University of Valencia
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Metaphysics and Physiology in Animal Magnetism According to Schopenhauer
Get PDFFor the German philosopher Arthur Schopenhauer, animal magnetism is a natural evidence of his metaphysics of the will. In turn, his metaphysics of the will reveals the true nature of animal magnetism. Therefore, animal magnetism can be approached from both natural and metaphysical points of view. From a metaphysical point of view, animal magnetism is an objectification of the will, while as a natural phenomenon it implies the laws of the physiology of the nervous system. According to Schopenhauer, the will acts directly on phenomena, given how it is not separated from the laws of the phenomenal reality it has created. The objective of the present work is to expose that, in order to produce the phenomenon of animal magnetism, the activity of the nervous system is as necessary as the action of the will
Coloboma retinocoroideo: estudio mediante retinografía, angiografía fluoresceínica, ecografía y tomografía de coherencia óptica = Retino-choroidal coloboma: Study through retinography, fluorescence angiography, ecography and optical coherence tomography
No full textEl coloboma retinocoroideo es la ausencia de retina-coroides por cierre inadecuado de la fisura óptica en el desarrollo embrionario. Está relacionado con aumento del riesgo de desprendimiento de retina respecto a la población general, sobre todo si la excavación relativa es > 0,15
Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages
Get PDFPeroxisome proliferator-activated receptors (PPARs) play a major role in regulating inflammatory processes, and dual or pan-PPAR agonists with PPARγ partial activation have been recognised to be useful to manage both metabolic syndrome and metabolic dysfunction-associated fatty liver disease (MAFLD). Previous works have demonstrated the capacity of 2-prenylated benzopyrans as PPAR ligands. Herein, we have replaced the isoprenoid bond by hydrazone, a highly attractive functional group in medicinal chemistry. In an attempt to discover novel and safety PPAR activators, we efficiently prepared benzopyran hydrazone/hydrazine derivatives containing benzothiazole (series 1) or 5-chloro-3-(trifluoromethyl)-2-pyridine moiety (series 2) with a 3- or 7-carbon side chain at the 2-position of the benzopyran nucleus. Benzopyran hydrazones 4 and 5 showed dual hPPARα/γ agonism, while hydrazone 14 exerted dual hPPARα/δ agonism. These three hydrazones greatly attenuated inflammatory markers such as IL-6 and MCP-1 on the THP-1 macrophages via NF-κB activation. Therefore, we have discovered novel hits (4, 5 and 14), containing a hydrazone framework with dual PPARα/γ or PPARα/δ partial agonism, depending on the length of the side chain. Benzopyran hydrazones emerge as potential lead compounds which could be useful for treating metabolic diseases
Impact of Maternal Smoking on Obstetric and Neonatal Outcomes in Twin Pregnancies: A Narrative Review
No full textMaternal smoking, including both traditional cigarettes and electronic ones, is a significant modifiable risk factor associated with adverse perinatal outcomes, especially in twin pregnancies. This narrative review aims to explore the impact of maternal smoking on obstetric and neonatal outcomes in twin pregnancies, which inherently carry a higher risk of complications. A literature search was conducted using the PubMed and EMBASE databases, selecting studies published between January 1994 and October 2024. The findings demonstrate a clear association between smoking and increased risks of preterm birth and fetal growth restriction (FGR) in twin pregnancies. These risks are exacerbated when smoking is combined with other factors, such as preeclampsia and elevated body mass index (BMI). Smoking was also associated with long-term post-natal complications, including respiratory problems like asthma, as well as cognitive and behavioral disorders. However, an association with preeclampsia was not found, and further studies are needed to clarify the relationship in the fields of preterm premature rupture of membranes (PPROM) and fetal death. The adverse effects of smoking are primarily due to reduced oxygen supply to the fetus, caused by nicotine-induced vasoconstriction and carbon monoxide exposure, leading to placental insufficiency and fetal hypoxia. These effects are amplified in twin pregnancies due to the increased physiological demands. The review highlights that smoking cessation interventions during pregnancy are crucial to mitigate these risks and improve maternal and neonatal health outcomes
Evaluation of the perceived social impacts of the Formula E Grand Prix of Santiago de Chile
Get PDFThe aim of this study is to analyse residents' perception of the social impact of the Formula E Grand Prix of Santiago de Chile. A sample of 414 residents was collected through a questionnaire made up of 46 items regarding possible positive and negative impacts. Descriptive analysis, confirmatory factorial analysis and cluster analysis were performed. The results showed two groups with different perceptions of this sporting event: realistic (n=152) and favourable (n=162). Sociodemographic variables referring to education level, civil status, income level, location of the family residence and political orientation contribute to significantly differentiating the clusters. The variables related to interest in the event, support for the celebration, attendance, participation and frequency of contact also contributed to significantly differentiating the groups. Citizens' high degree of support for holding the sporting event could be identified by a positive social representation of the even
