University of Valencia
Repositori d'Objectes Digitals per a l'Ensenyament la Recerca i la CulturaNot a member yet
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Contra els límits. Les reescriptures de la dictadura franquista
No full textEn aquest recull d’articles s’estudien les reescriptures literàries que foren condicionades pel context de la Guerra Civil i la dictadura franquista, amb una doble línia d’interés. D’una banda, de la mà d’investigadors i investigadores de diverses universitats, hi ha capítols en què s’aborda l’abast de les tisores de la censura i els resultats literaris que se’n deriven, amb estudis que s’acosten a les versions mutilades per la censura en relació amb els textos originals –alguns recuperats editorialment i d’altres en arxius personals o com a part dels expedients de censura. Hi comptem, d’altra banda, amb capítols dedicats a hipertextualitats vinculades a l’experiència de l’exili, que en certs casos presenten com a base les cultures dels països de destinació dels escriptors, on trobem versions de mites, obres o temes de les cultures dels llocs d’acollida incorporats a la literatura dels exiliats. La llista d’autors estudiats és àmplia: Josep Carner, Carles Riba, Agustí Bartra, Mercè Rodoreda, Llorenç Villalonga, M. Aurèlia Capmany, Joan Fuster, Manuel de Pedrolo, Jordi Coca, Jaume Fuster, Rodolf Sirera, Manuel Molins... Per tancar el llibre, recollim el testimoni d’un escriptor, el mallorquí Gabriel Janer Manila, que ens relata, de primera mà, els efectes de l’aparell repressor franquista en la seua trajectòria
When is environmental performance most valued? International evidence from the CDS market
Get PDFUsing a sample of 516 firms with CDS data from 37 countries for the period 2010-2022, this study finds that companies with higher environmental performance, particularly in emissions reduction and product innovation, exhibit a reduction in credit risk, supporting the risk mitigation perspective. Our results also highlight the importance of considering both internal and external factors when assessing the financial impact of sustainability initiatives. Firms with initially lower environmental performance, less exposure to the environmental sector, and higher credit ratings experience a more significant reduction in credit risk as they improve their environmental performance. In addition, the CDS market places a higher value on environmental efforts for firms located in countries with lower environmental scores, credit ratings and GDP growth. Conversely, out findings support the overinvestment view for firms in sectors with high environmental risk exposure or in countries with poor climate change performance. Overall, the effect of a firm's environmental performance on credit risk is heterogeneous rather than unifor
Investigations of Crucial Factors for the Non-Covalent Functionalization of Black Phosphorus (BP) using Perylene Diimide Derivatives for the Passivation of BP Nanosheets
Get PDFThe non-covalent functionalization of black phosphorus (BP) was studied with a scope of ten tailor-made perylene diimides (PDIs). A combination of UV/Vis-, fluorescence-, as well as Raman spectroscopy and atomic force microscopy was used to investigate the structural factors, which contribute to a pronounced PDI-BP interaction and thus support the protection of BP nanosheets against oxidative degradation. We were able to show, that water-soluble, amphiphilic PDIs with highly charged head groups can be used for the non-covalent functionalization of BP in aqueous media. Here, based on the hydrophobic effect, an efficient adsorption of the respective PDI molecules takes place and leads to the formation of a passivating film, yielding a considerable stabilization of the BP flakes under ambient conditions exceeding 30 days
El enfermo de cáncer: una aproximación a su representación social
Get PDFEsta investigación tiene como objetivo el análisis de la representación social del cáncer y de los enfermos oncológicos en la población española. Para ello se entrevistaron a 200 sujetos elegidos mediante muestreo al azar. El método utilizado fue la realización de entrevistas estructuradas que contenían asociaciones libres de palabras ante términos estimulo y preguntas semicerradas. Las respuestas obtenidas son analizadas a partir de análisis descriptivos y análisis de contenido. Los resultados nos indican que existe una representación social del cáncer y del enfermo oncológico y que parte de ella sufre variaciones en función de la pertenencia a determinadas categorías o grupos sociales. Estos resultados son relevantes en el contexto sanitario ya que dicho conocimiento permite a los sanitarios analizar su comunicación con el paciente y poder llevar a cabo un trato diferenciado del enfermo de cáncer, no por su pertenencia social a un grupo de enfermos determinado sino por sus peculiaridades personales lo que incrementa la efectividad de la acción profesional
Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits
