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Towards the establishment of a reference method for Mycobacterium avium drug susceptibility testing
No full text"Mycobacterium avium is the most common non-tuberculous mycobacteria (NTM)
associated with human infections. Treatment of M. avium disease is challenging, with
microbiological eradication typically requiring a multidrug antibacterial regimen over a prolonged
period. This scenario worsens as no standardized drug susceptibility testing guidelines are
available. This work aimed to evaluate the provisional European Committee for Susceptibility
Testing (EUCAST) reference protocol for minimum inhibitory (MIC) determination of slow growing NTM, correlate it with established molecular determinants and examine its usefulness
for testing new drugs.(...)"N/
As Vozes de Pessoa: A Paisagem Sonora enquanto ferramenta de recriação musical de poemas de Fernando Pessoa no ensino de Educação Musical no 2o ciclo do Ensino Básico
No full textO presente relatório foi elaborado no âmbito da Prática de Ensino Supervisionada
(PES) do Mestrado em Ensino de Educação Musical no Ensino Básico, da Faculdade de
Ciências Sociais e Humanas de Lisboa. Este relatório retrata o trabalho desenvolvido em
contexto de estágio numa escola de ensino pública do distrito de Lisboa, no ano letivo de
2023/2024.
Inicialmente, o relatório procura descrever de forma crítica e sucinta toda aquela
que foi a experiência que constituiu a PES. Numa primeira fase surge a contextualização
da escola de ensino pública onde decorreu o estágio e é também efetuada uma análise da
prática pedagógica, tendo em conta as linhas orientadoras pelas quais se rege a disciplina
de Educação Musical. Dentro deste ponto, inclui-se também a caracterização das turmas,
onde se insere uma descrição e reflexão sobre a experiência obtida junto da Unidade de
Apoio Especializado ao Aluno com Multideficiência. A análise e reflexão sobre as
componentes de observação e lecionação, assim como a descrição da participação em
projetos, eventos e reuniões, são pontos que também fazem parte deste capítulo. No final,
é realizada uma reflexão crítica sobre o papel do professor de Educação Musical, bem
como uma observação crítica geral à prática pedagógica.
De seguida, é apresentada a implementação, análise e reflexão do projeto
desenvolvido com base no tema das Paisagens Sonoras. Com foco na exploração e
improvisação musical e na sua interligação a poemas de heterónimos do poeta Fernando
Pessoa, é feito o retrato do projeto e das atividades desenvolvidas numa turma do 5º ano
de escolaridade. Com o objetivo de utilização das Paisagens Sonoras enquanto estímulo
para a criação e improvisação musical, este projeto procura refletir sobre a importância
que este tema possuiu não só nas competências criativas dos alunos, mas também na sua
transversalidade a outras áreas do saber. A partir da exploração vocal, este projeto reflete
nas possibilidades que este tema traz no que diz respeito à criação musical individual,
mas também em pequenos grupos, e no seu potencial enquanto ferramenta pedagógica
utilizando a poesia como material criativo para a performance musical. Depois de expostos os outputs do projeto e de realizada a sua análise, são ainda tecidas
considerações e implicações para o futuro do projeto.This report was written as part of the Supervised Teaching Practice (STP) of the
Master’s Degree in Teaching Music Education in Basic Education of the Faculty of Social
and Human Sciences in Lisbon. This report portrays the work carried out in the context
of an internship in a public school in the district of Lisbon, in the school year of
2023/2024.
Initially, the report seeks to critically and succinctly describe the entire experience
that made up the STP. The first stage is the contextualisation of the public school where
the internship took place and an analysis of the pedagogical practice, taking into account
the guidelines that apply to the subject of Musical Education. This section also includes
a characterisation of the classes, including a description and a reflection on the experience
gained with the Specialised Support Unit for Students with Multidisabilities. The analysis
and reflection on the observation and teaching components, as well as a description of the
participation in projects, events and meetings are also part of this chapter. At the end,
there is a critical reflection on the role of the Musical Education teacher, as well as a
general critical observation of the pedagogical practice.
Next, it is presented the implementation, analysis and reflection of the project
based on the theme of Soundscapes. The project and the activities carried out in a 5th
grade class, with a focus on musical exploration, improvisation and its interconnection
with poems written by the heteronyms of the poet Fernando Pessoa, are portrayed. Using
Soundscapes as a stimulus for musical creation and improvisation, this project seeks to
reflect on the importance that this theme has, not only in the creative skills of the students,
but also in its transversality to other areas of knowledge. Starting with vocal exploration,
this project reflects not only on the possibilities that this theme brings with regard to
individual musical creation, but also in small groups and in its potential as a pedagogical
tool using poetry as the creative material for a musical performance. Once the project’s
outputs have been presented and analysed, some considerations are made, as well as the
implications for the future of the project
A consulting lab on organic growth strategy for transactional track record (Ttr): analysis of Ttr-s potential growth opportunities
No full textThis project was developed between a SaaS firm providing private market intelligence through
an online platform and three Nova SBE students. The project explored growth possibilities for
the firm, with ambition to increase revenues 500% in the coming two years. The team worked
in collaboration with the d a three step holistic methodology: Diagnosis, Analysis and Implementation. These included analyses
of the market, internal capabilities, customer needs and competitors, as well as design thinking
workshops. The team concluded the project by providing a hierarchy of primary and secondary
recommendations, aimed at being impactful, actionable and sustainable
An Injectable Thermoreversible Hydrogel Loaded with ManNAc for GNE Myopathy
No full textFunding Information:
This research was funded by FCT/MCTES (PIDDAC, Portugal) under the programmatic projects UIDB/50020/2020, UIDP/50020/2020 and LA/P/0140/2020; and by the European Commission through GLYCOTwinning (Grant Agreement: 101079417), and Horizon 2020 research and innovation programme under the EJPRD COFUND-EJP N 825575 (EJPRD/0001/2020).
