97828 research outputs found
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Fístulas arteriovenosas endovasculares. Una nueva opción para los pacientes en hemodiálisis.
No full textCompendi d'articlesLa tesis doctoral gira en torno a los resultados obtenido con la utilización de un nuevo sistema endovascular para la realización de fístulas arteriovenosas en los pacientes en hemodiálisis. Se trata de una tesis por compendio de publicaciones en la que se han incluido un total de 4 publicaciones. Una de ellas se trata de un estudio prospectivo descriptivo de los resultados obtenidos durante el primer año de seguimiento tras su realización. Otro de ellos compara prospectivamente los resultados de estas fistulas endovasculares con fistulas realizadas de manera quirúrgica a lo largo de un año tras su realización. El tercero se trata de una revisión sistemática de la literatura en la que se observa la disparidad de género que se encuentran en la utilización de estos dispositivos a pesar de tratarse de métodos novedosos y el último de ellos es un caso clínico que ejemplifica los beneficios que podrían tener dichos sistemas mínimamente invasivos.The doctoral thesis focuses on the results obtained using a new endovascular system to create arteriovenous fistulas in hemodialysis patients. It is a thesis by a compendium of publications, which includes four papers. One of them is a prospective descriptive study of the outcomes during the first year of follow-up after the procedure. Another is a prospective comparison of the results of these endovascular fistulas versus surgically created fistulas over a one-year follow-up period. The third is a systematic review of the literature, highlighting the gender disparity observed in the use of these devices, despite being innovative methods. The final publication is a clinical case that illustrates the potential benefits of these minimally invasive systems.Programa de Doctorat en Cièncie
Gitanos en Castellón de la Plana: Avecindamiento forzoso, control y desigualdad (1739-1978)
No full textEl presente trabajo realiza un recorrido por la historia del Pueblo Gitano desde lo general -España- hasta lo particular -Castellón de la Plana-. La historia de los gitanos en Castellón ha transcurrido de manera paralela al resto del territorio: el peregrinaje, asentamiento, control y persecución, fueron consustanciales a la región. La tesis indaga en las causas del persistente rechazo y discriminación, amparados desde el punto de vista legal, pero con un trasfondo socioeconómico, que han alimentado los estereotipos e imagen negativa de la etnia gitana: nómada, trapacero, vago, embaucador, etc. que aún persiste. La historia de los gitanos en España se puede resumir afirmando que fueron aceptados como peregrinos, rechazados como vecinos y discriminados como españoles. Las campañas emprendidas en el siglo XXI por el Secretariado Gitano han puesto el énfasis en el conocimiento de su cultura. Nuevos tiempos y nuevas miradas a las que esperemos contribuir con nuestro estudio.This work takes a journey through the history of the Gypsy People from the general aspects –Spain– to the particular –Castellón de la plana–. The history of the gypsies in Castellón has happened parallel to the rest of the territory: pilgrimage, settlement, control and chase were consubstantial to the region. This thesis investigates the causes of persistent repulse and discrimination, protected from a legal point of view but with a social and economic background that has fed stereotypes and negative image of gypsy ethnic group: wandering, cheaters, lazy… which still remain today. The Gypsies history in Spain can be summed up saying that they were accepted as pilgrims, rejected as neighbours and discriminated like a Spaniards. The campaigns started in the 21st century by Gypsy Organisation has emphasized understanding their culture. These are new times and new perspectives, to which we hope to contribute through our study.Programa de Doctorat en Història i Estudis Contemporani
Attempts to detect retrotransposition and de novo deletion of Alus and other dispersed repeats at specific loci in the human genome
No full textDispersed repeat elements contribute to
genome instability by de novo insertion
and unequal recombination between
repeats. To study the dynamics of these
processes, we have developed single DNA
molecule approaches to detect de novo
insertions at a single locus and
Alu-mediated deletions at two different
loci in human genomic DNA. Validation
experiments showed these approaches
could detect insertions and deletions at
frequencies below 10(-6) per cell.