Get PDFUnmodified Ti6Al4V can osseointegrate, but sometimes this capacity needs to be improved. This study aimed to see how much porosity improves osseointegration in a Ti6Al4V implant. Three types of Ti6Al4V cylindrical-shaped implants (13.00 mm length × 5.00 mm diameter) were evaluated: solid sandblasted acid-etched, sintered, and porous 3D-printed (681.00 μm average pore size). Fifteen 20-week-old nullipara female parasite-free New Zealand California white rabbits were used, employing the femoral condyle defect model and undertaking μ-CT analysis and pull-out testing eight weeks later. On μ-CT densitometric analysis, the solid sandblasted rod showed the highest new bone growth around the implant. Bone growth was higher inside the implants for the porous 3D-printed (54.00 ± 5.00 mm3) than for the sintered (1.00 ± 0.05 mm3) and zero for the sandblasted implants. In the pull-out test, there were no statistically significant differences in the ANOVA analysis between the sintered (900.00 N ± 310.00 N) and porous 3D-printed (700.00 N ± 220.00 N) implants. Such differences did exist between the sandblasted material (220.00 N ± 50.00 N) and the two other materials (sintered p 0.002, porous p 0.034). The porous 3D-printed and sintered implant pull-out strength were significantly better than that of the solid rod sandblasted implant. Still, there were no statistically significant differences between the first two
Effects of acupuncture versus placebo on clinical status and potential specific effects in Fibromyalgia: an umbrella review of 11 meta-analyses
Get PDFBackground: The use of acupuncture is related to patients' expectations, and the therapeutic interaction effect remains a topic of debate in the literature. Accordingly, it is still unclear whether acupuncture can generate positive clinical effects in patients with fibromyalgia (FM). Objective: To determine the effectiveness of acupuncture versus placebo for clinical outcomes and determine the overall effect not attributed to specific effects in patients with FM. Design: Umbrella review of systematic reviews (SRs) and meta-analyses. Data sources and methods: An electronic search was performed in MEDLINE (via PubMed), Web of Science, CENTRAL, EMBASE, LILACS, CINAHL, PEDro, and SPORTDiscus databases from inception until December 2023. We selected studies with a clinical diagnosis of FM and that analyzed the effectiveness of acupuncture compared with a placebo. Pain intensity, functional status, fatigue, sleep quality, and depression symptoms were assessed. Effect sizes were calculated as the mean difference (MD) or standard mean difference (SMD). The quality of intervention reporting was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Results: Eleven SRs with 8399 participants were included. Compared with placebo, acupuncture was associated with reductions in pain intensity (MD = -1.13 cm, 95% CI -2.09 to -0.17, p < 0.001), physical function (SMD = -0.63, 95% CI -1.67 to 0.41, p = 0.06), sleep quality (SMD = -0.25, 95% CI -1.39 to 0.88, p = 0.06), and fatigue (SMD = 0.20, 95% CI = 0.17 to 0.22, p < 0.001). The proportion not attributable to specific effects (PCE) of acupuncture was 58% for pain intensity (PCE = 0.58, 95% CI 0.45 to 0.71), 57% for physical function (PCE = 0.57, 95% CI -0.07 to 1.20), and 69% for fatigue (PCE = 0.69, 95% CI 0.18 to 1.21). Conclusion: Acupuncture showed a statistically significant difference in decreased pain intensity and fatigue in women with FM. However, the certainty of evidence was low to very low; its effects are not clinically important, and more than 50% of the overall treatment effects were not attributed to the specific effects of acupuncture
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies
Get PDFGaining knowledge on the metabolism of a drug, the enzymes involved and its inhibition or induction potential is a necessary step in pharmaceutical development of new compounds. Primary human hepatocytes are considered a cellular model of reference, as they express the majority of drug-metabolis- ing enzymes, respond to enzyme inducers and are capable of generating in vitro a metabolic profile similar to what is found in vivo. However, hepato- cytes show phenotypic instability and have a restricted accessibility. Different alternatives have been explored in the past recent years to overcome the limi- tations of primary hepatocytes. These include immortalisation of adult or fetal human hepatic cells by means of transforming tumour virus genes, onco- genes, conditionally immortalised hepatocytes, and cell fusion. New strategies are currently being used to upregulate the expression of drug-metabolising enzymes in cell lines or to derive hepatocytes from progenitor cells. This paper reviews the features of liver-derived cell lines, their suitability for drug meta- bolism studies as well as the state-of-the-art of the strategies pursued in order to generate metabolically competent hepatic cell lines