La escritura académica en la Universidad / Academic Writing at University
No full textHace tiempo que se constatan las dificultades que la escritura académica plantea a los estudiantes. En este artículo se revisan las distintas actuaciones adoptadas por las universidades para abordar los modos de comunicar propios de la construcción del saber, en especial, de la escritura con finalidad epistémica. The difficulties that academic writing poses for students have long been noted. This article reviews the different actions taken by universities to address the modes of communication involved in the construction of knowledge, especially writing for epistemic purposes
El desafío de aplicar el modelo HIP en la educación secundaria: transformando hacia la democratización
Get PDFIntroducción: La sociedad contemporánea requiere transformaciones en sus instituciones y un modelo que acelere cambios profundos en las organizaciones. El modelo HIP (Hexágono de la Innovación Pública) facilita la creación de un entorno innovador adaptado a contextos específicos, mejorando la eficiencia institucional y promoviendo una transformación integral con un enfoque en el gobierno abierto y el cambio sistémico. Metodología: Este estudio, hemos empleando una metodología cualitativa basada en la investigación-acción, analizando el proyecto educativo del IES Moixent mediante un estudio de caso en el CEIP 'Ramón y Cajal' de Alpartir. Resultados: A través de cuestionarios autodiagnósticos, se identificaron deficiencias y se propuso una intervención para mejorar los vectores CO y OPEN, con un plan integral destinado a consolidar una Escuela Democrática entre 2022 y 2024. Discusión: La aplicación del modelo HIP permitió comprender el ecosistema escolar y delinear las acciones necesarias para la democratización educativa, con la participación activa de toda la comunidad educativa en la ejecución y evaluación del plan de acción. Conclusiones: Los datos obtenidos respaldan la adopción del modelo HIP, confirmando que, con una implementación adecuada, es posible lograr mejoras sustanciales en el ecosistema educativo, facilitando la transición hacia una Escuela Democrática
Introducció al Dret Civil. Tema 3.3. La persona. Els drets de la personalitat (III)
No full textTema 3.3. La persona. Els drets de la personalitat (III
Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders
Get PDFBackground Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the life span. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. Methods We conducted linear mixed models to estimate the rates of accelerated cortical thinning across 68 regions from the Desikan-Killiany atlas in individuals with schizophrenia compared with healthy control participants from a large longitudinal sample (ncases = 169 and ncontrols = 298, ages 16-70 years). We studied the correlation between gene expression data from the Allen Human Brain Atlas and accelerated thinning estimates across cortical regions. Finally, we explored the functional and genetic underpinnings of the genes that contribute most to accelerated thinning. Results We found a global pattern of accelerated cortical thinning in individuals with schizophrenia compared with healthy control participants. Genes underexpressed in cortical regions that exhibit this accelerated thinning were downregulated in several psychiatric disorders and were enriched for both common and rare disrupting variation for schizophrenia and neurodevelopmental disorders. In contrast, none of these enrichments were observed for baseline cross-sectional cortical thickness differences. Conclusions Our findings suggest that accelerated cortical thinning, rather than cortical thickness alone, serves as an informative phenotype for neurodevelopmental disruptions in schizophrenia. We highlight the genetic and transcriptomic correlates of this accelerated cortical thinning, emphasizing the need for future longitudinal studies to elucidate the role of genetic variation and the temporal-spatial dynamics of gene expression in brain development and aging in schizophrenia
Black fish, black fish, what do you see? Looking at the faces of orcas in animal advocacy documentary film
Get PDFAnimal advocacy documentaries have, in the last decades, established themselves as an identifiable subgenre of their own with strategic conventions such as featuring the gaze of the nonhuman animal "looking back" for moral shock and ethical purposes. This article examines the problematic gaze and face of a particular species, the orca, with regards to such convention, and sets out to analyze how Gabriela Cowperthwaite's Blackfish (2013) and William Neal's Long Gone Wild (2019) deal with the representation of orca faces, gazes, and bodies within their wider structural dichotomy of captivity and wilderness. To do so, the article first explores representations of orcas in fictional films and how they are connected to the wider context of the marine park industry. It then turns to the issue of facial representation and the image of interspecies bonding in the documentaries, and points out the editing strategies that determine the central role of the films' interviewees as guides in the meaning-making process of orca faces and bodies