However, bulk analysis of germline
(sperm) and somatic DNA showed no
evidence for genuine mutant molecules,
placing an upper limit of insertion and
deletion rates of 2 x 10(-7) and 3 x
10(-7), respectively, in the individuals
tested. Such re-arrangements at these
loci therefore occur at a rate lower
than that detectable by the most
sensitive methods currently available.Peer Reviewe
Bot vs Human: Implementation of bots for different modern board games in Unity
No full textTreball final de Grau en Disseny i Desenvolupament de Videojocs. Codi: VJ1241. Curs acadèmic: 2024-2025This TFG focuses on adapting several modern board games to the Unity engine, enabling the integration of various agents capable of playing any of the implemented games. Throughout the project, agents will be developed using different artifcial intelligence techniques. The game code will be made publicly available to encourage external participation in an agent development tournament, where user-created agents will compete in the selected games. Additionally, a separate contest will be organized, allowing participants to
play against a variety of bots developed during the tournament
El Diseño Universal para el Aprendizaje (DUA) en la universidad: superar las barreras para el aprendizaje y la participación del alumnado autista
No full textCompendi d'articles, Doctorat internacionalEsta tesis doctoral explora cómo la Universitat Jaume I (Castellón de la Plana) promueve una educación inclusiva desde la perspectiva del alumnado autista, utilizando el enfoque del Diseño Universal para el Aprendizaje (DUA). A través de una metodología cualitativa y siete estudios, se identifican diferentes barreras para su participación y aprendizaje, así como facilitadores desde el enfoque DUA. Aunque el profesorado muestra una actitud proactiva, desconoce cómo implementar prácticas más inclusivas. Los servicios de apoyo son clave, aunque requieren de una mayor coordinación entre los distintos agentes para garantizar que sus funciones sean verdaderamente efectivas. La propuesta formativa Encuentros impulsa el diálogo entre estudiantado, profesorado y especialistas para construir colectivamente conocimiento y avanzar hacia una universidad más inclusiva. La investigación concluye que la UJI muestra un compromiso con la inclusión, aunque señala la necesidad de un respaldo institucional más sólido, que impulse estas iniciativas como parte de su modelo universitario.This research explores how the Jaume I University (Castellón de la Plana) promotes inclusive education from the perspective of autistic students, using the framework of Universal Design for Learning (UDL). Through a qualitative methodology and seven studies, various barriers to their participation and learning are identified, as well as facilitators aligned with the UDL approach. Although faculty members display a proactive attitude, they often lack knowledge on how to implement more inclusive practices. Support services play a key role, although greater coordination among stakeholders is needed to ensure that their functions are truly effective. The training initiative Encuentros fosters dialogue among students, faculty, and specialists to collectively build knowledge and advance toward a more inclusive university. The research concludes that UJI demonstrates a commitment to inclusion, while also highlighting the need for stronger institutional support to drive such initiatives as part of its university model.Programa de Doctorat en Educaci
Inter-limb neuromuscular activity of the gastrocnemius muscle during unilateral and bilateral explosive jumps and relationship with jump performance
No full textUnderstanding the neuromuscular demands of explosive tasks is essential for enhancing performance and reducing injury risk. This study analyzed inter-limb activation of the medial and lateral gastrocnemius during take-off and landing phases of bilateral and unilateral countermovement jumps (CMJ) and horizontal jumps (HJ), examining its relationship with inter-limb asymmetry and performance. Twenty-six physically active participants performed CMJ and HJ tasks while bilateral surface electromyography was recorded from both gastrocnemius heads. Jump performance was evaluated using flight time (CMJ) and distance (HJ), and asymmetry indices were computed between dominant and non-dominant limbs. Results showed significantly greater muscle activity during take-off than landing across all conditions (p < 0.05). During CMJ landings, the medial gastrocnemius was more active than the lateral, with no activation differences found between unilateral and bilateral jumps. A moderate positive correlation was observed between CMJ performance and bilateral take-off asymmetry (r = 0.43, p = 0.02). Conversely, greater activation in the non-dominant gastrocnemius was negatively associated with performance in both CMJ and HJ (r = –0.39 to –0.48, p < 0.05). In conclusion, gastrocnemius muscles display phase-specific activation patterns. Moderate asymmetry during take-off may benefit performance, while excessive activation in the non-dominant limb may reflect compensatory strategies detrimental to jump efficiency
La intención emprendedora comercial y social: un modelo de antecedentes y desencadenantes del comportamiento emprendedor
No full textEsta tesis analiza el proceso emprendedor desde una perspectiva integral, explorando los factores que influyen en la formación de la intención emprendedora y su conversión en comportamiento efectivo, tanto en su vertiente comercial como social. El modelo propuesto incorpora valores personales (individualistas y colectivistas), capital social cognitivo (bonding y bridging) y eventos desencadenantes (realización personal, insatisfacción laboral, orientación a la innovación y herencia). Los resultados evidencian que los valores individualistas, especialmente los vinculados a la automejora, influyen significativamente en la intención emprendedora, incluso en proyectos de carácter social. Asimismo, se confirma que el capital social bonding facilita la intención comercial, y que la orientación a la innovación actúa como desencadenante del comportamiento. Finalmente, se valida empíricamente que una alta intención predice la acción emprendedora, sin diferencias sustanciales entre los tipos de emprendimiento. Estos hallazgos ofrecen implicaciones teóricas y prácticas para fortalecer políticas de apoyo y programas formativos en emprendimiento.This dissertation delves into the analysis of the entrepreneurial process that connects the formation of entrepreneurial intention with its manifestation as effective entrepreneurial behavior, considering both commercial and social forms of entrepreneurship. The study proposes a research model that identifies the factors explaining this transition by integrating personal, cognitive, social, and contextual variables. It highlights the role of personal values, cognitive social capital, and triggering events as key elements in the conversion of intention into action. Through a quantitative approach and structural equation modeling analysis (PLS-SEM) applied to entrepreneurs in the Valencian Region, the results show that individualistic values, particularly those oriented toward achievement and power, are significant determinants of entrepreneurial intention. Moreover, the study underscores the importance of specific triggering events, such as innovation orientation and family succession.Programa de Doctorat en Desenvolupament Local i Cooperació Internaciona
