97828 research outputs found
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Development of a tool for the parallel procedural generation of worlds inside a game engine and its application to a video game
No full textTreball final de Grau en Disseny i Desenvolupament de Videojocs. Codi: VJ1241. Curs acadèmic: 2024-2025This Bachelor’s Thesis presents the development of a tool for the procedural generation of 3D environments using a GPU-parallelized version of the Wave Function Collapse algorithm, integrated within the Unity engine. The tool enables users to defne custom tile sets and adjacency rules to generate worlds, offering an intuitive interface to manage tile and world creation. To validate the tool, a complete 3D top-down video game titled System Escape was developed. This game demonstrates the tool’s capabilities through procedurally generated planets within a dying solar system, where the player must escape before a supernova occurs. The game integrates resource collection, combat, upgrades, and survival mechanics. The tool signifcantly reduces development time while ensuring creative freedom and performance scalability. Performance tests show substantial improvements over CPU-based implementations, and the modular nature of the tool makes it suitable for a wide variety of game genres. This project highlights the potential of combining GPU computing with procedural generation techniques, and aims to contribute a robust and accessible asset to the Unity development community
Chemical tools targeting proteases: design, synthesis, and biological evaluation for therapeutic use
No full textDoctorat internacionalThis PhD thesis focuses on the design, synthesis, and evaluation of chemical compounds that inhibit proteases and degrade proteins essential for cellular recycling. It is divided into two parts: the first explores protein degradation in lysosomes, while the second examines the Ubiquitin-Proteasome System (UPS). The first part investigates cysteine proteases, their inhibition, and the use of activity-based probes (ABPs). Enzyme inhibitors are developed and converted into probes applied to cellular models related to neuroinflammation. The second part introduces the UPS, its role in protein degradation, and its therapeutic potential. Proteasome inhibitors are designed and synthesized, and PROTACs—molecules that target specific proteins for degradation—are explored. A case study investigates their application in signaling regulation in plants. This research opens new avenues for disease treatment and biotechnology.Programa de Doctorat en Cièncie
Chemical tools targeting proteases: design, synthesis, and biological evaluation for therapeutic use
No full textDoctorat internacionalThis PhD thesis focuses on the design, synthesis, and evaluation of chemical compounds that inhibit proteases and degrade proteins essential for cellular recycling. It is divided into two parts: the first explores protein degradation in lysosomes, while the second examines the Ubiquitin-Proteasome System (UPS). The first part investigates cysteine proteases, their inhibition, and the use of activity-based probes (ABPs). Enzyme inhibitors are developed and converted into probes applied to cellular models related to neuroinflammation. The second part introduces the UPS, its role in protein degradation, and its therapeutic potential. Proteasome inhibitors are designed and synthesized, and PROTACs—molecules that target specific proteins for degradation—are explored. A case study investigates their application in signaling regulation in plants. This research opens new avenues for disease treatment and biotechnology.Programa de Doctorat en Cièncie
Metal complexes with naphthalene-diimide and perylene-diimide-based ligands: supramolecular interactions and catalytic implications
No full textCompendi d'articlesThis doctoral thesis delves into the design and development of new ligand precursors and organometallic complexes through the combination of two different types of rylene-diimides (RDIs), with N-heterocyclic carbene (NHC)-based ligands. The novelty and interest of the results described in this doctoral thesis can be summarized in the following three points: • We show that imide functionalization of PDI/NDIs with NHC units can be used as a way to generate redox-switchable ligands with application in homogeneous catalysis. • We describe how the catalytic properties of a simple metal complex can be reversibly modified by using tailored-designed redox-switchable rylene-decorated NHC ligands, thus offering a new and simple approach to modulate the catalytic activity and to elucidate or review reaction mechanisms. • We describe and fully characterize a new type of (chloride)lp– π interaction between the chloride ligands of the Ir(III) complex and the heterocycles of the NDI/PDI moieties combining spectroscopic/computational determination of the lp–π interaction.Programa de Doctorat en Cièncie
Curso práctico de gestión de la cadena de suministro