Publisher Copyright:
© 2025 IEEE.GNE myopathy (GNEM) is a rare adult-onset disease characterized by atrophy and weakness of skeletal muscles caused by mutations in the GNE gene. There is no approved therapy, but clinical trials with supplementation with N-acetylmannosamine (ManNAc) alleviated the GNEM-associated decrease in sialylation. Nevertheless, oral intake of ManNAc has shown low absorption and high gastrointestinal adverse effects. In this regard, the aim of this work was to explore an alternative delivery route for ManNAc directly targeting the muscle tissues. For this we investigated the thermal responses of Pluronic F-127 gel and its muscle adhesion after subcutaneous injection, and the kinetics of release of gelencapsulated ManNAc in phosphate buffered saline medium. The results obtained show the thermal response of Pluronic F-127 represents a unique opportunity for its injectability and function as a drug delivery system directly acting on the muscle surrounding area and showing gel stability in the target area. Moreover, the continuous delivery of ManNAc from the gel (20% Pluronic F-127) was detected during 3h, at a continuous rate and slower than using a simple ManNAc solution. In conclusion, the data obtained in this work supports the possible use of the Pluronic F-127 thermoreversible hydrogel loaded with ManNAc in GNE myopathy therapy and research.authorsversionpublishe
Spark by Hilton: exploring strategic market entry in the Iberian Peninsula strategic positioning
No full textThe present thesis explores the strategic market entry opportunity of a new premium economy
hotel brand, Spark by Hilton, into the Iberian Peninsula. It examines the viability of this market
segment, identifies optimal regions, and analyses possible brand adaptations to ensure viability
and success. Employing a mixed-methods approach, and including a competitor analysis,
SWOT evaluation, and cultural insights via Hofstede’s model, the study highlights challenges
like market saturation, cultural alignment, and sustainability demands, providing thought through recommendations that emphasize the need for balancing global brand consistency with
local strategies to ensure successful entry and sustainable growth in this competitive landscape
Relatório de Estágio no Gabinete de Estudos Olisiponenses
No full textEste relatório é fruto da minha experiência de estágio no Gabinete de Estudos
Olisiponenses, organismo da Câmara Municipal de Lisboa, realizado enquanto
componente não-letiva do Mestrado em Edição de Texto, da Faculdade de Ciências
Sociais e Humanas da Universidade Nova de Lisboa.
A exposição das tarefas realizadas será articulada com uma reflexão sobre a minha
experiência enquanto revisora textual de textos científicos, a minha principal função.
Falarei ainda de todas as outras tarefas e oportunidades que tive, como a revisão de um
panfleto e as visitas guiadas a organismos da Câmara Municipal.This report is the result of my internship experience at the Gabinete de Estudos
Olisiponenses, an organism of the Lisbon City Council, carried out as a non-taught
component of the Master's degree in Text Editing at the Faculty of Social Sciences and
Humanities of NOVA University of Lisbon.
The exposure of the tasks carried out will be combined with a reflection on my
experience as a proofreader of scientific texts, my main role. I will also talk about all the
other tasks and opportunities I had, such as proofreading a pamphlet and the guided tours
to several organisms of the Lisbon City Council
Communications plan: how to make Santander the bank of choice for young adults in Portugal
No full textSantander Portugal’s position in the young adults' segment is weaker than desired. This project develops a detailed marketing plan for Santander Portugal, intending to achieve market leadership in the young adults’ segment. Secondary and primary research were conducted to obtain a holistic overview of the market, the company, and the target. This research was then used to develop a new and modified service mix for Santander, including two sub-brands, Santander Universidades and Santander Jovens Profissionais, followed by a financial analysis of the project
Stream IMC - how to leverage sogrape´s wine business in the Uk: promotion
No full textThe aim of this individual assignment was to determine the most appropriate brand activations (including promotions, such as trade promotions and consumer promotions) to be utilized in the re-launch of the Casa Ferreirinha fine wines -Vinha Grande, Callabriga and Quinta da Leda. As one of the main objectives of the marketing plan was to increase distribution, trade promotions were emphasized. The proposed strategy also includes consumer promotions (sampling) and experiential marketing
A nutritional supplement company on its sale
No full textMergers and acquisitions are important components of corporate development. This case
study examines the sell-side process of a nutritional supplement company alias “Ursette”
to a competitor alias “Leaf”. M&A advisors supported the shareholders of Ursette on the
sale to the private equity-backed company, Leaf. A private equity investor has recently
acquired a majority stake in Leaf, and the acquisition of Ursette is the first growth
acquisition under new ownership. Despite macroeconomic uncertainties and a tight
consumer economic environment, the advisors and the shareholders were able to find a
suitable partner and generated strategic value add
Stori: developing problem-solution fit for a peer-to-peer storage start-up
No full textThis study presents a comprehensive study of the development and validation of STORi, a peer to-peer storage platform. Through a series of experiments, the research explores the problem solution fit, focusing on value proposition, customer segmentation, and key activities.
Combined with further experiments on the product-market fir, the findings suggest that the
current marketing strategies may not effectively resonate with the target audience. The study
underscores the importance of continuous testing and refinement of assumptions regarding the
Business Model Canvas to enhance engagement and success