Metabolite Profiling and Antioxidant Activities in Seagrass Biomass
No full textIn this work, metabolite profiling of seeds and antioxidant analysis of fragments of two marine seagrasses, Posidonia oceanica and Cymodocea nodosa, were carried out to identify metabolite signature involved in seed viability and to evaluate the potential of fragments as a source of bioactive compounds. Using HILIC/QTOF-MS, UHPLC-MS and spectrophotometric analysis, seed metabolites and polyphenols and antioxidant activities,
such as those of radical scavenging (RSA), reduction (FRAP, CUPRAC) and complexation (CCA), of rhizome fragments were evaluated. Metabolite comparison between seeds revealed differences across development stages (germinated and non-germinated) and seed types (dormant and non-dormant), providing insights into metabolic activity potentially associated with germination processes and seed viability. Furthermore, polyphenol analysis
showed the highest content of caffeic acid in mature leaves (17.00 ± 0.02 µg g−1 dw for P. oceanica and 98.00 ± 0.03 µg g−1 dw for C. nodosa). Total phenolic content was correlated with flavonoids and with reduction and complexation activities. The combination of radical scavenging activity and t1/2 was higher in P. oceanica than C. nodosa and also surpassed the commercial synthetic antioxidant BHA. We conclude P. oceanica and C. nodosa exhibit distinct seed metabolite profiles related to germination and type of seeds, and that fragments are rich in antioxidants, with potential as sustainable sources of bioactive compounds
La intención emprendedora comercial y social: un modelo de antecedentes y desencadenantes del comportamiento emprendedor
No full textEsta tesis analiza el proceso emprendedor desde una perspectiva integral, explorando los factores que influyen en la formación de la intención emprendedora y su conversión en comportamiento efectivo, tanto en su vertiente comercial como social. El modelo propuesto incorpora valores personales (individualistas y colectivistas), capital social cognitivo (bonding y bridging) y eventos desencadenantes (realización personal, insatisfacción laboral, orientación a la innovación y herencia). Los resultados evidencian que los valores individualistas, especialmente los vinculados a la automejora, influyen significativamente en la intención emprendedora, incluso en proyectos de carácter social. Asimismo, se confirma que el capital social bonding facilita la intención comercial, y que la orientación a la innovación actúa como desencadenante del comportamiento. Finalmente, se valida empíricamente que una alta intención predice la acción emprendedora, sin diferencias sustanciales entre los tipos de emprendimiento. Estos hallazgos ofrecen implicaciones teóricas y prácticas para fortalecer políticas de apoyo y programas formativos en emprendimiento.This dissertation delves into the analysis of the entrepreneurial process that connects the formation of entrepreneurial intention with its manifestation as effective entrepreneurial behavior, considering both commercial and social forms of entrepreneurship. The study proposes a research model that identifies the factors explaining this transition by integrating personal, cognitive, social, and contextual variables. It highlights the role of personal values, cognitive social capital, and triggering events as key elements in the conversion of intention into action. Through a quantitative approach and structural equation modeling analysis (PLS-SEM) applied to entrepreneurs in the Valencian Region, the results show that individualistic values, particularly those oriented toward achievement and power, are significant determinants of entrepreneurial intention. Moreover, the study underscores the importance of specific triggering events, such as innovation orientation and family succession.Programa de Doctorat en Desenvolupament Local i Cooperació Internaciona
Autopercepción de competencias y entorno de prácticas en estudiantes de enfermería en el este de Inglaterra
No full textLa experiencia práctico-clínica tiene un papel esencial en la formación universitaria de las enfermeras. La percepción de los estudiantes de su entorno de prácticas y la autopercepción de su preparación para desenvolverse en dicho entorno aparecen destacados en la literatura. Se llevó a cabo un estudio descriptivo y transversal de tipo correlacional en estudiantes del Grado de Enfermería en una universidad del este de Inglaterra para analizar la relación entre el entorno en las prácticas clínicas y el nivel de competencia percibido por los participantes. Se encontró una asociación positiva entre el entorno y el nivel de competencia y diferencias significativas de competencia autopercibida entre los grupos. Los estudiantes del grado de Enfermería valoran de forma favorable su entorno de prácticas, lo cual influye en una autopercepción general positiva de su nivel de competencia. Sería recomendable explorar en mayor profundidad a los diferentes grupos de estudiantes.Practice experience plays an essential role in the undergraduate education of nurses. Students' perceptions of their practice environment and the self-perception of their preparedness to work in that environment are highlighted in the literature as relevant factors. A descriptive, cross-sectional, correlational study of undergraduate nursing students at a university in the East of England was conducted to examine participants' perceived level of competence and its relationship to the clinical practice environment. A positive association was found between environment and level of competence. There were significant differences in self-perceived competence between the groups. Nursing students rate their practice environment favourably, and this influences their overall positive perception of their level of competence. Further exploration of these findings in different groups of students would be advisable.Programa de Doctorat en Ciències de la Infermeri