aim of this study was to determine the risk factors contributing to the appearance of AWCD in open radical cystectomy.
Methods:
A retrospective, analytical, observational, descriptive study and multivariate analysis was conducted including patients who underwent open radical cystectomy for bladder cancer at the General University Hospital of Castellón between January 2018 and December 2021.
Results:
A total of 80 patients were included. The mean age was 70 years, with 86.3% being men. Sixteen presented with an evisceration (20%). Risk factors in the multivariate analysis were age, history of vascular or coronary disease, preoperative albumin, hemodynamic instability, and surgical time. Eight patients presented with an eventration (10%). A higher body mass index and a lower preoperative hemoglobin level were associated with eventration.
Conclusion:
The risk factors associated with abdominal wall closure defects are identifiable and preventable.Introducción:
Los defectos de cierre de la pared abdominal (DCPA) constituyen una causa de morbilidad y mortalidad en pacientes sometidos a laparotomía.
Objetivo:
Determinar los factores de riesgo asociados a la aparición de DCPA en pacientes sometidos a cistectomía radical abierta.
Métodos:
Se realizó un estudio retrospectivo, analítico, observacional y descriptivo con análisis multivariante. Se incluyeron pacientes con cáncer de vejiga sometidos a cistectomía radical abierta en el Hospital General Universitario de Castellón entre enero de 2018 y diciembre de 2021.
Resultados:
Se analizaron 80 pacientes, con una edad media de 70 años, de los cuales el 86,3% eran hombres. Se registró evisceración en 16 pacientes (20%). El análisis multivariante identificó como factores de riesgo la edad avanzada, antecedentes de enfermedad vascular o coronaria, niveles bajos de albúmina preoperatoria, inestabilidad hemodinámica y mayor tiempo quirúrgico. Además, 8 pacientes (10%) desarrollaron eventración, la cual se asoció a un índice de masa corporal elevado y un nivel reducido de hemoglobina preoperatoria.
Conclusión:
Los factores de riesgo asociados a los defectos de cierre de la pared abdominal son identificables y prevenibles
Programme for the development of Emotional Intelligence and Empathy for coexistence and reintegration in penitentiary centres
No full textTreball Final de Grau en Psicologia. Codi: PS1048. Curs: 2024/202
Integrating Low-Cost Eye-Trackers to Enhance Design Education: A Case Study in University Course
No full textThe integration of technology in the classroom should be based on low-cost devices and affordable solutions, allowing educators to fully explore their potential benefits. Product design education is undergoing a profound transformation in response to these changes. The aim of this study is to demonstrate the integration of low-cost eye-tracking (ET) technology within a product design process. This research presents a practical case involving a group of design students who incorporated an ET device, as well as an alternative tracking method (AT) that simulates eye movement, to develop a product following a custom design methodology. The impact of both the methodology and the low-cost technology was evaluated through surveys administered to forty-seven students. The evaluation focused primarily on “utility, novelty, and relevance” as key aspects. The results showed consistently high approval ratings for both technologies. However, ET received significantly higher and more favorable evaluations. A detailed analysis of the evaluated elements indicated a strong preference for ET in terms of utility, novelty, and relevance. Furthermore, a correlational analysis revealed that students associated the integration of low-cost technology with usefulness and a positive experience. The findings of this case study highlight that low-cost devices and innovative methodologies are effective tools for enhancing teaching and learning experiences for students, educators, and researchers