No full textMaterial docente desarrollado como base para impartir un curso breve orientado a personal técnico de las áreas de compras, recepción, almacén, logística, producción y operaciones. Enfoque descriptivo con analíticas simplificadas para facilitar su aplicación. Las reglas propuestas para el control del flujo de materiales son sencillas pero fundamentadas en métodos rigurosos. El contenido se completa con estudios de casos, práctica del juego de la cerveza, uso guiado de LLM como asistente cognitivo y generación de modelos de simulación
Participación de la señalización noradrenérgica fronto-cerebelosa en la adquisición y extinción de la preferencia de lugar condicionada inducida por cocaína
No full textDoctorat internacionalEsta tesis se centra en el estudio del papel del circuito fronto-cerebelar en los procesos de memoria relacionados con drogas de abuso, así como en los efectos de las manipulaciones de los β2-AR sobre memorias asociadas a drogas. Aunque los β-AR han sido ampliamente investigados, gran parte de la investigación previa ha utilizado manipulaciones farmacológicas no específicas que afectan tanto a β1- como a β2-AR, lo que dificulta la determinación de sus contribuciones individuales. Este estudio demuestra un papel específico de los β2-AR en los procesos de memoria relacionados con drogas, centrándose particularmente en la adquisición y extinción de la PLC. Los hallazgos de esta tesis son relevantes y prometedores, aunque es fundamental realizar investigaciones adicionales para profundizar en la comprensión del rol de los β-AR en los procesos de extinción y reconsolidación, para determinar su viabilidad como objetivos terapéuticos dirigidos a trastornos relacionados con la memoria.This thesis emphasizes the role of the mPFC and cerebellum in memory processes related to drugs of abuse, such as cocaine, and explores the effects of β2-AR manipulations on the formation, maintenance, and restoration of drug-related memories. Although β-ARs have been widely studied, much of the previous research has used non-specific pharmacological manipulations affecting both β1- and β2-ARs, making it difficult to determine their individual contributions. This study provides evidence highlighting the specific role of β2-ARs by administering β2-AR receptor agonists and antagonists in drug-related memory processes, particularly focusing on the acquisition and extinction of CPP.Programa de Doctorat en Psicologi
Tin-based perovskites for optoelectronic applications
No full textCompendi d'articles, Doctorat internacionalGiven the need for sustainable energy alternatives and the environmental impact of fossil fuels, this thesis explores tin-based halide perovskites (Sn-HPs) as an eco-friendly option compared to the traditional lead-based perovskites materials in solar cells and LEDs. This thesis tackles the main challenges limiting Sn-HPs, such as instability and oxidation, through three innovative studies. First, the use of additives like DipI and NaBH₄ significantly improves solar cell efficiency and long-term stability. Second, inkjet printing technology is applied to create lead-free, flexible PeLEDs, demonstrating scalable and industrially relevant fabrication methods. Third, a low-cost synthesis of 2D and 3D Sn-HPs microcrystals using acetic acid enhances stability and performance in light-emitting devices, with emissions from orange to near-infrared. These advances contribute to more durable, efficient, and scalable Sn-HPs technologies, bringing us closer to greener solutions in renewable energy and optoelectronics.Programa de Doctorat en Cièncie
La receptividad de la traducción al italiano de autores latinoamericanos en el público juvenil hispanófono: estudio de la Scuola Italiana di Montevideo
No full textEsta investigación doctoral analiza cómo estudiantes hispanohablantes de la Scuola Italiana di Montevideo reciben la literatura latinoamericana traducida al italiano. A partir de un estudio de caso, se examinan los factores que inciden en esta receptividad, como el origen del autor, las decisiones docentes y el marco institucional. Se estudian antologías escolares, enfoques didácticos empleados (como el CLIL y la traducción pedagógica) y trayectorias del profesorado. La tesis propone el concepto de “literatura traducida de reinserción”, una categoría original para pensar textos que, mediante la traducción, regresan al contexto donde fueron producidos, a través de una lengua de estudio. Los resultados muestran que los estudiantes valoran más los textos cuando se vinculan con sus intereses y experiencias, y que la nacionalidad del autor tiene un peso menor. Aunque el entorno normativo favorece el uso de literatura traducida, su integración didáctica no siempre se explicita. El trabajo combina análisis documental, entrevistas y encuestas a estudiantes.This doctoral research analyzes how Spanish-speaking students at the Scuola Italiana di Montevideo engage with Latin American literature translated into Italian. Using a case study approach, it examines