El Reglamento (UE) núm. 2020/1784 y su contribución al impulso de la digitalización de la cooperación judicial en materia civil y mercantil en la Unión Europea
Get PDFDurante los últimos años, y con mayor intensidad desde la crisis provocada por el COVID-19, la Unión Europea se ha marcado como objetivo potenciar el desarrollo de un mercado único digital, afectando directamente a políticas como la de cooperación judicial en materia civil y mercantil. Como resultado de este impulso, se han multiplicado los esfuerzos regulatorios, como se manifiesta en la elaboración del Reglamento (UE) núm. 2020/1784 relativo a la notificación y traslado en los Estados miembros de documentos judiciales y extrajudiciales en materia civil o mercantil ("notificación y traslado de documentos") (versión refundida). El cual, a pesar de su corta vida y debido a la efervescencia de esta actividad legislativa, ha sufrido ya dos modificaciones, para adaptarse a la gran velocidad con la que se suceden los intentos para favorecer la incorporación de herramientas digitales en este ámbito. De ahí la necesidad de analizar, no ya sólo los mecanismos digitales de notificación y traslado que ofrece el Reglamento (UE) núm. 2020/1784, sino poner este significativo instrumento en el contexto más amplio que supone la plena digitalización de cooperación judicial europea en materia civil o mercantil. During the past few years, and with greater intensity since the COVID-19 crisis, the European Union has set itself the objective of boosting the development of a digital single market, directly affecting policies such as judicial cooperation in civil and commercial matters. As a result of this impulse, regulatory efforts have multiplied, as illustrated by the elaboration of Regulation (EU) No 2020/1784 on the service in the Member States of judicial and extrajudicial documents in civil or commercial matters ("service of documents") (recast version). Despite its short life and due to the effervescence of this legislative activity, it has already undergone two amendments, in order to adapt to the rapid pace of attempts to promote the incorporation of digital tools in this field. Therefore, there is a need not only to analyse the digital service mechanisms offered by Regulation (EU) No 2020/1784, but also to place this significant instrument in the broader context of the full digitisation of European judicial cooperation in Civil or Commercial matters
Impacto de las variables macroeconómicas en el Índice de Desarrollo Humano: el caso de Chile, Perú, Colombia y Venezuela
No full textEl objetivo de esta investigación es determinar la relación existente entre el Índice de Desarrollo Humano (IDH) y distintas variables de carácter macroeconómicas para los países de Chile, Colombia, Perú y Venezuela entre el período 2000-2021. En una primera etapa, se aplicó un análisis de ANOVA, con el objeto de contrastar si existe una diferencia significativa entre los valores medios del IDH en los cuatro países. Posteriormente, se estimó un modelo econométrico de datos de panel para determinar qué factor económico es más influyente en el IDH. Se concluye que el PIB per cápita tiene un efecto positivo sobre el IDH, mientras que la tasa de desempleo y la tasa de pobreza tienen una relación inversa. Los resultados pueden orientar a las instituciones públicas y privadas a promover y aplicar políticas económicas en la reducción de la pobreza e incrementar el empleo
Vascular endothelial growth factor immunoexpression in oral paracoccidioidomycosis
Get PDFParacoccidioidomycosis (PCM) is a systemic mycosis endemic and limited to Latin America. Brazil is responsible for more than 80% of diagnosed cases in the world. Since PCM is not a notifiable disease, there are still no accurate data on its incidence in Brazil. Vascular endothelial growth factor (VEGF) is considered the main vascular endothelial growth factor expressed in the process of angiogenesis, both under physiological and pathological conditions. To date, there are not studies in the literature that evaluated the expression of VEGF in oral PCM lesions. Therefore, the objective of this study was to evaluate the prevalence of oral lesions of PCM diagnosed from 1998 to 2020; to analyze the immunoexpression of VEGF in oral lesions of PCM; and to compare the VEGF immunostaining with the clinical and microscopic aspects of these lesions. Clinical data of 98 cases of patients with oral PCM were evaluated. A total of 41 selected cases were quantitatively and qualitatively analysed by immunohistochemistry for VEGF. Our results showed that oral PCM preferentially affects white males, with mean age of 50.2 years, and the gingiva and the alveolar ridge. It was not possible to correlate VEGF immunoexpression with clinical and microscopic variables. Oral PCM is a relatively uncommon pathological condition and that, in our sample, the immunoexpression of VEGF was mild and observed in a reduced number of cases