the factors influencing this reception, such as the author’s origin, teachers’ decisions, and the institutional framework. The study explores school anthologies, teaching approaches employed (such as CLIL and pedagogical translation), and teachers’ trajectories. The dissertation introduces the concept of “reinsertion translated literature,” an original category for considering texts that, through translation, return to the context in which they were produced, via a study language. The findings show that students value texts more when they are connected to their interests and experiences, and that the author’s nationality carries less weight. Although the regulatory framework supports the use of translated literature, its didactic integration is not always made explicit. The research combines documentary analysis, interviews, and student surveys.Programa de Doctorat en Llengües Aplicades, Literatura i Traducci
Formación y continuidad de la imagen: la construcción de los imaginarios de Malinche y Pocahontas (s. XVI-XIX)
No full textDoctorat internacionalEl estudio analiza cómo la continuidad y variación de elementos visuales y literarios desarrollados entre los siglos XVI y XIX consolidaron el estereotipo de la "indígena colaboracionista", representado por Malinche y Pocahontas. Desde un enfoque iconológico, se examina cómo ambas figuras fueron construidas simbólicamente bajo un ideario eurocéntrico. Más allá de su papel histórico, la investigación estudia sus imágenes como representaciones fronterizas y transformadoras que legitimaron un modelo hegemónico y proyectaron sobre el cuerpo femenino los ideales y temores de la cultura dominante. El análisis abarca desde códices y grabados hasta obras decimonónicas, revelando cómo el arte actuó a modo de dispositivo ideológico. La tesis, dividida en dos tomos, propone una lectura crítica que entiende las imágenes como procesos vivos de reinterpretación, evidenciando las tensiones entre poder, género y alteridad en la construcción simbólica de ambas figuras.The study examines how the continuity and variation of visual and literary elements developed between the sixteenth and nineteenth centuries consolidated the stereotype of the "collaborationist Indigenous woman", embodied by Malinche and Pocahontas. From an iconological perspective, it explores the ways in which both figures were symbolically constructed within a Eurocentric framework. Beyond their historical roles, the research emphasizes their images as liminal and transformative representations that legitimized a hegemonic model and projected the dominant culture’s ideals and anxieties onto the female body. The analysis spans materials ranging from codices and engravings to nineteenth-century works, revealing how art functioned as an ideological device aimed at exposing the tensions between power, gender, and alterity.Programa de Doctorat en Història de l'Ar
Carga de enfermedad crónica y su relación con el tipo de enfermedad, calidad de vida y condiciones sociodemográficas en adultos de México.
No full textObjetivos: Adaptar transculturalmente y validar el instrumento para medir carga de la enfermedad crónica para el paciente GCPC-UN en adultos hospitalizados en una ciudad de Veracruz (México). El segundo objetivo consistió en: estudiar la carga de la enfermedad crónica según la enfermedad, nivel de calidad de vida y variables sociodemográficas en adultos hospitalizados en una ciudad de Veracruz. Metodología: estudio observacional, transversal con abordaje cuantitativo para adaptar transculturalmente y validar el instrumento GCPC-UN en una ciudad de Veracruz (México). Se utilizó el instrumento validado para estudiar la carga de la enfermedad crónica y su relación con la calidad de vida y las variables sociodemográficas de la muestra. Resultados: el instrumento para medir carga de la enfermedad crónica GCPC-UN es válido y confiable para su aplicación en el contexto mexicano. Existe correlación negativa entre los dominios de calidad de vida y las dimensiones de carga de la enfermedad crónica.The objective of the study was to culturally adapt and validate the GCPC-UN instrument to measure the burden of chronic disease in adults from a city in Veracruz, Mexico. Additionally, the burden was analyzed according to the type of disease, quality of life, and sociodemographic variables. This was an observational, cross-sectional, and quantitative study, in which the previously validated GCPC-UN instrument was applied. The validation showed a McDonald's Omega of 0.986 for the 46 items. A negative correlation was identified between quality of life domains and the dimensions of disease burden. The main predictors of burden were the frequency of need for care support, the Charlson comorbidity index, and the type of chronic disease. It is concluded that the GCPC-UN is a reliable and useful instrument for assessing disease burden in adults with chronic conditions, and its use is recommended in nursing practice.Programa de Doctorat en Ciències de la Infermeri